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All Journal HAYATI Journal of Biosciences Natural Science: Journal of Science and Technology Media Eksakta Indonesian Journal of Pharmaceutical Science and Technology Biocelebes Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia Jurnal Health Sains Jurnal Mandala Pengabdian Masyarakat Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Narra J Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Journal of Noncommunicable Diseases (JOND) Dedication : Jurnal Pengabdian Masyarakat Journal of Public Health and Pharmacy Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Medika: Medika Jurnal Pengabdian Farmasi dan Sains Journal of Tropical Pharmacy and Chemistry Indonesian Journal of Jamu Jurnal Dedikatif Kesehatan Masyarakat Poltekita: Jurnal Pengabdian Masyarakat

Yuliet Yuliet

Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Tadulako University, Jl. Sukarno-Hatta Km 9, Palu 94148, Indonesia

Author-ID : 425098

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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UJI AKTIVITAS ANTIDIABETES KOMBINASI GLIBENKLAMID DAN EKSTRAK DAUN SALAM (Syzygium polyanthumWight.) TERHADAP MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN Steffi Liem; Yuliet Yuliet; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Pharmacological therapy of Diabetes Mellitus (DM) is to use antidiabetic oral. Herbal medicine are also often used as an alternative treatment by patients. Even in some cases found patients combine drugs and herbal medicine to speed up the healing of DM. This study aims to know the effects of a combination of glibenclamide and bay leaf ethanol extract (BLEE) to decrease blood glucose levels and to determine its optimal combination dose as antidiabetic. The method was inducted alloxan at dose of 120 mg/kg BW intraperitoneally. The animal test used were mice which divided into 8 groups of tests, the negative control (Na CMC 0,5 %), positive control (glibenclamide 0,65 mg/kg BW), combination 1(glibenclamide+BLEE 250 mg/kg BW), combination 2 (glibenclamide+BLEE 500 mg/kg BW), combination 3 (glibenclamide+BLEE 750 mg/kg BW), BLEE 1 (250 mg/kg BW), BLEE 2 (500 mg/kg BW), and BLEE 3 (750 mg/kg BW). After 14 days study, data were analyzed by ANOVA showed the difference in decrease of blood glucose levels combination 2 (230±23,69) mg/dL and combination 3 (233,75±9,93) mg/dL were significantly different to the negative control (4±6,82) mg/dL, positive control (150,75±11,34) mg/dL, combination 1 (170±10,51) mg/dL, BLEE 1 (134,5±4,61) mg/dL, BLEE 2 (151,25±6,72) mg/dL, and BLEE 3 (158,75±17,64) mg/dL. While combination 2 and combination 3 were not significantly different. Combination of glibenclamide and bay leaf ethanol extract decreased blood glucose levels greater than a single dosage glibenclamide or bay leaf extract. Optimal doses decreased blood glucose levels was combination 2.

POTENSI EFEK HIPOGLIKEMIK KOMBINASI EKSTRAK ETANOL UMBI BAWANG HUTAN (Eleutherine bulbosa) DAN KULIT BATANG KAYU MANIS (Cinnamomum burmanii) PADA TIKUS (Rattus norvegicus) DIABETES YANG DIINDUKSI STREPTOZOTOSIN DAN TOLERANSI GLUKOSA Devyayu Prabaningsih; Yuliet Yuliet; Ririen Hardani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 1 (2016): (March 2016)
Publisher : Universitas Tadulako

Research on potential hypoglycemic effects of ethanol extract combination of onion forest bulbs (Eleutherine bulbosa) and burmani cortex (Cinnamomum burmanii) in streptozotocin (STZ)-induced diabetic and glucose tolerant rats (Rattus norvegicus) has been conducted. This study aimed to determine the hypoglycemic effect and the effective dose of ethanol extract combination of forest onion bulbs and cinnamon cortex. Extract was obtained by maceration using 96% ethanol. A number of 30 male rats were divided into 6 groups and each group consisted of 5 rats. The first group (negative control) was given Na.CMC; the second group (positive control 1) glibenclamide 0.45 mg/kgBW; the third group (positive control 2) acarbose 9 mg/kgBW; while the 4th, 5th, and 6th were successively given combination of ethanol extract of forest onion bulbs and cinnamon cortex at doses of 100+100, 50+50, and 25+25 mg/kgBW. Each rat group was intraperitoneally (ip) induced with STZ 40 mg/kgBW and then treated for 14 days, after the rats developed diabetic condition, glucose tolerance test was performed with the induction of sucrose 150mg/kgBW which was continued with observation in minute 60, 90, 120, 150, and 180. Treatment data were analyzed using ANOVA (analysis of variance) with 95% confidence interval. The results showed that ethanol extract combination of forest onion bulbs and cinnamon cortex had potential hypoglycemic effects in male rats of which the most effective combination dose was at a dose of 50 + 50 mg/kgBW

PENGARUH PEMBERIAN EKSTRAK DAUN SALAM (Syzygium polyanthum Wight.) TERHADAP GLIBENKLAMID DALAM MENURUNKAN KADAR GLUKOSA DARAH MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN Nur Hikmah; Yuliet Yuliet; Khildah Khaerati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 1 (2016): (March 2016)
Publisher : Universitas Tadulako

The use of herbal medicines and synthetic drugs simultaneously carried out by diabetics for the maintenance of blood glucose levels, such as the use of glibenclamide and bay leaf. This research was carried out to know the impact of administration bay leaf extract on glibenclamide in lowering blood glucose levels on mices that induced by alloxan. This research used 40 male mices which were divided into 8 groups. Before the experiment, the mices were first induced by alloxan (70 mg/kg BW) intravenously. The negative control was the group that given Na CMC 0,5%, KG was the control of glibenclamide 0,65 mg/kg BW, group DS1, DS2, DS3 were the control of single bay leaf extract with each dose 250 mg/kg BW, 500 mg/kg BW, and 750 mg/kg BW, group KD1, KD2, KD3 were the combination group of glibenclamide and bay leaf extract with each dose glibenclamide combined bay leaf extract 250 mg/kg BW, glibenclamide combined bay leaf extract 500 mg/kg BW, and glibenclamide combined bay leaf extract 750 mg/kg BW, with an hour interval. The data were statistically analyzed using ANOVA (Analysis of Variance) at 95% confidence interval with parameter of blood glucose levels difference between before and after treatment. The results showed that the administration of bay leaf extract gave significant impact on glibenclamide in lowering blood glucose levels and the effective dose was the combination of glibenclamide 0,65 mg/kg BW and bay leaf extract 250 mg/kg BW

AKTIVITAS PENGHAMBATAN PEMBENTUKAN BATU GINJAL (Antinefrolithiasis) EKSTRAK ETANOL DAUN GEDI MERAH (Abelmoschus moschtus Medik) PADA TIKUS PUTIH JANTAN Triana Riandani Djamhuri; Yuliet Yuliet; Khildah Khaerati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 1 (2016): (March 2016)
Publisher : Universitas Tadulako

Red Gedi (Abelmoschus moschatus Medik) is a plant found only in tropical climate areas such as Africa and Asia. Some people’s experience in Manado stated that red gedi plants can be used to treat various types of disease, one of them was kidney stones. Therefore, this study aimed to determine the activity and the effective dose of red gedi leaf extract as an inhibitor of kidney stone formation. The extract was prepared by maceration using ethanol 96%. Inhibitory activity test of kidney stone formation was done by firstly dividing the labrats into 6 groups. Each group consisted of 3 male rats. Both the first group (Normal control) and the second group (Negative control) weregiven Na.CMC 0.5%; the third group (Positive control) was given Batugin Elixir at a dose of 2.7 ml/kgBW; while the fourth, fifth, and sixth were respectively given red gedileaf extract at doses of 50, 100, and 150 mg/kgBW. After 2 hours, all treatment groups were induced with0.75% of ethylene glycol and 2% of ammonium chloride except for the normal control. Ratio of kidney weight and the level of calcium were then measured and calculated. Data obtained were statistically analyzed using ANOVA (Analysis Of variance) and continued with LSD (Least Significantly Difference). It can be concluded that ethanol extract of red gedileaves had inhibitory activity of kidney stones formation in all dose variation and the most effective one was at a dose of 150 mg/kgBW

ANALISIS KADAR ALBUMIN IKAN SIDAT (Anguilla marmorata dan Anguilla bicolor) DAN UJI AKTIVITAS PENYEMBUHAN LUKA TERBUKA PADA KELINCI (Oryctolagus cuniculus) Ariza Abu Bakar Putri; Yuliet Yuliet; Jamaluddin Jamaluddin
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 2 (2016): (October 2016)
Publisher : Universitas Tadulako

Eel is one kind of fish which contain albumin. Albumin is useful in the formation of new body tissue during growth and can accelerate the healing of body tissue. This study aimed to determine levels of albumin in the eels (Anguilla marmorata and Anguilla bicolor) as well as its effect of open wound healing tested at various concentrations. The albumin levels were determined using Bromocresol green method with three times repetition. The results showed that average albumin levels of Anguilla marmorata was 13,269 mg/100 g and Anguilla bicolor was 8,998 mg/100 g. Eel extract with the highest level of albumin was continued to pharmacological tests using 5 rabbits which had been open-wounded in 5 areas. Each rabbit was then given 5 treatments. The first two rabbits got positive control containing povidone iodine and negative control (ointment base), while the other three got albumin extract successively at concentration of 5%, 10% and 15%. The wounds were observed on days 1, 3, 5, 7, 10, 12, and 14. The data analysis for albumin levels was done using Independent T test and for open wound healing percentage using One Way ANOVA. The analysis results showed a significant difference of albumin levels between Anguilla marmorata and Anguilla bicolor and it found that the highest level of albumin was in Anguilla marmorata species. The effective extract concentration of albumin in wound healing was at concentration of 5% with wound healing percentage of up to 100%

UJI AKTIVITAS SERBUK JAMUR TIRAM PUTIH (Pleurotus ostreatus (Jacq.) P.Kumm) TERHADAP KADAR GLUKOSA DARAH PADA MODEL HEWAN HIPERKOLESTEROLEMIA-DIABETES Dwinthasari Meilinda Azhari; Yuliet Yuliet; Khildah Khaerati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 2 (2016): (October 2016)
Publisher : Universitas Tadulako

Research on the activity of white oyster mushroom powder (Pleurotus ostreatus (Jacq.) P.Kumm) against blood glucose levels in animal model of hypercholesterolemia-diabeties has been conducted. This research aimed to determine its activity as well as its effective dose in lowering blood glucose levels. A number of laboratory rats were divided into five groups and each group consisted of four rats. The 1st group (negative control) was given 0.5% suspension of Na-CMC; the 2nd and 3rd group (positive controls) were respectively given 0.45 mg/kgBW of Glibenclamide and 45 mg/KgBW of Metformin; while each of the 4th, 5th, and 6th groups was given the powder as much as of 250, 500 and 750 mg/kgBW. On day 1 to day 14, they were fed with high cholesterol food then induced with 30 mg/kgBW of streptozotocin, and on day 17 were treated with suspension of white oyster mushroom powder. On day 24 and day 31, the blood glucose levels were checked. Data of blood glucose levels difference between before and after treatment were calculated and statistically processed of which normality had been previously tested using Shapiro Wilk and homogeneity using Levene Test. Data that had normal distribution were statistically analyzed using ANOVA (analysis of variance) with 95% confidence interval and continued with Post hoc Duncan to see the differences among the groups which were significantly different. While, data that did not have normal distribution were analyzed using non-parametric statistics, Kruskal Wallis Test, and then further using Mann Whitney Test. The results showed that powder of white oyster mushroom had antidiabetic activity at effective dose of 250 mg/KgBW

AKTIVITAS DIURETIK KOMBINASI EKSTRAK BIJI PEPAYA (Carica papaya L) DAN BIJI SALAK (Salacca zalacca varietas zalacca (Gaert.)Voss) PADA TIKUS JANTAN GALUR WISTAR (Rattus norvegicus L) Nurihardiyanti Nurihardiyanti; Yuliet Yuliet; Ihwan Ihwan
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Research on diuretic activity of seed extract combination of papaya (Carica papaya L) and snake fruit (Salacca zalacca (Gaert.) Voss) to male wistar strain rats (Rattus norvegicus L.) has been conducted. This study aimed to determine the diuretic effect of the seed extract combination and its effective dose combination as diuretics. The extract was prepared by maceration method using ethanol 96%. Diuretic activity test was divided into 5 treatment groups. Each group consisted of 5 rats. Group 1 (negative control) was given suspension of Na-CMC 0.5%; Group 2 (positive control) was given furosemide 3.6 mg/kgBW; Group 3, 4, and 5 were given dose combination of snake fruit seed extract and papaya seed extract successively at “37.5 mg/kgBW + 7.5 mg/kgBW”; “70 mg/kgBW + 15mg/kgBW”; and “140 mg/kgBW + 30 mg/kgBW”. Each rat was then orally given warm distilled water (70°C) 10ml/100gBW as loading dose. The excreted urine volume was measured and recorded every 30 minutes for 6 hours which was continued to cumulative urine volume calculation. Furthermore, sample was taken from the cumulative urine to measure levels of sodium (Na), potassium (K), and the pH of the urine. Data were statistically analyzed using ANOVA (Analysis of Variance). The results showed that the effective extract dose combination was found in Group 5’s dose (140 mg/kgBW of snake fruit seed extract and 30 mg/kgBW papaya seed extract) with diuretic activity index of 1.48; urine pH of 7.52; sodium saluretic index of 1.62; and potassium saluretik index of 1.56

UJI AKTIVITAS ANTIINFLAMASI KOMBINASI DEKOKTA AKAR BELUNTAS (Pluchea indica L.) DAN INFUSA DAUN JAMBU BIJI (Psidium guajava L.) TERHADAP TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI KARAGENAN Ersamukti Rahmatullah Achmad; Yuliet Yuliet; Lutfiana Kusumawati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Marsh fleabane roots (Pluchea indica L.) and guava leaves (Psidium guajava L.) are traditionally used as an anti-inflammatory. The research has been conducted with the aim of knowing the anti-inflammatory effect of the combination of decoction of Marsh fleabane roots (Pluchea indica L.) and infusion of guava leaves (Psidium guajava L.), and also determining the effective concentration of such combination. The research used artificial edema method in white rat's leg ( Rattus norvegicus) with the observation for 6 hours on the change of leg volume in white rat. The measurement of white rat's leg volume used a pletismometer. The type of treatment was devided into 5 groups: negative control (Aquadest), positive control (Na Diclofenac), combination 1 (MFR 10% : IGL 8%), combination 2 (MFR 5% : IGL 5%), and combination 3 (MFR 8% : IGL 10%). The data obtained were processed using One-Way ANOVA method with the result seen on the percent inhibition of inflammation resulting concentration of MFR 5%: IGL 5% amounting to 23.47%, and subsequently combined with a concentration of MFR 10% : IGL 8% and concentrations MFR 8% : IGL 10% respectively by the percent inhibition of inflammation by 20.70% and 13.75%. The data obtained show the combination with a concentration of 5% : 5% have anti- inflammatory effect are better than the other combinations as well as comparable to the positive control

UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN PISANG AMBON (Musa paradisiaca L.) TERHADAP TIKUS PUTIH (Rattus norvegicus L.) YANG DIINDUKSI KARAGENAN Sukmawati Sukmawati; Yuliet Yuliet; Ririen Hardani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Anti-inflammatory activity test of ethanolic extract of banana leaf (Musa Paradisiaca L.) on carrageenan-induced paw edema in white male rats (Rattus novergicus L.) has been conducted. It was aimed to investigate and to determine the anti-inflammatory activity and its effective dose. The extract was prepared by maceration method using ethanol 96%. Anti-inflammatory activity test was performed in five different groups. Each group consisted of 5 rats. The 1st group (negative control) was given 0.5% CMC-Na suspension; the 2nd group (positive control) was given diclofenac sodium 9 mg/KgBW; the 3rd, 4th, and 5th groups were successively given the banana leaf extract as much as 500, 750 and 1000 mg/KgBW. Each rat was then induced by 1% carrageenan and tested using subplantar method. The inflamed paw diameter was measured using a calliper while the inflamed paw volume using pletysmometer. The measurements were done for 6 hours long with intervals of 60 minutes. The data was statistically analyzed using ANOVA (analysis of variance). The results showed that the negative control had a significant difference with the other treatment groups which did not show any anti-inflammatory effect. In conclusion, ethanolic extract of banana leaf has effective anti-inflammatory activity at a dose of 750 mg/KgBW

EFEK ANTIDIABETES EKSTRAK AIR KULIT BUAH PISANG AMBON (Musa paradisiaca L.) TERHADAP MENCIT (Mus musculus) MODEL HIPERGLIKEMIA Sri Indrawati; Yuliet Yuliet; Ihwan Ihwan
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Pisang Ambon (Musa paradisiaca L.) is one type of bananas usually consumed by Indonesian people. Besides its flesh which has high nutrition, its peels also has antioxidant activity. Antioxidants has the ability to reduce oxidative damage in people’s body with diabetes mellitus. Therefore, this study aimed to determine the antioxidant activity of the aqueous extract of Pisang Ambon peels and to determine it’s effective dose as an antidiabetic agent in hyperglycemic mice. This study used male mice which all have been intravenously induced with alloxan at a dose of 50 mg/kgBW. They were then divided into five groups. The first two groups got Na CMC 0.5% (negative control) and glibenclamide 0.65 mg/kgBW (positive control), while the other three got the aqueous extract of Pisang Ambon peels successively at doses of 400, 800, and 1200 mg/kgBW. The data were statistically analyzed using ANOVA (Analysis of Variance) at 95% confidence interval with parameter of blood glucose levels difference between before and after treatment. The results showed that the aqueous extract of Pisang Ambon peels had antidiabetic activity at an effective dose of 400 mg/kgBW in hyperglycemic mice which was comparable to glibenclamide

Co-Authors -, Khildah Abd. Rahman Razak Adisaputra, Arya Dibyo Agus Ritna Agustinus Widodo Agustinus Widodo Ahmad Ramadhan Ahmad, Iftitah Akhmad Khumaidi Alfia, Dhara Ali Djamhuri Alkaff, Firas F. Alkaff, Sylmina D. Amelia Rumi Amelia Rumi Amelia Rumi Andi Athira Masyta Andi Atirah Masyita Andi Atirah Masyita Andi Fadya Andrya B Andrya B Apriyanti Anastasia Arisca, Windhy Nur Ariza Abu Bakar Putri Armini Syamsidi Arwinda Alitsia Hasyim Asriana Sultan Asriani Hasanuddin Atirah Atirah Auliana, Rhizky S Bawiling, Viorenita Giovany Bustanul Arifin Cahyani, Rezki Cornelia Ayu Putri Daniel Happy Putra Darmayanti Dermiati T Dermiati T Devi Saputri Bahman Devyayu Prabaningsih DEWI RISMAYANTI Djaleha, Helena Fransisca Dwicahya, Bambang Dwinthasari Meilinda Azhari Elin Yulinah Elin Yulinah Sukandar Ersamukti Rahmatullah Achmad Evi Sulastri Fahrul Hardani, Muhammad FIRMANITA DWIMURTI Fitri Anggun Solehah Hamdani, Silviana Handayani, Tien Wahyu Hardani, Muhammad Fakhrul Heni Purwitasari I Ketut Adnyana Ihwam Ihwan Ihwan Ihwan Ihwan Iklima Indriani, Meri Feki Inggrid Yuliana Ingrid Faustine Ismail, Ihwan Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Joni Tandi Joni Tandi, Joni Jusri Nilawati Karmini Karmini khaerati Khildah Khaerati Khildah Khaerati Khildah Khaerati Khusnul Diana Khusnul Diana Kurniawan, Muh D. Lokong, Gladies Melinda Lutfiana Kusumawati Magfirah, Magfirah Mariyani Masyita, Andi Atirah Meike Rachmawati Mia Audina Miftahul Jannah Miranti Moh. Roem Moh. Tahir Mohamad Ikram Muhamad Rinaldhi Tandah Muhammad Anggriawan Muhammad Fahrul Hardani Muhammad Rinaldhi Tandah, Muhammad Rinaldhi Muhammad Sulaiman Zubair Muthi’ah H Z Nasrah Said Nela Sharon Ni Made Susilawati Ni Wayan Swintari Nifien Mokuna Niluh Puspita Dewi, Niluh Puspita Novalina Serdiati Nur Hikmah Nur Ramadhani Nurfajar, Rifda Nurihardiyanti Nurihardiyanti Nurwalyani, Nurwalyani Nurwijayanti Oryza Sativa Padmawati, Retna S. Perwitasari, Dyah A. Postma, Maarten J. R. Rokhman, Muhammad Ramadhanil Ramadhanil Rasuane Noor Rauf, Saidah Recky Patala Revina Triani Richard, Tricia Andini Rindiani, Ni Luh Rini Saputri Ririen Hardani Ririen Hardani Ririen Ririen Ririn Hardani Ritha Pratiwi Salamah, Sovia Shella Desiana Sitti Kholidah Sombolinggi, Marzelany M Sri Indrawati Steffi Liem Suci Hanifah Sugeng Santoso Sukmawati, Sukmawati Syaputra, Gunawan Syariful Anam Tirza Retno Kinasih Baginda Triana Riandani Djamhuri Tricia Andini Tuldjanah, Muthmainah Tunreng, Muh. Fadil Usman Wijaya, Berniawan Witanti, Alun Yonelian Yuyun Yusriadi Yusriadi Zulkarnain Zulkarnain

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