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All Journal Medula Pharmascience Wikrama Parahita : Jurnal Pengabdian Masyarakat Jurnal Ilmu Kedokteran dan Kesehatan JURNAL MUTIARA KESEHATAN MASYARAKAT JURNAL PENELITIAN PERAWAT PROFESIONAL Wellness And Healthy Magazine JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal teknologi Kesehatan Borneo Nusantara Hasana Journal Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Journal of Student Research Jurnal Kedokteran Ibnu Nafis Jurnal Kesehatan Metro Sai Wawai JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Sangging, Putu Ristyaning Ayu
Fakultas Kedokteran, Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Korelasi NT-proBNP dengan Fraksi Ejeksi pada Pasien Gagal Jantung: Tinjauan Pustaka Darma, I Wayan Dika Aditia; Sangging, Putu Ristyaning Ayu
Medula Vol 16 No 2 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i2.1769

Abstract

Heart failure is a complex clinical syndrome characterized by typical signs and symptoms resulting from structural or functional cardiac abnormalities that impair the ability of the ventricles to fill with or eject blood effectively. It remains a major global health problem with high morbidity and mortality rates. One of the most widely used biomarkers for assessing disease severity and prognosis in heart failure is N terminal pro brain natriuretic peptide or NT proBNP. Elevated NT proBNP levels occur in response to increased ventricular wall stress and volume overload and are closely related to the degree of left ventricular dysfunction, which is commonly assessed by left ventricular ejection fraction or LVEF. Numerous studies have demonstrated a significant negative correlation between NT proBNP levels and ejection fraction, particularly in patients with heart failure with reduced ejection fraction, where higher NT proBNP concentrations are observed as LVEF decreases. In contrast, in patients with heart failure with preserved ejection fraction, this relationship is not consistently linear. This variability is influenced by additional factors such as diastolic dysfunction, the presence of comorbid conditions, increased myocardial stiffness, and structural cardiac remodeling that may not be fully reflected by ejection fraction values alone. This literature review aims to analyze the relationship between NT proBNP levels and ejection fraction in patients with heart failure based on findings from national and international studies published over the past ten years. A clear understanding of this relationship is essential to define the diagnostic and prognostic value of NT proBNP and to support its use in therapeutic monitoring and risk stratification in patients with heart failure.
Evaluasi kadar CRP High Sensitivity sebagai Marker Risiko Kardiovaskular pada Dewasa Muda: Indonesia Rachmantiawan, Aldiano; Sangging, Putu Ristyaning Ayu
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1773

Abstract

Atherosclerosis and cardiovascular disease originate from chronic low grade inflammatory processes, making high sensitivity C reactive protein or hs CRP widely studied as a cardiovascular risk marker, including in young adults. This study is a narrative review of 16 articles published between 2019 and 2025 that examine hs CRP in young adults aged 18 to 45 years and its association with cardiometabolic risk factors, cardiovascular disease events, and clinical outcomes. The review findings indicate that in overweight or obese young adults, elevated hs CRP levels are associated with central obesity, atherogenic dyslipidemia, impaired fasting glucose, and higher blood pressure. In addition, irregular sleep patterns and short term variability in diastolic blood pressure are also linked to increased hs CRP levels, suggesting the presence of subclinical inflammation early in life. In older populations and in patients with established cardiovascular disease, high hs CRP levels are reported to predict cardiovascular disease incidence, carotid plaque formation, cardiometabolic multimorbidity, functional disability, and short term mortality. However, hs CRP is not associated with the progression of coronary artery calcification and demonstrates substantial intra individual variability. Overall, hs CRP has potential value as an additional marker to identify young adults at higher cardiovascular risk. Nevertheless, hs CRP is not sufficient as a single screening tool and should be interpreted alongside traditional cardiovascular risk factors and lifestyle patterns. Repeated measurements are recommended to improve risk assessment accuracy and to account for biological variability in hs CRP levels.
Hubungan Asupan Black Garlic Terhadap Gambaran Histopatologi Ginjal Tikus Putih (Rattus Norvegicus) Galur Sprague-Dawley Yang Diinduksi Minyak Jelantah Dimas, Dimas; Sangging, Putu Ristyaning Ayu
Medula Vol 16 No 2 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i2.1790

Abstract

Cooking oil consumed orally contains toxic substances that can cause cell damage in the kidneys. Black garlic contains antioxidants that can have an anti-toxic effect on the kidneys. This study is a true experimental study using a posttest only control group design to determine whether there is a relationship between black garlic intake and renal histopathology in Sprague-Dawley strain white rats (Rattus norvegicus) induced by used cooking oil. In this study, there were 25 rat samples divided into 5 groups: a control group with distilled water (K1), a control group with waste oil (K2), a 200mg/kgBW group (P1), a 400mg/kgBW group (P2), and an 800mg/kgBW group from the black garlic dose (P3). Microscopic aspects such as cellular infiltration, edema, and necrosis were assessed to evaluate the histopathology of the kidney. The data obtained were then statistically tested using One-Way ANOVA and PostHoc LSD tests. Based on the results of the One-Way ANOVA statistical test, a p-value of 0.000 was obtained, and group P3 had the lowest renal histopathological damage compared to groups P1 and P2. There was a relationship between black garlic intake and the histopathology of the kidneys of Sprague-Dawley strain white rats (Rattus norvegicus) induced by waste oil, and the group with a black garlic dose of 800 mg/kgBW had the lowest histopathological damage to the kidneys compared to the other treatment groups.
Peran Laju Endap Darah dalam Evaluasi Penyakit Inflamasi Kronik Purnama Sari, Faraztya; Sangging, Putu Ristyaning Ayu; Graharti, Risti
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1821

Abstract

Chronic inflammation is a persistent immune response resulting from continuous inflammatory stimuli, such as chronic infections, autoimmune diseases, and metabolic disorders, and plays a significant role in the pathogenesis of various chronic diseases. Continuous evaluation of inflammatory activity requires laboratory parameters that are easily accessible and capable of reflecting long-term inflammatory processes. The erythrocyte sedimentation rate (ESR) is a non-specific hematological test that remains widely used in clinical practice to assess systemic inflammation. Elevated ESR values occur as a result of changes in acute-phase proteins, particularly fibrinogen and immunoglobulins, which promote erythrocyte aggregation and accelerate the sedimentation process. This review article aims to discuss the role of ESR in the evaluation of chronic inflammatory diseases, including the mechanisms underlying ESR elevation, its advantages, limitations, and comparison with other inflammatory biomarkers. ESR has advantages in representing stable chronic inflammation, its simplicity, and relatively low cost; however, it also has limitations, including low specificity and a slow response to changes in inflammatory activity. Therefore, ESR should be interpreted comprehensively in conjunction with clinical evaluation and other inflammatory biomarkers to support optimal management of chronic inflammatory diseases.
POLYGENIC RISK SCORE SEBAGAI PREDIKTOR DIABETES MELLITUS TIPE 2: SYSTEMATIC RIVIEW Ni Ketut Diah Ayu Pramisswari; Ety Apriliana; Selvi Marcellia; Putu Ristyaning Ayu Sangging
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1881

Abstract

Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disease with a significant genetic contribution. Polygenic risk score (PRS) has been developed to integrate the cumulative effects of multiple genetic variants to improve T2DM risk prediction. This Systematic review aimed to evaluate the role of PRS in predicting T2DM incidence, disease progression, and related complications across different populations. This study was conducted in accordance with the PRISMA guidelines, with a literature search performed using the PubMed database and keywords related to PRS and T2DM. Included studies were observational in design and assessed the association between PRS and T2DM incidence or clinical outcomes. Three main studies with case-control, cross-sectional, and cohort designs were analyzed. The results demonstrated that PRS was significantly associated with increased T2DM risk, disease progression, and metabolic complications such as liver fibrosis, including in the context of organ transplantation. Integration of PRS with traditional clinical risk factors improved predictive performance. PRS has the potential to support precision-based T2DM risk stratification, although further cross-population validation is still required.
Dynamics and Literature Review of Malaria Cases in Indonesia in the Development of Diagnosis and Management in 2020-2025 Sangging, Putu Ristyaning Ayu; Zahira TS, Shifa Tanjia; Al Ayubi, M. Mahdi; Aurelia, Faizah Zahra; Satria, Rasha Andhika; Putra, Rangga Pratama Wahyuono
Jurnal Kesehatan Metro Sai Wawai Vol. 19 No. 1 (2026): Jurnal Kesehatan Metro Sai Wawai
Publisher : Poltekkes Kemenkes Tanjung Karang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jkmsw.v19i1.5448

Abstract

Malaria remains a major public health problem in Indonesia, especially in eastern provinces such as Papua and West Papua. The period 2020–2025 is critical because it combines the national malaria elimination program with disruptions to health services during the COVID-19 pandemic. Understanding trends in diagnosis and clinical management is important to strengthen national strategies. This systematic review summarizes evidence on malaria trends in Indonesia from 2020 to 2025, focusing on diagnostic developments and treatment practices. A systematic search was conducted in PubMed, Scopus, Google Scholar, ScienceDirect, SINTA, and Garuda using keywords such as “malaria,” “Indonesia,” “diagnosis,” “management,” “RDT,” “microscopy,” “PCR,” and “ACT.” Articles published between January 2020 and February 2025 were screened using PRISMA guidelines. Studies were included if they reported malaria incidence, diagnostic methods, treatment strategies, or surveillance outcomes in Indonesia. Of 1,182 records identified, five studies met the final inclusion criteria. Data were extracted and analyzed narratively. The findings show that microscopy remains the gold standard for malaria diagnosis. However, its effectiveness is limited by uneven distribution of trained personnel and laboratory capacity. Rapid Diagnostic Tests (RDTs) are increasingly used in remote areas because they are practical and easy to use, although their sensitivity decreases in cases with low parasite levels. Polymerase Chain Reaction (PCR) offers better detection of low-density and mixed infections, but its use is largely restricted to research centers and tertiary laboratories. For treatment, Artemisinin-based Combination Therapy (ACT) remains the main therapy for uncomplicated malaria, while intravenous artesunate is the first-line treatment for severe cases. Across the reviewed studies, early diagnosis, appropriate use of antimalarial drugs, and reduction of mosquito exposure were consistently linked to better outcomes. Screening of students from endemic areas who were studying in non-endemic provinces did not detect asymptomatic malaria cases. Overall, the review shows both progress and ongoing challenges. Diagnostic capacity has improved, but regional disparities remain. Strengthening laboratory skills, better integrating RDT, microscopy, and PCR approaches, and improving surveillance and referral systems are essential to reach the 2030 malaria elimination target. Future research should focus on monitoring treatment response, mapping drug resistance, and evaluating the implementation of diagnostic strategies.
HUBUNGAN NEUTROPHIL-TO-LYMPHOCYTE RATIO DENGAN DERAJAT HIPERTENSI DAN DERAJAT KARDIOMEGALI PADA PASIEN HIPERTENSI Ramadhian, Muhammad Ricky; Josephine, Felicia Key; Wardani, Nanda Fitri; Sangging, Putu Ristyaning Ayu
Jurnal Mutiara Kesehatan Masyarakat Vol 10 No 2 (2025): Jurnal Mutiara Kesehatan Masyarakat
Publisher : Program Studi Kesehatan Masyarakat Universitas Sari Mutiara Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jmkm.v10i2.6868

Abstract

Latar belakang: Hipertensi yang tidak terkontrol merupakan penyebab timbulnya berbagai komplikasi kardiovaskuler. Kardiomegali sering ditemukan pada pasien gagal jantung sebagai akibat dari hipertensi berat dan tidak terkontrol. Pada foto toraks disebut kardiomegali jika nilai cardiothoracic ratio lebih dari 50%, dan diklasifikasikan menjadi derajat ringan, sedang dan berat. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan NLR dengan derajat hipertensi dan derajat kardiomegali pada pasien hipertensi. Metode: Penelitian  ini bersifat deskriptik analitik dengan desain potong lintang. Variabel yang dianalisis adalah NLR dengan derajat hipertensi dan NLR dengan derajat kardiomegali. Hasil: Dari 31 subjek penelitian, sebagian besar berjenis kelamin perempuan sebesar 64,5%. Kelompok usia terbanyak adalah 59-64 tahun, yaitu sebesar 29%. Subjek penelitian didominasi oleh hipertensi derajat 1 dan derajat 2, masing-masing sebesar 45,2%. Nilai NLR minimum adalah 0,96 dan nilai maksimum 14,33 dengan simpangan baku 4,07. Uji korelasi Spearman menunjukkan nilai koefisien korelasi (r) sebesar 0,421 dengan signifikansi 0,021 (p<0,05) untuk hubungan NLR dengan derajat hipertensi, serta koefisien korelasi (r) sebesar 0,341 dan signifikansi 0,061 (p>0,05) untuk hubungan NLR dengan derajat kardiomegali. Kesimpulan: Terdapat hubungan yang positif dan signifikan antara NLR dengan derajat hipertensi, dan hubungan yang positif antara NLR dengan derajat kardiomegali walaupun tidak signifikan secara statistik.
Molecular Docking Studies and ADME-Tox Prediction of Phytocompounds from Lycopersicon esculentum mill. as a Drug Candidate for Alopecia Treatment Oktoba, Zulpakor; Patala, Recky; Sayoeti, Muhammad Fitra Wardhana; Sangging, Putu Ristyaning Ayu; Soleha, Tri Umiana
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24836

Abstract

Alopecia is a disorder of the hair follicles that causes hair loss, either in limited areas or throughout the entire body. This study aims to evaluate the potential and molecular interactions of compounds found in the Rampai plant (Lycopersicon esculentum Mill.). The Rampai plant is known to contain various secondary metabolites such as alkaloids, flavonoids, arbutin, amygdalin, and pectin, which have the potential to be developed as antialopecia drug candidates through an in-silico approach to androgen receptors (PDB ID: 4K7A) and ADME-Tox profile predictions. The in-silico approach was conducted using the molecular docking method to predict the interaction between the active compounds from the Rampai plant and the androgen receptor using Autodock Tools 1.5.7 and Vina software, while the ADME-Tox analysis was conducted through the pkCSM platform. The molecular docking results showed that the reference ligand (Minoxidil) had an affinity energy of −7.353 kcal/mol, while the test compound with the best affinity was isorhamnetin with a value of −8.398 kcal/mol, which was lower (more stable) than Minoxidil. In addition, the ADME-Tox prediction results for isorhamnetin show favorable pharmacokinetic characteristics, especially in terms of skin permeability, absorption and distribution. Thus, isorhamnetin has the potential as an androgen receptor antagonist and a role in the development of therapies for alopecia.
Co-Authors Adinda Husna Cahyana Agung Ikhssani Agustyas Tjiptaningrum Ahmad Duta Al-Ihya Al Ayubi, M. Mahdi Alghani, Sulthan Rafi Almaina Puteri Jasmine Almaina Amira Nabila Andi Nafisah Angelica Philia Christy Anggraeni Janar Wulan Annisarahma, Lyvia Aprilia, Intan Rahma Ardian Reza Putra Arfa Salma Firnandya Ari Irawan Ari Irawan Ari Wahyuni Aulia Nur Fitriatsani Aurelia, Faizah Zahra Aurora Awindya Nareswari Azizah Nur Rahmah Bagus Pratama Brigitta Shinta dewi Carissa Aprilia Y Cholyviona W.S Handhayani Citra Yuliyanda Pardilawati Cut Karel Dithia Daffa Fahreiza Daffa Fahreiza Darma, I Wayan Dika Aditia Devina Hardianto Devira Fitriani Kamal Devya Aulia Dian Isti Angraini Dilla Syahra Noor Fitri Dimas, Dimas Dzakwan Cedri Ketierteu Ellysa Angguman Putri Ety Apriliana Evan Christian Christian Fadila Gustiani Daraz Fadilah Alwiyah Faiq Razaan Razaan Farid Hammadi Faridi Pani Farraz Kanya Syahra Fathunnisa, Ridha Riano Fayza Syachrani Fityah Zabrina Hidayat Ganesha Rahman Hakim Ghina Salsabila Fenty PNR Gusnirwan, Alief Hanifah Qollama Astrid Hanna Mutiara Helmi Ismunandar Hendri Busman Herlambang, Geri Indra Imtinan Khoirunnisa Indah Kurnia Putri Waruwu Indah Salsabila Indri Windarti Intanri Kurniati Isabela Irene Pangestu Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi Josephine, Felicia Key Julianti, Dinul Aliya Kalih, Abigael Ludwina Kamila Nastiti Karima, Nisa Keziah Tirtawijaya Khairun Nisa Kurnia Fithrananda Kurniawaty, Evi Laja, Rana Salsabila Putri Lintang Lestari Cahya Sawitri Mafalda Marzon Maria Devi Melni Armadani Mentari Putri Maharani Mira Yustika Mochamad Fauzan Dava Muhamad Zaidan Algifari Muhammad Ammar Naufal Muhammad Arsy Kamal Faadhil Muhammad Fitra Wardhana Sayoeti Muhammad Maulana Muhammad Ricky Ramadhian Muhammad Rizki Akbar, Muhammad Rizki Mukhbita, Khalila Alya Mukhlis Imanto, Mukhlis Nabila Alsa Sagia Nabila Shafira Nabila Yoli Rahmadani Nadhia Wihelga Nahrassyiah Rahma Putri Ni Ketut Diah Ayu Pramisswari Ni Putu Sari Widiyani Noval Ramadirta Nurul Fadhilah Az-zahro Nurul Utami Oktafany Oktafany Oktoba, Zulpakor Pardilawati, Citra Yulianda Pardilawati, Citra Yuliyanda Prasetyo, Muhammad Purwono Purnama Sari, Faraztya Putra, Rangga Pratama Wahyuono Qoriba, Fathan RA Genta Syakira Hatta Rachel Agustin Inggrid Zefanya Rachmantiawan, Aldiano Rafi Gutra Aslam rahmawati, selvi Rahmi Zuraida Raihanah Nabilah Rani Himayani Rani Himayani Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Recky Patala Regita Dwi M Reisyah Syahfira Rifka Putri Dewi Rika Lisiswanti Risti Graharti Rizqiani Astrid Nasution Rudiyanto, Waluyo Salsabila Haqya Kusuma Salshabilla, Annisa Santhi, Komang Ria Yuliana Satria, Rasha Andhika Selvi Marcellia Sembiring, Dustin Delano Pranata Setiorini, Anggi Shiddiq, Muhammad Nasrullah Nur Shinta Nareswari, Shinta Simanungkalit, Jesica Natalia Sinulingga, Anselmus Libreya Siti Shafira Elfreda Suharmanto Suryani Agustina Daulay Susianti Susianti Sutarto Sutarto Sutyarso Sutyarso Syahrani Alya Murfi Syalwa Meutia Syiva Ulhayah Tamaulina Br Sembiring Tiasti, Jania Tri Umiana Soleha Tsurayya Fathma Zahra Utami, Winda Trijayanthi Wardani, Nanda Fitri Yashila Rahimah Zahira TS, Shifa Tanjia Zahra, Siti Aqila Zayatri Nurul Jannaty Zheva Aprillia Yozevi