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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Akuntabilitas Manajemen Pendidikan Jurnal Sains dan Teknologi Farmasi E-Dimas: Jurnal Pengabdian kepada Masyarakat Empowerment : Jurnal Pengabdian Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal SOLMA JURNAL EKONOMI PENDIDIKAN DAN KEWIRAUSAHAAN Martabe : Jurnal Pengabdian Kepada Masyarakat PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline Jurnal Ilmu Kefarmasian Indonesia Indonesian Journal of Halal Research International Journal of Economics Development Research (IJEDR) BERNAS: Jurnal Pengabdian Kepada Masyarakat Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Entrepreneurship Bisnis Manajemen Akuntansi (E-BISMA) International Journal of Engineering, Science and Information Technology INTERNATIONAL JOURNAL OF CULTURAL AND SOCIAL SCIENCE Jurnal Locus Penelitian dan Pengabdian Pharmaceutical Sciences and Research (PSR) Indonesian Journal of Medical Chemistry and Bioinformatics E-JRM Amkop Management Accounting Review (AMAR) Jurnal Multidisiplin Indonesia Indonesian Journal of Community Empowerment Jurnal Sains dan Kesehatan
Hadi Sunaryo
Fakultas Farmasi Dan Sains Universitas Muhammadiyah Prof. Dr. Hamka
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A Computational Exploration: Docking Analysis of Compounds from Foeniculum vulgare as Potential Aromatase Inhibitors for Endometriosis Candidate Therapy Suryandari, Dwi Anita; Sari, Puji; Sunaryo, Hadi; Istiadi, Khaerunissa Anbar
Indonesian Journal of Medical Chemistry and Bioinformatics
Publisher : UI Scholars Hub

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Aromatase inhibitors (AI) have controlling symptoms and size of endometriotic implants, making them a promising second-line therapy for endometriosis treatment.pretreatment with letrozole, an AI, combined with leuprolide acetate and resveratrol has been found to improve in vitro fertilization (IVF) outcomes in women mild endometriosis.in this study we screening and analysis of ten phenolic compounds from Foeniculum vulgare using molecular docking with Mcole server.from this results showed that three phenolic trans resveratrol (TR), caempherol coumaril (CC) have low gibbs energy compare with resveratrol (R). The binding modalities of compound TR and compound R were hydrogen-bonding between the hydroxyl and oxygen atom and Thr310 and hydrophobic interactions with Phe187, Ala272, Asp275, Ala189.and compound R exhibited cation-π interactions between Val336 as binding activity from aromatase.aromatase inhibitors and resveratrolfrom fennel lies in the potential of resveratrol to modulate hormonal pathways, including aromatase inhibition.
Molecular Insights into Propylthiouracil as a Thyroid Peroxidase Inhibitor: A Computational Study Approach Suryandari, Dwi Anita; Yunaini, Luluk; Sunaryo, Hadi; Istiadi, Khaerunissa Anbar; Pratomo, Irandi Putra
Indonesian Journal of Medical Chemistry and Bioinformatics
Publisher : UI Scholars Hub

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Thyroid peroxidase (TPO) is a crucial enzyme in the biosynthesis of thyroid hormones, catalyzing the iodination of tyrosine residues in thyroglobulin and the coupling of iodotyrosines to form thyroxine (T4) and triiodothyronine (T3). Propylthiouracil (PTU) is an antithyroid drug commonly used to manage hyperthyroidism by inhibiting TPO. Understanding the molecular interactions between TPO and PTU can provide insights into the inhibitory mechanisms and guide the design of more effective antithyroid medications. Objective: This study aims to elucidate the binding interactions between TPO and PTU through molecular docking, providing a detailed understanding of how PTU inhibits TPO activity. Methods: The three-dimensional structure of TPO was obtained from Prosite and modelling by swissmodel and prepared for docking. The structure of PTU was optimized, and molecular docking was performed using AutoDock. The binding affinity, binding poses, and key interactions between TPO and PTU were analyzed. Visualization of the docking results was performed using PyMOL to identify critical residues involved in PTU binding. Results: The docking analysis revealed that PTU binds effectively to the active site of TPO with a binding affinity of -5.45 kcal/mol. The interaction involves coordination with the heme group and several key residues, including His239, which coordinates the heme, and Ser314, which forms hydrogen bonds with PTU. Additionally, hydrophobic interactions with residues Phe241 and Ile399 stabilize the binding of PTU in the active site. Conclusion: The docking study highlights the significant interactions between PTU and TPO, elucidating the molecular basis of TPO inhibition by PTU. The binding affinity and key interactions identified in this study provide a foundation for the design of more potent antithyroid drugs.
The Prospect of Indonesian Herbal as An Alternative Treatment for Covid-19 Patient: A Literature-Based Study SUNARYO, HADI; Hidayati, Wahyu
Indonesian Journal of Medical Chemistry and Bioinformatics
Publisher : UI Scholars Hub

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Coronavirus disease 2019 (COVID-19) is a new disease caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease has several symptoms from mild to severe and could lead to death for comorbidities and the elderly. Therefore, the infections and mortality cases keep growing day by day, moreover many authorities are trying to suppress it by applying several health protocols, including medicines. Several studies were conducted on drug discovery from plants to cure the disease. The article aimed to do a narrative review about the prospect of JAMU becoming an alternative medicine to cure COVID-19 by mapping the literature deposited on PubMed which reported medicinal plants as an alternative medicine for COVID-19 by using a text mining program. There are approximately 30,191 articles on PUBMED related to COVID-19 and medicine. Medicinal plants with antiviral and anti-inflammatory activities are the best plants for COVID-19. JAMU, an Indonesian traditional medicine, has an outstanding possibility to be applied in the COVID-19 strategy to recover patients and prevent infections.
Efektivitas Kepemimpinan Transformasional Kepala Sekolah melalui Komitmen Kerja terhadap Kinerja Guru Merdeka Belajar Efendi, Feriawan; Sunaryo, Hadi; Harijanto, Djony
Jurnal Akuntabilitas Manajemen Pendidikan Vol. 11 No. 2 (2023): September
Publisher : Faculty of Educational Sciences, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jamp.v11i2.60605

Abstract

Penelitian ini bertujuan untuk mengidentifikasi pengaruh kepemimpinan transformasional terhadap komitmen kerja, pengaruh kepemimpinan transformasional terhadap kinerja guru dalam implementasi merdeka belajar, mengidentifikasi pengaruh komitmen kerja terhadap kinerja guru dalam implementasi merdeka belajar, serta mengevaluasi pengaruh kepemimpinan transformasional terhadap kinerja guru dalam implementasi merdeka belajar melalui variabel intervening yaitu komitmen kerja. Metode yang dipakai yaitu survei dengan pendekatan kuantitatif, sampel penelitian sejumlah 244 guru terdiri dari bapak dan ibu guru dari tiga SMA Sekolah Penggerak dan tiga SMK Pusat Keunggulan yang berada di wilayah Blitar yang berfokus pada implementasi merdeka belajar. Hasil penelitian menemukan bahwa gaya kepemimpinan transformasional yang dipraktikkan oleh kepala sekolah mampu meningkatkan komitmen kerja guru dalam implementasi merdeka belajar, penerapan gaya kepemimpinan transformasional oleh kepala sekolah dapat meningkatkan kinerja guru terlebih dalam implementasi merdeka belajar, terdapat keterkaitan antara komitmen kerja dengan kinerja guru dalam implementasi kurikulum merdeka, serta hasil penelitian menunjukkan bahwa penerapan gaya kepemimpinan transformasional secara efektif mampu menumbuhkan komitmen kerja dan memediasi hubungan antara gaya kepemimpinan tersebut dengan kinerja guru merdeka belajar.
Pengaruh Kualitas Pelayanan, Kualitas Produk Dan Harga Produk Terhadap Kepuasan Pelanggan Pada Nice So Kota Malang Sejati, Eling Rosa; Sunaryo, Hadi; Mustapita, Arini Fitria
E-JRM : Elektronik Jurnal Riset Manajemen E-JRM : Elektronik Jurnal Riset Manajemen Vol. 13 No. 01
Publisher : UNIVERSITAS ISLAM MALANG

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Abstract This research aims to determine the influence of service quality, product quality and product price on Nice So customer satisfaction in the city of Malang. In the current era, there are many types of businesses that carry out various kinds of innovations based on customer needs. An example of a form of business that is widely known to the public is Nice So. It is a supermarket that provides products for daily needs, one of which is accessories, fashion equipment, office stationery and electronic equipment. The research method used was quantitative. Sampling used non-probability sampling with purposive sampling technique totaling 87 respondents. Data analysis uses multiple linear regression analysis. The results of this research show that simultaneously service quality, product quality and product price have a significant effect on customer satisfaction. Partially, product quality has a significant effect on customer satisfaction and product price has a significant effect on customer satisfaction. However, this research proves that service quality does not have a significant effect on customer satisfaction. Keywords: Customer Satisfaction, Service Quality, Product Quality, Product Price, Nice So 
Pengaruh Lingkungan Kera, Motivasi Dan Budaya Organisasi Terhadap Komitmen Kerja (Pegawai Kantor Kecamatan Woha Kabupaten Bima) Taslim, M.; Sunaryo, Hadi; Rizal, Mohammad
E-JRM : Elektronik Jurnal Riset Manajemen E-JRM : Elektronik Jurnal Riset Manajemen Vol. 13 No. 01
Publisher : UNIVERSITAS ISLAM MALANG

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Abstract This research is a type of quantitative research. Where the population in this study was used as a sample using a saturated sample with a population of 75 respondents. By collecting data using the Correlation method, it aims to determine the partial influence between the variables of Work Environment, Motivation, and Organizational Culture on Employee Work Commitment. The Work Environment has a partial positive and significant influence on Work Commitment. Motivation does not have a partially significant effect on Work Commitment. Organizational Culture has a partially positive and significant influence on Work Commitment. The results of the Coefficient of Determination concluded that the magnitude of the influence of the variables Work Environment, Motivation, Organizational Culture on Work Commitment, with the rest influenced by other variables that were not studied in this study Keywords: Work Environment, Motivati on, and Organizational Culture towards Work Commitment 
Pengaruh Influencer Marketing, Word of Mouth Dan Brand Image Terhadap Purchase Intention Pada Produk Scarlett whitening (Studi Mahasiswa FEB Universitas Islam Malang Angkatan 2020) Ulya, Naylia Fadhilatul; Sunaryo, Hadi; Mustapita, Arini Fitria
E-JRM : Elektronik Jurnal Riset Manajemen E-JRM : Elektronik Jurnal Riset Manajemen Vol. 13 No. 01
Publisher : UNIVERSITAS ISLAM MALANG

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Abstract This research aims to identify the influence of Influencer Marketing, Word of Mouth, and Brand Image on Purchase Intentions for Scarlett Whitening products. The sample used in this research uses the Snowball sampling technique, which is a data source sampling technique which at first is small in number, over time it becomes large and to determine the sample size using the Slovin formula which has a sample size of 82 samples used in the results of this research as well as showing There is a significant positive influence between Influencer Marketing, Word of Mouth and Brand Image variables on Purchase Intentions for Scarlett Whitening products. Likewise, the Influencer Marketing, Word of Mouth and Brand Image variables have a partial and simultaneous influence on the Purchase Intention variable for Scarlett Whitening products. Keywords: Influencer Marketing, Word of Mouth, and Brand Image
Pengaruh Lingkungan Kerja, Motivasi Kerja Dan Disiplin Kerja Terhadap Kinerja Karyawan Pramiswari, Galih Intan; Sunaryo, Hadi; Rahman, Fahrurrozi
E-JRM : Elektronik Jurnal Riset Manajemen E-JRM : Elektronik Jurnal Riset Manajemen Vol. 12 No. 02
Publisher : UNIVERSITAS ISLAM MALANG

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Abstract The study seeks to investigate the impact of the workplace environment, motivation, and adherence to work discipline on the performance of employees (at the Batu City Regional Financial and Asset Agency Office). This type research employs a quantitative approach. approach and the data collection method used in this research is questionnaire data. In this research, the sample used was 48 employees who would be used as research objects. The analytical method used in this research is multiple linear analysis with hypothesis testing using the F test and t test. Based on the results of this research, it shows that the work environment, work motivation and work discipline simultaneously influence employee performance, while partially the work environment influences employee performance, work motivation influences employee performance and work discipline influences employee performance Keywords: Work Environment, Motivation, Discipline And Employee Performance
Pengaruh Lingkungan Kerja, Kompetensi dan Etos Kerja Terhadap Kinerja Karyawan (Studi Pada Karyawan UMKM Tahu Kres KWB) Amrullah, Angkoso Ahmad; Sunaryo, Hadi; Suharto, M. Khoirul Anwarudin Broto
E-JRM : Elektronik Jurnal Riset Manajemen E-JRM : Elektronik Jurnal Riset Manajemen Vol. 13 No. 01
Publisher : UNIVERSITAS ISLAM MALANG

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Abstract This study aims to examine and explain the influence of the work environment, competence and work ethic on employee performance at KWB Tahu Kres UMKM. The sample used in this study were 31 employees using the saturated sample technique. The data analysis method used in this study is quantitative data analysis using multiple linear regression analysis. Testing the data used is testing the simultaneous hypothesis (Test F) and testing the partial hypothesis (Test t). The results of this study indicate that simultaneously (Test F) the variables of the work environment, competence and work ethic have a significant effect on employee performance at the UKM Tahu Kres KWB. Meanwhile, based on the results of the partial test (t test) the work environment variable has a significant effect on employee performance at the UMKM Tahu Kres KWB, the competency variable has a significant effect on the performance of employees at the UMKM Tahu Kres KWB, the work ethic variable has a significant effect on the performance of employees at the UMKM Tahu Kres KWB. Keywords: Work Environment, Competence, Work Ethic and Employee Performance
Pengaruh Karakteristik Individu, Komunikasi, Dan Kerjasama Tim Terhadap Kinerja Pegawai Agustin, Faikotul Wulan; Sunaryo, Hadi; Suharto, M. Khoirul Anwarudin Broto
E-JRM : Elektronik Jurnal Riset Manajemen E-JRM : Elektronik Jurnal Riset Manajemen Vol. 13 No. 01
Publisher : UNIVERSITAS ISLAM MALANG

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Abstract This study aims to describe and analyze the influence of individual characteristics, communication, and teamwork on employee performance. The type of research used in this study is quantitative research. The population in this study were employees of Field 1 of the Pasuruan Regency Environmental Service. The determination of the number of samples used saturated samples with a total of 83 employees as respondents. The results of the study stated that individual characteristics, communication, and teamwork simultaneously influenced employee performance and partially individual characteristics and teamwork had a positive and significant effect on employee performance while communication did not affect employee performance. Keywords: Individual Characteristics, Communication, Teamwork, Employee Performance
Co-Authors . Sediarso . Sediarso . Sediarso, . AA Sudharmawan, AA Adia Putra Wirman Adia Putra Wirman, Adia Putra Aggasy, Savira Yustinah Agustin, Faikotul Wulan Ajiningtyas, Rahtanaya Amin, Muhammad Sirojuddin Amrullah, Angkoso Ahmad Apriyanto, Guntur Ari Widayanti Arini Fitria Mustapita Bariroh, Tahyatul Chamid Alif, A’an Abdul Daram Heriansyah DIAN LESTARI Dwi Anita Suryandari Dwitiyanti Dwitiyanti Dwiyani Sudaryanti Efendi, Feriawan Ekafianti, Firdayani Elly Wardani, Elly Ema Dewanti Etin Diah Permanasari Fahrurrozi Rahman Farida, Eka Fatahillah, Mulki Fikriansyah, M. Firhan Azis Fith Khaira Nursal Fitri Hidayah, Ratna Fujianti, Fujianti Hariati, Wiwik Harijanto, Djony Hariyanti Hariyanti Hariyanti Hariyanti Hayati Hayati Hayati Hayati Hayati, Hayati Ika Resty Kania Ika Resty Kania, Ika Resty Imam Bushiri, Moh Irandi Putra Pratomo Isra, Rafiq Al Jamaliah Jamaliah Jeni Susyanti Kartika Sari, Devel Khaerunissa Anbar Istiadi Khalikussabir, Khalikussabir Khalishatunnada Khalishatunnada Kristiana, Helda Luluk Yunaini Lusi Putri Dwita M. Abi Rafdi M. Agus Salim Al Fathoni Mayangsari, Jihanning Yudha Mobaraq, Moh. Rizki Fajar Mohammad Rizal, Mohammad Muhammad Zaki Sopiani Muhammad Zaki Sopiani, Muhammad Zaki Mukti, Shinta Aulia Cahya Mulki Fatahillah Mulki Fatahillah, Mulki Ni Putu Ermi Hikmawanti Niadianti, Elivia Nikmatullah, Nurul Azmah Numlil Khaira Rusdi, Numlil Khaira Nurjanah, Desi Nurul Amalia Nurul Amalia Nurul Amalia Nurul Azmah Nikmatullah Nurul Azmah Nikmatullah Oktadio Erikardo Pardiman Pardiman Pardiman Permatasari, Indriani Detty Pramiswari, Galih Intan Prasetyo, Rachmad Eka Prasetyo, Rachmad Eka Prisiska, Fahjar Puji Sari Purbasari, Euis Putri, Vera Eselia R, Rizky Arcinthya Rahmadini, Nuriza Rahmat, Amalia Retno Lia Sari Rini Prastiwi Riyanti, Hurip Budi Rizky Arcinthya R Rizky Arcinthya R RIZKY ARCINTHYA RAHMANIA Rizky Rafiqul Safira, Easy Salim, M. Agus Samiratul Mufidah Saraswati, Ety Sari Nurlaily, Sari Sediarso Sediarso, Sediarso Sejati, Eling Rosa Septiana Tri Pamungkas Siska Siska siska siska Siska Siska siska, siska Siti Asiyah Sopiani, Muhammad Zaki Suharto, M. Khoirul Anwarudin Broto Suja’i, Ahmad Yusuf Imam Suriantika, Cipto Suwandini, Amelian Nisa Syahbandono, Tri Hutomo Syahputra, Hafiz Firdaus Taslim, M. Tri Hutomo Syahbandono Tri Hutomo Syahbandono Ulya, Naylia Fadhilatul Vera Ladeska Wahyu Hidayati wardani, teja kusuma Wati Sukmawati Wati Sukmawati Wati Sukmawati Wati, Ice Trisna Zamahsari, Mohammad Fikri