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All Journal International Journal of Public Health Science (IJPHS) Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Food and Pharmaceutical Science Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Berkala Ilmu Kesehatan Kulit dan Kelamin Majalah Obat Tradisional JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika Jurnal Penelitian Pendidikan IPA (JPPIPA) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Biologi Tropis Majalah Farmaseutik Media Farmasi PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Farmasi Indonesia Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Jurnal Abdimas Mahakam CERATA Jurnal Ilmu Farmasi SPEKTA (Jurnal Pengabdian Kepada Masyarakat : Teknologi dan Aplikasi) Jurnal Insan Farmasi Indonesia SINTA Journal (Science, Technology, and Agricultural) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Pharmaceutical Sciences and Research (PSR) Journal of Halal Science and Research Sciences of Pharmacy Jurnal Farmasetis Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram Journal of Food and Pharmaceutical Sciences CERATA Medical Sains : Jurnal Ilmiah Kefarmasian E-Amal: Jurnal Pengabdian Kepada Masyarakat Jurnal Kefarmasian Indonesia Pharmacon: Jurnal Farmasi Indonesia Indonesian Journal of Jamu Folia Medica Indonesiana
Nining Sugihartini
Fakultas Farmasi, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Formulation and Evaluation of a Sunscreen Spray Containing Butterfly Pea Flower (Clitoria ternatea) Extract as a Natural Antioxidant Rudi Kusuma, Nyoman; Sulistyani, Nanik; Sugihartini, Nining
Media Farmasi: Jurnal Ilmu Farmasi Vol. 23 No. 1 (2026): March 2026
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v23i1.31747

Abstract

Butterfly pea flower (Clitoria ternatea) is rich in anthocyanins with recognized antioxidant activity; however, its application in spray-based sunscreen formulations and its effect on photoprotective performance remain insufficiently explored. This study aimed to formulate and evaluate a sunscreen spray containing butterfly pea extract (BPE) in combination with ethylhexyl methoxycinnamate and to determine the optimal extract concentration based on antioxidant activity, SPF value, and formulation stability. Five formulations were prepared: F0 (without BPE), F1 (0% BPE + 0.8% BHT), and F2–F4 containing 1%, 2%, and 3% BPE, respectively. Evaluations included DPPH radical scavenging activity, SPF determination, antibacterial testing, and physical quality assessment. The antioxidant activity of BPE in spray formulations showed moderate activity, with IC₅₀ values of 90.53±1.0, 87.50±1.9, and 86.94±1.4 μg/mL for 1%, 2%, and 3% concentrations, respectively, compared to 49.90±0.9 μg/mL for the pure extract. Although the antioxidant activity in formulations was lower than the pure extract due to dilution effects, increasing BPE concentration significantly improved SPF values (27.36±2.7; 29.42±1.1; 31.98±0.9; p<0.05). No significant difference was observed between 2% and 3% concentrations in both antioxidant and SPF evaluations. Therefore, 2% BPE was considered the optimal concentration, offering comparable efficacy with improved material efficiency for potential industrial production. All formulations met acceptable physical quality parameters, while antibacterial activity was not observed. This study demonstrates the feasibility of incorporating C. ternatea extract into sunscreen spray systems and provides a scientific basis for developing plant-based antioxidant-enhanced photoprotective formulations.
Molecular Mechanisms of Sechium edule Based on Network Pharmacology and Molecular Docking on Hypertension Santoso, Rahmat; Kintoko; Sugihartini, Nining
Jurnal Penelitian Pendidikan IPA Vol 12 No 2 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i2.14114

Abstract

Chayote is a fruit that has been used for centuries to treat various diseases, including hypertension. However, how the chemical compounds derived from chayote work in treating hypertension remains unclear. Integrating molecular docking and network pharmacology to elucidate the active constituents and potential mechanisms of chayote in treating hypertension. Initially, 50 active compounds from chayote and 97 key targets related to hypertension were identified through network pharmacology analysis. Then, the results of molecular docking and simulations showed: gibberellin A4; gibberellin A7; gibberellin A29; gibberellin A38; gibberellin A44; stigmasta-3,5-dien-7-one; stigmasterol and routinely overcome hypertension through the regulation of ACE, AKT1, ALB, SRC, and TNF genes. These compounds and genes may be key factors of chayote fruit in treating hypertension. Pathway enrichment analysis showed that the antihypertensive effect of chayote is regulated by the gibberellin A7 and TNF signaling pathways. These pathways are primarily associated with anti-oxidative stress, anti-inflammatory responses, and β-cell protection. This study identified the active constituents and potential signaling pathways involved in the antihypertensive effect of chayote. Result: These findings provide a theoretical basis for understanding the mechanism of the antihypertensive effect of chayote. Furthermore, this study may help develop health supplements or natural antihypertensive drugs based on chayote.
Co-Authors . Sismindari Achmad Fudholi Achmad Fudholi Achmad Fudholi Achmad Fudholi Aditya Noviadi Rakhmatullah Afriyani, Neti Agung Putu S.P.Kristyawan Aina Fatkhil Haque, Aina Fatkhil Aji Pamungkas Alvionida, Fitra Amraini Amelia Ani Guntarti Any Guntarti Any Guntarti Arif Budi Setianto Astryna, Syarifah Yanti Atri Sri Ulandari Auliah Rahmi Latif Azis Ikhsanudin Bayu Herdi Al Huda Deasy Vanda Pertiwi Delia Komala Sari, Delia Komala Desrianti, Cindy Desyandri Desyandri Diah Pratimasari Diyan Sakti Purwanto Diyan Sakti Purwanto Endah Nurlaela Endah Nurlaela Endang Lukitaningsih Erma Pranawati ERMAWATI, DIAN EKA Erna Astuti Erna Astuti Erwin Fauzana Evi Nuryanti Fadzil Latifah Firsty, Girly Risma Fitra Alvionida Fitri Rahmawanti Fitriah Ardiawijianti Iriani Fudholi, Achmad Fudholi, Achmad Gina Lestari Gina Lestari, Gina Girly Risma Firsty Gita Puspita Hafid, Indah Fitria Hana Hanifah Hari Susanti Hari Susanti Heru Sasongko Ichwan Ridwan Rais Iis Wahyuningsih Jannah, Syauqul Kintoko Kintoko Kintoko Kintoko, Kintoko Kurniawan, Muhammad Fariez Laela Hayu Nurani Laila, Wahyu Kumil Lalu Muhammad Irham Lela Sulastri, Lela Lena Maulina Lena Maulina, Lena M Alif Fajri Marchaban . Miratun Syarifah Mohamad Ikram Muhammad Alfian, Muhammad Muhammad Fariez Kurniawan Muhammad Fariez Kurniawan Muhammad Yusron Maulana El-Yunusi Mukhlishah, Neneng Rachmalia Izzatul Nanik Sulistyani Nina Salamah NINGRUM, TYAS SARI RATNA Novitasari, Putri Rachma Nugrahini, Febrina Nugroho, Nazih Basuki Nurhayati Nurhayati Nuri Ari Efiana Nurlaela, Endah Nyoman Rudi Kusuma Olvia Becatami Widyantoro Olvia Becatami Widyantoro, Olvia Becatami Pertiwi, Deasy Vanda Pramono, Suwidjiyo Pramono, Suwidjiyo Puput Herawati Said Hasan Rahmat Hidayat Rahmat Santoso, Rahmat Rahmawati, Desty Restia Raka Sukmabayu W.S Ratih Saridewi Rikadyanti Rikadyanti Rinanda Yeshi Wiradhika Ririn Suharsanti, Ririn Ristiono, Hendi Rosmiyanti, Yanti Rukaya, Benazir Evita Ryan Radix Rahadhian, Muhammad Sapto Yuliani Sapto Yuliani Sapto Yuliani Sismindari . Sismindari Sismindari Sismindari Sismindari Sismindari Sismindari Sismindari, Sismindari Sismindari, Sismindari Siti Athiyah Umaiyah Siti Ayu Marlina Sri Mulyaningsih Sri Mulyaningsih Srimuliani Arbie Suwidjiyo Pramono Suwidjiyo Pramono Suwidjiyo Pramono Suwidjiyo Pramono Suwidjiyo Pramono. Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Teuku Nanda Saifullah, Teuku Nanda Trecya Fujiastuti Trecya Fujiastuti, Trecya Tusilowati, Defita Andri Ulfa Ramdhani M Uswatun Chasanah Vivi Sophia Waliyyin Razan Qanit wardhani, Riska risty Widyantoro, Olvia Becatami Widyasari Putranti Wisnu Kundarto Wuryandari, Tutik Wuryandari, Tutik Yayan Rizikiyan Zaenab Zaenab Zainab Zainab Zainab Zainab Zainab