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All Journal Elkawnie Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Al-Kimia Adi Widya : Jurnal Pengabdian Masyarakat JMM (Jurnal Masyarakat Mandiri) Pharmasipha Lex Librum: Jurnal Ilmu Hukum Jambura Journal of Chemistry Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Journal of English Language and Education Indonesian Journal of Pharmaceutical Education Jurnal Kolaboratif Sains Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Journal of Business Management and Economic Development JAPB Parapemikir Jurnal Ilmiah Farmasi International Journal of Multilingual Education and Applied Linguistics Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products Jurnal Riset dan Pengabdian Interdisipliner SIMPUL: Jurnal Ilmu Politik dan Hukum Lex Librum : Jurnal Ilmu Hukum
Muhammad Taupik
Jurusan Farmasi, Fakultas Olahraga Dan Kesehatan, Universitas Negeri Gorontalo
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Pembaharuan Undang-Undang Nomor 40 tahun 2007 Tentang Perseroan Terbatas Dalam Rangka Memaksimalkan Program Tanggung Jawab Sosial Lingkungan Hamzah, Rosyidi; Adinda, Fadhel Arjuna; Admiral, Admiral; Taupik, Muhammad; Amin, Muhammad Nur
Lex Librum : Jurnal Ilmu Hukum Vol. 11 No. 1 (2024): Desember
Publisher : Sekolah Tinggi Ilmu Hukum Sumpah Pemuda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46839/lljih.v11i1.904

Abstract

Article 74 of Law Number 40 of 2007 concerning Limited Liability Companies establishes social and environmental responsibilities for companies operating in or related to natural resources. Companies based on information and technology must also be accompanied by changes in legal norms, especially in the field of implementing environmental social responsibility. According to Law Number 40 of 2007 concerning Limited Liability Companies, only companies whose business activities are related to natural resources or businesses that impact the environment are subject to environmental social responsibility, while IT startups and digital businesses do not disturb natural resources and do not affect the environment. Changes in society are indeed followed by changes in legal norms. The older a law gets, the more weaknesses and shortcomings it will have. Changes in norms governing environmental social responsibility must be adjusted to the current business climate. Environmental Social Responsibility should also be mandated for companies operating in the digital business sector. To maximize environmental social responsibility for large companies operating in the digital business sector, it must be supported by adequate legal norms.
Efektivitas Metabolit Sekunder Fungi Endofit Tumbuhan Mangrove (Rhizophora Mucronata Poir) Terhadap Biofilm Bakteri Yang Diisolasi Dari Nasogastric Tube: The Effectiveness of Secondary Metabolites of Endophytic Fungi from Mangrove Plants (Rhizophora Mucronata Poir) Against Bacterial Biofilms Isolated from Nasogastric Tubes Adinda Mutmainnah Putri Rumiki; Mahdalena Sy. Pakaya; A. Mu'thi Andy Suryadi; Muhammad Taupik; Multiani S. Latif
Jurnal Kolaboratif Sains Vol. 8 No. 12: Desember 2025
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v8i12.9142

Abstract

Biofilm adalah komunitas mikroorganisme dan produk ekstraselulernya yang melekat pada permukaan, baik biologis maupun nonbiologis. Keberadaan biofilm ini melindungi bakteri dari sistem imun dan pengobatan antibiotik. Pada alat medis seperti Nasogastric tube (NGT), biofilm berpotensi menyebabkan komplikasi klinis, termasuk infeksi saluran pencernaan, resistensi antibiotik, hingga infeksi sistemik. Penelitian ini bertujuan mengetahui efektivitas metabolit sekunder fungi endofit tumbuhan mangrove (Rhizophora mucronata) terhadap bakteri biofilm yang diisolasi dari NGT. Metode yang digunakan adalah eksperimental, melibatkan uji optimasi pembentukan, uji pencegahan, uji penghambatan, dan uji penghancuran biofilm. Hasil uji optimasi menunjukkan positif pada kedua media, dengan pembentukan biofilm ditandai perubahan warna bening menjadi ungu dari atas tabung sampai pangkal bawah tabung. Pada uji pencegahan biofilm mendapatkan hasil yang baik pada bakteri uji biofilm NGT pasien A dengan nilai intensitas MGV sebesar 123,80, sedangkan uji penghambatan hasil yang baik pada bakteri uji biofilm NGT pasien A dengan nilai MGV sebesar 119,38, sedangkan uji penghancuran hasil yang baik didapatkan pada bakteri uji biofilm pasien A dengan nilai MGV 120,34. Nilai MGV tersebut melebihi skala minimal di bawah 10% MGV tabung kosong. Dengan demikian, Metabolit sekunder fungi endofit tumbuhan mangrove dapat mencegah, menghambat, dan menghancurkan bakteri biofilm yang diisolasi dari Nasogastric tube pasien A.
Evaluasi Kepatuhan Minum Obat Pada Pasien Pengidap Hiperkolesterolemia Di Puskesmas Kota Selatan Saputro, Prio Adi; Abdulkadir, Widy Susanti; Manno, Mohamad Reski; Taupik, Muhammad; Anggai, Rifka Anggraini
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Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jrpi.v3i1.36623

Abstract

Hypercholesterolemia is a condition in which blood cholesterol levels exceed the normal range, representing a major public health concern. This condition is closely associated with cardiovascular diseases, which, according to the WHO (2018), are the leading cause of death worldwide. The increasing prevalence of high cholesterol in Indonesia is influenced by changes in diet and lifestyle. Medication adherence plays a crucial role in achieving therapeutic success and optimal health outcomes. This study aimed to determine the level of medication adherence among patients with hypercholesterolemia at Kota Selatan Public Health Center (Puskesmas). The study employed a quantitative descriptive design using a survey method. The population consisted of 61 patients, with 31 respondents selected as the sample. The instrument used was the Morisky Medication Adherence Scale-8 (MMAS-8), and the data were analyzed using univariate analysis. The results showed that the level of medication adherence among patients was moderate, with 17 respondents (54,83%) categorized as adherent and 14 respondents (45,17%) as non-adherent. The highest adherence was observed among patients aged 24-44 years (100%), males (75%), those with a diploma or bachelor's education (86%), and those undergoing treatment for less than one year (67%). Overall, the level of medication adherence among patients with hypercholesterolemia at Kota Selatan Public Health Center was classified as moderate. Increased education and patient support are recommended, particularly for older adults, women, and those with education levels, to enhance treatmentt success.
PENAPISAN FITOKIMIA DAN UJI TOKSISITASFRAKSI DAUN KAYU PUTIH (Malaleuca leucadendraL.) DENGAN METODEBrine Shrimp Lethality Test (BSLT) A. Djakaria, Abdul Rahman; Hasan, Hamsidar; Taupik, Muhammad; Papeo, Dizky Ramadani Putri; Uno, Wiwit Zuriati; Anggai, Rifka Anggraini
Journal of Pharmacology and Natural Products Vol. 3 No. 1 (2026): Volume 3, Nomor 1, Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Melaleuca leucadendramerupakan salah satu tanaman yang memiliki potensi sebagai obat tradisional.Tujuan penelitian ini adalah untuk mengidentifikasi komponen kimia dan menguji efek toksisitasdengan metode Brine Shrimp Lethality Test (BSLT) pada fraksi daunkayu putih (Malaleuca Leucadendra).Metode ekstraksi yang digunakan adalah maserasi bertingkat dengan pelarut berdasarkan tingkat kepolaran yang berbeda yaitu n-heksan, klorofrom, etil asetat dan metanol.Identifikasi komponen kimia dengan menggunakan uji tabung dan uji KLT, pengujian toksisitas menggunakan metode Brine Shrimp Lethality Test (BSLT).Hasil skrining fitokimia semua fraksi yaitu n-heksan, klorofrom, etil asetat dan methanol positif mengandung senyawa alkaloid, flavonoid, tanin, terpenoid. Hasil pengujian toksisitas menggunakan larva udang dengan fraksi n-heksan, kloroform, etil asetat dan metanol didapatkan diperoleh nilai LC50masing-masing sebesar 218,43µg/mL; 81.20 µg/mL; 111,85 µg/mL; dan 58,52 µg/mL. Semua nilai LC50 termasuk kedalam kategori toksik.
Effect of Centrifugation on Nanoemulsion Stability with Tween, PEG, Poloxamer 188, and Transcutol-p Rahmola, Fauziah; Mustapa, Mohamad Adam; Paneo, Mohamad Aprianto; Djuwarno, Endah Nurrohwinta; Taupik, Muhammad
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 1 (2026): Volume 3 Nomor 1 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i1.271

Abstract

This study evaluated the effect of centrifugation speed on the physical stability of a nanoemulsion base formulated with grapeseed oil (long-chain triglyceride, LCT) and stabilized using Tween 80–PEG 400, Poloxamer 188, and Transcutol-P, as a preliminary platform for topical and oral pharmaceutical applications. A descriptive–experimental design was employed. Nanoemulsion bases were prepared by the aqueous titration method followed by 60-minute sonication. Four formulations (F1–F4) contained 5% grapeseed oil and 2% Poloxamer 188, while Tween 80/PEG 400 levels and Transcutol-P (0.5–2%) were varied. Accelerated physical stability was assessed by centrifugation at 2000, 4000, 6000, and 8000 rpm for 30 minutes, followed by organoleptic observation, emulsion type determination, pH measurement, and viscosity testing. All formulations remained visually stable at 2000 rpm. At 4000 rpm, F1–F2 showed increased turbidity with a thin top layer (incipient creaming), whereas F3–F4 remained stable without phase separation. At 6000 rpm, F1–F2 became more turbid with the onset of a surface oil layer, while F3–F4 maintained stability. At 8000 rpm, F1–F2 exhibited complete phase separation; F3 showed a slight oil layer; and F4 was the most stable, showing only minimal turbidity without total phase breaking. All formulations were classified as oil-in-water (O/W). The pH ranged from 6.0 to 7.0 (mean 6.45 ± 0.42) and viscosity from 176 to 220 cP (mean 196.25 ± 18.89). In conclusion, increasing centrifugation speed effectively differentiated formulation robustness, with F4 demonstrating the highest resistance to mechanical stress up to 8000 rpm.
Characterization of Tannic Acid Chemically Crosslinked PVA Chitosan Hydrogel Upara, Nana Nurindah; Taupik, Muhammad; Latif, Multiani S; Rasdianah, Nur; Suryadi, A. Mut’hi Andy
Jurnal Farmasi Teknologi Sediaan dan Kosmetika Vol. 3 No. 1 (2026): Volume 3 Nomor 1 Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jftsk.v3i1.287

Abstract

Hydrogel is a hydrophilic material that can absorb and retain large amounts of water through the formation of hydrogen bonds between polymer functional groups to form a stable three-dimensional network. The physicochemical characteristics of hydrogels are greatly influenced by the cross-linking process that determines the network density and stability of the preparation. This study aims to determine the effect of variations in the concentration of tannic acid as a chemical crosslinker on the physicochemical characteristics of polyvinyl alcohol (PVA)-chitosan-based hydrogels. Hydrogels were formulated with varying concentrations of tannic acid of 1%, 3%, and 5%, then evaluated including organoleptic tests, pH, viscosity, spreadability, adhesion, swelling index, irritation test, and characterization using Fourier Transform Infrared (FTIR). The results showed that increasing the concentration of tannic acid caused the formation of a denser hydrogel network, which was characterized by a decrease in the swelling index value and an increase in adhesion and changes in viscosity. The pH values ​​of all formulas were within the physiological pH range of the skin. Irritation tests on 20 panelists showed that all formulas did not cause irritation reactions. FTIR analysis confirmed the presence of molecular interactions between PVA, chitosan, and tannic acid through hydrogen bond formation. Overall, variations in the concentration of tannic acid as a chemical crosslinker affected the physicochemical characteristics of the PVA–chitosan hydrogel and resulted in stable preparations with good quality
Isolasi Dan Karakterisasi Mikroba Endofit Penghasil Enzim Katalase dari Tanaman Manggis (Garcinia mangostana L.) Djuwarno, Endah Nurrohwinta; Pakaya, Mahdalena Sy.; Taupik, Muhammad; Hasan, Hamsidar; sri, Sri Budiarti Utami
Journal of Pharmacology and Natural Products Vol. 3 No. 1 (2026): Volume 3, Nomor 1, Tahun 2026
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jpnp.v3i1.138

Abstract

Mikroba endofit adalah mikroba yang hidup di dalam jaringan tumbuhan dan mampu membentuk koloni dalam jaringan tumbuhan tanpa memberikan efek negatif pada inangnya. Mikroba Endofit dapat berupa bakteri maupun jamur. Bakteri atau jamur tersebut dapat menghasilkan senyawa metabolit yang dapat berfungsi sebagai antibiotik, antivirus, antikanker, antidiabetes, antimalaria, antioksidan, antiserangga, zat pengatur tumbuh dan penghasil enzim. Penelitian ini bertujuan untuk mengisolasi serta mengkarakterisasi secara makroskopik dan mikroskopik mikroba endofit dari tanaman manggis (Garcinia mangostana L.). Penelitian ini menggunakan metode eksperimental yang dilakukan di Laboratorium Mikrobiologi Farmasi dengan metode Direct planting untuk isolasi serta pengamatan morfologi secara makroskopis dan mikroskopis untuk karakterisasi. Hasil Isolasi didapatkan 6 isolat mikroba endofit yaitu 2 isolat bakteri endofit (BA1 dan BA2) dan 4 isolat jamur endofit (JA1, JD1, JD2 dan JK) dengan ciri karakteristik yang berbeda antara satu dengan yang lain.
Co-Authors A Admiral A. Djakaria, Abdul Rahman A. Mu'thi Andy Suryadi A. Mu’thi Andy Suryadi A. Mu’thi Andy Suryadi A. Mu’thi Andy Suryadi Abdi Dzul Ikram Hasanuddin Adam Mustapa, Moh Adam Mustapa, Muhammad Adinda Mutmainnah Putri Rumiki Adinda, Fadhel Arjuna Ahmad Farhani AM. Andy Suryadi Amin, Muhammad Nur Andi Suryadi, A. Mu’thi Andy Suryadi, A. Mu'thi Andy Suryadi, A. Mu’thi Anggai, Rifka Anggraini Antuli, Zikran Nazar Antuli Aprianto Paneo, Mohamad Ariani H. Hutuba Ariani H. Hutuba Banne, Pratiwi Zesika Beby Bestari Djuarno, Endah Nurrohwintah Dr. Apt. Hamsidar Hasan S.Si.,M.Si Endah Nurrohwinta Djuwarno Faramita Hiola Febriana, Afifah Jihan Friskawati Hanapi Gita Potabuga Hamzah, Rosyidi Harwanto, Yelisnawati Hayati, Rahmi Hiola, Faramita Hutuba, Ariani Ishak Isa Ismail, Rahmawati Jafar La Kilo Jamiah Jamiah, Jamiah Julianty Akuba Kaino, Ratni Kasim, Sesha Ramadhani Khairil Pahmi kopman, aldafarista Krisdianti, Nana La Ode Aman LATIF, MULTIANI S Liansyah Angga Saputra Madania . Madania, Madania Mahdalena Sy Pakaya mahdalena sy. pakaya Makkulawu, Andi Maku, Mohamad Aditya Manno, Mohamad Reski Moh Adam Mustapa Mohamad Adam Mustapa Mohamad Aprianto Paneo molote, kasibee molote Muh. Ihsan Muhamad Handoyo Sahumena Muhamad Handoyo Sahumena Muhammad Nur Amin Muhammad Ricky Ramadhian Muhammad Rizal Firmanda Aditya Mursyidah, Andi Nana Krisdianti Nur Ain Thomas Nur Oktaviana Nur Rasdianah Nuri Suryani Nurul Istiqomah Pakaya, Juniarista Jessica Panu, Karmila Papeo, Dizky Ramadani Putri Payuyu, Alifia Pradana, Riski Puluhulawa, Lisa Efriani Radjak, Fahmi As Rahmawati, Nuzu Rahmola, Fauziah Ramadhan L, Aditya Rannu, Jumriani Riska Wahyuni, Nor Riski Pradana Robert Tungadi S. Latif, Multiani Saputro, Prio Adi Selvi Marcellia Singgih Subiyantoro Siti Surya Indah Nurdin Sitti Gonibala, Sintia sri, Sri Budiarti Utami Suryadi, A Mu'thi Andy Suryadi, A. Mu'thi Andy Suryadi, A. Muthi Andi Suryadi, A. Mut’hi Andy Suryani, Nuri Teti Surriyati Tuloli Teti Sutriyati Tuloli Teti Sutriyati Tuloli Upara, Nana Nurindah Widy Susanti Abdulkadir Widy Susanti Abdulkadir Wiwin Rewini Kunusa Wiwit Zuriati Uno Zulfikar Ahmad