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All Journal International Journal of Public Health Science (IJPHS) Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Food and Pharmaceutical Science Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Majalah Obat Tradisional JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Biologi Tropis Majalah Farmaseutik Media Farmasi PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Farmasi Indonesia Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Jurnal Abdimas Mahakam CERATA Jurnal Ilmu Farmasi SPEKTA (Jurnal Pengabdian Kepada Masyarakat : Teknologi dan Aplikasi) Jurnal Insan Farmasi Indonesia SINTA Journal (Science, Technology, and Agricultural) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Pharmaceutical Sciences and Research (PSR) Journal of Halal Science and Research Sciences of Pharmacy Jurnal Farmasetis Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram Journal of Food and Pharmaceutical Sciences CERATA Medical Sains : Jurnal Ilmiah Kefarmasian E-Amal: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Jamu

Nining Sugihartini

Fakultas Farmasi, Universitas Ahmad Dahlan, Yogyakarta, Indonesia

Author-ID : 388808

Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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The Profile of Anti-inflammatory Activity of Syzigium Aromaticum Volatile Oil in Lotion with Variation Composition of Oleic Acid and Propylene Glycol as Enhancer Fitriah Ardiawijianti Iriani; Nining Sugihartini; Tedjo Yuwono
Majalah Obat Tradisional Vol 22, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Essential oil of clove (Syzygium aromaticum) containing eugenol has an anti-inflammatory activity. The study was aimed to develop the formulation of lotion by adding of oleic acid and propylene glycol as penetration enhancer. The effect of enhancer composition was also studied. Lotion was prepared with the composition of oleic acid (AO) and propylene glycol (PG) as follow: 1:0 (FI), 0,5:0,5 (FII), 0:1 (FIII). Capacity an anti-inflammatory of formulation based on parameters of the amount of cells with COX-2 expression, the number of inflammatory cells and the epidermis thickness was evaluated using male mouse strain BALb/C induced by crotton oil as inflammatory agents. The results showed that the increasing composition propylene glycol caused the decreasing of the amount of cells with COX-2 expression (p <0.05), the inflammatory cells (P <0.05) and the epidermis thickness (p <0.05)

Uji Transport Emulgel Minyak Atsiri Bunga Cengkeh dengan Penambahan Enhancer Propilen Glikol dan Asam Oleat Muhammad Fariez Kurniawan; Nining Sugihartini; Tedjo Yuwono
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 3 (2019): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Kuncup bunga cengkeh mengandung senyawa eugenol yang merupakan minyak atsiri yang terbuktisebagai antiinflamasi. Untuk mendapatkan efek antiinflamasi yang optimal diperlukan suatu rancanganformulasi sediaan topikal berupa emulgel minyak atsiri bunga cengkeh (MABC) dengan penambahanenhancer kombinasi propilen glikol (PG) dan asam oleat (AO) yang dapat meningkatkan kemampuan eugenoldalam menembus lapisan kulit sehingga didapatkan daya antiinflamasi yang optimal dengan metodeSimplex Lattice Design (SLD). Diformulasikan 3 formula emulgel dengan perbandingan PG dan AO dalamemulgel: 100%:0% (FI); 50%:50% (FII); dan 0%:100% (FIII). Masing-masing formula dilakukan uji transportdengan alat uji difusi tegak Franz menggunakan media kulit punggung mencit dan ditetapkan kadarnyamenggunakan Kromatografi Cair Kinerja Tinggi (KCKT) serta diukur parameter uji transport yang meliputidaya permeabilitas, flux, koefisien difusi dan lag time. Data yang diperoleh dianalisis menggunakan metodeSLD. Analisis data yang diperoleh menunjukkan adanya peningkatan pada parameter flux, permeabilitas,dan koefisien difusi serta penurunan pada lag time secara signifikan pada emugel dengan enhancer dibandingkan emulgel tanpa penambahan enhancer propilen glikol dan asam oleat. Diperoleh formulasi optimum emulgel MABC dengan penambahan 100% enhancer propilen glikol sebagai formula yang mempunyai parameter flux, permeabilitas, koefisien difusi, dan lag time paling baik dan nilai enhancement ratio 1,05 – 1,94.

The influence of ethanol fractions of infusa of Plantago major L. leaves in effectivity of octyl methoxycinnamate as active ingredient of sunscreen Nining Sugihartini; Marchaban .; Suwidjiyo Pramono.
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Octyl methoxycinnamate is an active ingredient of that is degraded by solar irradiation resulting it usage as sunscreen becomes less effective. An antioxidant has capability as a photo-protector. Flavonoid in the ethanolic fraction of Plantago major, L. leaves is reported to have an antioxidant. This research was aimed to examine the influence of the addition of the ethanolic fraction of Plantago major, L. leaves to the effectiveness of octyl methoxycinnamate as a sunscreen. In this research, two formulas were prepared. Formula I contained octyl methoxycinnamate per se and formula II contained a mixture (1:1) of octyl methoxycinnamate and ethanolic fraction of Plantago major, L. leaves. Both formulas were exposed to the sun light for 5 hours (09.00-14.00 WIB) in which samples were taken every hour. The effectiveness of octyl methoxycinnamate was calculated based on the percentage of erythema transmission and the percentage of pigmentation transmission, prior and after the irradiation by the sun light for 5 hours. The statistical data analysis was performed based on the Student t test with a confidence level of 95%. The addition of the ethanol fraction of Plantago major, L. leaves significantly reduced the percentage of the erythema transmission after solar irradiation (p

Gambaran Histopatologi Organ Hati dan Ginjal Mencit Balb/c setelah Pemberian Krim Ekstrak Teh Hijau (Camellia sinensis L.) Nining Sugihartini; M Alif Fajri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Background:Development of green tea extract formulation with the addition of enhancers to increase the ability of epigallocatechin gallate to penetrate the skin layers has been done. Objective: The purpose of this study was to determine the effect of green tea extract cream that containing enhancers on the profile of kidney and liver histopathology. Methods: The study used 4 groups which each group was treated with different concentrations of extract (2,0%; 2,5%; 3,0%; 3,5%) and 1 control group. After 24 hours and 14 days of application of the cream, the mice were sacrificed. The liver and kidneys were weighed and made preparations histopathology. Results: The results of the study showed that there similar (p>0,05) of the weight ratio of the liver and kidneys of Balb/c mice after 24 hours and 14 days. As well the histopathological test indicated that there similar (p>0,05) of the liver and kidneys after 24 hours and 14 days of administration of green tea extract cream. Conclusions: The levels concentration of green tea extract in cream (2,0%; 2,5%; 3,0%; 3,5%) that contain enhancers do not affect the liver and kidney histopathological of Balb/c mice.

Curcumin and Extract of Plantago major, L Increased SPF Value of Cold Cream Base Nining Sugihartini
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp43-47

Octyl methoxycinnamate as the active material of the sunscreen would be degradated after being exposed to the sunlight. Curcumin, rice flour and the extract of Plantago major, L was the material that could function as the sunscreen. The aim of this research was to know the SPF value and the physical characteristics of cream of the sunscreen with the active material octyl methoxycinnamate after the addition of the optimum composition of curcumin and the extract of Plantago major, L and the optimum composition of rice flour and the extract of Plantago major, L.In this research three formulas was examined, i.e. the formula I with the active material octyl methoxycinnamate, the formula II with the active material octyl methoxycinnamate and the optimum composition curcumin and the extract of Plantago major, L, Formula III with the active material octyl methoxycinnamate and the optimum composition rice flour and the extract of Plantago major, L. SPF value of each formula was determined by using the Petro method (1981) using UV spectrofotometric method at a l 290 nm-320 nm. The physical characteristics i.e. the power spread, the adhesiveness and the viscosity were also examined analysed with Anova one way at a confidence level 95%. Result of the research show that SPF value increased after the addition of the optimum composition of curcumin and the extract of Plantago major, L. The physical characteristics of cream of the sunscreen do not change after the addition of the optimum composition curcumin and the extract of Plantago major, L and the optimum composition rice flour and the extract of Plantago major, L.Key words: Octyl methoxycinnamate,curcumin,flour rice,extract of Plantago major, L,sunscreen

Formulation Cream of Extract Moringa oleifera Leave as Antiaging Nining Sugihartini; Evi Nuryanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Moringa oleifera leaf as natural material has the activity to protect skin because it contains antioxidants. Therefore, the development of dosage forms in the form of a antiaging cream is required to be used by the human. Purpose: To determine the concentration of extract moringa oleifera leaf which will provide the ability as antiaging. Methods: Extract of moringa oleifera leaf was obtained by maceration methods by ethanol 70% as solvent. Then extract was formulated in dosage forms an antiaging cream with concentration of variations are formula I (0%), formula II (3%), formula III (6%) and the formula IV (9%). After that cream was evaluated with parameters moisture, evenness, pore, spot and wringkle on human probandus whom have used the cream for 14 days. Results: Increasing the concentration of Moringa oleifera leaf extract led to a decreasing evenness (p<0.05) which efective on concentration 3%. Conclusion: The concentration of Moringa oleifera leaf extract that can be used as antiaging which decreasing evenness was 3%.

STABILITAS EPIGALOKATEKIN GALAT DALAM KRIM EKSTRAK TEH HIJAU DENGAN VARIASI KONSENTRASI ANTIOKSIDAN VITAMIN C 1% DAN VITAMIN E 1% Nining Sugihartini; Hari Susanti; Zaenab Zaenab; Hana Hanifah; Siti Ayu Marlina
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 13, No 2 (2016)
Publisher : Sanata Dharma University

Epigallocatechingallate (EGCG) in green tea extract has activity as an anti-inflammatory agent. On the other hand the stability of EGCG is poor because of the oxidation. The aim of this study was to determine the influence of Vitamine C and Vitamine E in formulation of green tea extract cream to the stabiliy of EGCG. The green tea extract was obtained from the extraction process by infundation followed by fractination with ethyl acetate as the solvent. The three formulas were compiled in similar composition with the concentration of vitamine C 1% (FI), Vitamine E 1% (FII) and there was no Vitamine C and Vitamine E (FIII) as a control. The EGCG level was determinated by TLC-densitometry methode. The stability parameter was determinated by calculated of the Q10 of each formula. The result of this study showed that the parameter of t90 of EGCG with Vitamine C 1%, Vitamine E 1% and control addition were 0.0108 hours, 0.0087 hours, 0.0084 hours, respectively. Stability of EGCG in green tea leaf extract cream with addition of the vitamin C 1% was higher than it stability with the addition of vitamin E 1%. The concentration of Vitamin C 1% was the optimum concentration as antioxidant in formulation of green tea extract cream.

REVIEW : KARAKTERISTIK FISIK DAN DAYA IRITASI MINYAK ATSIRI BUNGA CENGKEH (Syzygium aromaticum) DALAM BEBERAPA TIPE BASIS SEBAGAI ANTI-INFLAMASI Amraini Amelia; Nining Sugihartini; Hari Susanti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 2 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

ABSTRACT This review aims to determine the types of bases that can be used every day, which are effective and efficient as anti-inflammatory drugs. The research method used was to review the development of clove essential oil formulations that have been carried out using various concentrations of various types of bases including M / A type cream, A / M type cream, water soluble base, lotion, emulgel, hydrocarbons, hydrogels and absorbents. The recommended formulation is type M / A cream with a concentration of 5% clove flower essential oil. The types of bases studied were M / A cream, type A / M cream, water soluble base, lotion, emulgel, hydrocarbons, hydrogels and absorption properties which had good physical properties and did not irritate the skin of the test animals. This review refers to several national and international journals released in the last ten years, from 2010 to 2020.

PHYSICAL STABILITY TEST AND ETHANOL CREAM IRRITATION TEST OF Moringa oleifera L. Nining Sugihartini; Zainab Zainab; Aji Pamungkas
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

The development of topical dosage forms of Moringa leaf extract cream has been carried out because of its properties that can moisturize the skin. A pharamceutical preparation must meet the requirements of stability and non toxic. The study aimed to determine the effect of variations un the concentration ethanol extract cream of Moringa leaf of physical stability and irritability. Ethanol extract of Moringa leaves was obtained by maceration method with 50% ethanol solvent. The extract was then formulated in the form of O/W base scarring with concentrations of 1% (F1), 3% (F2), and 5% (F3). Creams were evaluated for physical stability including mechanical tests (centrifugation) and physical stability at room temperature (25 Ã‚Â± 2oC) with parameters pH, viscosity on days 1, 7, 14, 21 and 28. In addition, creams were also evaluated for their irritability in vivo with using test animals (rabbits). The data obtained were analyzed using one-way ANOVA test. The results of the physical stability test showed that an increase in the concentration of Moringa leaf extract caused an increase in viscosity (P <0.5) and a decrease in pH (P <0.5) but did not affect physical stability (mechanical test) and its irritating effect. F2 (1%) has a pH of 7.61 while F4 (5%) is 7.01. Based on the results of the study, it is concluded that variations in the concentration of ethanol extract of Moringa leaves can affect the physical stability of the cream and do not affect its irritation properties. Moringa leaf ethanol extract cream with a concentration of 5% (F4) has physical stability and does not irritate the skin better than other formulas. Keywords: extract of moringa leaves, cream, physical properties test, irritation test, stability

The Purification effect on Organoleptic Profile, Yield, Total Phenol and Total Flavonoids from 96% Ethanol Extract of Moringa (Moringa oleifera. L) leaves. Bayu Herdi Al Huda; Hari Susanti; Nining Sugihartini
Jurnal Farmasi Indonesia Vol 17 No 2 (2020): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v17i2.983

Purification extract ethanol 96% of Moringa dry leaves was carried out to increase the active substance content and to obtain a more attractive color. The purpose of this study was to determine the type of solvent in the fractionation which provides a higher active substance content than the extract. This research begins with maceration of dried Moringa leaves with 96% ethanol. The filtrate that has been dried then purified. Purification begins with dissolving the extract in hot distilled water with a ratio of 1:10, after that ethyl acetate or n-hexane is added to the same amount as hot distilled water in a separating funnel, shaking it. The ethyl acetate or n-hexane phase is taken then the filtrate obtained is combined. The 96% ethanol extract (E1), ethyl acetate (E2) and n-hexane (E3) were then evaluated with parameters of organoleptic, % yield, total phenol, and total flavonoids. Data were analyzed statistically one way ANOVA with confidence level of 95%. The measurement results for E1, E2, and E3 in the yield were 15.81%;22.18%;20%, the total phenol was 28.94±0.54mgGAE/g; 29.44±0.93mgGAE/g; 11,41±0,12mgGAE/g, and total flavonoids 3,19±0.13%; 9,92±0.06%; 5.81±0.18% respectively. The consistency, smell and taste, all are identical, while in color, E2 is more yellowish green and brighter, making it more attractive. Statistically, there were significant differences between E1, E2, and E3 in total phenols and flavonoids. Thus it can be concluded that E2 significantly higher total phenol and flavonoids than E1 and E3.

Co-Authors . Sismindari Achmad Fudholi Achmad Fudholi Achmad Fudholi Achmad Fudholi Aditya Noviadi Rakhmatullah Afriyani, Neti Agung Putu S.P.Kristyawan Aina Fatkhil Haque, Aina Fatkhil Aji Pamungkas Alvionida, Fitra Amraini Amelia Ani Guntarti Any Guntarti Any Guntarti Astryna, Syarifah Yanti Atri Sri Ulandari Auliah Rahmi Latif Azis Ikhsanudin Bayu Herdi Al Huda Deasy Vanda Pertiwi Delia Komala Sari, Delia Komala Desrianti, Cindy Desyandri Desyandri Diah Pratimasari Diyan Sakti Purwanto Diyan Sakti Purwanto Endah Nurlaela Endah Nurlaela Endang Lukitaningsih Erma Pranawati ERMAWATI, DIAN EKA Erna Astuti Erna Astuti Erwin Fauzana Evi Nuryanti Fadzil Latifah Firsty, Girly Risma Fitra Alvionida Fitri Rahmawanti Fitriah Ardiawijianti Iriani Fudholi, Achmad Fudholi, Achmad Gina Lestari Gina Lestari, Gina Girly Risma Firsty Gita Puspita Hafid, Indah Fitria Hana Hanifah Hari Susanti Hari Susanti Heru Sasongko Ichwan Ridwan Rais Iis Wahyuningsih Jannah, Syauqul Kintoko Kintoko Kintoko, Kintoko Kurniawan, Muhammad Fariez Kusuma, Nyoman Rudi Laela Hayu Nurani Laila, Wahyu Kumil Lalu Muhammad Irham Lela Sulastri, Lela Lena Maulina Lena Maulina, Lena M Alif Fajri Marchaban . Miratun Syarifah Mohamad Ikram Muhammad Alfian, Muhammad Muhammad Fariez Kurniawan Muhammad Fariez Kurniawan Muhammad Yusron Maulana El-Yunusi Mukhlishah, Neneng Rachmalia Izzatul Nanik Sulistyani Nina Salamah NINGRUM, TYAS SARI RATNA Novitasari, Putri Rachma Nugrahini, Febrina Nurhayati Nurhayati Nuri Ari Efiana Nurlaela, Endah Olvia Becatami Widyantoro Olvia Becatami Widyantoro, Olvia Becatami Pertiwi, Deasy Vanda Pramono, Suwidjiyo Pramono, Suwidjiyo Puput Herawati Said Hasan Rahmat Hidayat Rahmawati, Desty Restia Raka Sukmabayu W.S Ratih Saridewi Rikadyanti Rikadyanti Rinanda Yeshi Wiradhika Ririn Suharsanti, Ririn Ristiono, Hendi Rosmiyanti, Yanti Rukaya, Benazir Evita Ryan Radix Rahadhian, Muhammad Sapto Yuliani Sapto Yuliani Sapto Yuliani Sismindari . Sismindari Sismindari Sismindari Sismindari Sismindari Sismindari Sismindari, Sismindari Sismindari, Sismindari Siti Athiyah Umaiyah Siti Ayu Marlina Sri Mulyaningsih Sri Mulyaningsih Srimuliani Arbie Suwidjiyo Pramono Suwidjiyo Pramono Suwidjiyo Pramono Suwidjiyo Pramono Suwidjiyo Pramono. Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Teuku Nanda Saifullah, Teuku Nanda Trecya Fujiastuti Trecya Fujiastuti, Trecya Tusilowati, Defita Andri Ulfa Ramdhani M Uswatun Chasanah Vivi Sophia Waliyyin Razan Qanit wardhani, Riska risty Widyantoro, Olvia Becatami Widyasari Putranti Wisnu Kundarto Wuryandari, Tutik Wuryandari, Tutik Yayan Rizikiyan Zaenab Zaenab Zainab Zainab Zainab Zainab Zainab

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