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All Journal International Journal of Public Health Science (IJPHS) Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Food and Pharmaceutical Science Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Berkala Ilmu Kesehatan Kulit dan Kelamin Majalah Obat Tradisional JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika Jurnal Penelitian Pendidikan IPA (JPPIPA) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Biologi Tropis Majalah Farmaseutik Media Farmasi PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Farmasi Indonesia Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Jurnal Abdimas Mahakam CERATA Jurnal Ilmu Farmasi SPEKTA (Jurnal Pengabdian Kepada Masyarakat : Teknologi dan Aplikasi) Jurnal Insan Farmasi Indonesia SINTA Journal (Science, Technology, and Agricultural) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Pharmaceutical Sciences and Research (PSR) Journal of Halal Science and Research Sciences of Pharmacy Jurnal Farmasetis Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram Journal of Food and Pharmaceutical Sciences CERATA Medical Sains : Jurnal Ilmiah Kefarmasian E-Amal: Jurnal Pengabdian Kepada Masyarakat Jurnal Kefarmasian Indonesia Pharmacon: Jurnal Farmasi Indonesia Indonesian Journal of Jamu Folia Medica Indonesiana

Nining Sugihartini

Fakultas Farmasi, Universitas Ahmad Dahlan, Yogyakarta, Indonesia

Author-ID : 388808

Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Pengaruh Purifikasi Terhadap Kandungan Zat Aktif dan Aktivitas Antioksidan Ekstrak Etanol 50% Daun Kelor (Moringa oleifera L.) Diyan Sakti Purwanto; Hari Susanti; Nining Sugihartini
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.1232

Purification extract ethanol 50% of Moringa dry leaves was carried out to increase the active substance content of flavonoids, β-carotene, saponins and tannins which have antioxidant activity. The purpose of this study was to determine the optimal solvent between ethyl acetate and n-hexane in the ethanol extract fractionation of 50% Moringa leaves. The viscous extract obtained was then purified by fractionation. Fractionation was carried out by dissolving the viscous ethanol extract of 50% Moringa leaves (E1) in aquadest of 70ºC and then adding ethyl acetate to a separating funnel to obtain ethyl acetate (E2) fraction. In addition, the viscous ethanol extract of 50 % Moringa leaves (E1) was fractured with n-hexane (E3). The extract and fraction were evaluated for the parameters including the water level of the extract with gravimetry, levels the β-carotene by HPLC and the antioxidant activity with DPPH . Data were analyzed statistically with a confidence level of 95%. The results the water level of the ethanol extract of 50% Moringa leaves is 4.16 with a CV of 4.62%. The β-carotene level on fractured with n-hexane (E3) then ethyl acetate fraction (E2) and ethanol extract 50 % (E1) that is 1.48 ± 0.01%, 1.19 ± 005% and 0.73 ± 0.01%. While antioxidant activity (IC50) were the most optimal in the n-hexane fraction(E3) then ethanol extract 50 % (E1) and ethyl acetate fraction (E2) that is 40.83 ± 0.04 ug/ml, 47.75 ± 0.09 ug/ml and 58.79 ± 0.10ug/ml. The ethanol extract of 50% Moringa leaves and n-hexane fraction were included in the very strong category while the ethyl acetate fraction was included in the strong category so that it has the potential to be an antioxidant.

FORMULASI SEDIAAN KRIM A/M DENGAN VARIASI KONSENTRASI EKSTRAK ETANOL DAGING BUAH PEPAYA (Carica Papaya) MENGGUNAKAN EMULGATOR TWEEN 80 DAN SPAN 80 Gita Puspita; Nining Sugihartini; Iis Wahyuningsih
Media Farmasi XXX Vol 16, No 1 (2020): Media Farmasi
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Papaya (Carica papaya) contains flavonoid and phenolic compounds proven to have sunscreen and antithyrosinase activity. For this reason, there is a need to formulate them in the form of cream preparations. This study analyzes the effect of the ethanol extract concentration of papaya flesh in the form of A / M cream preparations on their physical properties. The extracts were obtained using the maceration method with 70% ethanol solvent in A / M cream preparations and concentrations of 1%, 3%, and 5% through Tween 80 and Span 80 emulgators. Creams were evaluated for physical properties, including pH, adhesion, dispersion, viscosity, and physical stability. The test results showed that an increase in the concentration of ethanol extract led to a decrease in pH (p <0.05), viscosity (p <0.05), adhesion (p <0.05), and an increase in dispersion (p <0.05). Additionally, phase separation occurs at a concentration of 5% papaya fruit extract cream. These results show that variations in the ethanol extract concentration of papaya fruit influence the physical properties of A / M cream.Keywords: Carica papaya; A / M cream; Physical Properties.Pepaya (Carica papaya) mengandung senyawa flavonoid dan fenolik yang terbukti memiliki aktivitas sebagai tabir surya dan antitirosinase sehingga perlu diformulasikan dalam bentuk sediaan krim. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh konsentrasi ekstrak etanol daging buah papaya dalam bentuk sediaan krim A/M terhadap sifat fisik sediaan. Ekstraksi buah papaya diperoleh dengan metode maserasi dengan pelarut etanol 70% dalam sediaan krim A/M dengan konsentrasi 1% (FI), 3% (F2) Dan 5% (F3). Krim dievaluasi sifat fisik meliputi pH, daya lekat, dan daya sebar, viskositas dan stabilitas fisik. Hasil uji menunjukkan bahwa peningkatan konsentrasi ekstrak etanol buah papaya menyebabkan penurunan pH (p<0.05), viskositas (p<0.05), daya lekat (p<0.05), peningkatan daya sebar (p<0.05). Terjadi pemisahan fase pada konsentrasi 5% krim ekstrak buah papaya. Berdasarkan hasil dapat disimpulkan bahwa variasi konsentrasi ekstrak etanol daging buah papaya memiliki pengaruh terhadap sifat fisik krim A/MKata kunci : Carica papaya; krim A/M; Sifat Fisik

SIFAT FISIK KRIM TIPE M/A EKSTRAK ETANOL DAUN KELOR [Moringa oleifera L] DENGAN VARIASI KONSENTRASI MENGGUNAKAN EMULGATOR ASAM STEARAT DAN TRIETANOLAMIN Rikadyanti Rikadyanti; Nining Sugihartini; Sapto Yuliani
Media Farmasi XXX Vol 16, No 1 (2020): Media Farmasi
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Flavonoid compounds in moringa leaves have high antioxidants and can be used to prevent the effects of free radicals. Therefore, Moringa leaf extract needs to be formulated in the form of M / A cream. The purpose of this study determines the effect of cream concentration on physical properties, such as pH, spreadability, adhesion, and viscosity, as well as the stability of the cream. Moringa leaf extract was macerated using 50% ethanol solvent and further formulated in the form of M / A cream preparations with various concentrations, including Formula I (0%), Formula II (1%), Formula III (3%), and Formula IV 5%. The creams were evaluated for physical properties, including pH, spreadability, adhesion, and viscosity, as well as stability. The test results showed that an increase in the concentration of the ethanol extract of Moringa leaves in cream type M / A led to a decrease in pH, viscosity, adhesion, and increased spreadability. An increase in the concentration of ethanol extract of Moringa leaves influence the physical properties of M / A type creams, such as a decrease in pH, viscosity, adhesion, increased spread, though it is unstable at a concentration of 5%.Keywords: M / A cream, Moringa leaf Ethanol Extract, physical propertiesSenyawa flavonoid yang terkandung dalam daun kelor (Moringa oleifera L) memiliki antioksidan yang tinggi sehingga dapat digunakan sebagai zat yang dapat mencegah efek radikal bebas. Oleh karena itu ekstrak daun kelor perlu diformulasikan dalam bentuk sediaaan krim M/A. Penelitian ini untuk mengetahui pengaruh konsentrasi krim terhadap sifat fisik (pH, daya sebar, daya lekat, viskositas) dan stabilitas krim tipe M/A ekstrak etanol daun kelor. Ekstrak daun kelor dimaserasi dengan menggunakan pelarut etanol 50%. Ekstrak kemudian di formulasikan dalam bentuk sediaan krim M/A dengan variasi konsentrasi yaitu Formula I (0%), Formula II (1%), Formula III (3%), dan Formula IV 5%. Krim dievaluasi sifat fisik (pH, daya sebar, daya lekat, viskositas) dan stabilitas. Hasil uji menunjukan bahwa adanya peningkatan konsentrasi ekstrak etanol daun kelor dalam krim tipe M/A menyebabkan penurunan pH, viskositas, daya lekat, dan peningkatan daya sebar. Dengan adanya peningkatan konsentrasi ekstrak etanol daun kelor memiliki pengaruh terhadap sifat fisik krim tipe M/A yaitu terjadi penurunan pada Ph, viskositas, daya lekat, peningkatan daya sebar dan tidak stabil pada konsentrasi 5%.Kata kunci : krim M/A, Ekstrak Etanol daun kelor, sifat fisik

SIFAT FISIK KRIM TIPE A/M DENGAN VARIASI KONSENTRASI EKSTRAK ETANOL DAUN KELOR (Moringa oliefera) MENGGUNAKAN EMULGATOR TWEEN 80 DAN SPAN 80 Auliah Rahmi Latif; Nining Sugihartini; Ani Guntarti
Media Farmasi XXX Vol 16, No 1 (2020): Media Farmasi
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Moringa leaf extract with 50% ethanol solution has antioxidant activities, as well as sunscreen and tyrosinase enzyme inhibition. The utilization is optimized by formulating A / M cream preparations. This study determines the effect of the concentration of Moringa leaf extract with 50% ethanol extract solution on the physical properties of the preparation. Moringa leaves are extracted with 50% ethanol using the maceration method. The extract was formulated in type A / M creams with 3 concentration variations, including 1%, 3%, and 5%. Creams were evaluated for physical properties, such as dispersion, adhesion, pH, viscosity, and stability of the preparation. The results showed an increase in the concentration of ethanol extract of Moringa leaves with an influence on the physical properties of A / M cream. It has the potential to increase the spreadability (p <0.05), decrease pH (p <0.05), adhesion (p <0.05), viscosity (p <0.05). Physical stability test results showed a % separation of the A / M cream ethanol extract of Moringa leaves. Keywords: A/M cream, Moringa leaf Ethanol Extract, physical propertiesEkstrak daun kelor dengan larutan penyari etanol 50% memiliki aktivitas sebagai antioksidan, tabir surya serta penghambatan enzim tirosinase. Khasiat tersebut dioptimalkan pemanfaatannya dengan mengformulasikan dalam sediaan krim tipe A/M. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi ekstrak daun kelor dengan larutan penyari etanol 50% terhadap sifat fisik sediaan. Daun kelor diekstraksi dengan etanol 50% menggunakan metode maserasi. Ekstrak diformulasikan dalam krim tipe A/M dengan 3 variasi konsentrasi yaitu 1%(FI), 3%(FII), 5%(FIII). Krim dievaluasi sifat fisik diantaranya daya sebar, daya lekat, pH, viskositas, dan stabilitas sediaan. Hasil menunjukkan peningkatan konsentrasi ekstrak etanol daun kelor memiliki pengaruh terhadap sifat fisik krim A/M yaitu dapat meningkatkan daya sebar (p<0,05), menurunkan pH (p<0,05), daya lekat (p<0,05) , viskositas (p<0,05). Hasil uji stabilitas fisik menunjukkan terjadi pemisahan pada krim A/M ekstrak etanol daun kelor 5%.Kata kunci : krim A/M, Ekstrak Etanol daun kelor, sifat fisik

FORMULASI KRIM M/A DENGAN VARIASI KONSENTRASI EKSTRAK BUAH PEPAYA (Carica papaya L.) MENGGUNAKAN EMULGATOR ASAM STEARAT DAN TRIETANOLAMIN Srimuliani Arbie; Nining Sugihartini; Iis Wahyuningsih
Media Farmasi XXX Vol 16, No 1 (2020): Media Farmasi
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Papaya fruit extract acts as a sunscreen and antityrosinase because it contains phenolic compounds such as flavonoids. The direct use of the extract on the skin is very impractical and therefore needs pharmaceutical preparation, specifically the cream. This study determines the effect of the ethanol extract concentration of papaya on the oil cream base in water and the physical properties of the preparation. Papaya fruit extracts were obtained by the maceration method using 70% ethanol and formulated as oil-type cream preparations. This involved a variation of extract concentration of 1%, 3%, and 5% using a triethanolamine emulgator. The cream preparations were evaluated for physical properties, including determination of pH, spreadability, adhesion, viscosity, and stability testing. The results showed that increasing the concentration of papaya extract affects physical properties, such as reducing the pH value (p <0.05), viscosity (p <0.05), and adhesion (p <0.05), as well as increasing the value of dispersion (p <0.05). Physical stability of the papaya extract cream preparation did not occur at 1% and 3% extract concentrations. However, there was a separation at 3% extract concentration marked by creaming.Keywords: Papaya fruit, Oil cream in water, Physical PropertiesEkstrak buah pepaya memiliki aktivitas sebagai tabir surya dan antitirosinase karena mengandung senyawa fenolik seperti flavonoid. Penggunaan ekstrak secara langsung di kulit sangat tidak praktis, untuk itu dipilih suatu sediaan farmasi yaitu sediaan krim. Tujuan penelitian ini adalah untuk mengetahui pengaruh konsentrasi ekstrak etanol daging buah pepaya dalam basis krim minyak dalam air terhadap sifat fisik sediaan.Ekstrak buah pepaya diperoleh dengan metode maserasi menggunakan etanol 70%. Ekstrak kemudian diformulasikan dalam bentuk sediaan krim tipe minyak dalam air dengan variasi konsentrasi ekstrak 1%, 3% dan 5%. Sediaan krim ekstrak buah pepaya dievaluasi sifat fisik meliputi penetapan pH, daya sebar, daya lekat, viskoisitas dan uji stabilitas. Hasil penelitian menunujukan bahwa peningkatan konsentrasi ekstrak buah pepaya dapat mempengaruhi sifat fisik yaitu : menurunkan nilai pH (p<0,05), viskositas (p<0,05), daya lekat (p<0,05) dan dapat meningkatkan nilai daya sebar (p<0,05). Stabilitas fisik pada sediaan krim ekstrak buah pepaya tidak terjadi pemisahan pada formula I dan II tetapi terjadi pemisahan pada formula III yang ditandai adanya creaming.Kata Kunci: Buah pepaya, Krim, Sifat Fisik.

Formulasi dan Uji Anti Inflamasi Masker Peel Off Ekstrak Etanol Buah Mengkudu (Morinda citrifolia L.) Miratun Syarifah; Nining Sugihartini; Laela Hayu Nurani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Infl ammation of the skin often occurs in acne-prone skin. Acne can be prevented in variousways, one of them by maintaining clean skin. Noni fruit (Morinda citrifolia L.) with the active ingredientof scopoletin has been proven to be eff ective as an anti-infl ammatory. Noni is dried into simplicia,extracted was ethanol 96% solvent until it becomes concentrated extract. The extract is formulated intoa peel off mask with a concentration variation of 5%, 10 and 15%. The masks produced is evaluated forphysical characteristic of pH, viscosity, spreadability, and adhesivity test), as well as anti-infl ammatoryproperties using mice with the parameters of COX-2 expression and irritation test using rabbit. Theevaluation results of the physical characteristic of the peel off mask fulfi lled the physical characteristicrequirements of the peel off mask preparation. Whereas in the viscosity test there were groups thatmet the viscosity requirements, namely the formula I and II groups and the group that did not meet theviscosity requirements, namely the formula III group. Anti-infl ammatory test in mice showed that themask lead to reduction in the amount of COX-2 expression. The best formula in 3 preparations wasindicated in formula I with COX-2 expression value of 22.635%. The results of irritation test on rabbitsdid not cause irritation. According to the test results it can be concluded that the optimum value of theethanol extract concentration is shown in formula I with a concentration of 5%.

UJI IRITASI SERTA EVALUASI SIFAT FISIK EMULGEL MINYAK ATSIRI BUNGA CENGKEH DENGAN METODE SIMPLEX LATTICE DESIGN Muhammad Fariez Kurniawan; Nining Sugihartini; Tedjo Yuwono
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 5 No. 1 (2018)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Salah satu bahan alam yang sudah terbukti mampu mengatasi inflamasi adalah minyak atsiri bunga cengkeh (MABC). Penelitian ini bertujuan untuk mengevaluasi sifat fisik dan uji iritasi sediaan emulgel MABC dengan penambahan enhancer berupa kombinasi asam oleat dan propilen glikol untuk meningkatkan kemampuan penetrasi MABC 10% MABC dengan ditambahkan enhancer 10% kombinasi propilen glikol dan asam oleat dengam metode Simplex Lattice Design (SLD) untuk mengetahui formula yang akan memiliki parameter uji fisik dan uji iritasi terbaik. Parameter uji fisik yang dilakukan adalah uji viskositas, pH, daya sebar, dan daya lekat emulgel sedangkan uji iritasi dilakukan dengan hewan uji kelinci putih jantan. Data yang diperoleh dihitung dengan metode Simplex Lattice Design. Emulgel MABC dengan penambahan enhancer kombinasi propilen glikol dan asam oleat yang dihasilkan mempunyai sifat fisik yang baik dan tidak mengiritasi kulit hewan uji. Komposisi optimum campuran enhancer sesuai metode SLD adalah 100% propilen glikol.

IRRITATION TEST AND PHYSICAL PROPERTIES OF UNGUENTUM VOLATILE OIL OF Syzygium aromaticum IN HYDROCARBON BASE Neneng Rachmalia Izzatul Mukhlishah; Nining Sugihartini; Tedjo Yuwono
Majalah Farmaseutik Vol 12, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Essential oil of clove (Syzygium aromaticum) with the active compound eugenol has been widely studied and well known efficacious as antiinflammatory, and advanced research related to the formulation continues. Formula in this study was the topical dosage form an ointment using a hydrocarbon base (Vaseline album and Paraffin liquidum). Aim of this study was to know the physical properties and the power of irritation from ointment of clove essential oil (MABC) hydrocarbon base. The ointment was made by the melting method with concentration of MABC 5% (F1), 10% (FII) and 15% (FIII). Then the ointment of the third formula was evaluated its physical properties (spreadibility, adhesivity and pH). It was also evaluated the irritation’s properties on the skin by using a male guinea pigs test animals by the method of Draize test. The data were analyzed statistically with a confidence level of 95%. The statistical shows that were method significant differences between the formula. The increasing concentration of MABC, causes the greater of spreadibility (p<0,05) and adhesivity (p <0.05 between F 1 and FIII). On the other hand, the Kruskal Wallis test of pH shows there was no significant difference (p> 0.05). The results of irritation Draize test shows that an ointment base MABC hydrocarbon with concentration of 5%, 10% and 15% does not cause irritation.

Sifat Fisik Dan Daya Iritasi Gel Ekstrak Etanol Herba Pegagan (Centella asiatica L.) dengan Variasi Jenis Gelling Agent Trecya Fujiastuti; Nining Sugihartini
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 12 No. 01 Juli 2015
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRAK Pegagan (Centella asiatica L.). memiliki khasiat sebagai antibakteri, sehingga perlu dibuat dalam sediaan yang praktis dan nyaman dipakai seperti dalam bentuk gel. Pembuatan gel dari ekstrak etanol herba pegagan memerlukan gelling agent yang tepat agar diperoleh sediaan gel yang memenuhi syarat sifat fisik dan tidak menimbulkan iritasi. Penelitian ini bertujuan untuk mengetahui pengaruh jenis gelling agent terhadap sifat fisik dan daya iritasi sediaan gel ekstrak etanol herba pegagan. Ekstrak diperoleh dengan metode maserasi menggunakan etanol 70%. Ekstrak tersebut dibuat menjadi sediaan gel dengan basis HMPC (F I), basis HMPC dan ekstrak (F II), basis carbopol (F III), basis carbopol dan ekstrak (F IV), Basis CMC Na (F V) dan basis CMC Na dan ekstrak (F VI). Gel kemudian diuji organoleptis, sifat fisik (uji pH, uji daya sebar, uji daya lekat), dan uji iritasi. Data yang diperoleh kemudian dianalisis statistik menggunakan analisis ANOVA dan Kruskall-Wallis dengan taraf kepercayaan 95%. Hasil penelitian menunjukkan bahwa variasi gelling agent berpengaruh terhadap daya sebar dan daya lekat sediaan gel ekstrak etanol herba pegagan. Daya sebar gel dengan gelling agent PMC memiliki daya sebar yang paling besar yaitu: 52,282 ± 2,515 mm2. Daya lekat gel dengan formula gelling agent carbopol ditambah ekstrak pegagan memiliki daya lekat yang paling besar yaitu 3,614 ± 0,128 detik. Berdasarkan uji iritasi, sediaan gel ekstrak etanol herba pegagan dengan variasi gelling agent tidak menyebabkan iritasi kulit pada marmut dan juga tidak mempengaruhi nilai pH. Dari hasil penelitian dapat disimpulkan bahwa gelling agent yang paling baik untuk sediaan ekstrak etanol herba pegagan adalah carbopol karena carbopol memiliki daya sebar yang baik, daya lekat baik dan tidak menimbulkan iritasi. Kata kunci: daya iritasi, gelling agent, pegagan (Centella asiatica L), sifat fisik. ABSTRACT Pegagan has activity as an antibacterial, so that required to be formulated into comfortable and practical used dosage form such as gel. Formulation of ethanolic exctract of Centella asiatica need gelling agent in order to obtain a gel which fulfill the physical properties requirement of gel and not cause irritation effect. The aim of the research to know the influence of the type of gelling agent toward the physical properties and irritation potential of gel of ethanolic extract of Centella asiatica, L. The extract was gotten by maceration method by using 70% ethanol. The extract was formulated become gel. The physical properties of gel was evaluated by organoleptic test, pH test, adhesivity test, spreadebility test, and skin irritation test. Data was analyzed with statical analysis using ANOVA test ab kruskall wallis test and then continued with Mann Withney test with 95% of confident level. Result of the research indicate that variation of gelling agent have an effect on spreadability and adhesivity of gel of ethanolic extract of Centella asiatica, L. The gel that has biggest spreadibility power is gel with HPMC formulation with the value 52.282 ± 2.515 mm2 and the smallest spreadibility power is gel with carbopol combinated with extract formulation with value 27.818 ± 1.023 mm2. While for the smallest adhesivity value on gel with HPMC formulation is 1.632 ± 0.289 second, and then the biggest adhesivity value on gel with carbopol is added extract is 3.614 ± 0.128 second. Variation of gelling agent did not influence of all of the gel formulas did not have irritation effect to marmut skin and pH value. The right gelling agent for ethanolic extract of Centella asiatica, L is carbopol because carbopol has a good spreadibility, good adhesivity, and minimal of irritation effect. Key words: Centella asiatica L, gelling agent, physical properties of gel, irritable potential.

Gel formulation of ethanol extract of mangosteen peel (Garcinia mangostana L.) as a medication for burns in wistar rats Nining Sugihartini; Rinanda Yeshi Wiradhika
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 2, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss2.art6

Background: Mangosteen peel (Garcinia mangostana L.) has been shown to stimulate the regeneration of damaged body cells and have an antimicrobial activity that can be beneficial in healing burns. Therefore, it is necessary to make it into a gel dosage form that has the advantages of being easily washed with water, high adhesion, cooling of the skin, and good drug release. Objective: To determine the effect of varying concentrations of ethanol extract of mangosteen peel in a gel formulation on wound healing in burns and the physical properties of the gel. Methods: Mangosteen peel extract was obtained by maceration method using ethanol 70%. This extract was formulated in a gel dosage form with variations of extract concentration, namely F I (5%), F II (10%), and F III (15%). The gels were then tested for their physical properties (organoleptic, homogeneity, pH, spreadability, adhesiveness, and physical stability) and their activity against burns experimentally using mice as test animals. Burns were made by using a hot plate with an area of 2 cm x 2 cm. Results: The increase of extract concentration could increase spreadability (p>0.05), adhesiveness (p>0,05), and percentage of healing activity against burns as shown by a significant difference between FI and FIII. On the other hand, the difference in the concentration of the extract did not affect pH (all formulations have pH of 3.5); all formulas also remained homogenous and stable after centrifugation. Conclusion: The best physical properties and wound healing activity for burns was shown by the gel with the ethanol extract of mangosteen peel at a concentration of 15%.

Co-Authors . Sismindari Achmad Fudholi Achmad Fudholi Achmad Fudholi Achmad Fudholi Aditya Noviadi Rakhmatullah Afriyani, Neti Agung Putu S.P.Kristyawan Aina Fatkhil Haque, Aina Fatkhil Aji Pamungkas Alvionida, Fitra Amraini Amelia Ani Guntarti Any Guntarti Any Guntarti Arif Budi Setianto Astryna, Syarifah Yanti Atri Sri Ulandari Auliah Rahmi Latif Azis Ikhsanudin Bayu Herdi Al Huda Deasy Vanda Pertiwi Delia Komala Sari, Delia Komala Desrianti, Cindy Desyandri Desyandri Diah Pratimasari Diyan Sakti Purwanto Diyan Sakti Purwanto Endah Nurlaela Endah Nurlaela Endang Lukitaningsih Erma Pranawati ERMAWATI, DIAN EKA Erna Astuti Erna Astuti Erwin Fauzana Evi Nuryanti Fadzil Latifah Firsty, Girly Risma Fitra Alvionida Fitri Rahmawanti Fitriah Ardiawijianti Iriani Fudholi, Achmad Fudholi, Achmad Gina Lestari Gina Lestari, Gina Girly Risma Firsty Gita Puspita Hafid, Indah Fitria Hana Hanifah Hari Susanti Hari Susanti Heru Sasongko Ichwan Ridwan Rais Iis Wahyuningsih Jannah, Syauqul Kintoko Kintoko Kintoko Kintoko, Kintoko Kurniawan, Muhammad Fariez Laela Hayu Nurani Laila, Wahyu Kumil Lalu Muhammad Irham Lela Sulastri, Lela Lena Maulina Lena Maulina, Lena M Alif Fajri Marchaban . Miratun Syarifah Mohamad Ikram Muhammad Alfian, Muhammad Muhammad Fariez Kurniawan Muhammad Fariez Kurniawan Muhammad Yusron Maulana El-Yunusi Mukhlishah, Neneng Rachmalia Izzatul Nanik Sulistyani Nina Salamah NINGRUM, TYAS SARI RATNA Novitasari, Putri Rachma Nugrahini, Febrina Nugroho, Nazih Basuki Nurhayati Nurhayati Nuri Ari Efiana Nurlaela, Endah Nyoman Rudi Kusuma Olvia Becatami Widyantoro Olvia Becatami Widyantoro, Olvia Becatami Pertiwi, Deasy Vanda Pramono, Suwidjiyo Pramono, Suwidjiyo Puput Herawati Said Hasan Rahmat Hidayat Rahmat Santoso, Rahmat Rahmawati, Desty Restia Raka Sukmabayu W.S Ratih Saridewi Rikadyanti Rikadyanti Rinanda Yeshi Wiradhika Ririn Suharsanti, Ririn Ristiono, Hendi Rosmiyanti, Yanti Rukaya, Benazir Evita Ryan Radix Rahadhian, Muhammad Sapto Yuliani Sapto Yuliani Sapto Yuliani Sismindari . Sismindari Sismindari Sismindari Sismindari Sismindari Sismindari Sismindari, Sismindari Sismindari, Sismindari Siti Athiyah Umaiyah Siti Ayu Marlina Sri Mulyaningsih Sri Mulyaningsih Srimuliani Arbie Suwidjiyo Pramono Suwidjiyo Pramono Suwidjiyo Pramono Suwidjiyo Pramono Suwidjiyo Pramono. Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Tedjo Yuwono Teuku Nanda Saifullah, Teuku Nanda Trecya Fujiastuti Trecya Fujiastuti, Trecya Tusilowati, Defita Andri Ulfa Ramdhani M Uswatun Chasanah Vivi Sophia Waliyyin Razan Qanit wardhani, Riska risty Widyantoro, Olvia Becatami Widyasari Putranti Wisnu Kundarto Wuryandari, Tutik Wuryandari, Tutik Yayan Rizikiyan Zaenab Zaenab Zainab Zainab Zainab Zainab Zainab

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