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All Journal HAYATI Journal of Biosciences Natural Science: Journal of Science and Technology Media Eksakta Indonesian Journal of Pharmaceutical Science and Technology Biocelebes Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia Jurnal Health Sains Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Narra J Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Journal of Noncommunicable Diseases (JOND) Dedication : Jurnal Pengabdian Masyarakat Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Medika: Medika Jurnal Pengabdian Farmasi dan Sains Journal of Tropical Pharmacy and Chemistry Jurnal Dedikatif Kesehatan Masyarakat Poltekita: Jurnal Pengabdian Masyarakat
Yuliet Yuliet
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Tadulako University, Jl. Sukarno-Hatta Km 9, Palu 94148, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Uji Efek Antidiabetes Ekstrak Akar Garcinia rostrata Hassk.ex Hook.f Pada Mencit Jantan (Mus musculus) Dengan Metode Toleransi Glukosa Dan Induksi Aloksan Nifien Mokuna; Ramadhanil Ramadhanil; Yuliet Yuliet
Biocelebes Vol. 8 No. 2 (2014)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Abstract

Traditional medical treatment is one of the ways to lower the glucose level in the blood. It is a plant Garcinia rostrata Hassk.ex Hook.f one of the plants which has a potential to lower the glucose level in blood. This is supported by alkaloid, flavonoid, saponin efficacious as an anti-diabetic. Therefore, hypoglycemia activity of Garcinia rostrata Hassk.ex Hook.f root extract test was conducted by using glucose tolerance and alloxan methods at mice. The objective of this research is to know the hypoglycemia activities of Garcinia rostrata Hassk.ex Hook.f root extract and to know the effective dosage of Garcinia rostrata Hassk.ex Hook.f to lower the glucose in blood of the male mice by utilizing glucose tolerance and alloxan induction method. Garcinia rostrata Hassk.exHook root extract was taken trough reflux method by using 96% ethanol as distillation. In addition, a test by using male mice (Mus musculus) was conducted, where the mice were grouped into five groups, those were controlled glibenclamide positive group, negative control Na CMC 0,5%, dosage 1 (130 mg/Kg BW), dosage 2 (195 mg/kg BW), and dosage 3 (230 mg/Kg BW). The results showed that the root extract of Garcinia rostrata Hassk.ex Hook.f have hypoglycemic activity and effective dose for lowering blood glucose levels in glucose tolerance method is 3 (230 mg / kg bw)doses, while a dose of 1 (130 mg / kg bw) have the effect of lowering blood glucose levels were not significantly different with 2 (195 mg / kg bw) doses and 3 (230 mg / kg bw) doses but it's better than the positive control glibenclamide on alloxan induction method. Keywords: Garcinia rostrata Hassk.ex Hook.f root, glucose tolerance, alloxan induction.
Uji Efek Antidiabetes Ekstrak Daun Hibiscus surattensis L. Pada Mencit (Mus musculus) Jantan Dengan Mentode Toleransi Glukosa dan Induksi Aloksan Revina Triani; Ramadhanil Ramadhanil; Yuliet Yuliet
Biocelebes Vol. 9 No. 1 (2015)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Abstract

Diabetes is a clinical syndrome characterized with an improvement of blood glucose or hyperglycemia which is caused by relative or absolute insulin deficiency, and can cause protein and fat metabolism disorder when it is untreated as soon as possible. The technology and science advance is not able to rule out traditional cure of anti-diabetic which is from local wisdom in society. The society of Sumari is one of the Indonesians whom utilizes plants as a herbal cure. A Hisbiscussurattensis L leaf or the local name “tamoenju” is utilized by the society of Sumari as an anti-diabetic herbal hereditary to lower the level of glucose. Therefore, it is necessary for scientific evidence regarding the effects of hypoglycemic on the plant in two methods; those are oral glucose tolerance test and alloxan induction. Hibiscus surattensis L extract was taken trough distillation process with 96% of ethanol as a solvent. Male mice (Mus musculus) were divided into five groups of treatment, namely negative control Na CMC, glibenclamide positive control, dosages 500 mg/Kg BB, 750 mg/Kg BB, and 1000 mg/Kg BB, where the acquired result of the research indicated that the Hibicus surattensis L leaf extract with 750 mg/Kg BB dosage has the most effective activities of hypoglycemic as an anti-diabetic. Keywords: Hibiscus surattensis L, anti-diabetic, Glucose Tolerance, Alloxan Induced.
EFEK ANTIPIRETIK EKSTRAK DAUN PALIASA (Kleinhovia hospita L.) TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus L.) YANG DIINDUKSI VAKSIN DIFTERI PERTUSIS TETANUS Shella Desiana; Yuliet Yuliet; Ihwan Ihwan
Biocelebes Vol. 12 No. 1 (2018)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Abstract

Paliasa (Kleinhovia hospita L.) is a plant that is empirically used as a fever-lowering drugs. Antipyretic activity test Paliasa leaf ethanol extract of the white male rats (Rattus norvegicus) aims to determine the effect of the antipyretic effect of ethanol extract of leaves Paliasa and determine the effective dose as an antipyretic. Tests were carried out using inducers of fever vaccine Diphtheria Tetanus Pertussis (DPT) 0.2 ml. The antipyretic tests effect is divided into six treatment groups. The first group was given Na CMC 1% and DPT vaccine induced as a negative control, a group of the 2nd given paracetamol as a positive control, all three groups were given Na CMC 1% as the normal control group 4th, 5th, and 6th each given Paliasa leaf ethanol extract at a dose of 100 mg/kg BW, 200 mg/kg BW, and 300 mg/kg BW. Rectal temperature measurements carried out for 6 hours with a 30 minute interval. Temperature measurement data were statistically analyzed using One way ANOVA followed by Duncan test at 95% confidence level. Antipyretic activity test results showed that the ethanol extract of leaves Paliasa have antipyretic activity in male rats and the effective dose is 200 mg/kg BW.
EFEKTIVITAS EKSTRAK DAUN KERSEN (Muntingia calabura L.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL TIKUS PUTIH JANTAN (Rattus norvegicus L.) YANG DIINDUKSI PAKAN TINGGI LEMAK Cornelia Ayu Putri; Yuliet Yuliet; Khildah Khaerati
Biocelebes Vol. 12 No. 1 (2018)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Abstract

Muntingia calabura L. leaves contains saponin and flavonoid that can reduce blood cholesterol levels. This study aimed to examine the effect and the effective dose of M. calabura L. leaves extract to decrease total cholesterol levels of white rats induced by high-fat diet. Extract was found by using ethanol 96% in maseration method. Before doing a different treatment , all the subjects were given a high-fat meal for 14 days to increase the blood total cholesterol levels. The subject were twenty five rats divided into 5 groups as follow: negative control (0.5% Na-CMC), positive control (Simvastatin 1.8 mg/200 g BW), ethanol M. calabura L. leaves extract in various concentration (50; 100; 150 mg/kg BW). All rats were given a different oral treatment for 14 days. Rats blood was taken to measure total cholesterol levels by using Nesco Multicheck Tester on the 7th day after acclimatization, the 14th day after high-fat food induced, and the 7th and 14th day after treatments. The data was analized using non parametric Kruskal Wallis and Mann Whitney statistical test at α = 0.05. The results showed that the ethanol extract of M. calabura L. leaves have an effect to decrease blood total cholesterol levels and the most effective dose to decrease total cholesterol levels were 50 mg/kg BW.
EFEKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN SUMAMBU (Hyptis capitata Jacq.) PADA TIKUS PUTIH JANTAN (Rattus norvegicus L.) YANG DIINDUKSI DENGAN KARAGENAN Mia Audina; Yuliet Yuliet; Khildah Khaerati
Biocelebes Vol. 12 No. 2 (2018)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Abstract

One of the medical plants that can be used as an anti-inflamation treatment is sumambu leaf (Hyptis capitata Jacq.). Most of people in binangga village, Subdistric of central Parigi, Regency of Parigi Moutong, have been used this sumambu leaf for deducting inflammation, swelling, and painful. The aimed of this research is to know the effectiveness of the anti-inflamation of Sumambu leaf (Hyptis capitata Jacq.) towards white male mouse (Rattus novergicus L.) which has been given carrageenan induction. The extract was made by using a maseration method using 96% ethanol liquid. The test of the effectiveness of anti-inflamation was divided into your treatments which each treatment was consist of five mice which have been given negative control  0.5% CMC-Na suspension ;100 mg/KgBW, 200 mg/KgBW, 300 mg/KgBW of sumambu leaf extract. After 60 minutes, 0.1 ml carregeenan has been injected using subplantar method at the paw of the mice. The inflamation volume measured using  pletysmometer for 6 hours.  The data collection was statistically analyzed by ANOVA (Analysis of variance) one direction and continued to Duncan test. The results of this research  showed that the three doses of sumambu extract which are ES 100 mg/KgBW, 200 mg/KgBW, 300 mg/KgBWhave the effect of anti-inflamation. Moreover, it can be said that the result of this research showed that the dose that has a lower inflamation percent was ES 300 mg/KgBW. Keywords: Anti-inflammation, Hyptis capitata Jacq., Carrageenan, Inflamed Paw Volume.
Efek Akar Garcinia rostrata Hassk.ex Hook.f Terhadap Penurunan Kadar Glukosa Darah Mencit Jantan (Mus musculus) Yang Diinduksi Aloksan Devi Saputri Bahman; Yuliet Yuliet; Ihwan Ihwan
Biocelebes Vol. 12 No. 2 (2018)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Abstract

Garcinia rostrata Hassk.ex Hook.f is a plant that empirically used for lowering blood glucose levels. This study aims to determine antidiabetic activity of the n-hexane, ethyl acetate and ethanol-water fractions of its root Garcinia rostrata Hassk.ex Hook.f extract as well as to compare their effects to Glibenclamide as the positive control in alloxan-induced mice. The mice divided into five groups. The first group was given Na.CMC 0.5% (as negative control) and the second one was given Glibenclamide 0.65 mg/kgBW (as positive control), while the other three was given of n-hexane, ethyl acetate and ethanol-water fractions, each at a dose of 130 mg/kgBW. Before given the treatment, the mice was induced by alloxan at a dose of 150 mg/kgBW, by intraperitonial route. At fourth day after induced, the mice its raising blood glucose level >200 mg/dL was given a treatment 25 days by oral route. The level of mice blood glucose was measured 4 times at day 4, 11, 18, and 25, the blood is taken from lateralis vein tail of mice.  Data obtained were statistically analyzed by ANOVA and continued by Duncan test. Based on those results, it can be concluded that the ethanol-water fraction at doses of 130 mg/kgBW has antidiabetic activity in hyperglycemic that is comparable to Glibenclamide. Whereas, ethyl acetate fraction, at dose of 130 mg/kgBW has greater activity in lowering blood glucose level than glibenclamide. Keywords: Garcinia rostrata Hassk.ex Hook.f,  Fraction,  n-hexane,  Ethyl acetate, Ethanol-water, Alloxan. 
PENGARUH PEMBERIAN TOPIKAL EKSTRAK ETANOL DAUN PECUT KUDA (Stachytarpheta jamaicensis (L.) Vahl) TERHADAP PENYEMBUHAN LUKA BAKAR DERAJAT II PADA PUNGGUNG KELINCI (Oryctolagus cuniculus) Muhammad Anggriawan; Yuliet Yuliet; Khildah Khaerati
Biocelebes Vol. 12 No. 2 (2018)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Abstract

Pecut kuda (Stachytarpheta jamaicensis (L.) Vahl) is one of plant that has the potentials to heal various diseases, one of them as an alternative in the cure of burns. Pecut kuda leaf has been used hereditary by some people at Layana Wintu, Mantikulore subdistrict, Donggala regency for cure of burns. This research is conducted to find out the effect of topical administration of ethanol extract of pecut kuda leaf towards healing burns second degree on the rabbit’s back (Oryctolagus cuniculus) by using many extract concentration variation which are 1%, 3% and 5% with gel basic as the carrier. Testing was conducted on 5 rabbits, each rabbit was induced on his back by 5 burns for five treatments with burns diameter is 2 cm . Burns that has been induced was given each treatments which are negative control (gel basic without extract), ethanol extract of pecut kuda leaf in basic gel with each concentration 1%, 3% and 5%. Positive control used bioplacenton gel. Later, the burns diameter was measured on certain day during 28 days. Data that are achieved was  statistically analyzed  with  one way anova method and is continued by testing post hoc duncan with 95% confidance level. The reasult of this research shows every extract ethanol concentration variation of pecut kuda leaf have activity to heal burns. Extract ethanol concentration of pecut kuda leaf which is efective in healing burns is 3% concentration.Keywords: Gel, (Stachytarpheta jamaicensis (L.) Vahl), Burns, Oryctolagus cuniculus
AKTIVITAS EKSTRAK KULIT BATANG LANGSAT (Lansium parasiticum (Osbeck) Sahni & Bennet) TERHADAP KELARUTAN KALSIUM BATU GINJAL SECARA in vitro Nur Ramadhani; Yuliet Yuliet; Khildah Khaerati
Biocelebes Vol. 12 No. 2 (2018)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Abstract

The kidney stone is a stone which is found in the kidney or other parts of urinary tract. The most frequently type of stone encountered are composed of calcium crystals. As much as 60% content of kidney stones consist of calcium oxalate, phosphate, carbonate, uric acid, magnesium, and ammonium. Langsat (Lansium parasiticum (Osbeck) Sahni & Bennet) is a plant that may dissolve kidney stones and smooth urination, particularly its bark. This study aims to determine the activity as well as the greatest concentration of Langsat bark ethanol extract in dissolving dissolves calcium of kidney stones conducted in vitro. The ethanol extract was obtained by maceration method using 96% ethanol followed by phytochemical screening test and thin layer chromatograpy (TLC) profiling of the extract. Chromatogram result shows that the extract contains flavonoids. The research methodology conducted was the kidney stone powder dissolution in the ethanol extract of Langsat bark after being destructed with concentrations of respectively 0.5%, 1% and 1.5% then incubated in 37ºC temperature for 3 hours. The solubility of calcium was assayedby measuring the calcium (Ca) levelsat the beginning and at after being incubated with the kidney stone.The positive control used was Calcusol® and the negative onewas aquadest. The dissolved calcium levels were measured by using Atomic Absorption Spectrophotometer at  λ = 422.7 nm. The research results show that Langsat Bark ethanol extract has the activity in dissolving the calcium of kidney stones in vitro of which concentration with greatestactivity of calcium dissolution is 1.5% w/v. Keywords: Kidney Stone, Langsat, Lansium parasiticum, Calcium.
EFEK ANTIPIRETIK EKSTRAK DAUN CABE RAWIT (Capsicum annum L) TERHADAP TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI VAKSIN Difteri Pertusis Tetanus Inggrid Yuliana; Yuliet Yuliet; Khildah Khaerati
Biocelebes Vol. 12 No. 3 (2018)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Abstract

Leaves cayenne pepper (Capsicum annuum L) is a plant that empirically has been used as a fever-lowering. This study aims to determine the effect of the antipyretic effect of leaf extract of cayenne pepper and determine the effective dose as an antipyretic. Tests carried out using fever inducers ie vaccine DPT (Diphtheria Tetanus Pertussis) 0.2 ml. Tests the antipyretic effect is divided into six treatment groups. The first group was given Na-CMC 1% as the normal control group were given a 2nd Na-CMC and DPT vaccine induced a 0.2 ml as a negative control group all 3 were given paracetamol as a positive control, a group of 4th, 5th and all six were given the leaf extract of cayenne pepper with a dose of 100 mg/kg BW, 200 mg/kg BW, and 300 mg/kg BW. Rectal temperature measurement is carried out for 6 hours with intervals of 30 minutes. Temperature measurement data were statistically analyzed using oneway ANOVA test. Antipyretic activity test results showed that the leaf extract of cayenne pepper has antipyretic activity in male rats and the dose that effectively lower rectal temperature of rat is 300 mg/kg BW.
Efek Akar Garcinia rostrata Hassk.ex Hook.f Terhadap Penurunan Kadar Glukosa Darah Mencit Jantan (Mus musculus) Yang Diinduksi Aloksan Devi Saputri Bahman; Yuliet Yuliet; Ihwan Ihwan
Biocelebes Vol. 13 No. 1 (2019)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (206.242 KB)

Abstract

Garcinia rostrata Hassk.ex Hook.f is a plant that empirically used for lowering blood glucose levels. This study was aimed to determine antidiabetic activity of the n-hexane, ethyl acetate and ethanol-water fractions of its root Grostrata Hassk.ex Hook.f extract as well as to compare their effects to Glibenclamide as the positive control in alloxan-induced mice. The mice divided into five groups. The first group was given Na.CMC 0.5% (as negative control) and the second one was given Glibenclamide 0.65 mg/kgBW (as positive control), while the other three was given of n-hexane, ethyl acetate and ethanol-water fractions, each at a dose of 130 mg/kgBW. Before given the treatment, the mice was induced by alloxan at a dose of 150 mg/kgBW, by intraperitonial route. At fourth day after induced, the mice its raising blood glucose level >200 mg/dL was given a treatment 25 days by oral route. The level of mice blood glucose was measured 4 times at day 4, 11, 18, and 25, the blood is taken from lateralis vein tail of mice.  The Data were analyzed by ANOVA and continued by Duncan test. Based on those results, it can be concluded that the ethanol-water fraction at doses of 130 mg/kgBW has antidiabetic activity in hyperglycemic that is comparable to Glibenclamide. Whereas, ethyl acetate fraction, at dose of 130 mg/kgBW has greater activity in lowering blood glucose level than glibenclamide.
Co-Authors Abd. Rahman Razak Adetya Maryani Adisaputra, Arya Dibyo Agus Ritna Agustinus Widodo Agustinus Widodo Akhmad Khumaidi Alfia, Dhara Ali Djamhuri Alkaff, Firas F. Alkaff, Sylmina D. Amelia Rumi Amelia Rumi Amelia Rumi Andi Athira Masyta Andi Atirah Masyita Andi Atirah Masyita Andi Fadya Andrya B Andrya B Apriyanti Anastasia Arisca, Windhy Nur Ariza Abu Bakar Putri Armini Syamsidi Arwinda Alitsia Hasyim Asriani Hasanuddin Atirah Atirah Bustanul Arifin Cahyani, Rezki Cornelia Ayu Putri Darmayanti Dermiati T Dermiati T Devi Saputri Bahman Devyayu Prabaningsih DEWI RISMAYANTI Djaleha, Helena Fransisca Dwicahya, Bambang Dwinthasari Meilinda Azhari Elin Yulinah Sukandar Elin Yulinah Sukandar Ersamukti Rahmatullah Achmad Evi Sulastri FIRMANITA DWIMURTI Fitri Anggun Solehah Gina N. Putri Hamdani, Silviana Hardani, Muhammad Fakhrul Heni Purwitasari I Ketut Adnyana Ihwam Ihwan Ihwan Ihwan Iklima Indriani, Meri Feki Inggrid Yuliana Ingrid Faustine Ismail, Ihwan Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Joni Tandi Joni Tandi, Joni Jusri Nilawati Karmini Karmini Khaerati Khildah - Khildah Khaerati Khildah Khaerati Khildah Khaerati Khusnul Diana Khusnul Diana Kurniawan, Muh D. Lokong, Gladies Melinda Lutfiana Kusumawati Mariyani Marzelany M Sombolinggi Masyita, Andi Atirah Meike Rachmawati Mia Audina Moh. Roem Mohamad Ikram Muhamad Rinaldhi Tandah Muhammad Anggriawan Muhammad F. Haq Muhammad Fahrul Hardani Muhammad Fahrul Hardani Muhammad Sulaiman Zubair Muthi’ah H Z Nasrah Said Nela Sharon Ni Luh Rindiani Ni Made Susilawati Ni Wayan Swintari Nifien Mokuna Niluh Puspita Dewi Novalina Serdiati Nur Hikmah Nur Ramadhani Nurihardiyanti Nurihardiyanti Nurul Awwaliyah P. Firman Oryza Sativa Padmawati, Retna S. Perwitasari, Dyah A. Postma, Maarten J. Putri A. Arta R. Rokhman, Muhammad Ramadhanil Ramadhanil Rasuane Noor Rauf, Saidah Recky Patala Revina Triani Rhizky S Auliana Rini Saputri Ririen Hardani Ririen Hardani Ririen Ririen Ririn Hardani Ritha Pratiwi S. Malasugi Salamah, Sovia Shella Desiana Sinta Amelia Siti B. Al-Amri Sitti Kholidah Sri Indrawati Steffi Liem Sugeng, Santoso Sukmawati, Sukmawati Syahna Shaldan Syamsul Lakahoro Syaputra, Gunawan Syariful Anam Tirza Retno Kinasih Baginda Triana Riandani Djamhuri Tricia Andini Tunreng, Muh. Fadil Usman Umar, Miranti Wa Ode S. Musnina Yonelian Yuyun Yusriadi Yusriadi Zulkarnain Zulkarnain