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All Journal Althea Medical Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Damianus Journal of Medicine Journal of Agromedicine and Medical Sciences Majalah Kedokteran Sriwijaya Molecular and Cellular Biomedical Sciences (MCBS) Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science Jurnal Penelitian dan Pengembangan Pelayanan Kesehatan Jurnal Dunia Kesmas Journal Health & Science : Gorontalo Journal Health and Science Community SRIWIJAYA JOURNAL OF MEDICINE Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia J-Kesmas: Jurnal Kesehatan Masyarakat (Indonesian Journal of Public Health) World Nutrition Journal Best Journal (Biology Education, Sains and Technology) Sriwijaya Journal of Surgery Indonesian Journal of Global Health research International Journal Of Science, Technology & Management (IJSTM) Jurnal Cahaya Mandalika International Journal of Community Service Bioscientia Medicina : Journal of Biomedicine and Translational Research Media Publikasi Promosi Kesehatan Indonesia (MPPKI) TRILOGI: Jurnal Ilmu Teknologi, Kesehatan, dan Humaniora TROPHICO: Tropical Public Health Journal Indonesian Journal of Cancer Jurnal Sehat Indonesia (JUSINDO) Khidmah: Jurnal Pengabdian Kepada Masyarakat Eduvest - Journal of Universal Studies Jurnal Ilmu Kesehatan Masyarakat Jurnal Pengabdian Ilmu Kesehatan
Iche Andriyani Liberty, Iche Andriyani
Department Of Public Health And Community Medicine, Universitas Sriwijaya, Palembang
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Peran Polimorfisme Promotor Gen Interleukin-10 pada Penyakit Kusta: Tinjauan Sistematik Oktariana, Desi; Saleh, Irsan; Hafy, Zen; Liberty, Iche Andriyani
Majalah Kedokteran Indonesia Vol 73 No 1 (2023): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.73.1-2023-816

Abstract

Introduction: Leprosy remains a significant problem in Indonesia as the number of cases has not been eliminated until now. One of the cytokines that plays a role in the disease is interleukin-10 (IL-10), which has a dominant anti-inflammatory effect and influences the immunopathogenesis of leprosy. Genetic factors, including the IL-10 gene promoter polymorphism, affect the amount of IL-10 produced, thereby increasing the risk of leprosy. Therefore, the objective of this study is to gather information on the role of IL-10 gene promoter polymorphism in the development of leprosy.Method: A systematic review method was used to identify, evaluate, and extensively discuss published works through national and international journals such as Google Scholar, Science Direct, Elsevier, EBSCO, Medline, PubMed, Proquest, and Wiley. The study was conducted by searching relevant keywords related to the research topic in these databases. Subsequently, article selection was performed based on predetermined inclusion and exclusion criteria. The selected articles were then evaluated for quality to ensure accuracy and reliability of the presented information. Finally, the results of this systematic review were used to obtain accurate and up-todate information regarding the role of IL-10 gene promoter polymorphism in leprosy.Results: This systematic review analyzed a total of 14 articles and revealed that results varied among study populations. However, there is consistent evidence to suggest that the IL-10 gene promoter polymorphism is associated with leprosy, which was found in the majority of the study populations.Conclusion: IL-10 gene promoter polymorphism tends to be associated with leprosy.
Correlation between Vitamin D and Hemoglobin Levels in Anemia during Pregnancy Sari, Sagita Darma; Partan, Radiyati Umi; Lestari, Peby Maulina; Liberty, Iche Andriyani
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 6 (2025): June 2025
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v8i6.7310

Abstract

Introduction: Anemia in pregnancy is a serious health problem for pregnant women that can increase the risk of postpartum hemorrhage, low birth weight, and fetal growth retardation. Low intake of foods that are sources of vitamin D causes low concentrations of vitamin D (25 Hydroxyvitamin D), which can increase hepcidin expression, thereby disrupting iron hemostasis which ultimately causes anemia in pregnant women. This study aims to determine the correlation between vitamin D levels and hemoglobin in anemia in pregnancy. Methods: This study used a case-control design with 68 pregnant women as respondents. Vitamin D levels were examined using 25 (OH) D levels and the ELFA method. Data on age, body mass index (BMI), frequency of pregnancy, education, and frequency of antenatal care visits were analyzed using the chi-square test and logistic regression analysis. Results: The results of the study show that the most significant proportion occurred in the age range of 20 – 35 years (84.5%), the majority of respondents had a normal body mass index (60.3%), respondents with a pregnancy frequency of 1-3 were 86.8%, most respondents had secondary education (63.2%), respondents who had regular prenatal visits amounted to 86.8%, the majority of respondent had a vitamin d insufficiency levels (48.5%). Bivariate analysis show revealed that significant influencing factors of anemia pregnancy were age (p=0.008), BMI (p=0.040), and frequency of ANC (p=0.012). There is no correlation between hemoglobin levels and vitamin D (p=0.707). Conclusion: This study did not correlate vitamin D levels and hemoglobin levels.
A Systematic Literature Review: PvK12 and PfK13 Gene Mutations as Markers of Resistance to Artemisin Susiwati, Susiwati; Anwar, Chairil; Hafy, Zen; Liberty, Iche Andriyani
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6599

Abstract

P. falciparum and P. vivax are among the most dangerous types of plasmodium , as they cause morbidity and mortality. Long-term use of Anti-Malaria Drugs (OAM) causes resistance. The purpose of this study was to determine the mutation of the pvk12 and pfk13 genes as a marker of resistance to artemisinin . This study used a systematic review method that was compiled based on the Preferred Reporting Items for Systematic Reviews and Meta Analyzes (PRISMA). The article search used five databases, namely PubMed, Google Scholar, BMC, Portal Garuda and the National Library (Perpusnas) of Indonesia. The keywords and boolean operators used in the literature search were "artemisinin", "resistance", "mutation", "gen", "plasmodium falciparum", "kelch 12", "kelch 13", "PvK12" PfK13" The inclusion criteria for this study were articles published at least in 2018 (the last 5 years). The exclusion criteria were paid articles, textbooks , articles systematic literature review , articles that use languages other than English and Indonesian. The results of a systematic review use 688 articles and finished of 10 articles showed that 8 articles found that there were no mutations in the pvk12 and pfk13 genes as markers of resistance to artemisinin and 2 articles found that there were mutations in the pvk12 and pfk13 genes as markers of resistance to artemisinin.
The Role of Toll-Like Receptor-2 in the Pathogenesis of Pulmonary Tuberculosis Sudarto, Sudarto; Hafy, Zen; Saleh, Irsan; Liberty, Iche Andriyani; Ahmad, Zen; Lubis, Fadhyl Zuhry; Hu, Owen; Salutondok, Welly
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6797

Abstract

Pulmonary tuberculosis (PTB), primarily caused by Mycobacterium tuberculosis (M.tb), remains a major global health burden. Toll-like receptor 2 (TLR-2), a critical component of the innate immune system, plays a key role in the host-pathogen interaction by recognizing specific components of the mycobacterial cell wall and initiating downstream inflammatory pathways. However, the dual role of TLR-2 in both protective immunity and immune evasion by M.tb contributes to the complexity of TB pathogenesis. This study aims to investigate the role of Toll-Like Receptor-2 (TLR-2) in the pathogenesis of pulmonary tuberculosis, including its immunological mechanisms, relationships with disease severity, and the potential of TLR-2 as a diagnostic and therapeutic target. This literature review systematically analyzed molecular mechanisms involving TLR-2 signaling in pulmonary TB using peer-reviewed primary and secondary sources from experimental and clinical studies. Emphasis was placed on signal transduction (NF-κB and MAPK), cytokine profiles, antigen presentation, and the impact of TLR-2 gene polymorphisms on TB susceptibility. Activation of TLR-2 through ligands such as lipoproteins, lipoarabinomannan (LAM), and PE/PPE proteins initiates immune responses via MyD88-dependent pathways, leading to the release of proinflammatory cytokines (TNF-α, IL-6, IL-12). TLR-2 also enhances the function of macrophages and dendritic cells, promoting Th1-mediated immunity. However, chronic or excessive stimulation of TLR-2 can suppress antigen processing, promote IL-10 expression, inhibit phagolysosome fusion, and facilitate M. tb survival within host macrophages. Polymorphisms in the TLR-2 gene (e.g., rs3804099) have been associated with increased susceptibility and variable clinical outcomes in PTB. TLR-2 plays a paradoxical role in pulmonary tuberculosis by mediating both protective immunity and facilitating immune evasion by M.tb. Understanding the balance of TLR-2 signaling and genetic variation is crucial for developing immunomodulatory therapies and personalized interventions in TB management.
Analisis Faktor-Faktor yang Berhubungan dengan Kejadian Computer Vision Syndrome Sebagai Dasar Upaya Pengembangan Kebijakan di PT X Ananda, Nadiya; Liberty, Iche Andriyani; Utari, Sri; Nurdin, Nugi
TRILOGI: Jurnal Ilmu Teknologi, Kesehatan, dan Humaniora Vol 6, No 2 (2025)
Publisher : Universitas Nurul Jadid

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33650/trilogi.v6i2.11984

Abstract

Computer Vision Syndrome (CVS) is a collection of symptoms arising from excessive computer use, including eye strain, watery eyes, itching, redness, dryness, blurred vision, and neck pain or headaches. According to WHO data, approximately 40–90% of workers who use computers experience CVS, as also reported by employees at PT. X. This study aims to analyze the relationship between factors such as age, length of service, gender, use of glasses, refractive disorders, eye rest time, working duration, lighting level, use of air conditioners, and Visual Display Terminal (VDT) settings with the incidence of CVS among PT. X employees. This mixed methods study involved 120 employees who work in front of computers daily. Data were collected using questionnaires, interviews, and observation, then analyzed both quantitatively and qualitatively. The results showed that 78.3% of respondents experienced CVS. Significant relationships were found between age, gender, years of service, use of glasses, refractive errors, eye rest time, lighting, and VDT arrangement with the occurrence of CVS. The main protective factor was the use of glasses, while dominant risk factors included suboptimal lighting and being male. These findings highlight the importance of promotive and preventive policies, such as eye health education, implementation of ergonomic SOPs, and regular health checks to reduce CVS prevalence and improve work productivity at PT. X.
Association of Vitamin D Deficiency and Diabetic Foot Ulcer Patients in Dr Mohammad Hoesin General Hospital Palembang Dahlan, Kemas; Yususf, Fahmi Jaka; Irfannuddin, Irfannuddin; Murti, Krisna; Muradi, Akhmadu; Liberty, Iche Andriyani
Jurnal Sehat Indonesia (JUSINDO) Vol. 7 No. 1 (2025): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v7i01.149

Abstract

Vitamin D plays a role in the healing process of diabetic foot ulcers (DFU); it can improve the immune system, regulate inflammation function, and regulate growth factors in diabetes mellitus (DM). The immunomodulatory effects of vitamin D include reduced production of IL-2, IL-6, and TNF-alpha and increased production of IL-10. It also increases the activity of antimicrobial peptides (AMP) such as cathelicidin, and it promotes the differentiation of monocytes into macrophages, phagocytosis, and the production of lysosomal enzymes. Furthermore, vitamin D stimulates growth factors including vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF-β). In this study, the incidence of DM and DFU in DM patients at RSUP Dr. Mohammad Hoesin Palembang will be compared to serum vitamin D levels. This research uses quantitative methods with an analytical observational design. The Mean vitamin D serum level was 11,727 ng/mL, and there was a significant association between serum vitamin D deficiency and DFU (p-value; 0.036 < 0.05). There was a significant association between serum vitamin D deficiency and DFU occurrence (p-value; 0.036 < 0.05) in Mohammad Hoesin General Hospital Palembang. Based on the results of this study, we proposed that patients with diabetic foot ulcers should have their serum vitamin D levels checked, and that vitamin D should be given to them as part of their therapy.
Association between household income and gestational weight gain among pregnant women in Palembang Faustina, Corinna; Melizah, Ardesy; Liberty, Iche Andriyani
World Nutrition Journal Vol. 9 No. S1 (2025): Vol. 9 No. S1 (2025): Selected conference proceedings of the Nutri Symposium 2
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V09.S1.0014

Abstract

Palembang is the city with the highest incidence of anemia in 2023, a condition that linked to maternal malnutrition. Gestational weight gain (GWG) is one of the indicator of maternal nutritional status. One of the factor that may influence the nutritional status is household income because it determines how a person afford their own nutrition. This study used a cross-sectional design and was conducted from August to October 2024. Data collection involved body weight measurement using the TANITA BC-601 and structured questionnaires. GWG was calculated as the difference between current body weight and pre-pregnancy weight, then the adequacy of GWG was assessed by comparing current weight with the ideal weight for gestational age. Eligible participants included singleton pregnant women without chronic illnesses who had completed the triple elimination program and received antenatal care at public health centers or private midwifery practices. Data analysis was performed with Chi Square analysis by using SPSS 27th version.
Systematic Literature Review: Pengaruh puasa terhadap nafsu makan pada obesitas dan bukan obesitas Tanzila, Raden Ayu; irfannuddin, irfannuddin; Kesuma, Yudianita; Liberty, Iche Andriyani
Majalah Kedokteran Andalas Vol. 47 No. 2 (2024): MKA April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i2.p203-216.2024

Abstract

Background: Fasting is the voluntary act of abstaining from food, drink, or both, as well as from anything that breaks the fast for a certain time. In medicine, fasting has an important role in various diseases and health. Several studies have assessed the benefits of fasting in various physiological and pathological conditions, one of which is an appetite in obese and non-obese people. Objective: Writing an article in the form of a systematic literature review aims to analyze the effect of various fasting methods on appetite. Method: Systematic literature review method by taking 19 international journals, according to the specified keyword criteria. Results: From the results of the systematic review analysis, it was found that fasting affects subjective appetite by changing appetite scores and objective appetite by changing appetite regulation parameters such as leptin, ghrelin, PYY, adiponectin, and neuropeptide Y (NPY). Conclusion: It was concluded that fasting had positive benefits on appetite in both obese and healthy individuals. This systematic literature review is expected to be a reference for future researchers and further research can be carried out using a more varied literature search database.
Consumption of Sugar-Sweetened Beverages Is Related to Fasting Blood Glucose and the Nutritional Status among Young Adults in Indonesia Syahranni, Dhanya; Kurniati, Ardesy Melizah; Liberty, Iche Andriyani; Husin, Syarif; Zulissetiana, Eka Febri
Althea Medical Journal Vol 12, No 3 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n3.4139

Abstract

Background: Habitual consumption of sugar-sweetened beverages (SSBs) is linked to elevated blood glucose and increased body weight. Medical students often experience high stress, which may increase SSBs consumption. This study aimed to examine the associations between SSB consumption, fasting blood glucose, body mass index (BMI), and waist circumference among medical students.Methods: A cross-sectional study was conducted in October 2022 using a total sampling method involving 184 first-year students at the Faculty of Medicine Universitas Sriwijaya, Palembang, Indonesia. SSBs consumption was assessed using a semi-quantitative food frequency questionnaire (SQ-FFQ). Fasting blood glucose was measured by  glucometer after an overnight fast. Body height, weight, and waist circumference were measured using a stadiometer, digital scale, and tape measure, respectively. Physical activity was assessed with the International Physical Activity Questionnaire–Short Form (IPAQ-SF). Associations were tested using Kruskall Wallis, independent t-test, and chi square as appropriate.Results: Most students consumed SSBs 3–4 times per week and in amount >495 mL. The volume of SSBs consumption was associated with BMI (p=0.02), fasting blood glucose (p<0.001), and waist circumference (p<0.01). Similarly, the frequency of SSBs consumption was associated with fasting blood glucose (p=0.04) and waist circumference (p<0.01), but not with BMI (p=0.16). Conclusion: Consumption of SSBs among students is high. Frequent and high-volume consumption of SSBs is associated with elevated fasting blood glucose levels and the nutritional status, whereas higher volume is associated with increased BMI. Reducing SSB intake and promoting healthier beverage choices may support a sustainable healthy lifestyle in young adults. 
Correlation of Vitamin D Intake with Hemoglobin Levels in Pregnant Women Sari, Sagita Darma; Partan, Radiyati Umi; Lestari, Peby Maulina; Liberty, Iche Andriyani
Indonesian Journal of Global Health Research Vol 6 No S5 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS5.4162

Abstract

Pregnancy anemia called " potential danger to mother and child " ( potential endanger mother and child ), increasing risk antepartum hemorrhage , postpartum hemorrhage and surgery caesarean emergency . In babies risky malformation Congenital and Low Birth Weight Infants . The incidence of pregnancy anemia in Indonesia is experiencing increase every year . By clinical anemia closely connection with vitamin D deficiency . Vitamin D plays a role in arrange distribution substance iron inside body . Objective: to analyze the correlation of vitamin D intake with hemoglobin levels in pregnant women. Method : Cross Sectional research design. The sample was pregnant women in the Gandus Palembang Health Center working area who were taken by consecutive sampling, totaling 91 people. Data analyzed using a simple liner regression test. Results: The average hemoglobin level in pregnant women was 11.49 gr / dl and the average vitamin D intake was 12.05 µg. Pregnant women who had sufficient vitamin D intake ≥ 15 µg were 9 people (10%). Pregnant women with hemoglobin levels ≥ 11 gr / dl as many as 58 people (63.7%). The results of the simple linear regression test obtained p value = 0.028 and R square value 0.053. Conclusion: there is a correlation between vitamin D intake and hemoglobin levels in pregnant women with the effect of vitamin D intake on hemoglobin levels of 5.3%.
Co-Authors ., Mariana Abdusallam Abdussalam Abdussalam Achmad Ridwan Adrina Esther Liaw Afrida Yolanda Putri Ahmad, Zen Aldi Alfian Alisha Milenia Utami Ananda, Nadiya Andrina, Hana Anwar, Chairil Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardesy Melizah Kurniati Argentina, Fiva aryani, Inda astri Bahrun Indawan kasim Chairil Anwar Chairil Anwar Dahlan, Kemas Dalilah Dalilah Dewi Rosariah Ayu Dwi Handayani Dwi Lisa Nuraini Eddy Roflin Eddy Roflin Eka Febri Zulissetiana Ellysa Carolinna Elvi Sunarsih Emma Novita Emma, Emma Novita Fachmi Idris Faustina, Corinna Fifa Argentina Fitriani, Hidiyati Gita Dwi Prasasty Hamzah Hasyim Hanna Marsinta Uli Hari Kusnanto Josef Hertanti Indah Lestari, Hertanti Indah Hu, Owen Indri Seta Septadina Irfannuddin Irfannuddin Irma Yunita Puspayani Irsan Irsan Jasmine Rana Sahirah Jihan Natra Shafira Jihan Natra Shafira Kamaluddin, Muhammad Totong Kesty, Cindy Kevin.S Kirana, Junneka Sarah Krisna Murti Krisna Murti Litania Leona Hidayat Lubis, Fadhyl Zuhry Lukman Waris M. Ammar Luthfi Kurniawan M. Farhan Fadhillah Machlery.AP Mariana Mariana Mariana Mariatul Fadilah Marta Hendry, Marta Maruf Agung Muhammad Amin Muhammad Aziz Muhammad Aziz Muhammad Aziz Muhammad Aziz Muhammad Farhan Muhammad Irsan Saleh Muhammad Zainal Fikri Mulawan Umar Muradi, Akhmadu Nani Sari Murni Neubrina Raesuky Sukamto Novita, Emma Novrikasari Novrikasari, Novrikasari Nugraha Juliyanda Nur Alam Fajar Nur Alam Fajar Nurdin, Nugi Nurliyantika, Rizka Oktariana, Desi Pariyana Pariyana Pariyana Pariyana Pariyana Pariyana pariyana, Pariyana Peby Maulina Lestari, Peby Maulina Phey Liana Plorinda, Vanesha Pratama, Benny Putra Primadika Rubiansyah Pulungan, Rafiah Maharani Puspa Zuleika, Puspa Putri Mirani Qodir, Nur Radiyati Umi Partan, Radiyati Umi Rasyid, Riana Sari Puspita Ratu Ayu Dewi Sartika Ririn Puspita Risti, Sanely Rizal Zainal Rose Malfiana Salutondok, Welly Saputra, Ricky Sari, Sagita Darma Septiandani, Randy Rakhmat Stevanny, Bella Subandrate Sudarto Sudarto Susiwati, Susiwati Syafira Nofwanda Syahranni, Dhanya Syakurah, Rizma Adila Syarif Husin Syarif Husin Syarif Husin Syarif Husin Syauki Ikhsan, Diyaz Syifa Inanta Mulia Nasution Tanzila, Raden Ayu Tjekyan, Suryadi Tri Hari Irfani, Tri Hari Tungki Pratama Umar Utama, Meria Utami, Anissa Citra Utari, Sri Yuanita Windusari Yuanita Windusari Yudhie Tanta Yudianita Kesuma, Yudianita Yulia Farida Yahya Yusnilasari Yusnilasari Yususf, Fahmi Jaka Zen Hafy Zulkarnain, Mohamad