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All Journal PHARMACON Pharmaciana: Jurnal Kefarmasian BAHASA DAN SASTRA Jurnal Farmasi Klinik Indonesia English Review: Journal of English Education Pharmascience Tazkia Islamic Finance and Business Review Syntax Literate: Jurnal Ilmiah Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JELL (Journal of English Language and Literature) STIBA-IEC Jakarta Silampari Bisa: Jurnal Penelitian Pendidikan Bahasa Indonesia, Daerah, dan Asing Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ JTP - Jurnal Teknologi Pendidikan Jurnal Teknik JURNAL FARMASI GALENIKA Jurnal Riset Kesehatan Poltekkes Depkes Bandung Jurnal Dinamika UMT Lingua Rima: Jurnal Pendidikan Bahasa dan Sastra Indonesia Jurnal Insan Farmasi Indonesia Jurnal Abdimas Kartika Wijayakusuma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Locus Penelitian dan Pengabdian Jurnal Talenta Sipil Jurnal Pembelajaran Sastra The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Jurnal Farmasi Indonesia Edukasi Masyarakat Sehat Sejahtera (EMaSS) Guruku: Jurnal Pendidikan dan Sosial Humaniora Jurnal Sadewa: Publikasi Ilmu Pendidikan, Pembelajaran dan Ilmu Sosial Jurnal Gizi dan Dietetik Jurnal Medika Farmaka Inaba of Community Services Journal The Indonesian Journal of Computer Science Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Inovasi Bahan Lokal dan Pemberdayaan Masyarakat Jurnal Teknik Sipil Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Agus Sulaeman
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Journal : Pharmascience

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Efek Kombinasi Ekstrak Etanol Rimpang Kunyit (Curcuma longa L.) dan Daun Pegagan (Centella asiatica (L.) Urb) terhadap Ekspresi Gen eNOS pada Jaringan Hati Tikus Obes Sulaeman, Agus; Agustian, Salim; Susilawati, Elis; Muhsinin, Soni; Kaniawati, Marita; Feliana, Marita
Jurnal Pharmascience Vol 12, No 2 (2025): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.23813

Abstract

Obesitas adalah kondisi patologis akibat akumulasi lemak berlebih yang meningkatkan risiko gangguan metabolik, termasuk disfungsi endotel yang ditandai oleh penurunan produksi Nitric Oxide (NO) sintesis oleh enzim Endothelial Nitric Oxide Synthase (eNOS). Penelitian ini bertujuan mengevaluasi efek kombinasi ekstrak etanol rimpang kunyit (Curcuma longa L.) dan daun pegagan (Centella asiatica (L.) Urb) terhadap kadar NO serum dan ekspresi gen eNOS pada jaringan hati tikus obesitas. Penelitian eksperimental ini menggunakan tikus jantan yang diinduksi obesitas dengan pakan tinggi lemak dan karbohidrat selama 60 hari. Tikus dibagi enam kelompok: normal (kontrol negative), obesitas (kontrol positif), pembanding orlistat 10,8 mg/kgBB, ekstrak kunyit 200 mg/kgBB, ekstrak pegagan 20 mg/kgBB, dan kombinasi kunyit-pegagan 200:100 mg/kgBB. Parameter yang diukur meliputi berat badan, kadar NO serum (metode Griess), ekspresi gen eNOS (qPCR), kadar SGOT dan  SGPT. Hasil menunjukkan kombinasi ekstrak secara signifikan menurunkan berat badan dan meningkatkan kadar NO dibandingkan kelompok obesitas (p < 0,05), meningkatkan ekspresi gen eNOS serta secara (p< 0,05) signifikan menurunkan kadar SGOT dan SGPT . Penelitian ini mengindikasikan potensi kombinasi ekstrak kunyit dan pegagan sebagai agen preventif disfungsi endotel pada obesitas melalui peningkatan produksi NO dan regulasi ekspresi gen eNOS serta berperan sebagai hepatoprotektor. Kata Kunci: Ekstrak Kunyit, Ekstrak Pegagan, Ekspresi Gen eNOS, Jaringan Hati, Obesitas  Obesity is a pathological condition caused by excessive fat accumulation that increases the risk of metabolic disorders, including endothelial dysfunction characterized by decreased Nitric Oxide (NO) synthesis by the enzyme Endothelial Nitric Oxide Synthase (eNOS). This study aims to evaluate the effects of a combination of ethanol extracts of turmeric rhizome (Curcuma longa L.) and gotu kola leaves (Centella asiatica (L.) Urb) on serum NO levels and eNOS gene expression in the liver tissue of obese rats. This experimental study used male rats induced to become obese with a high-fat and high-carbohydrate diet for 60 days. The rats were divided into six groups: normal (negative control), obese (positive control), orlistat 10.8 mg/kgBW, turmeric extract 200 mg/kgBW, gotu kola extract 20 mg/kgBW, and turmeric-gotu kola combination 200:100 mg/kgBW. The measured parameters included body weight, serum NO levels (Griess method), eNOS gene expression (qPCR), SGOT and SGPT levels. The results showed that the combination of extracts significantly reduced body weight and increased NO levels compared to the obesity group (p < 0.05), increased eNOS gene expression, and significantly (p < 0.05) decreased SGOT and SGPT levels. This study indicates the potential of the combination of turmeric and pegagan extracts as a preventive agent for endothelial dysfunction in obesity through the enhancement of NO production and regulation of eNOS gene expression as well as acting as a hepatoprotector.
Co-Authors Adinda, Deistha Adzkia, Muhammad Fasya agung, fred Agustian, Salim Agustina Indri Hapsari Ahmad Suherman Akbar Rulazi, Bagus Ali Sulaiman Ali Sulaiman Anne Yuliantini Aolina, Shelin Ardadinata, Raihan Arief, Mansur Ariyana Ariyana Ariyana, Ariyana Asherlia, Dwita Astuti, Ayu Dwi Aulia Nurfazri Istiqomah Aulia, Arsy Auliyaa, Millata Azhari, Swary Anistri Bachrudin, Panji Bayinah, Ai Nur Deni Iskandar Destianto, Anto Dewi, Nova Freena Dhiani, Yanni Dimas R. Pambudi Djoko Widodo Dwitantika, Bryan Eka Cahyani, Dhiana Eka Gumilang, Nurani Eka Wardatul Jannah eko putra, eko Elysia, Syahda Embas Saraswati, Dewa Ayu Enawar, Enawar Ernawati Ernawati Fatmawati, Eva Fauziyah, Azkia Nurul Fauziyah, Roro Nur Feliana, Marita Garnadi Jafar, Garnadi Gatot Susilo Lawrence Ghassani, R Wulandari Goziyah Goziyah Goziyah, Goziyah gumilar, mulus Hamumeha, Abigail Diwa Hanna Sundari Hapsari , Agustina Indri Haryanti, Reni Hasimun, Patonah Hastuti, Widi Heny Sulistyowati Herdiansah , Yudi Herdiansah, Yudi Hoon, Kim Dong Hossanti Ntobu, Febri Hun, Kim Dong Idar Ira Miranti, Ira Irawan, Farid Irman, Deni Irviansyah, Cepy Okta Isdiany, Nitta Isybillah Ahmad, Afifah Judiono Judiono Juli Yani Kamiri, Kamiri Larson Boling Sau, Barth Lindasari, Heni Lutfiyah, Fifih M Ramadhan Saputro Maia de Fatima Freitas, Floriana Malik Al Akbar, Ayatullah Mamat Rahmat Maria Hendriyani, Rina Marita Kaniawati Marliani, Lia Maryati Dewi, Maryati Maulana, Didit Mia N. A. Fatin Mona Fitria Muhamad Agung Muhamad Iqbal mulus gumilar Mutoharoh Mutoharoh Nori Anggraini, Nori Novia Adiningsih, Arum Nunung Nurhasanah Nurfadillah, Ilham Nurfazri Istiqomah, Aulia Nurfazri, Aulia Nurjaman, Jajang Patonah Prasasti, Tresna Dewi Pratiwi, Aulya Yudha Purawinangun, Ira Anisa Pusparini Pusparini Putra, Hendra Mahakam Rafiansyah, Rafli Rizki Rahmat Santoso, Rahmat Rahmatullah, Muhammad Firdaus Rauda Ramdania, Diena Regi Fasya Septrian Resdiana, Rafli Aridzalrahman Reza Pratama Rizkyanto, Dheva Ferdinand Rofi’i, Agus Roni Farfian Roni Hidayat Rosmana, Dadang Rossa Rosefa Simanjuntak Royani, Ani Rum, Ira Adiyati Saleky, Yohannes Willihelm Salma Tia Salsabila Saputra, Nanda Saputro, M. Ramadhan SARI APRIYANI Sayeti, Ety Siti Supriyati Soni Muhsinin Stiani, Sofi Nurmay Sumarjo, Dwi Nur Ida Islamiati Suri Darmawan, Ammar Susilawati, Elis Syaharuddin Kasim Syahrizal Syahrizal Syarifuddin Wahid Syarifuddin Wahid Tundreng, Syarifuddin Udayanto, Nugroho Sungkono Vallini, Lia Wati, Afifah Ashma Widartika Widartika Widianto, Asriadi Prihandika Winara, Zahra Winasari, Winasari Winda Dwihudhana Witri Priawantiputri Xbal Meiprasetyo Yani Mulyani Yayuk Febriyanthi , Anggita Yenny Moviana, Yenny Yermia Ademi Dedeo Yuliani, Rany Yunita, Dilla Zinan, Daula Zahra