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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. E-Jurnal Medika Udayana Jurnal Kedokteran Brawijaya Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Masyarakat Damianus Journal of Medicine Mutiara Medika: Jurnal Kedokteran dan Kesehatan Majalah Kedokteran Sriwijaya The Indonesian Biomedical Journal Nusantara Medical Science Journal Medical Laboratory Technology Journal Indonesian Journal of Cardiology Indonesian Journal of Obstetrics & Gynecology Science Jurnal Kesehatan Manarang FITOFARMAKA: Jurnal Ilmiah Farmasi Majalah Kedokteran Andalas Jurnal Biomedika Jurnal Riset Kesehatan Poltekkes Depkes Bandung Majalah Kesehatan Pharmamedika Majalah Kedokteran Neurosains Majalah Sainstekes Contagion: Scientific Periodical Journal of Public Health and Coastal Health Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Aplikasi dan Inovasi Iptek (JASINTEK) Indian Journal of Forensic Medicine & Toxicology Jurnal Ilmiah Kesehatan (JIKA) Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Molucca Medica Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Majalah Anestesia & Critical Care (MACC) Mandala of Health : A Scientific Journal Physical Therapy Journal of Indonesia Neurona Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal) MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Andi Alfian Zainuddin
Departemen Ilmu Kesehatan Masyarakat Dan Ilmu Kedokteran Komunitas, Fakultas Kedokteran, Universitas Hasanuddin
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Spatial Distribution of Drug-Resistant Tuberculosisin Makassar City, South Sulawesi Province, Indonesia Zainuddin, Andi Alfian; Soma, Andang Suryana; Kasim, Muhammad Firdaus; Ramadany, Sri; Djaharuddin, Irawati
KEMAS: Jurnal Kesehatan Masyarakat Vol 18, No 2 (2022)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v18i2.36436

Abstract

This study aims to determine the domicile distribution, find out the high-risk areas, and determine the risk of drug-resistant tuberculosis patients based on patient location in 15 districts of Makassar City from Tuberculosis register data of South Sulawesi Provincial Health Office in December 2017 – April 2019 period. Gen Xpert rapid or drug sensitivity examinations were used to define drug-resistant tuberculosis. The domicile location of patients was geocoded by maps in Google Earth and aggregated per area by using Kernel Density analysis using ArcView GIS 10.3 software. We found that drug-resistant tuberculosis cases tended to be clustered in the western part of Makassar City, an area with a fairly high population density. There were areas with the highest concentration of predicted cases as a high risk of transmission of drug-resistant TB, around the Bontoala District, Makassar District, and Mamajang District. Healthcare facilities located in hot spots area need to be equipped with molecular rapid test facilities and conduct drug sensitivity tests for all suspected tuberculosis patients. Further research needs to be carried out to determine the distribution of tuberculosis patients who are sensitive and resistant to drugs.
Perbandingan Respon Terapi dan Toksisitas Regimen Kemoterapi Kombinasi antara Paclitaxel, Carboplatin, dan Ifosfamide (TIP) dengan Paclitaxel dan Carboplatin (TP) pada Kanker Serviks Stadium IIb Nagusman Danil; Sharvianty Arifuddin; Eddy Hartono; Nur Rakhmah; Ajardiana Ajardiana; Syahrul Rauf; Andi Alfian Zainuddin
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 1 Maret 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6n1.451

Abstract

Tujuan: Mengetahui perbandingan respon terapi dan toksisitas regimen kemoterapi kombinasi Paclitaxel Carboplatin Ifosfamide dengan Paclitaxel Carboplatin pada kanker serviks stadium IIB.Metode: Sebanyak 30 pasien yang baru terdiagnosis kanker serviks stadium IIB dibagi menjadi dua kelompok terapi kombinasi yaitu kelompok Paclitaxel-Carboplatin-Ifosfamide (TIP) dan Paclitaxel-Carboplatin (TP). Volume tumor dan respon terapi diukur sebelum dan sesudah tiga siklus kemoterapi.Hasil:Tingkat penurunan rata-rata volume tumor pada kelompok Paclitaxel-Carboplatin-Ifosfamide dan Paclitaxel-Carboplatin sebesar (23,66% vs 39,08%). Tidak ada perbedaan secara bermakna angka respon parsial, angka respon progresif dan tidak ada respon antara kelompok dengan Paclitaxel-Carboplatin-Ifosfamide dengan kelompok Paclitaxel-Carboplatin dengan p > 0,05. Hasil antara Paclitaxel-Carboplatin-Ifosfamide dan Paclitaxel-Carboplatin pada respon parsial (46,7 % vs 73,3%), respon progresif (13,3% vs 13.3%), dan tidak ada respon (40,0 % vs 1,3%) dan toksisitas kelas 2 lebih dominan pada kelompok Paclitaxel-Carboplatin-Ifosfamide yaitu mual, kerontokan (53,3%) dan fatique, muntah (46,7%).Kesimpulan: Regimen kemoterapi kombinasi Paclitaxel-Carboplatin lebih efektif dalam menurunkan ukuran tumor kanker serviks stadium IIB dengan efek samping yang lebih minimal dibandingkan kombinasi Paclitaxel-Carboplatin-Ifosfamide.Comparison of Therapy Response and Toxicity of Combination Chemotherapy Regimens Between Paclitaxel, Carboplatin And Ifosfamide (PCI) with Paclitaxel and Carboplatin (PC) in Stadium IIB Cervical CancerAbstractObjective: To compare the therapeutic response and toxicity of a combination chemotherapy regimen of Paclitaxel Carboplatin Ifosfamide with Paclitaxel Carboplatin in stage IIB cervical cancer. Methods: A total of 30 patients newly diagnosed with stage IIB cervical cancer were divided into two combination therapy groups, namely the Paclitaxel-Carboplatin-Ifosfamide (PCI) and Paclitaxel-Carboplatin (PC) groups. Tumor volume and clinical response were measured before and after three cycles. Result: The average reduction rate of tumor volume in the Paclitaxel-Carboplatin-Ifosfamide and Paclitaxel-Carboplatin groups was (23.66% vs 39.08%). There was no significant difference in the partial response rate, progressive response rate and no response between the Paclitaxel-Carboplatin-Ifosfamide group and the Paclitaxel-Carboplatin group with p > 0.05. Results between Paclitaxel-Carboplatin-Ifosfamide and Paclitaxel-Carboplatin on partial response (46.7% vs 73.3%), progressive response (13.3% vs 13.3%), and no response (40.0% vs 1, 3%) and class 2 toxicity was more dominant in the Paclitaxel-Carboplatin-Ifosfamide group namely nausea, hair loss (53.3%) and fatigue, vomiting (46.7%). Conclusion: The Paclitaxel-Carboplatin combination chemotherapy regimen is more effective in reducing the tumor size of stage IIB cervical cancer with lower side effects than the Paclitaxel-Carboplatin-Ifosfamide combination.Key words: cervical cancer, chemotherapy, side effects
Analysis Of The Relationship Between HBA1C and Serum Galectin-3 Levels in Subjects With Type 2 Of Diabetes Mellitus Zaifah Firayanti; Yuyun Widaningsih; Liong Boy Kurniawan; Himawan Sanusi; Andi Alfian Zainuddin; Tenri Esa
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 5, No 2 (2023): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v5i2.15076

Abstract

Type 2 diabetes mellitus is a disease characterized by increased blood glucose levels known as hyperglycemia. This disease can be diagnosed by examining HbA1c (glycated hemoglobin). Hemoglobin A1c is a minor component of hemoglobin related to glucose. Meanwhile, galectin-3 is a protein encoded in humans by the LGALS3 gene. This study aimed to clarify the relationship between HbA1c and serum galectin-3 levels in patients with type 2 diabetes. This study was conducted using an observational analysis technique with a cross-sectional study design. This research was conducted at the Clinical Pathology Laboratory, Hasanuddin University State University Hospital, and Laboratorium Universitas Hasanuddin Medical Research Center State College Hospital Universitas Hasanuddin Makassar. This research was conducted from January to March 2023. The population in this study were all patients with type 2 DM who visited the Hasanuddin University Hospital (RSPTN-UH) for treatment a total of 112 patients. Research sampling technique with non-probability purposive sampling. The sample of this study was 60 patients. Data analysis with the Independent T-test or Mann-Whitney test. The results of the study were that serum Galectin-3 levels in uncontrolled type 2 diabetes mellitus had a higher average value of 20.18 ± 6.15 ng/mL compared to controlled type 2 diabetes mellitus, namely 14.80 ± 6.41 ng/ mL although there was a statistically significant difference (p=0.012) but no significant correlation was found between HbA1c and serum Galectin-3 levels in type 2 diabetes mellitus subjects (r=0.176 p=0.179) with the distribution of data in the Scatterplot not forming a linear relationship pattern. It is recommended that type 2 Diabetes Mellitus patients carry out an HbA1c examination as an effective test to control glucose levels, reduce the risk of complications, and maintain a healthy lifestyle to avoid type 2 DM.Keyword: HbA1c, Serum Galectin-3, Type 2 Diabetes Mellitus
Analysıs of Urınary Albumın and Urınary Synaptopodın Levels in Type 2 Dıabetes Mellıtus Subjects Afni Juhairia Laisouw; Liong Boy Kurniawan; Yuyun Widaningsih; Tenri Esa; Himawan Sanusi; Andi Alfian Zainuddin; Theosobia Grace Orno
Medical Laboratory Technology Journal Vol. 9 No. 1 (2023): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v8i2.514

Abstract

Hyperglycemia from diabetes mellitus affects many body organs and interferes with normal function. Kidney function decreased in approximately one-third of patients with diabetes mellitus before the development of albuminuria. The purpose of this study was to analyze differences in urine albumin and urine synaptopodin levels in type 2 diabetes mellitus (T2DM) and non-DM subjects, differences in urine synaptopodin levels in T2DM subjects with and without nephropathy, to analyze the correlation between urine albumin and urine synaptopodin in T2DM subjects and the cut-off analysis of sensitivity and specificity of urinary synaptopodin in diagnosing diabetic nephropathy. A sample of 60 subjects comprised 40 T2DM subjects and 20 non-DM subjects. Urinary synaptopodin levels were examined using the ELISA method, and albuminuria levels using the immunoturbidimetric method. Based on statistical analysis, the results showed that there were differences in urine albumin levels in T2DM and non-DM subjects (p*= < 0.001), there were differences in urine synaptopodin levels in T2DM and non-DM subjects (p*= < 0.001), there were no differences in urine synaptopodin levels with and without nephropathy in T2DM subjects (p*= 0.090), a relationship was found between urine albumin and urinary synaptopodin in T2DM subjects (p*= 0.048, r= 0.314) and the cut off of urinary synaptopodin in diagnosing nephropathy was ³0.39 ng/mL, sensitivity 64.7% and specificity 56.5%. We recommend further prospective studies with larger sample sizes to compare urinary synaptopodin levels and microalbuminuria (MAU) as markers for early detection of DN in T2DM subjects.
Analysis of Urinary Fibronectin Levels in Patients with Type 2 Diabetes Mellitus and Non-Diabetes Mellitus Muh Anshar J; Liong Boy Kurniawan; Nurahmi Nurahmi; Andi Alfian Zainuddin; Husaini Umar; Mansyur Arif
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 1 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i1.7752

Abstract

Diabetic nephropathy is a microvascular complication associated with high glucose levels in individuals with diabetes mellitus (DM). Fibronectin, an early marker of diabetic nephropathy, can indicate the occurrence and progression of renal damage. This cross-sectional study aimed to compare urinary fibronectin levels in patients with type 2 diabetes mellitus and non-diabetes mellitus. A sample of 50 DM patients was divided into two groups: the DM group and the non-DM group. Urinary fibronectin levels were measured using the ELISA method, while albuminuria levels were determined by the albumin-to-creatinine ratio (ACR). Statistical analysis was performed to assess the relationship between urinary fibronectin levels and urine albumin. Results: The average urinary fibronectin level in DM patients was 2.07 ± 3.04 ng/mL, which was slightly higher than the level observed in non-DM patients (1.09 ± 0.56 ng/mL). However, this difference was not statistically significant (p 0.05). Additionally, there was no significant relationship found between urinary fibronectin levels and urine albumin (p = 0.001). Conclusion: The findings of this study indicate that urinary fibronectin levels in individuals with DM were slightly higher than those without DM. However, this difference did not reach statistical significance. The lack of a significant relationship between urinary fibronectin levels and urine albumin suggests that fibronectin may provide additional information about renal damage in DM patients, independent of albuminuria. Further research is necessary to explore the clinical significance of urinary fibronectin as a potential biomarker for diabetic nephropathy.
PENGARUH TEKNIK INJEKSI STEROID DENGAN TUNTUNAN ULTRASONOGRAFI TERHADAP LUARAN KLINIS PASIEN CARPAL TUNNEL SYNDROME Mariana Sutopo; Yudy Goysal; David Gunawan Umbas; Susi Aulina; Louis Kwandou; Andi Alfian Zainuddin
NEURONA Vol 36 No 1 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v36i1.52

Abstract

     EFFECT OF STEROID INJECTION TECHNIQUE WITH ULTRASOUND GUIDANCE ON CLINICAL OUTCOMES IN CARPAL TUNNEL SYNDROME PATIENTSABSTRACTIntroduction: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy in the upper extremity and one of the diseases that causes disability, thereby reducing productivity. This study purpose is to determine the effect of steroid injection techniques with and without ultrasound guidance on clinical outcomes in patients with CTS.Method: This study was a clinical trial with a non-randomized pretest-posttest-control group design. This study subjects were 36 patients with CTS, consisting of 18 wrists receiving steroid injection with ultrasound guidance and 18 wrists without ultrasound guidance.Results: The results showed a significant change in the Symptom Severity Scale (SSS) and Functional Status Scale (FSS) (p<0.05) after treatment in the steroid injection group with and without ultrasound guidance. The results of the unpaired t-test on changes in the SSS between the groups who received steroid injection with ultrasound guidance and without ultrasound guidance showed no significant difference (p>0.05). The results of the Mann-Whitney test on changes in FSS scores between groups who received steroid injections with and without ultrasound guidance showed no significant differences (p>0.05).Discussion: Decrease in Boston SSS and FSS after steroid injections in both groups were in accordance with theory that steroid injection can quickly bind directly to nerve cell receptors and inhibit production of proinflammatory mediators. Whereas results of the study comparing effectiveness of steroid injection techniques with ultrasound guidance and without ultrasound guidance were not significant because observations were only made for 1 week.Keywords: Carpal tunnel syndrome, functional status scale, steroid injection, symptom severity scale, USG-guidedABSTRAKPendahuluan: Carpal tunnel syndrome (CTS) adalah neuropati jebakan yang paling sering pada ekstremitas atas dan merupakan salah satu penyakit yang menyebabkan disabilitas, sehingga menurunkan produktivitas. Penelitian ini bertujuan mengetahui pengaruh teknik injeksi steroid dengan dan tanpa tuntunan ultrasonografi terhadap luaran klinis pada pasien carpal tunnel syndrome.Metode: Penelitian ini adalah uji klinis dengan rancangan non-randomized pretest-posttest-control-group. Penelitian ini dilakukan terhadap 36 pasien CTS, terdiri dari 18 pergelangan tangan yang mendapat injeksi steroid dengan tuntunan USG dan 18 pergelangan tangan tanpa tuntunan USG.Hasil: Hasil penelitian menunjukkan adanya perubahan Symptom Severity Scale (SSS) dan Functional Status Scale (FSS) yang bermakna (p<0,05) setelah perlakuan pada kelompok injeksi steroid dengan dan tanpa tuntunan USG. Hasil uji-t tidak berpasangan terhadap perubahan SSS antara kelompok yang mendapat injeksi steroid dengan tuntunan USG dan tanpa tuntunan USG menunjukkan perbedaan tidak bermakna (p>0,05). Hasil uji Mann-Whitney terhadap perubahan skor FSS antara kelompok yang mendapat injeksi steroid dengan tuntunan USG dan tanpa tuntunan USG menunjukkan perbedaan tidak bermakna (p>0,05).Diskusi: Penurunan SSS dan FSS kuesioner Boston setelah dilakukan injeksi steroid pada kedua kelompok ini sesuai dengan teori bahwa injeksi steroid dapat dengan cepat berikatan langsung dengan reseptor sel saraf. Ikatan steroid dengan reseptor di sel saraf dapat menghambat produksi mediator proinflamasi. Sedangkan hasil penelitian yang membandingkan efektivitas teknik injeksi steroid dengan tuntunan USG dan tanpa tuntunan USG tidak bermakna karena pengamatan hanya dilakukan selama 1 minggu.Kata kunci: Carpal tunnel syndrome, functional status scale, injeksi steroid, symptom severity scale, USG-guided
HUBUNGAN ANTARA KADAR LIPID DARAH DENGAN DERAJAT HERNIASI DISKUS INTERVERTEBRALIS Elsa Ana Purika; Susi Aulina; Audry Devisanty Wuysang; Andi Alfian Zainuddin
NEURONA Vol 36 No 2 (2019)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v36i2.66

Abstract

   THE CORRELATION BETWEEN SERUM LIPID LEVELS WITH THE SEVERITY OF INTER-VERTEBRAL DISC HERNIATIONABSTRACTIntroduction: Inter-vertebral Disc Herniation (IDH) is one of the common causes of low back pain (LBP). High level of blood lipids is a risk factor for atherosclerosis, and responsible as the cause of decreased blood supply to the intervertebral discs which basically has minimal vascularization, thus, it is estimated that there is a relationship between blood lipid levels and IDH.Aim: To identify the correlation between serum lipid levels with the severity of IDH.Methods: Clinical trials with cross sectional designs were carried out on subjects with IDH during April to June 2018 in Dr. Wahidin Sudirohusodo Hospital, Makassar. Serum lipid levels (HDL, LDL, triglyceride and total cholesterol) were examined and the degree of disc herniation (1 to 4) was assessed. Data analyzed using the Spearman correlation test.Results: In this study there were 40 subjects, 15 males and 25 females, with mean age 50.75 (30-62) years old. Most patients were found with degrees of IDH 2 and 3 (total 75%). The Spearman correlation test showed that there was a negative correlation between HDL with degrees of IDH, as well as a positive correlation between LDL and triglycerides with degrees of IDH, but there was no correlation between total cholesterol levels with degrees of IDH.Discussion: The lower the HDL level, the higher the degree of IDH. On the other hand, the higher the level of LDL and triglycerides, the higher the degree of IDH.Keywords: Inter-vertebral disc herniation, low back pain, serum lipid levelsABSTRAKPendahuluan: Herniasi diskus intervertebralis (HDI) merupakan salah satu penyebab nyeri punggung bawah (LBP) yang cukup sering terjadi. Tingginya kadar lipid darah merupakan faktor risiko untuk aterosklerosis, dan bertanggung jawab sebagai penyebab menurunnya suplai darah pada diskus intervertebralis yang pada dasarnya sudah minim vaskularisasi, sehingga diperkirakan terdapat hubungan antara kadar lipid darah dengan penyakit degenerasi diskus intervertebralis.Tujuan: Mengetahui hubungan antara kadar lipid darah dengan derajat herniasi diskus intervertebralis.Metode: Penelitian potong lintang terhadap subjek dengan herniasi diskus intervertebralis yang berobat ke RSUP Dr. Wahidin Sudirohusodo, Makassar, selama bulan April-Juni 2018. Dilakukan penilaian kadar lipid darah (HDL, LDL, trigiliserida, dan kolesterol total) serta derajat herniasi diskus intervertebralis (1 sampai 4) berdasarkan gejala klinis dan gambaran MRI. Analisis data menggunakan uji korelasi Spearman.Hasil: Didapatkan 40 subjek yang terdiri atas 15 orang laki-laki dan 25 orang perempuan dengan rerata usia 50,75 (30–62) tahun. Mayoritas subjek mengalami HDI derajat 2 dan 3 (total 75%). Uji korelasi Spearman menunjukkan adanya korelasi negatif antara kadar HDL dengan derajat HDI, serta korelasi positif antara kadar LDL dan trigliserida dengan derajat HDI, namun tidak terdapat korelasi antara kadar kolesterol total dengan derajat HDI.Diskusi: Semakin rendah kadar HDL, maka semakin berat derajat HDI. Sebaliknya semakin tinggi kadar LDL dan trigliserida, maka semakin berat derajat HDI.Kata kunci: Herniasi diskus intervertebralis, kadar lipid darah, nyeri punggung bawah
Correlation of Lipid Profile and Apolipoprotein B/A-I Ratio with Insulin Resistance in Non-Diabetes Mellitus Subjects Andi Heriadi Palloge; Liong Boy Kurniawan; Yuyun Widyaningsih; Husaini Umar; Nurahmi Nurahmi; Andi Alfian Zainuddin
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 1 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i1.2198

Abstract

Obesity is defined as an increase in total body mass due to excess fat, as measured by the body mass index. Obesity affects metabolism through factors such as insulin resistance, which triggers the development of chronic diseases. Lipid and ApoB/ApoA-I ratios can be considered additional assessments, especially in patients at high risk of cardiovascular diseases such as diabetes. This study aims to determine the relationship between lipid and ApoB/ApoA-I ratios with Homa-IR in in non-diabetes mellitus adult subjects. The method used in this study was a cross-sectional study involving a total of 80 non-diabetic adult subjects, consisting of 38 male and 42 female subjects. The results showed that there were significant differences between the ratios of CHOL/HDL, TG/HDL, ApoB/ApoA-I, and HOMA-IR in non-obese and obese non-DM adult subjects (4.64 ± 2.18 vs 5.23 ± 1.87, p = 0.045; 2.38 ± 1.20 vs. 3.18±1.77, p=0.013;0.58±0.17 vs. 0.66±0.17, p=0.035 and 1.47±0.80 vs. 3.34±4.37, p = 0.000), and there was no significant difference between LDL/HDL (p = 0.117). The correlation test results between the ratios of CHOL/HDL to HOMA-IR, LDL/HDL to HOMA-IR, TG/HDL to HOMA-IR, and ApoB/ApoA-I to HOMA-IR in non-DM adult subjects (p=0.05, r=0.308; p=0.037, r=0.233; p=0.000, r=0.402; p=0.19, r=0.261). This study concluded that there was a significant correlation between lipid and ApoB/ApoA-I ratios with Homa-IR in non-diabetes mellitus adult subjects.
HUBUNGAN KOMORBIDITAS DENGAN GAMBARAN CT SCAN TORAKS PADA PASIEN TERKONFIRMASI COVID-19 suminto, silvia; Asriyani, Sri; Latief, Nikmatia; Alfian, Andi; Djaharuddin, Irawaty; Murtala, Bachtiar
E-Jurnal Medika Udayana Vol 13 No 1 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i01.P01

Abstract

Penelitian ini bertujuan untuk mengetahui hubungan komorbiditas dengan gambaran CT scan toraks pada pasien terkonfirmasi COVID-19. Penelitian ini dilaksanakan di Departemen Radiologi RSUP dr. Wahidin Sudirohusodo Makassar dengan jumlah sampel sebanyak 192 pasien terkonfirmasi COVID-19. Analisis karakteristik gambaran CT scan toraks pasien dilakukan pada lung dan mediastinal window untuk melihat gambaran Groundglass opacity (GGO),konsolidasi, crazy paving, halo sign, air bronchogram sign (ABS), fibrosis, nodul, limfadenopati mediastinum, dan efusi pleura. Perbedaan proporsi gambaran CT scan berdasarkan komorbiditas diuji dengan chi-square. Hasil penelitian menunjukkan terdapat hubungan yang signifikan antara pasien dengan riwayat komorbiditas terhadap gambaran GGO, konsolidasi, crazy paving, nodul, fibrosis, efusi (semua nilai p<0,05). Terdapat hubungan yang signifikan pada pasien dengan riwayat hipertensi dengan gambaran GGO, dan crazy paving (keduanya p<0,05), riwayat diabetes mellitus dengan gambaran konsolidasi (p<0,05), riwayat CKD dengan gambaran efusi pleura (p<0,05), riwayat keganasan dengan gambaran nodul (p<0,05), riwayat CAD dengan gambaran crazy paving (p<0,05), dan riwayat tuberkulosis dengan gambaran fibrosis, tree in bud dan nodul (p<0,05).
AKURASI DIAGNOSTIK NILAI ADC MRI DALAM MEMPREDIKSI TUMOR JARINGAN LUNAK JINAK DAN GANAS BERDASARKAN HASIL PEMERIKSAAN HISTOPATOLOGI AMIN, ROSMINI; Ilyas, Muhammad; Muis, Mirna; Zainuddin, Andi Alfian; Johan, Muhammad Phetrus; Latief, Nikmatia
E-Jurnal Medika Udayana Vol 12 No 7 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i07.P16

Abstract

ABSTRACT DWI with ADC mapping adds value to conventional MRI imaging by offering assessment of cellularity functionality with the potential to help differentiate between benign and malignant lesions. The aim of this study is to assess the accuracy of the ADC value MRI in predicting soft tissue tumors benign and malignant. This study was carried out by the Radiology Installation of Wahidin Sudirohusodo Hospital from February 2020 to August 2022 with a sample of 36 people and an age range of 9-74 years. The statistical method used was to calculate the value of sensitivity, specificity, Positive Predictive Value and Negative Predictive Value to assess accuracy as well as ROC and Mann Whitney tests. The results show that it consists of 36 samples with soft tissue tumors (malignant: 25 samples and benign : 11 samples). The mean value of ADC for malignant soft tissue tumors is 0.998 ± 0.526 x 10-3mm2/s and benign is 1.705 ± 0.665 x 10-3mm2/s. With a Cut Off value to distinguish malignant and benign soft tissue tumors of 1,265 x 10-3 mm2/s, with a sensitivity of 81.8%, specificity of 80%, Positive Predictive Value 64.3%, Negative Predictive Value 90.9%, Accuracy 80.5% and AUC 0.81. The accuracy of the ADC MRI value is 80.5%, indicating that the ADC value can be used as an additional modality to help predict benign and malignant soft tissue tumors. Keywords: Soft tissue tumor, MRI, DWI, ADC, Histopathology
Co-Authors . Ahmadwirawan . Prihantono . Sulmiati A. Kaisar Adiwijaya Putra A.A. Ketut Agung Cahyawan W Abdul Hakim Alkatiri Abdul Muis Abdul Qadar Punagi Achi Rasma Welaty Achmad Chusnu Romdhoni Achmad, Djumadi Afni Juhairia Laisouw Agusalim Bukhari Agustining Rahayu Ajardiana Ajardiana Akhtar Fajar Muzakkir Akhtar Fajar Muzakkir Ali Aspar Mappahya Ali Aspar Mappahya Alia Amalia Amalia Amalia Amin, Muzakkir AMIN, ROSMINI Amir, Muzakkir Amran, Muhammad Yunus Andi Asadul Islam Andi Heriadi Palloge Andi Husni Tanra Andi Khairul Anaam Andi Kurnia Bintang Andi Kurnia Bintang, Andi Kurnia Andi Miftah Khaerati Darmawan Annisa Anwar Mutaher Anshory Sahlan Arden, Ferdinand Ari Andini Junaedi Ari Santri Arif Santoso Arif, Asnita Asriyani, Sri Asriyani, Sri Asriyanti, Sri Audry Devisanty Wuysang Azis, Zainab Baan, Junus Bachtiar Murtala Bachtiar Murtala Bachtiar Murtala Bachtiar Murtala Bachtiar Murtala Bachtiar Murtala Bachtiar, Nur Amelia Badjeber, Alvia Novita Bahar, Ashari Bambang Widyantoro Basri, Muhammad Iqbal Berty. J Nelwan Blow, David Budu Budu Bukhari, Agussalim Burhanudin, Danang P Cahyono Kaelan Cahyono Kaelan Cahyono Kaelan Cahyono Kaelan, Cahyono Cangara, Husni Cangara, M. Husni Daniel PL Tobing Daud, Nu’man As David Gunawan Umbas David Gunawan Umbas Dian Zamroni Dianawaty Amiruddin Dina Fatiyah Bakri Djafar, Zaenab Djaharuddin, Irawati Djaharuddin, Irawaty Dwi Yuda Herdanto Eddy Hartono Eddyman W Ferial Eka Sunarwidhi Prasedya Elsa Ana Purika Emilya Jufianti Erlyn Limoa Erman Muliawan Fadjar Perkasa, Muhammad Faisal Muchtar Farid Nurmantu Faridin Faridin Faridin, Faridin Fathlina, F. Ferawati Dakio Firdaus Hamid Gaffar, Masyita Gatot. S. Lawrence Ghaznawie, Aussie Fitriani Goysal, Yudy Haizah Nurdin Halim, Wijoyo Hamsu Kadriyan Harsali F. Lampus Harun Muchsin, Achmad Herman, Teddy Marzuki Herpan Syafii Harahap Himawan Sanusi Himawan Sanusi HP, Faridin Husaini Umar Husaini Umar Husnah, Kurniawati Husnul Mubarak Husnul Mubarak Idar Mappangara, Idar Idham Jaya Ganda, Idham Jaya Idris, Nurlaily Ika Yustisia Ilhamjaya Patellongi Ilhamjaya, Andi Meutiah Ilsa Hunaifi Indra, Ryan Irawati Djaharuddin Irawaty Djaharuddin Irmalita Irmalita Irsyadat, Andi Muhammad Isman Firdaus Isra&#039; Wahid J Nelwan, Berti Jeanie Dewi Wangsa Jerny Dase Johan, Muhammad Phetrus Jumraini Tammasse Jumraini Tammasse Juniarsih, Juniarsih Junus A.B. Baan Juzar, Dafsah Arifa Kai, Rosita Kalatiku, Jane Magdalena Karya Triko Biakto Kasim, Hasyim Kasim, Muhammad Firdaus Kastiran, Andi Muhammad Akram Kiki Amelia Marlina Kurnia Bintang, Andi Kurniawati, Wensri sevni Latief, Nikmatia Latief, Nikmatia Liong Boy Kurniawan Liong Boy Kurniawan Liong Boy Kurniawan Liong Boy Kurniawan Lotisna, Mimi Louis Kwandou Madeng, A. Arsidin Mappa Mansyur Arif Mariana Sutopo Melda Warliani Melda Warliani Melda Warliani Memah, Maya Fane Meryana*, A. Kurnia Bintang**, Muh. Akbar**, Susi Aulina**, Yudy Goysal**, Arifin Limoa*** Meta Mahendradatta Mirna Muis Mirna Muis Mirna Muis Mirna Muis Miskad, Upik Mochammad Hatta Mochammad Hatta Mohammad Hatta Muh Anshar J Muh. Ilyas Muh. Nasrum Massi Muhammad Akbar Muhammad Akbar Muhammad Amsyar Akil Muhammad Fadhil Muhammad Fadjar Perkasa, Muhammad Fadjar Muhammad Ilyas Muhammad Ilyas Muhammad Ilyas Muhammad Ilyas Muis, Mirna Mustamir, Nasrullah Mustika Hutabarat Sari Muzakkir Amin Muzakkir Amir Muzakkir Muzakkir Muzakkir, Akhtar Fajar Nagusman Danil Nelly Ni Ketut Sungowati Nilla Mayasari Nita Mariana Nova Audrey Luetta Pieter Nur Aeni M.A. Fattah Nur Rakhmah Nurahmi Nurahmi Nurahmi Nurahmi Nuralam Sam Nurcholish Akbar Monayo Nurdin, Nurhaya Nurlaily Idris Nurlaily Idris Nu’man AS Daud Ogirahma Paulus Sugianto Peter Kabo Prihantono, Prihantono Rachmawarni Bachtiar, Rini Rafikah Rauf Rahmawati Minhajat1 Rasita, Yoeke Dewi Rauf, Rafikah Reinaldo Sunggiardi Ridwan Rina Masadah Riza Linda Rizalinda Sjahril Rosita Kai RR. Ella Evrita Hestiandari Rumaisah Hasan RUNTUWENE, INNEKE MAGDALENA S. Zulfikar. G. Assegaf Said, Suryani Saidah Syamsuddin Samban, Ida Shanti Riskiyani Sharvianty Arifuddin Shinta, Pricilla Siahaan, Surya Perdana Silvia Suminto, Silvia Siska Suridanda Danny Sitti Rafiah Soma, Andang Suryana Sonny Teddy Lisal Sri Asriyani Sri Asriyani Sri Asriyani Sri Asriyani Sri Jayanti Sri Ramadany, Sri Sri Ramadhany Suardi AL Susi Aulina Susi Aulina Syahrul Rauf Syakri Syahrir Syamsul Hilal Salam Syarifuddin Wahid Sylvia Evelyn Aritonang Sylvia Evelyn Aritonang talawo, Vivi Yuniarti Tammasse, Jumraini Tanady, Kevin Julius Tarigan, Ngalasantaru Janstar Tawali, Suryani Tenri Esa Tenri Esa Teuku Fadlian Syah Theosobia Grace Orno Tiorisman, Nola Tommy R. Habar Uleng Bahrun Upik A. Miskad, Upik A. Veraferial Muchtar Wa Ode Sri Nikmatiyah Walenna, Nirwana Fitriani Wenda Anastasia Wensri sevni Kurniawati Wuysang, Audry Devisanty Yogi Andrew Taruk Padang Yose Waluyo Yudy Goysal Yuliawati Yuliawati Yundari, Yundari Yuyun Widaningsih Yuyun Widaningsih Yuyun Widyaningsih Zaifah Firayanti