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All Journal Medula Wikrama Parahita : Jurnal Pengabdian Masyarakat Jurnal Ilmu Kedokteran dan Kesehatan JURNAL MUTIARA KESEHATAN MASYARAKAT JURNAL PENELITIAN PERAWAT PROFESIONAL Wellness And Healthy Magazine JK Unila (Jurnal Kedokteran Universitas Lampung) Nusantara Hasana Journal Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Journal of Student Research Jurnal Kedokteran Ibnu Nafis JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Jurnal teknologi Kesehatan Borneo

Sangging, Putu Ristyaning Ayu

Fakultas Kedokteran, Universitas Lampung

Author-ID : 5620167

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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HUBUNGAN NEUTROPHIL-TO-LYMPHOCYTE RATIO DENGAN DERAJAT HIPERTENSI DAN DERAJAT KARDIOMEGALI PADA PASIEN HIPERTENSI Ramadhian, Muhammad Ricky; Josephine, Felicia Key; Wardani, Nanda Fitri; Sangging, Putu Ristyaning Ayu
Jurnal Mutiara Kesehatan Masyarakat Vol 10 No 2 (2025): Jurnal Mutiara Kesehatan Masyarakat
Publisher : Program Studi Kesehatan Masyarakat Universitas Sari Mutiara Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jmkm.v10i2.6868

Latar belakang: Hipertensi yang tidak terkontrol merupakan penyebab timbulnya berbagai komplikasi kardiovaskuler. Kardiomegali sering ditemukan pada pasien gagal jantung sebagai akibat dari hipertensi berat dan tidak terkontrol. Pada foto toraks disebut kardiomegali jika nilai cardiothoracic ratio lebih dari 50%, dan diklasifikasikan menjadi derajat ringan, sedang dan berat. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan NLR dengan derajat hipertensi dan derajat kardiomegali pada pasien hipertensi. Metode: Penelitian ini bersifat deskriptik analitik dengan desain potong lintang. Variabel yang dianalisis adalah NLR dengan derajat hipertensi dan NLR dengan derajat kardiomegali. Hasil: Dari 31 subjek penelitian, sebagian besar berjenis kelamin perempuan sebesar 64,5%. Kelompok usia terbanyak adalah 59-64 tahun, yaitu sebesar 29%. Subjek penelitian didominasi oleh hipertensi derajat 1 dan derajat 2, masing-masing sebesar 45,2%. Nilai NLR minimum adalah 0,96 dan nilai maksimum 14,33 dengan simpangan baku 4,07. Uji korelasi Spearman menunjukkan nilai koefisien korelasi (r) sebesar 0,421 dengan signifikansi 0,021 (p<0,05) untuk hubungan NLR dengan derajat hipertensi, serta koefisien korelasi (r) sebesar 0,341 dan signifikansi 0,061 (p>0,05) untuk hubungan NLR dengan derajat kardiomegali. Kesimpulan: Terdapat hubungan yang positif dan signifikan antara NLR dengan derajat hipertensi, dan hubungan yang positif antara NLR dengan derajat kardiomegali walaupun tidak signifikan secara statistik.

Case Report: Nicotine Addiction-Adolescence obsession Mira Yustika; Agung Ikhssani; Putu Ristyaning Ayu Sangging
Jurnal teknologi Kesehatan Borneo Vol 2 No 2 (2021): Jurnal Teknologi Kesehatan Borneo
Publisher : POLTEKKES KEMENKES PONTIANAK

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jtkb.v2i2.40

Nicotine dependence is a chronic relapse defined as a compulsive desire to use it, regardless of social consequences, loss of control over intake, and appearance of withdrawal symptoms. Nicotine dependence develops over time as a person continues to use nicotine. The most commonly used tobacco product is cigarettes, but any form of tobacco use and use of e-cigarettes can lead to dependence. Nicotine dependence is a serious public health problem because it causes continued tobacco use, which is one of the leading preventable causes of death worldwide, causing more than 8 million deaths per year. The result of the journal review is that preventing the use of tobacco products among adolescents is critical to ending nicotine addiction worldwide. The impact caused by nicotine tends to be bad, so stopping is the way out. Different levels of influence should be considered in interventions aimed at adolescent smokers, including psychological influences, addictions, peers and parents. This review article contains about the effect of nicotine on adolescents and what strategies can be done to stop the problem.

Analisis Faktor Prediksi Peningkatan Kontrol Glikemik Pada Pasien Diabetes Melitus Tipe 2 Di RSUD Abdul Moeloek Provinsi Lampung Periode Januari-Desember 2022 Ananda, Yovani Tria; Kurniati, Intanri; Carolia, Novita; Sangging, Putu Ristyaning Ayu
Medula Vol 16 No 3 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i3.1910

The 2018 Basic Health Research report indicated that prevalence of Diabetes Mellitus (DM) in Indonesia increased to 8,3%. This rise was accompanied by an increase in obesity prevalence, a major risk factor for DM, from 14,8% in 20113 to 21,8% in 2018. These findings suggest that the number of individuals with DM in Indonesia is substantial and continues to grow annually. Data from Bandar Lampung City in 2021 showed that out of 6,467,624 individuals aged ≥15 years, approximately 198,046 (3%) were diagnosed with DM. This study aimed to analyze the association between predictive factors and glycemic control among patients with type 2 diabetes mellitus at Abdul Moeloek Hospital, Lampung Province, during January-December 2022. This research employed an observational study with a cross-sectional design. Secondary data were obtained from medical records of both inpatient and outpatient type 2 diabetes mellitus patients. Data analysis was performed using the Chi-Square test, with the Mann-Whitney test as an alternative. The result demonstrated significant associations between age at diagnosis (p=0,006), duration of Diabetes (p=0,012), body mass index (p=0,016), and comorbidities (p=0,020) with glycemic control. In conclusion, age at diagnosis, duration of disease, body mass index, and comorbid conditions were significantly associated with glycemic control among patients with type 2 diabetes mellitus receiving oral antidiabetic drugs and insulin therapy at Abdul Moeloek Hospital, Lampung Province, during January-December 2022.

HUBUNGAN ANTARA HORMONE REPLACEMENT THERAPY DENGAN RISIKO KANKER PAYUDARA PADA WANITA PASCAMENOPAUSE: THE ASSOCIATION BETWEEN HORMONE REPLACEMENT THERAPY AND BREAST CANCER RISK IN POSTMENOPAUSAL WOMEN Devya Aulia; Windarti, Indri; Graharti, Risti; Sangging, Putu Ristyaning Ayu
Jurnal Kedokteran Ibnu Nafis Vol. 14 No. 2 (2025): Desember 2025
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/jkin.v14i2.1064

Kanker payudara adalah penyebab utama kematian akibat kanker pada wanita, dengan insidensi global meningkat akibat faktor genetik, lingkungan, hormonal, dan gaya hidup, di mana estrogen dan progesteron mendorong proliferasi sel payudara melalui reseptor estrogen yang dapat memicu transformasi malignan. Pada wanita pascamenopause, penurunan estrogen diatasi dengan Hormone Replacement Therapy (HRT), yang meredakan gejala menopause dan mencegah osteoporosis, namun meningkatkan risiko kanker payudara. Kajian literatur ini meninjau hubungan HRT dengan risiko kanker payudara berdasarkan bukti epidemiologis, mekanisme biologis, dan temuan klinis. Metode yang digunakan adalah narrative review melalui pencarian artikel di PubMed, ScienceDirect, dan Google Scholar (2019–2025) dengan kata kunci “hormone replacement therapy”, “breast cancer risk”, dan “HRT breast cancer”, mencakup RCT, kohort, atau studi prospektif. Hasil telaah menunjukkan bahwa terapi estrogen tunggal menurunkan risiko kanker payudara 22% (HR 0.78; 95% CI 0.65–0.93) pada wanita pascahisterektomi, sedangkan kombinasi estrogen–progestin meningkatkan risiko 28% (HR 1.28; 95% CI 1.13–1.45). Studi kohort mengonfirmasi peningkatan risiko pada penggunaan kombinasi lebih dari lima tahun, terutama pada wanita dengan indeks massa tubuh rendah dan densitas payudara tinggi. Temuan ini menunjukkan bahwa peningkatan risiko terutama disebabkan oleh komponen progestin, sementara estrogen sendiri memiliki efek minimal. Stratifikasi risiko individu penting dalam mempertimbangkan manfaat dan risiko jangka panjang terapi HRT.

Show Abstract | Download Original | Original Source | Check in Google Scholar

Korelasi NT-proBNP dengan Fraksi Ejeksi pada Pasien Gagal Jantung: Tinjauan Pustaka I Wayan Dika Aditia Darma; Putu Ristyaning Ayu Sangging
Medula Vol 16 No 2 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i2.1769

Heart failure is a complex clinical syndrome characterized by typical signs and symptoms resulting from structural or functional cardiac abnormalities that impair the ability of the ventricles to fill with or eject blood effectively. It remains a major global health problem with high morbidity and mortality rates. One of the most widely used biomarkers for assessing disease severity and prognosis in heart failure is N terminal pro brain natriuretic peptide or NT proBNP. Elevated NT proBNP levels occur in response to increased ventricular wall stress and volume overload and are closely related to the degree of left ventricular dysfunction, which is commonly assessed by left ventricular ejection fraction or LVEF. Numerous studies have demonstrated a significant negative correlation between NT proBNP levels and ejection fraction, particularly in patients with heart failure with reduced ejection fraction, where higher NT proBNP concentrations are observed as LVEF decreases. In contrast, in patients with heart failure with preserved ejection fraction, this relationship is not consistently linear. This variability is influenced by additional factors such as diastolic dysfunction, the presence of comorbid conditions, increased myocardial stiffness, and structural cardiac remodeling that may not be fully reflected by ejection fraction values alone. This literature review aims to analyze the relationship between NT proBNP levels and ejection fraction in patients with heart failure based on findings from national and international studies published over the past ten years. A clear understanding of this relationship is essential to define the diagnostic and prognostic value of NT proBNP and to support its use in therapeutic monitoring and risk stratification in patients with heart failure.

Hubungan Asupan Black Garlic Terhadap Gambaran Histopatologi Ginjal Tikus Putih (Rattus Norvegicus) Galur Sprague-Dawley Yang Diinduksi Minyak Jelantah Dimas Dimas; Putu Ristyaning Ayu Sangging
Medula Vol 16 No 2 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i2.1790

Cooking oil consumed orally contains toxic substances that can cause cell damage in the kidneys. Black garlic contains antioxidants that can have an anti-toxic effect on the kidneys. This study is a true experimental study using a posttest only control group design to determine whether there is a relationship between black garlic intake and renal histopathology in Sprague-Dawley strain white rats (Rattus norvegicus) induced by used cooking oil. In this study, there were 25 rat samples divided into 5 groups: a control group with distilled water (K1), a control group with waste oil (K2), a 200mg/kgBW group (P1), a 400mg/kgBW group (P2), and an 800mg/kgBW group from the black garlic dose (P3). Microscopic aspects such as cellular infiltration, edema, and necrosis were assessed to evaluate the histopathology of the kidney. The data obtained were then statistically tested using One-Way ANOVA and PostHoc LSD tests. Based on the results of the One-Way ANOVA statistical test, a p-value of 0.000 was obtained, and group P3 had the lowest renal histopathological damage compared to groups P1 and P2. There was a relationship between black garlic intake and the histopathology of the kidneys of Sprague-Dawley strain white rats (Rattus norvegicus) induced by waste oil, and the group with a black garlic dose of 800 mg/kgBW had the lowest histopathological damage to the kidneys compared to the other treatment groups.

Co-Authors Adinda Husna Cahyana Agung Ikhssani Agustyas Tjiptaningrum Ahmad Duta Al-Ihya Alghani, Sulthan Rafi Almaina Puteri Jasmine Almaina Amira Nabila Ananda, Yovani Tria Andi Nafisah Angelica Philia Christy Anggraeni Janar Wulan Annisarahma, Lyvia Ardian Reza Putra Arfa Salma Firnandya Ari Irawan Ari Irawan Ari Wahyuni Aulia Nur Fitriatsani Aurora Awindya Nareswari Azizah Nur Rahmah Bagus Pratama Brigitta Shinta dewi Carissa Aprilia Y Cholyviona W.S Handhayani Citra Yuliyanda Pardilawati Cut Karel Dithia Daffa Fahreiza Daffa Fahreiza Devina Hardianto Devira Fitriani Kamal Devya Aulia Dian Isti Angraini Dilla Syahra Noor Fitri Dimas Dimas Dzakwan Cedri Ketierteu Ellysa Angguman Putri Ety Apriliana Evan Christian Christian Fadila Gustiani Daraz Fadilah Alwiyah Faiq Razaan Razaan Farid Hammadi Faridi Pani Farraz Kanya Syahra Fathunnisa, Ridha Riano Fayza Syachrani Fityah Zabrina Hidayat Ganesha Rahman Hakim Ghina Salsabila Fenty PNR Gusnirwan, Alief Hanifah Qollama Astrid Hanna Mutiara Helmi Ismunandar Hendri Busman Herlambang, Geri Indra I Wayan Dika Aditia Darma Imtinan Khoirunnisa Indah Kurnia Putri Waruwu Indah Salsabila Indri Windarti Intanri Kurniati Isabela Irene Pangestu Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi Josephine, Felicia Key Julianti, Dinul Aliya Kalih, Abigael Ludwina Kamila Nastiti Karima, Nisa Keziah Tirtawijaya Khairun Nisa Kurnia Fithrananda Kurniawaty, Evi Laja, Rana Salsabila Putri Lintang Lestari Cahya Sawitri Mafalda Marzon Maria Devi Melni Armadani Mentari Putri Maharani Mira Yustika Mochamad Fauzan Dava Muhamad Zaidan Algifari Muhammad Ammar Naufal Muhammad Arsy Kamal Faadhil Muhammad Maulana Muhammad Ricky Ramadhian Muhammad Rizki Akbar, Muhammad Rizki Mukhlis Imanto, Mukhlis Nabila Alsa Sagia Nabila Shafira Nabila Yoli Rahmadani Nadhia Wihelga Nahrassyiah Rahma Putri Ni Ketut Diah Ayu Pramisswari Ni Putu Sari Widiyani Noval Ramadirta Novita Carolia Nurul Fadhilah Az-zahro Nurul Utami Oktafany Oktafany Oktoba, Zulpakor Pardilawati, Citra Yulianda Pardilawati, Citra Yuliyanda Purnama Sari, Faraztya Qoriba, Fathan RA Genta Syakira Hatta Rachel Agustin Inggrid Zefanya Rachmantiawan, Aldiano Rafi Gutra Aslam rahmawati, selvi Rahmi Zuraida Raihanah Nabilah Rani Himayani Rani Himayani Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Regita Dwi M Reisyah Syahfira Rifka Putri Dewi Rika Lisiswanti Risti Graharti Rizqiani Astrid Nasution Rudiyanto, Waluyo Salsabila Haqya Kusuma Salshabilla, Annisa Santhi, Komang Ria Yuliana Selvi Marcellia Sembiring, Dustin Delano Pranata Setiorini, Anggi Shinta Nareswari, Shinta Simanungkalit, Jesica Natalia Sinulingga, Anselmus Libreya Siti Shafira Elfreda Suharmanto Suryani Agustina Daulay Susianti Susianti Sutarto Sutarto Sutyarso Sutyarso Syahrani Alya Murfi Syalwa Meutia Syiva Ulhayah Tamaulina Br Sembiring Tiasti, Jania Tri Umiana Soleha Tsurayya Fathma Zahra Utami, Winda Trijayanthi Wardani, Nanda Fitri Yashila Rahimah Zayatri Nurul Jannaty Zheva Aprillia Yozevi

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