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All Journal International Journal of Public Health Science (IJPHS) Majalah Kedokteran Bandung Althea Medical Journal Nexus Biomedika Nexus Kedokteran Translasional Jurnal Riset Kesehatan Majalah Obat Tradisional The Indonesian Biomedical Journal Smart Medical Journal Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kesehatan Manarang Al-sihah: The Public Health Science Journal Indonesian Journal of Medicine Journal of Maternal and Child Health Indonesia Jurnal Kebidanan YARSI Medical Journal Jurnal Review Pendidikan dan Pengajaran (JRPP) Abdimas Universal World Nutrition Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Abdidas Indonesian Journal of Global Health research Nusantara Science and Technology Proceedings Narra J Proceeding ISETH (International Summit on Science, Technology, and Humanity) Biocaster : Jurnal Kajian Biologi Literasi Kesehatan Husada: Jurnal Informasi Ilmu Kesehatan Jurnal Pendidikan Kesehatan Media Penelitian dan Pengembangan Kesehatan Jurnal Info Kesehatan
Ida Nurwati
Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Biocaster : Jurnal Kajian Biologi

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The Role of Interleukin 1β, Fibroblast Growth Factor, Fibroblasts, Keratinocytes, Granulation Tissue and Collagen Density in the Wound Healing Phase (Study of Wound Healing in the Inflammation, Proliferation, and Remodeling Phases) Christanto, Antonius; Cilmiaty, Risya; Setiamika, Made; Yudhani, Ratih Dewi; Dirgahayu, Paramasari; Pamungkasari, Eti Poncorini; Nurwati, Ida
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.399

Abstract

This scoping review explores the roles of interleukin 1β, fibroblast growth factor, fibroblasts, keratinocytes, granulation tissue, and collagen density in the wound healing process, focusing on inflammation, proliferation, and remodeling phases. A systematic literature search identified studies investigating molecular and cellular mechanisms involved in wound repair. Findings reveal that fibroblast-derived exosomes carrying miR-93-5p inhibit autophagy, delaying diabetic wound healing. Controlled growth factor delivery enhances angiogenesis, fibroblast proliferation, and collagen deposition, accelerating tissue regeneration. SPRR1B+ keratinocytes facilitate rapid re-epithelialization, while granulation tissue provides essential scaffolding for cell migration and neovascularization. Elevated IL-1β impairs healing by increasing matrix metalloproteinases, degrading collagen. Natural compounds like red fruit oil and Binahong leaf extract promote angiogenesis and collagen synthesis. Genetic variations in inflammatory cytokines influence healing outcomes, indicating potential for personalized therapies. This review consolidates current evidence, providing insights into cellular and molecular interactions critical for effective wound repair and guiding future regenerative medicine strategies.
Co-Authors A. Guntur Hermawan Adi Prayitno Ambar Mudigdo Anik Lestari Asrial, An A. Baihaqy, Fathu Thaariq Bambang Purwanto Betty Saptiwi Betty Saptiwi Betty Saptiwi Brian Wasita Christanto, Antonius Danus Hermawan Danus Hermawan Dicky Maulana Lazuardi Diding H P Diding Heri Prasetyo Diding Heri Prasetyo Dono Indarto Dyah Rahmawatie Ratna Budi Utami Dyah Ratna Budiani Dyah Ratna Budiani Dyah Ratna Budiani Eriana Melinawati Eric Edwin Yuliantara Eti Poncorini Pamungkasari Fadhilah, Azzahra Nur Fahmi, Muhammad Izzul Widad Gresmita Rindi Winarti Hadi, Cahyono Harioputro, Dhani Redhono Hermawan, Danus Hermawan, Danus Ika Tristanti Indri Erwhani Jarot Subandono Jarot Subandono Jarot Subandono Khoirunnisa, Rahmi Lazuardi, Dicky Maulana Mahendra, Fadia Yuda Martini Martini Martini Martini Martini Martini Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Mutmainah Mutmainah Nabila Aushaf Prasetyo Nafisa, Putri Amalina Nanang Wiyono Noni Kartika Sari Nugroho, Anung N. Nur Hafidha Hikmayani Nur Hafidha Hikmayani Nutria Widya Purna Anggraini Octavia, Dhamayanti Eka Pamungkasari, Eti P. Paramasari Dirgahayu Prihandjojo Andri Putranto Pudjiastuti, Anggit Putranto, R. Prihandjojo Andri Putranto, Wachid Rachmi Fauziah Rahayu Rahardjo, Setyo Sri Ratnasari Ratnasari Reviono Reviono Risya Cilmiaty A. R. Risya Cilmiaty AR Risya Cilmiaty, Risya Rosyida, Rufaida Rusliana, Eka Sari, Noni Kartika Sarsanti, Arifa Sherina Noor Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Selfi Handayani Selfi Handayani Selfi Handayani Selfi Handayani Setiamika, Made Setianto, Budi Y. Sigit Setyawan Sineri, Dessy Ikasartika Siti Aisyah Siti Marufah Soetrisno Soetrisno Soewondo, Widiastuti Sri Hartati Hadinoto Sri Haryati Sri Sulistyowati Sumardiyono Sumardiyono Sumardiyono, S Tonang Dwi Ardyanto Uki Retno Budihastuti Vitri Widyaningsih Wahyu Anjas Sari Wesliaprilius, Todung Antony Wiyono, Nanang Wuriani, Wuriani Yarso, Kristanto Y. yoseph Indrayanto Yudhani, Ratih Dewi Yulia Sari Yulyanti, Yulyanti