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All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Universa Medicina AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Jurnal Medik Veteriner Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Parasite Science Ovozoa: Journal of Animal Reproduction journal of Basic Medical Veterinary Journal of Pharmaceutical and Sciences. Journal of Fisheries & Marine Jurnal Agro Veteriner
Lilik Maslachah
Department Of Veterinary Basic Medicine, Faculty Of Veterinary Medicine, Universitas Airlangga, Surabaya, East Java, 60115. Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Universa Medicina

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Increase in neutrophil count after repeated exposure of Plasmodium berghei-infected mice to artemisinin Maslachah, Lilik; Sugihartuti, Rahmi
Universa Medicina Vol 36, No 1 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.49-58

Abstract

Background Leukocytes play an important role in the elimination of malaria infection. The leukocyte profile upon elimination of the malaria parasites that have been exposed to antimalarials and are subsequently capable of faster growth has not been researched. The aim of this research was to evaluate the role of mouse leukocytes in the elimination of parasites as shown by the leukocyte profile.Methods An experimental research with post test only control group design was conducted involving 24 male mice of the Swiss Albino strain weighing 20 g -30 g, and 2.5 months old. They were randomized into four groups: two control groups (K1, KP) and two treatment groups (P1, P4). Artemisinin at a dose of 0.04 mg/g body weight was given to the mice for 3 days, starting 2 days after infection. The leukocyte profile was observed on the 2nd, 5th, 8th, and 10th day after infection. The results were analyzed by two-way Anova.Results As shown in treatment control group KP and treatment group P4, P. berghei that had been passaged in the mice and were still viable after repeated exposure to artemisinin, may cause changes in leukocyte profile. On the 10th day of infection, the neutrophil percentage in group P1 showed a significantly different decrease when compared with the other groups (K1, KP and P4) (p<0.05).Conclusion Repeated exposure to artemisinin of mice infected with P. berghei can cause changes in neutrophil profile in mice.
Induction of Plasmodium falciparum strain 2300 dormant forms by artemisinin Lilik Maslachah; Yoes Prijatna Dachlan; Chairul A. Nidom; Loeki Enggar Fitri
Universa Medicina Vol. 34 No. 1 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.25-34

Abstract

BACKGROUND The presence of Plasmodium falciparum resistance and decreased efficacy of artemisinin and its derivatives has resulted in the issue of malaria becoming increasingly complex, because there have been no new drugs as artemisinin replacements. The aims of this research were to evaluate in vitro changes in ultrastructural morphology of P. falciparum 2300 strain after exposure to artemisinin. METHODS The research used an experimental design with post test only control group. Cultures of P. falciparum 2300 strain in one control and one mutant group were treated by exposure to artemisinin at IC50 10-7 M for 48 hours. Ultrastructural phenotypic examination of ring, trophozoite and schizont morphology and developmental stage in the control and mutant group were done at 0, 12, 24, 36, 48 hours by making thin blood smears stained with 20% Giemsa for 20 minutes and examined using a microscope light at 1000x magnification. RESULTS Dormant forms occurred after 48 hours of incubation with IC50 10-7 M artemisinin in the control group. In the mutant group, dormant forms, trophozoites with blue cytoplasm and normal schizont developmental stages were seen. Ultrastructural phenotypic morphology at 0, 12, 24, 36, 48 hours showed that in the control group dormant formation already occurred with exposure to IC50 10-7 M, while in the mutant group dormant formation occurred only with exposure to IC50 2.5x10-5 M. CONCLUSION Exposure to artemisinin antimalarials in vitro can cause phenotypic morphological changes of dormancy in P. falciparum Papua 2300 strain.
Co-Authors Adiana Mutamsari Witaningrum Agustina, Firanda Al Arif, M Anam Al arif, Mohammad Anam Al-Anshori, Akhmad Afifudin Andreas Berny Yulianto, Andreas Berny Arief Budiman Ayu, Zerlinda Dyah Boedi Setiawan Candika, Yossy Imam Chairul A. Nidom Chairul A. Nidom Chairul Anwar Chandra, Evania Haris Cholifah, Siti Chusnul Chusniati, Sri Dadik Rahardjo, Dadik David Mohamad Qadafi Dewi, Aprilia Kurnia Eko Agus Suyono Endang Suprihati Hani Plumeriastuti Hendarti, Gracia Angelina Hermin Ratnani Hernanda, Ary Setya Herry Agoes Hermadi Hidajati, Nove Hidanah, Sri Hidayatik, Nanik Hisyam, Mirza Atikah Madarina Indriyanti, Astrid Ismi, Alif Noviana Kadek Rachmawati Khoirunnisa, Itrah Koestanti S, Emy Kurnijasanti, Rahma Legowo, Djoko Loeki Enggar Fitri Lucia Tri Suwanti, Lucia Tri Luqman, Epy Muhammad Mahendra Pujiyanto Mirino, Mario Navyseal Mochamad Donny Koerniawan Mochamad Lazuardi Muhammad Hambal Munawer Pradana Mustofa Helmi Effendi Nunuk Dyah Retno Lastuti Nusdianto Triakoso Poedji Hastutiek Pratama, Abrian Panggalih Indra Pujiyanto, Mahendra Putri, Anandia Nafisah Raharjo, Hartanto Mulyo Rahmi Sugihartuti, Rahmi Ratna Damayanti Rochmah Kurnijasanti Rusyawardani, Aldis Ingrid Sabdoningrum, Emy Koestanti Saputra, Rakan Mahiid Saraswati, Afif Tasya Sarudji, Suryanie Soeharsono Soeharsono Sri Mulyati Suherni Susilowati Suhud, Mohamad Kharis Sukmanadi, Moh. Sukmanadi, Mohammad Sulaiman, Azhari Athaillah Supranianondo, Koesnoto Suprihati , Endang Supriyadi Suzanita Utama Tacharina, Martia Rani Tatik Hernawati Tintin Sukartini Sukartini, Tintin Sukartini Tita Damayanti Lestari Tri Wahyu Suprayogi Tyaningsih, Wiwiek Ulfah Juniarti Siregar Utomo, Gogik Satrio Margo Widiyatno, Thomas Valentinus Widjiati Widjiati, Widjiati Widya Paramita Lokapirnasari Widya Paramita Lokapirnasari Wiwik Misaco Yuniarti Yoes Prijatna Dachlan Yulianna Puspitasari Zhaza Afililla