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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. E-Jurnal Medika Udayana Jurnal Kedokteran Brawijaya Jurnal Kesehatan Masyarakat Damianus Journal of Medicine The Indonesian Biomedical Journal Nusantara Medical Science Journal Jurnal Kesehatan Manarang Majalah Kesehatan Pharmamedika Jurnal Ilmiah Kesehatan (JIKA) Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Molucca Medica Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Physical Therapy Journal of Indonesia Neurona Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Andi Alfian Zainuddin
Bagian Ilmu Kesehatan Masyarakat/Ilmu Kedokteran Komunitas Fakultas Kedokteran Universitas Hasanuddin
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Comparison of Giving Mecobalamin Supplements to Improve the Severity of Painful Diabetic Neuropathy Irsyadat, Andi Muhammad; Aulina, Susi; Goysal, Yudy; Zainuddin, Andi Alfian; Lotisna, Mimi; Amran, Muhammad Yunus
Jurnal Ilmiah Kesehatan (JIKA) Vol. 6 No. 3 (2024): Volume 6 Nomor 3 Desember 2024
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v6i3.874

Abstract

Diabetic Painful Neuropathy (DPN) is caused by the progressive loss of nerve fibers due to hyperglycemia, oxidative stress, andhomocysteinemia. Mecobalamin supplementation has shown potential in improving peripheral neuropathy symptoms by enhancing nerve conduction and alleviating neuropathic pain. However, its efficacy data remains limited. This research to investigated the effect of mecobalamin supplementation on the severity of Painful Diabetic Neuropathy in type 2 diabetes mellitus patients. This research is a non-randomized clinical trial, 16 patients were given 500 ?g of intramuscular Mecobalamin 8 times over 30 days (n=8) and 5 times over 10 days (n=8). Subjects underwent measurements VAS, TSS, BDNC and ENMG before and after intervention. VAS (p-value=0,022), TSS (p-value=0,020) and BDC (p-value=0,003) was significant improved in 8 times administration group. VAS (p-value=0,045) dan BDC (p-value=0,014) was significant improved in 5 times administration group, where TSS improved but not significant. The 8 times administration group was better compared to the 5 times administration group in improvement of VAS (p-value=0,016). Based on this research, The addition of mecobalamin 8 times and over 5 times in the management of Diabetic Neuropathic Pain can be useful in reducing neuropathic pain.
Effects of a virtual reality exergame on cardiorespiratory function in older adults Bakri, Dina Fatiyah; Warliani, Melda; Waluyo, Yose; Mubarak, Husnul; Mayasari, Nilla; Zainuddin, Andi Alfian
Physical Therapy Journal of Indonesia Vol. 6 No. 2 (2025): July-December 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i2.321

Abstract

Introduction: With increasing life expectancy, the elderly population is at higher risk for cardiorespiratory decline. Exercise is known to reduce this decline, but adherence to exercise programs can be low. Virtual reality (VR) exergaming offers an engaging alternative, potentially increasing motivation while providing similar benefits. This study aimed to evaluate the effectiveness of VR exergaming in improving cardiorespiratory function in elderly individuals. Methods: A randomized controlled trial was conducted with 40 elderly participants (VR exergaming, n=24; conventional aerobic exercise, n=16). Both groups exercised three times per week for six weeks. The VR group used Ring Fit Adventure on the Nintendo Switch, while the control group performed structured aerobic exercises. Cardiorespiratory parameters—heart rate (HR), respiratory rate (RR), blood pressure (BP), predicted maximal oxygen uptake (VO₂ max) from the 6-minute walking test (6MWT), peak expiratory flow rate (PEFR), and peak cough flow rate (PCFR)—were assessed before and after the intervention. Results: Significant improvements were observed in VO₂ max, RR, BP, PEFR, and PCFR in both groups, though HR did not change significantly. Despite baseline differences in VO₂ max, overall improvements were comparable between the two groups. Conclusion: VR exergaming was as effective as conventional exercise in improving cardiorespiratory function in older adults and offers an engaging and enjoyable alternative.
Comparative effects of exergame intervention on cardiorespiratory function in obese and normal-weight adults Darmawan, Andi Miftah Khaerati; Mubarak, Husnul; Aritonang, Sylvia Evelyn; Sam, Nuralam; Warliani, Melda; Zainuddin, Andi Alfian
Physical Therapy Journal of Indonesia Vol. 6 No. 2 (2025): July-December 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i2.323

Abstract

Background: Obesity is a major risk factor for cardiovascular disease and metabolic disorders. Exergaming offers an accessible, interactive alternative to promote physical activity. This study aimed to assess the changes in the 6-minute walk test (6MWT), heart rate recovery (HRR), and maximal oxygen uptake (VO2max) in adults with obesity and normal weight after a six-week exergame intervention. Methods: A quasi-experimental pre-post study involved 29 adults (15 obese, 14 normal BMI) who participated in exergame sessions three times of 40 minutes weekly for six weeks. Inclusion criteria included adults aged 18–45 years with a BMI of 18.5–24.9 kg/m² (normal) or ≥25 kg/m² (obese), normal or corrected vision, and willingness to complete the intervention. Exclusion criteria included individuals with cardiovascular, neurological, or uncontrolled medical conditions, recent surgery or hospitalization, pregnancy, participation in other exercise programs within the previous four weeks, cognitive or sensory impairments, withdrawal from the study, repeated absences, or adverse events such as cybersickness. Outcomes included 6MWT distance, HRR, and VO2max. The paired T-test or Wilcoxon test was used for within-group comparisons, and the independent T-test or Mann-Whitney test for between-group analysis. Results: Significant within-group improvements were observed after the intervention. The 6MWT distance increased by 26.21 m, from 364.48 ± 46.92 m to 390.69 ± 43.17 m (p < 0.001). HRR improved by 11.14 bpm, from 24.41 ± 8.35 bpm to 35.55 ± 8.92 bpm (p = 0.003). VO2max increased by 0.79 mL/kg/min, from 14.91 ± 1.85 to 15.70 ± 1.84 mL/kg/min (p < 0.001). However, between-group differences were not statistically significant for 6MWT (p = 0.397), peak heart rate (p = 0.739), HRR (p = 0.220), and VO2max (p = 0.397), indicating similar improvements in both groups. Conclusion: Six weeks of exergaming significantly improved functional capacity and cardiorespiratory fitness comparably in both obese and normal-weight adults, suggesting it was an inclusive and practical option for community-based physical activity programs.
The effect of a virtual reality exergame on handgrip strength and cognitive function in post-stroke patients Wangsa, Jeanie Dewi; Hasan, Rumaisah; Nikmatiyah, Wa Ode Sri; Waluyo, Yose; Mubarak, Husnul; Zainuddin, Andi Alfian
Physical Therapy Journal of Indonesia Vol. 6 No. 2 (2025): July-December 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i2.322

Abstract

Background: More than 60% of stroke patients have chronic neurological impairments that impair hand strength and cognitive function, lowering their quality of life. While virtual reality (VR) exergames have been extensively researched as adjuvant therapies, evidence of their simultaneous effects on motor and cognitive skills is scarce. This study aimed to evaluate the impact of VR exergames on handgrip strength and cognitive function in post-stroke patients. Methods: The study used a randomized controlled trial design with 60 subacute post-stroke patients who were randomly assigned to either the control group, which received conventional care (occupational therapy and physiotherapy), or the intervention group (conventional care plus VR exergame therapy) for eight weeks. This study included first-time stroke patients with onset ≥1 month, mild to moderate hemiparesis (MMT ≥ 3), and hemodynamic stability. Participants with significant spasticity (MAS > 3), aphasia, or uncontrolled comorbidities were excluded. Before, during, and after the intervention, handgrip strength and cognitive function were tested using the Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina). Results: After 8 weeks of therapy, the intervention group showed a significant increase in handgrip strength (+3.9 points, p-value= 0.040) and MoCA-Ina scores (+5 points, p-value= 0.007) compared to the control group. Conclusion: Integrating VR exergames with conventional rehabilitation significantly improves handgrip strength and cognitive function in post-stroke patients compared to traditional therapy alone.
Integrating Human Reliability Assessment into Health Promotion Strategies to Reduce Patient Mortality and Preventive to Legal Issue Assegaf, S. Zulfikar. G.; AL, Suardi; Dase, Jerny; Mutaher, Annisa Anwar; Nelwan, Berty. J; Zainuddin, Andi Alfian; Lawrence, Gatot. S.
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 12: DESEMBER 2025 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v8i12.8567

Abstract

Introduction: Human error is one of the leading factors in medical negligence cases worldwide. These errors may include a range of actions such as misdiagnosis, medication errors, and procedural mistakes. Based on studies and reports from several major hospitals in Indonesia, as well as reports from the Hospital Patient Safety Committee (Komite Keselamatan Pasien Rumah Sakit – KKPRS), incidents related to patient safety in the ICU remain considerably high. Human Reliability Analysis (HRA) is a method used to prevent human error by analysing and assessing the likelihood of human mistakes within a work system and by developing mitigation strategies to minimise such errors. The HRA method involves several techniques and approaches that can be applied in healthcare settings to enhance patient safety and prevent medical negligence. Methods: This qualitative descriptive-exploratory study was conducted in the ICU of Dr. Wahidin Sudirohusodo General Hospital from January to March 2025. Thirty ICU healthcare workers were recruited through total sampling. Mortality data were reported only for contextual description, not as a direct outcome of HRA, in order to avoid conflating qualitative error mapping with quantitative outcomes. Results: ICU nurses demonstrated a higher potential for human error compared to anesthesiology residents. The ICU mortality rate was 45%, with chronic kidney disease, malignancies, and cardiovascular disorders identified as the leading causes of death. These figures are presented descriptively and not interpreted as effects of HRA Conclusion: The SHERPA approach provided insight into potential errors, their impact, and contributing factors, enabling recommendations to strengthen ICU safety systems. These findings underline the urgent need for medical audits and suggest potential implications of SHERPA in reducing medico-legal risks, rather than establishing causal effects on mortality reduction.
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Hakim Alkatiri Achmad, Djumadi AL, Suardi Ali Aspar Mappahya Amalia Amalia Amin, Muzakkir AMIN, ROSMINI Amran, Muhammad Yunus Anaam, Andi Khairul Andi Asadul Islam Andi Kurnia Bintang, Andi Kurnia Arif, Asnita Aritonang, Sylvia Evelyn Asriyani, Sri Asriyani, Sri Asriyanti, Sri Assegaf, S. Zulfikar. G. Azis, Zainab Baan, Junus Bachtiar Murtala Bachtiar, Nur Amelia Bahar, Ashari Bakri, Dina Fatiyah Basri, Muhammad Iqbal Blow, David Burhanudin, Danang P Cahyono Kaelan, Cahyono Cangara, Husni Cangara, M. Husni Darmawan, Andi Miftah Khaerati Dase, Jerny David Gunawan Umbas Djaharuddin, Irawati Djaharuddin, Irawaty Fadjar Perkasa, Muhammad Fathlina, F. Ghaznawie, Aussie Fitriani Goysal, Yudy Halim, Wijoyo Harun Muchsin, Achmad Hasan, Rumaisah Hatta, Mohammad Herman, Teddy Marzuki Herpan Syafii Harahap HP, Faridin Husnah, Kurniawati Idham Jaya Ganda, Idham Jaya Idris, Nurlaily Ilsa Hunaifi, Ilsa Irsyadat, Andi Muhammad J Nelwan, Berti Johan, Muhammad Phetrus Juniarsih, Juniarsih Kai, Rosita Kalatiku, Jane Magdalena Kasim, Hasyim Kasim, Muhammad Firdaus Latief, Nikmatia Latief, Nikmatia Lawrence, Gatot. S. Liong Boy Kurniawan, Liong Boy Lotisna, Mimi Madeng, A. Arsidin Mappa Mayasari, Nilla Melda Warliani Meryana*, A. Kurnia Bintang**, Muh. Akbar**, Susi Aulina**, Yudy Goysal**, Arifin Limoa*** Miskad, Upik Mubarak, Husnul Muhammad Akbar Muhammad Fadhil Muhammad Fadjar Perkasa, Muhammad Fadjar Muhammad Ilyas Muis, Mirna Mustamir, Nasrullah Mutaher, Annisa Anwar Muzakkir, Akhtar Fajar Nelwan, Berty. J Nikmatiyah, Wa Ode Sri Nita Mariana Nurdin, Nurhaya Paulus Sugianto, Paulus Prihantono, Prihantono Rafiah, Sitti Rauf, Rafikah Rina Masadah Said, Suryani Sam, Nuralam Samban, Ida Shanti Riskiyani Shinta, Pricilla Solly Aryza Soma, Andang Suryana Sri Ramadany, Sri Syarifuddin Wahid talawo, Vivi Yuniarti Tammasse, Jumraini Tanady, Kevin Julius Tarigan, Ngalasantaru Janstar Tiorisman, Nola Uleng Bahrun, Uleng Upik A. Miskad, Upik A. Wahid, Isra' Walenna, Nirwana Fitriani Waluyo, Yose Wangsa, Jeanie Dewi Wuysang, Audry Devisanty Yundari, Yundari