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Dian Ratih Laksmitawati
Universitas Pancasila
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Journal of Social Research

 1 
Study Of The Anti-Obesity Potential Of Chlorogenic Acid Through Molecular Docking Faridah, Faridah; Mumpuni, Esti; Purnomo, Hari; Laksmitawati, Dian Ratih; Simanjuntak, Partomuan
Journal of Social Research Vol. 3 No. 2 (2024): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v3i2.1910

Abstract

Chlorogenic acid, the primary constituent found in green coffee, is believed to possess anti-obesity properties. Numerous studies have indicated that the etiology of obesity is predominantly influenced by genetic factors. This study employs molecular docking techniques to estimate the effectiveness and toxicity of chlorogenic acid as an anti-obesity agent, focusing on its interaction with PLANTS. Initially, the validation process involved confirming the target cell or receptor (PDB code) which included PPAR-? (3NOA, 2ATH), pancreatic lipase (5ZUN), ghrelin (6ZYF), leptin (3V6O), and melanocortin (6W25, 7F58) through the utilization of YASARA software. In addition, the process of docking chlorogenic acid compounds and a positive control (for comparative purposes) was conducted on target cells utilizing the PLANTS program. The toxicity test and prediction of lethal dose (LD 50) were conducted on active substances and positive controls using the ProTox-II program. Chlorogenic acid exhibits anti-obesity properties by acting as an inhibitor of the ghrelin hormone, as seen by its activity at PDB code 6ZYF with a docking score of -19.7099 higher than the positive controls bupropion -18.5269 and naltrexone -18.5871. Furthermore, it has been determined to possess a generally safe profile, with an LD50 value of 5000 mg/kg body weight. The docking studies indicate that chlorogenic acid exhibits anti-obesity activity specifically at PDB code 6ZYF, where it functions as an inhibitor of the ghrelin hormone. Chlorogenic acid typically exhibits modest efficacy as an anti-obesity agent, hence presenting potential avenues for enhancing its effectiveness by structural modifications
Co-Authors . Syamsudin Ahmad Faried Ana Yupita Liza Andayani, Nurita Andreas Infianto Ani Retno Prijanti Annisa Septyana Putri Ayu Werawati Bagus Bahtiar Bambang Ponco Priosoeryanto Cahyaning Riski Wijayanti Caroline Tan Sardjono CAROLINE TAN SARDJONO Chandra, Pra Panca Bayu Claudia Tiffani Dedy Kurniawan Deni Rahmat Deni Rahmat Devina Harti Syaputri Diah Kartika Pratami Diar Gustianti Istita Edwin Tomasoa Effionora Anwar Effionora Anwar Elisabeth Ninung Yuliarti Esti Mumpuni Esti Mumpuni Esti Mumpuni Esti Mumpuni, Esti Faradiba Faradiba Faridah Faridah Ferry Sandra Hanna Sari W Kusuma Hanna Sari Widya Kusuma HARI PURNOMO Hendig Winarno Hendig Winarno Hesti Utami Ramadaniati Hesti Utami Ramadaniati Hikariastri, Pangartika Indah Zahara Ivans Panduwiguna James Ibrahim Jayati, Turpuk Mannaria Jeanette Mangiwa Jeanne A. Pawitan Jeanne Adiwinata Pawitan Juliana Irem Adriana Purukan Katharina Aditya Candra Utukaman Kusmardi Kusmardi Kusmardi Kusmardi Laili Savitri Noor Laksono Trisnantoro Larasinta, Nadia Lia Warti Liliek Nurhidayati Magdalena Niken Oktovina Marwati, Umi Marybet Tri Retno Handayani Meilda Ayu Bathini Mita Restina Moch Futuchul Arifin Mohamad Sadikin Mohammad Sadikin Mokhamad mahroji Muhammad Hanafi Mulatsari, Esti Noor, Laili Savitri Novia Maulina Novia Maulina Nuraini Nuraini Nurita Andayani Okta, Fauzia Noprima Oriza Safrini Oriza Safrini Panca, Pra Panca Bayu Chandra Pangartika Hikariastri Partana, Citra Prastuti Partomuan Simanjuntak Patminingsih, Nanik Pra Panca Bayu Chandra Pra Panca Bayu Chandra Prasasta Sutedjo Prih Sarnianto Prih Sarnianto Prih Sarnianto Prilasari, Sharon Alia Rachmawati Noverina RAHMAT, DENI Rahmawati, Siti Irma Ramadaniati, Hesty Utami Ranald Irwanto Ratih Rinendyaputri Renni Septini Rikkit Sihombing Rilianawati Rilianawati Riska Eka Putri, Riska Eka Rizal Rizal Rizal Rizal Ronald Irwanto Ronald Irwanto Natadidjaja Ros Sumarny Ros Sumarny ROS SUMARNY Rudi Asmajaya Sahat Saragi Sampurno Sampurno Sampurno Sampurno Sarwono Waspadji Seila Arumwardana Selvy Devita Anggeraini Shelly Taurhesia Simbolon, Roslan Simbolon, Roslan Siti Umroh Noor Sutarno Syamsudin Abdillah Teulis Sumiartini Tomasoa, Edwin Trisna Lestari Umi Marwati Utukaman, Katharina Aditya Candra Vergie Indriani Wahono Sumaryono Wahyu Widowati Wahyu Widowati Wireni Ayuningtyas Yoppy Mayrosa Yudha Sukowati Yusi Anggraini Yusi Anggriani Yusi Anggriani Zahara, Indah