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All Journal Mechatronics, Electrical Power, and Vehicular Technology JURNAL TEKNOLOGI LINGKUNGAN Abdimas Medical Journal of Indonesia CHEMPUBLISH JOURNAL Universa Medicina Jurnal Kreativitas PKM Jurnal Respirologi Indonesia Jurnal Respirasi (JR) PREPOTIF : Jurnal Kesehatan Masyarakat Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Informa: Jurnal Penelitian dan Pengabdian Masyarakat Jurasik (Jurnal Riset Sistem Informasi dan Teknik Informatika) Jurnal Pendidikan Guru Jurnal Farmasi dan Sains Indonesia (JFSI) JOURNAL LA MEDIHEALTICO Jurnal Pengabdian Masyarakat (ABDIRA) Innovative: Journal Of Social Science Research Musyarakah: Journal of Sharia Economics (MJSE) PCJN Pharmaceutical and Clinical Journal of Nusantara Accounting Analysis Journal Jurnal Sains dan Kesehatan Jurnal Ilmiah Nusantara Research In Management and Accounting (RIMA) Toga Jurnal Keguruan dan Ilmu Pendidikan Preventif : Jurnal Kesehatan Masyarakat
Arif Santoso
Research Center for Electrical Power and Mechatronics, Indonesian Institute of Sciences, Komp. LIPI Bandung, Jl. Sangkuriang, Gd. 20. Lt. 2, Bandung 40135
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Suppression of Staphylococcus epidermidis Skin Wound Infection by Citrus aurantifolia Lime Peel Ethanolic Extract: A Concentration-Response Analysis Putri, Amalia Eka; Santoso, Arif; Ginaris, Rifkarosita Putri
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 2 No. 01 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v2i03.56

Abstract

Staphylococcus epidermidis is a coagulase-negative Staphylococcus (CoNS) that causes a spectrum of superficial skin infections including wound infections, folliculitis, and burn-associated skin sepsis, particularly through its capacity to form highly resistant biofilms. The emergence of methicillin-resistant S. epidermidis (MRSE) with polysaccharide intercellular adhesin (PIA)-mediated biofilm has severely limited available therapeutic options. This study assessed the concentration-dependent bacteriostatic activity and minimum inhibitory concentration (MIC) of Citrus aurantifolia lime peel ethanolic extract against S. epidermidis ATCC 12228 using the Kirby-Bauer disc diffusion method on Muller Hinton Agar (MHA). Extract from lime peels sourced in Tulungagung, East Java was prepared by ethanol maceration. Fourteen concentrations (0.5–150 mg/mL) were tested in triplicate. The MIC was 1 mg/mL (inhibition zone 6.73 ± 0.06 mm). Inhibition zones increased progressively from 6.73 mm (MIC, 1 mg/mL) to 11.60 ± 0.35 mm (150 mg/mL), with the very strong threshold (>10 mm) first crossed at 70 mg/mL. Concentration-response linearity was confirmed (R² > 0.97). The positive control (tetracycline 30 µg) produced 28.17 ± 0.59 mm. These findings establish a pharmacological basis for incorporating lime peel extract into wound care and topical antiseptic formulations targeting S. epidermidis.
Co-Authors Abdul Azis, Asrul Adib Khusnul Rois, Adib Khusnul Adnan, Endy Amir Mahmud Ana Rima Setijadi Anas Fadli Wijaya Andarini, Sita Andromeda, Rossalyn Anggit Dwi Hartanto, Anggit Dwi Anggita, Dwi Anwar Muqorobin Arfiansyah, Mochammad Aris Asy'hari, Mohammmad Alif As’ad, Suryani Bukhari, Agussalim Candrakusuma, Muslih Choirul Huda Diyan Martha , Rahma Djaharuddin, Irawaty Elisna Syahruddin Ema Utami Ermayanti, Sabrina Estiko Rijanto Fathoni, M. Faiz Fauzi Ahmad Muda Hamid, Firdaus Haryati Haryati Hendri Maja Saputra Hidayat, Moulid Ida Ayu Putu Sri Widnyani Imanez, Ketzia Adrian Infianto, Andreas Irandi Putra Pratomo IRFAN IDRIS Iskandar, Harun Jasminarti, Ida Ayu Joko Prayitno Susanto Kholifah, Siti Nurriyatul Kinasih, Tutug Kumalasari, Nurul Chamidah Kurniawan, Ferry Dwi Laksmi Wulandari Lihawa, Nurjannah Liong Boy Kurniawan, Liong Boy Lukmanul Khakim Lukni Maulana Martanty Aditya, Martanty MARTHA, RAHMA DIYAN Marwah, Sry Midriem Mirdanies Milenia Tasya, Syavira Muadhifah, Afidatul Muadifah, Afidatul Muhammad Ilyas Mulyamin, Winda Mustafa, Maulana Saggaf Nawa Suwedi Ngibad, Khoirul Ning Iriyanti Noni Novisari Soeroso Nurdian Susilowati Nurjanah, Mutia Hariani Nurjannah, Mutia Hariani Prasenohadi, Prasenohadi Pratiwi, Widya Wahyu Putra, Andika Chandra Putrawan, Harry Azka Putri, Amalia Eka Rahayu, Selvia Rahma Diyan Martha Rahmawati, Rahmawati Ratu, Modestus Reba Anindyajati Pratama, Reba Anindyajati RIAN ANGGIA DESTIAWAN Riastus Nayanti Rifkarosita Putri Ginaris Rizqi Andry Ardiansyah Roni Permana Saputra Safitri, Yunita Diyah Santoso, Andintia Aisyah Sari Lestari Sari, Puji Novita Sari, Trianita Setyawan, Ungky Agus Sri Melati Munir Sri Suwarni Sukma Aditya Sulastri Sulastri Syahril, Erlin Syukroni, Azid Teguh Pudji Purwanto Tokumo, Kentaro Tri Rahardjo Sutardi Vikita Windarwati Vita Susanti Widaningsih, Yuyun Wijaya, Cathrine Meryani Wiriansya, Edward Pandu Wulandari, A. Ratna Yustisia, Ika Zaini, Jamal Zainuddin, Alfian