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All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Universa Medicina AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Jurnal Medik Veteriner Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Parasite Science Ovozoa: Journal of Animal Reproduction journal of Basic Medical Veterinary Journal of Pharmaceutical and Sciences. Journal of Fisheries & Marine Jurnal Agro Veteriner
Lilik Maslachah
Department Of Veterinary Basic Medicine, Faculty Of Veterinary Medicine, Universitas Airlangga, Surabaya, East Java, 60115. Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Journal of Fisheries

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The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro Mahendra Pujiyanto; Zhaza Afililla; Lilik Maslachah; Thomas Valentinus Widiyatno; Mochamad Donny Koerniawan; Eko Agus Suyono; Arief Budiman; Ulfah Juniarti Siregar; Lucia Tri Suwanti
Jurnal Ilmiah Perikanan dan Kelautan Vol. 14 No. 2 (2022): JURNAL ILMIAH PERIKANAN DAN KELAUTAN
Publisher : Faculty of Fisheries and Marine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jipk.v14i2.34766

Abstract

Highlight Research One of the content of microalgae that is beneficial for health is polysaccharides Polysaccharides of Indonesian microalgae can be promoted as anti-malarial Polysaccharides from Glagah, Spirulina and East Java microalgae inhibited the growth of plasmodium in vitro and had IC50 values of 3.18 µg/mL, 5.43µg/mL and 9.87 µg/mL, respectively   Abstract Malaria is an infectious disease caused by protozoan parasites of the genus Plasmodium that categorized as deadliest diseases in the world. Artemisinin and its derivatives are still recommended drugs for malaria therapy, however, there have been indications that Plasmodium parasites are resistant to this drug. Therefore, a study on polysaccharides from microalgae may be a potential as bioactive compound for anti-malaria. The aim of this study was to determine the effectiveness of the mixed microalgae polysaccharides as anti-malarial in vitro. Polysaccharides were extracted from three microalgae Spirulina sp., mixed microalgae Glagah and mixed microalgae East Java using the alkaline extraction method. The anti-malarial activity test refers to the concentration of polysaccharides used in calculating the IC50 value by probit analysis.  The concentration of polysaccharides of the three microalgae used were 0; 0.01; 0.01, 1, 10 and 100 µg/mL. The results showed that the IC50 values of polysaccharides of Glagah, Spirulina sp. and East Java microalgae were 3.18 µg/mL, 5.43µg/mL, and 9.87 µg/mL, respectively. In Conclusion, polysaccharides of Indonesian mixed microalgae can be promoted as anti-malarial.
Co-Authors Adiana Mutamsari Witaningrum Agustina, Firanda Al Arif, M Anam Al arif, Mohammad Anam Al-Anshori, Akhmad Afifudin Andreas Berny Yulianto, Andreas Berny Arief Budiman Ayu, Zerlinda Dyah Boedi Setiawan Candika, Yossy Imam Chairul A. Nidom Chairul A. Nidom Chairul Anwar Chandra, Evania Haris Cholifah, Siti Chusnul Chusniati, Sri Dadik Rahardjo, Dadik David Mohamad Qadafi Dewi, Aprilia Kurnia Eko Agus Suyono Endang Suprihati Hani Plumeriastuti Hendarti, Gracia Angelina Hermin Ratnani Hernanda, Ary Setya Herry Agoes Hermadi Hidajati, Nove Hidanah, Sri Hidayatik, Nanik Hisyam, Mirza Atikah Madarina Indriyanti, Astrid Ismi, Alif Noviana Kadek Rachmawati Khoirunnisa, Itrah Koestanti S, Emy Kurnijasanti, Rahma Legowo, Djoko Loeki Enggar Fitri Lucia Tri Suwanti, Lucia Tri Luqman, Epy Muhammad Mahendra Pujiyanto Mirino, Mario Navyseal Mochamad Donny Koerniawan Mochamad Lazuardi Muhammad Hambal Munawer Pradana Mustofa Helmi Effendi Nunuk Dyah Retno Lastuti Nusdianto Triakoso Poedji Hastutiek Pratama, Abrian Panggalih Indra Pujiyanto, Mahendra Putri, Anandia Nafisah Raharjo, Hartanto Mulyo Rahmi Sugihartuti, Rahmi Ratna Damayanti Rochmah Kurnijasanti Rusyawardani, Aldis Ingrid Sabdoningrum, Emy Koestanti Saputra, Rakan Mahiid Saraswati, Afif Tasya Sarudji, Suryanie Soeharsono Soeharsono Sri Mulyati Suherni Susilowati Suhud, Mohamad Kharis Sukmanadi, Moh. Sukmanadi, Mohammad Sulaiman, Azhari Athaillah Supranianondo, Koesnoto Suprihati , Endang Supriyadi Suzanita Utama Tacharina, Martia Rani Tatik Hernawati Tintin Sukartini Sukartini, Tintin Sukartini Tita Damayanti Lestari Tri Wahyu Suprayogi Tyaningsih, Wiwiek Ulfah Juniarti Siregar Utomo, Gogik Satrio Margo Widiyatno, Thomas Valentinus Widjiati Widjiati, Widjiati Widya Paramita Lokapirnasari Widya Paramita Lokapirnasari Wiwik Misaco Yuniarti Yoes Prijatna Dachlan Yulianna Puspitasari Zhaza Afililla