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All Journal Medula Wikrama Parahita : Jurnal Pengabdian Masyarakat Jurnal Ilmu Kedokteran dan Kesehatan JURNAL MUTIARA KESEHATAN MASYARAKAT JURNAL PENELITIAN PERAWAT PROFESIONAL Wellness And Healthy Magazine JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal teknologi Kesehatan Borneo Nusantara Hasana Journal Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Journal of Student Research Jurnal Kedokteran Ibnu Nafis Jurnal Kesehatan Metro Sai Wawai JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Sangging, Putu Ristyaning Ayu
Fakultas Kedokteran, Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Hubungan Konsumsi Kafein dengan Kejadian Depresi Indah Salsabila; Putu Ristyaning Ayu Sangging; Intanri Kurniati; Ratna Dewi Puspitasari
Medula Vol 13 No 6 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i6.488

Abstract

Depression is a mood disorder. Depression is characterized by a feeling of sadness that lasts continuously and for a long time, which can interfere with a person's physical condition and social life. Around 121 million people in the world suffer from depression. It is estimated that only 30% of people with depression get proper treatment. This number does not include people who have clinical symptoms of depression but are not actually diagnosed. Some patients are also considered not to get proper treatment. The number of Indonesian populations aged more than 15 years and diagnosed with depression is 12 million sufferers. Pharmacological therapy in depressed patients is antidepressants such as serotonin and noradrenaline reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs). However, there are side effects that can result from long-term use of these drugs. Therefore, other treatments such as giving herbal medicines are needed to reduce symptoms in people with depression. Giving caffeine with the right dose can reduce the risk of depression, because of its ability to block the adenosine receptor subunit. However, caffeine consumption with doses above 68mg and below 509mg per day is assessed to have the opposite effect that increases the risk of developing depression.
Skleritis dan Rheumatoid Arthritis Cut Karel Dithia; Putu Ristyaning Ayu Sangging; Rani Himayani
Medula Vol 13 No 6 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i6.715

Abstract

Rheumatoid arthritis is the result of a chronic inflammatory process that involves the immune system. One of the antibodies that is often detected in RA and scleritis patients is rheumatoid factor (RF). RF are antibodies produced by the immune system to attack the body's own tissues, including joints and synovial membranes. Another part of the antibody effect that is cyclic anti-citrate antibody (Anti-CCP), is an antibody that recognizes citrulinating proteins in body tissues, namely certain protein modifications that occur in RA patients and are considered as important factors in the pathogenesis of this disease. Increased RF levels can occur in patients with RA as well as in patients with scleritis. Scleritis is an inflammatory condition of the sclera, which is the thick white layer that lines the front of the eyeball. The etiology or cause of scleritis is still not known with certainty, apart from uncertain etiology, there are factors that can increase the risk of developing scleritis, such as autoimmune diseases, infections, vascular disorders, trauma, and drugs. This literature review discusses the relationship between rheumatoid arthritis and scleritis.  
Obstructive Sleep Apnea (OSA) pada Usia Produktif Annisarahma, Lyvia; Karima, Nisa; Sangging, Putu Ristyaning Ayu; Rudiyanto, Waluyo
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.951

Abstract

Obstructive sleep apnea (OSA) is a sleep disorder which characterized by cessation of breathing for more than 10 seconds. A blockage in the upper respiratory tract may be the cause of OSA. One known risk factor for OSA is smoking. Moreover, the degree of physical activity might also influence OSA risk. This article is a literature review with a variety of the latest sources that are relevant to the topic. The sources used were obtained from the search engine for health journals. The prevalence of OSA in the productive age community in Asia is 4.1 - 7.5%. Some factors that affect the symptoms of OSA, especially in productive age, namely obesity, male sex, old age, genetic, smoking habits, and small upper airway diameter. OSA is characterized by snoring, periodic apnea, hypoxemia during sleep and hypersomnolence during the day. Some symptoms of OSA are snoring hard and annoying, stopping repeated breathing during sleep at night, insomnia, fatigue, and drowsiness during the day. Death from OSA in productive age is usually caused by complications after having OSA in the long period ahead.
Tinjauan: Malondialdehyde (MDA) sebagai Marker Stres Oksidatif Berbagai Penyakit Gusnirwan, Alief; Sangging, Putu Ristyaning Ayu
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.990

Abstract

Oxidative Stress is a condition of imbalance between free radicals and antioxidants in the body. This can be caused by the excessive production of reactive oxygen species (ROS) or reactive nitrogen species (RNS), which can damage biomolecules such as lipids, proteins, and nucleic acids. Various factors, including environmental elements like UV rays, radiation, pollutants, smoking, heavy metals, and exposure to drugs, can trigger this condition. Malondialdehyde (MDA) serves as a stable and accurate biomarker of oxidative stress and can indicate the oxidation processes within cell membranes. Elevated concentrations of MDA are associated with pathological conditions and can lead to damage to blood vessel walls, the development of heart diseases, changes in cell membrane properties, and DNA mutations, contributing to the formation of cancer and genetic diseases. Numerous studies have shown significantly different MDA levels between healthy individuals and those with specific diseases, and MDA values correlate with the severity of various illnesses. Understanding the mechanisms of oxidative stress and measuring biomarkers like MDA provide crucial insights into the role of oxidative stress in the pathology of diverse diseases, opening avenues for the development of more effective prevention and treatment strategies.
Benign Prostat Hyperplasia : a review Alghani, Sulthan Rafi; Sangging, Putu Ristyaning Ayu
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1005

Abstract

The prostate gland is a vital organ that often experiences enlargement, including in a non-malignant form known as Benign Prostatic Hyperplasia (BPH). BPH, which is common in elderly men, is a leading cause of medical intervention in men over 60 years of age and affects quality of life. Epidemiology of BPH, with a prevalence reaching 70-90% in men over 60 years. Although exact data in Indonesia is not yet available, leading hospitals report BPH cases with an average age of sufferers around 66-67 years. Symptoms of BPH, such as difficulty urinating and other clinical complaints, can affect the sufferer's quality of life. Risk factors, including age, family history, obesity, employment history, and diabetes. Prevention and education are also a major concern, with an emphasis on healthy eating patterns, physical activity, reducing caffeine and alcohol consumption, and daily behavior to minimize BPH symptoms. Potential complications include urinary tract obstruction which can lead to infection and even kidney failure if left untreated.
Tatalaksana Hipertensi Salshabilla, Annisa; Pardilawati, Citra Yulianda; Sangging, Putu Ristyaning Ayu; Oktarlina, Rasmi Zakiah
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1042

Abstract

Hypertension is called the "silent killer" because there are no specific symptoms for sufferers and it is the main cause of death throughout the world. Hypertension or high blood pressure is a condition where systolic blood pressure increases ≥ 140 mmHg and diastolic blood pressure ≥ 90 mmHg. According to WHO (World Health Organization), an estimated 1.28 billion adults aged 30-79 years suffer from hypertension worldwide. Riskesdas data for 2018 states that the prevalence of hypertension in Indonesia is 658,201. The pathophysiology of hypertension occurs through the process of forming angiotensin I into angiotensin II by angiotensin I converting enzyme (ACE). Management of hypertension includes non-pharmacological management and pharmacological management. Some non-pharmacological management measures include weight loss, implementing Dietary Approaches to Stop Hypertension (DASH), adopting a low salt diet, consuming potassium supplements, increasing physical activity, and reducing alcohol consumption. Recommended pharmacological therapy in hypertensive patients such as ACEi or ARB with CCB or thiazide/thiazide-like diuretics.
ANALISIS DAN INTERPRETASI CAIRAN SEREBROSPINAL (LCS) DALAM PERAWATAN NEUROKRITIS UNTUK KONDISI NEUROLOGIS AKUT, ARTIKEL REVIEW Sinulingga, Anselmus Libreya; Sangging, Putu Ristyaning Ayu; Soleha, Tri Umiana
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1125

Abstract

Cerebrospinal fluid (LCS) is a clear fluid circulating in the intracranial and spinal compartments. Under normal conditions, the composition of LCS remains constant. However, in various neurological disease especially in acute conditions, the composition, quantity and its pressure can be altered. The importance of CSF in the diagnosis of neurological diseases has been enhanced with the development of techniques that allow direct measurement or indirect analysis of CSF composition. These methods not only aid in diagnosis but also in assessing the severity and prognosis of the neurological conditions faced by patients. For instance, measuring glucose levels in CSF can help differentiate between subarachnoid hemorrhage due to an aneurysm and other types of hemorrhagic stroke. By measuring the levels of various LCS components using relevant techniques, diagnosis, severity and prognostication of neurological conditions like infections, subarachnoid hemorrhage, demyelinating conditions, tumor like conditions, etc. can be done. In the context of emergency care, a good understanding of changes in CSF and their relevance to the patient's clinical condition enables doctors to make more accurate decisions regarding management and treatment. Therefore, CSF analysis is crucial not only for initial diagnosis but also for monitoring and assessing the response to therapy. In this review, alterations in LCS components and its relevance to the emergency care physician to help in the management of patients are enumerated.
Phosphatidylserine Exposure in Thalassemia Β Patients Sangging, Putu Ristyaning Ayu; Sutyarso, Sutyarso; Busman, Hendri
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1162

Abstract

Thalassemia is a genetic disorder that involves the formation of abnormal hemoglobin. Thalassemia is divided into two main categories namely alpha and beta thalassemia depending on the hemoglobin chain affected. Although some categories of thalassemia are mild and cause only mild anemia and iron deficiency problems in patients, other, more severe forms of thalassemia can result in death. Thalassemia sufferers can get treatment according to the severity of the condition. The degree of ineffective erythropoiesis is known to be associated with clinical severity in individuals with thalassemia. However, the association of ineffective erythropoiesis biomarker levels with different thalassemia genotypes is limited. Studies have explored levels of red blood cells exposed to phosphatidylserine and ineffective erythropoiesis biomarkers in patients with different genotypes. Based on the results of the review, beta thalassemia patients have the highest GDF-15 levels, followed by patients with non-deletal alpha thalassemia. Patients with non-delesional alpha thalassemia showed elevated hemoglobin levels and decreased GDF-15 levels after splenectomy. Patients with beta thalassemia and non-delesional alpha thalassemia had the highest levels of red blood cell exposure to PS and ineffective erythropoiesis biomarkers, which correlated with the clinical severity of thalassemia. Differences in erythropoiesis rates are not effective in thalassemia, which emphasizes the need for different treatment approaches in patients with different thalassemia genotypes.
Hubungan Rasio Limfosit Monosit (RLM) dengan Fraksi Ejeksi Ventrikel Kiri pada Pasien Gagal Jantung Muhammad Ainul Yaqin; Putu Ristyaning Ayu Sangging; Suryani Agustina Daulay
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1339

Abstract

In the pathogenesis of heart failure, there is an inflammatory process that has a close relationship, where both influence each other. The lymphocyte monocyte ratio (LMR) is a cheap and easy inflammatory biomarker and is considered to function as a predictor of poor clinical outcomes in heart failure patients. This study is an analytical descriptive study conducted with a cross-sectional design. The sampling technique was carried out using consecutive sampling techniques from samples that met the inclusion and exclusion criteria. In this study, a chi-square test was carried out to test for significant relationships between variables. Researchers used secondary data from 86 medical record data. A total of 23.26% of samples had low LMR (≤2) with low ejection fraction (≤40%) and 3.49% had low LMR (≤2) and high left ventricular ejection fraction (>40%). On the other hand, there were 44.18% of samples that had high RLM (>2) with low left ventricular ejection fraction (≤40%) and there were 29.07% of samples that had high RML (>40%) and low left ventricular ejection fraction (≤2). The results of the chi-square test stated that the p value of both variables was 0.02 with an odds ratio of 4.386. Therefore, it can be concluded that there is a significant relationship between the lymphocyte monocyte ratio (LMR) and left ventricular ejection fraction in heart failure patients at Dr. H. Abdul Moeloek Hospital, Lampung Province in 2023.
Kekuatan Genggaman Tangan pada Dewasa Muda Tiasti, Jania; Setiorini, Anggi; Nareswari, Shinta; Sangging, Putu Ristyaning Ayu
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1665

Abstract

Handgrip strength (HGS) is an important indicator that reflects both musculoskeletal health and overall well-being. Hand grip strength is widely applied in research and clinical practice because its measurement is simple, reliable, and able to represent overall muscle strength. The assessment of HGS is conducted using a handgrip dynamometer, which operates based on specific principles. However, the limited literature on normative data for young adult populations hinders the interpretation of handgrip performance in this age group. One normative study reported that in healthy young adults, the average HGS reached 36.32 kg in men and 22.96 kg in women. These values may vary depending on ethnicity, level of physical activity, and lifestyle habits. Factors influencing HGS include body composition, anthropometric characteristics, sex, age, nutritional status, and physical fitness. Physiologically, men tend to have higher HGS than women due to differences in muscle mass, hormonal levels, and muscle fiber distribution. The decline of HGS with increasing age is closely related to sarcopenia, a condition characterized by reduced muscle strength, mass, and function associated with aging. Therefore, maintaining handgrip strength from an early age is crucial to support daily activities, preserve independence in older age, and serve as an indicator of future health risks.
Co-Authors Adinda Husna Cahyana Agung Ikhssani Agustyas Tjiptaningrum Ahmad Duta Al-Ihya Al Ayubi, M. Mahdi Alghani, Sulthan Rafi Almaina Puteri Jasmine Almaina Amira Nabila Andi Nafisah Angelica Philia Christy Anggraeni Janar Wulan Annisarahma, Lyvia Aprilia, Intan Rahma Ardian Reza Putra Arfa Salma Firnandya Ari Irawan Ari Irawan Ari Wahyuni Aulia Nur Fitriatsani Aurelia, Faizah Zahra Aurora Awindya Nareswari Azizah Nur Rahmah Bagus Pratama Brigitta Shinta dewi Carissa Aprilia Y Cholyviona W.S Handhayani Citra Yuliyanda Pardilawati Cut Karel Dithia Daffa Fahreiza Daffa Fahreiza Darma, I Wayan Dika Aditia Devina Hardianto Devira Fitriani Kamal Devya Aulia Dian Isti Angraini Dilla Syahra Noor Fitri Dimas, Dimas Dzakwan Cedri Ketierteu Ellysa Angguman Putri Ety Apriliana Evan Christian Christian Fadila Gustiani Daraz Fadilah Alwiyah Faiq Razaan Razaan Farid Hammadi Faridi Pani Farraz Kanya Syahra Fathunnisa, Ridha Riano Fayza Syachrani Fityah Zabrina Hidayat Ganesha Rahman Hakim Ghina Salsabila Fenty PNR Gusnirwan, Alief Hanifah Qollama Astrid Hanna Mutiara Helmi Ismunandar Hendri Busman Herlambang, Geri Indra Imtinan Khoirunnisa Indah Kurnia Putri Waruwu Indah Salsabila Indri Windarti Intanri Kurniati Isabela Irene Pangestu Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi Josephine, Felicia Key Julianti, Dinul Aliya Kalih, Abigael Ludwina Kamila Nastiti Karima, Nisa Keziah Tirtawijaya Khairun Nisa Kurnia Fithrananda Kurniawaty, Evi Laja, Rana Salsabila Putri Lintang Lestari Cahya Sawitri Mafalda Marzon Maria Devi Melni Armadani Mentari Putri Maharani Mira Yustika Mochamad Fauzan Dava Muhamad Zaidan Algifari Muhammad Ammar Naufal Muhammad Arsy Kamal Faadhil Muhammad Maulana Muhammad Ricky Ramadhian Muhammad Rizki Akbar, Muhammad Rizki Mukhbita, Khalila Alya Mukhlis Imanto, Mukhlis Nabila Alsa Sagia Nabila Shafira Nabila Yoli Rahmadani Nadhia Wihelga Nahrassyiah Rahma Putri Ni Ketut Diah Ayu Pramisswari Ni Putu Sari Widiyani Noval Ramadirta Nurul Fadhilah Az-zahro Nurul Utami Oktafany Oktafany Oktoba, Zulpakor Pardilawati, Citra Yulianda Pardilawati, Citra Yuliyanda Prasetyo, Muhammad Purwono Purnama Sari, Faraztya Putra, Rangga Pratama Wahyuono Qoriba, Fathan RA Genta Syakira Hatta Rachel Agustin Inggrid Zefanya Rachmantiawan, Aldiano Rafi Gutra Aslam rahmawati, selvi Rahmi Zuraida Raihanah Nabilah Rani Himayani Rani Himayani Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Regita Dwi M Reisyah Syahfira Rifka Putri Dewi Rika Lisiswanti Risti Graharti Rizqiani Astrid Nasution Rudiyanto, Waluyo Salsabila Haqya Kusuma Salshabilla, Annisa Santhi, Komang Ria Yuliana Satria, Rasha Andhika Selvi Marcellia Sembiring, Dustin Delano Pranata Setiorini, Anggi Shiddiq, Muhammad Nasrullah Nur Shinta Nareswari, Shinta Simanungkalit, Jesica Natalia Sinulingga, Anselmus Libreya Siti Shafira Elfreda Suharmanto Suryani Agustina Daulay Susianti Susianti Sutarto Sutarto Sutyarso Sutyarso Syahrani Alya Murfi Syalwa Meutia Syiva Ulhayah Tamaulina Br Sembiring Tiasti, Jania Tri Umiana Soleha Tsurayya Fathma Zahra Utami, Winda Trijayanthi Wardani, Nanda Fitri Yashila Rahimah Zahira TS, Shifa Tanjia Zahra, Siti Aqila Zayatri Nurul Jannaty Zheva Aprillia Yozevi