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All Journal Althea Medical Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Urology Damianus Journal of Medicine Journal of Agromedicine and Medical Sciences Majalah Kedokteran Sriwijaya Molecular and Cellular Biomedical Sciences (MCBS) Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science Jurnal Penelitian dan Pengembangan Pelayanan Kesehatan Jurnal Dunia Kesmas Journal Health & Science : Gorontalo Journal Health and Science Community SRIWIJAYA JOURNAL OF MEDICINE Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) J-Kesmas: Jurnal Kesehatan Masyarakat (Indonesian Journal of Public Health) World Nutrition Journal Best Journal (Biology Education, Sains and Technology) Sriwijaya Journal of Surgery Indonesian Journal of Global Health research International Journal Of Science, Technology & Management (IJSTM) Jurnal Cahaya Mandalika International Journal of Community Service Bioscientia Medicina : Journal of Biomedicine and Translational Research TRILOGI: Jurnal Ilmu Teknologi, Kesehatan, dan Humaniora TROPHICO: Tropical Public Health Journal Indonesian Journal of Cancer Jurnal Sehat Indonesia (JUSINDO) Khidmah: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmu Kesehatan Masyarakat Jurnal Pengabdian Ilmu Kesehatan Indonesian Journal of Global Health Research Public Health Policy and Administration Journal
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DARTOS FASCIA AS AN INTERPOSITIONAL LAYER IN HYPOSPADIAS URETHROPLASTY: A SYSTEMATIC REVIEW Marta Hendry; Krisna Murti; Besut Daryanto; Iche Andriyani Liberty
Indonesian Journal of Urology Vol 33 No 2 (2026)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v33i2.1142

Abstract

Introduction: Hypospadias is a common congenital anomaly of the male genitalia (1 in 300 births), characterized by a ventrally displaced meatus, often with chordee and a dorsal hooded prepuce. Objective: This systematic review evaluated the role of dartos fascia as an interpositional layer in primary hypospadias repair. Material & methods: Search was conducted in PubMed, EMBASE, Scopus, CENTRAL, and Web of Science (2019–2025) for studies in patients ≤18 years undergoing hypospadias repair. Primary outcomes were urethrocutaneous fistula (UCF), dehiscence, meatal/urethral stenosis, and reoperation; secondary outcomes were infection and cosmetic scores. Narrative synthesis was used. Results: Eleven studies met criteria, predominantly distal TIP. No randomized trial compared any second layer versus none; one cohort (n=425) showed similar UCF with periurethral/dartos coverage versus none (6.7% vs 7.3%). A randomized trial favored double- over single-layer dartos (3.3% vs 23.3%). Another trial found ventral preferable to dorsal dartos with fewer flap-related complications at similar UCF rates. Tunica vaginalis flap reduced UCF and improved cosmetics but is more invasive. Platelet-rich fibrin adjunct lowered UCF and infection in two studies. Spongioplasty produced comparable UCF but higher meatal stenosis, though selected robust spongiosum allowed zero fistulas. Conclusion: Dartos remains the workhorse; double-layer and ventral harvest optimize outcomes, while tunica vaginalis and PRF offer effective alternatives in selected cases. Further randomized trials are needed to clarify the necessity of a second layer. Keywords: Hypospadias, urethroplasty, dartos fascia, urethrocutaneous fistula, tunica vaginalis flap.
The Role of Proinflammatory Cytokine GM-CSF as A Therapy for Diabetic Ulcers: A Systematic Review Pariyana Pariyana; Krisna Murti; Iche Andriyani Liberty; Muhammad Totong Kamaluddin
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.5677

Abstract

Diabetic ulcers represent a prevalent complication among patients with poorly controlled diabetes mellitus, often resulting from inadequate blood glucose regulation, neuropathy, peripheral artery disease, and suboptimal wound care. This systematic review aims to evaluate the therapeutic efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF) for diabetic ulcers. The review utilized databases such as PubMed, ProQuest, and Google Scholar, with only six articles meeting the eligibility criteria for analysis. The findings suggest that GM-CSF exhibits therapeutic potential by enhancing neovascularization, promoting keratinocyte proliferation, facilitating granulation tissue formation, and reducing wound diameter. These results highlight the potential of GM-CSF as a therapeutic agent for diabetic ulcers. Nevertheless, the current body of research is limited, necessitating further studies with larger populations and diverse GM-CSF administration methods to substantiate these findings.
A Systematic Literature Review: PvK12 and PfK13 Gene Mutations as Markers of Resistance to Artemisin Susiwati Susiwati; Chairil Anwar; Zen Hafy; Iche Andriyani Liberty
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6599

Abstract

P. falciparum and P. vivax are among the most dangerous types of plasmodium , as they cause morbidity and mortality. Long-term use of Anti-Malaria Drugs (OAM) causes resistance. The purpose of this study was to determine the mutation of the pvk12 and pfk13 genes as a marker of resistance to artemisinin . This study used a systematic review method that was compiled based on the Preferred Reporting Items for Systematic Reviews and Meta Analyzes (PRISMA). The article search used five databases, namely PubMed, Google Scholar, BMC, Portal Garuda and the National Library (Perpusnas) of Indonesia. The keywords and boolean operators used in the literature search were "artemisinin", "resistance", "mutation", "gen", "plasmodium falciparum", "kelch 12", "kelch 13", "PvK12" PfK13" The inclusion criteria for this study were articles published at least in 2018 (the last 5 years). The exclusion criteria were paid articles, textbooks , articles systematic literature review , articles that use languages other than English and Indonesian. The results of a systematic review use 688 articles and finished of 10 articles showed that 8 articles found that there were no mutations in the pvk12 and pfk13 genes as markers of resistance to artemisinin and 2 articles found that there were mutations in the pvk12 and pfk13 genes as markers of resistance to artemisinin.
The Role of Toll-Like Receptor-2 in the Pathogenesis of Pulmonary Tuberculosis Sudarto Sudarto; Zen Hafy; Irsan Saleh; Iche Andriyani Liberty; Zen Ahmad; Fadhyl Zuhry Lubis; Owen Hu; Welly Salutondok
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6797

Abstract

Pulmonary tuberculosis (PTB), primarily caused by Mycobacterium tuberculosis (M.tb), remains a major global health burden. Toll-like receptor 2 (TLR-2), a critical component of the innate immune system, plays a key role in the host-pathogen interaction by recognizing specific components of the mycobacterial cell wall and initiating downstream inflammatory pathways. However, the dual role of TLR-2 in both protective immunity and immune evasion by M.tb contributes to the complexity of TB pathogenesis. This study aims to investigate the role of Toll-Like Receptor-2 (TLR-2) in the pathogenesis of pulmonary tuberculosis, including its immunological mechanisms, relationships with disease severity, and the potential of TLR-2 as a diagnostic and therapeutic target. This literature review systematically analyzed molecular mechanisms involving TLR-2 signaling in pulmonary TB using peer-reviewed primary and secondary sources from experimental and clinical studies. Emphasis was placed on signal transduction (NF-κB and MAPK), cytokine profiles, antigen presentation, and the impact of TLR-2 gene polymorphisms on TB susceptibility. Activation of TLR-2 through ligands such as lipoproteins, lipoarabinomannan (LAM), and PE/PPE proteins initiates immune responses via MyD88-dependent pathways, leading to the release of proinflammatory cytokines (TNF-α, IL-6, IL-12). TLR-2 also enhances the function of macrophages and dendritic cells, promoting Th1-mediated immunity. However, chronic or excessive stimulation of TLR-2 can suppress antigen processing, promote IL-10 expression, inhibit phagolysosome fusion, and facilitate M. tb survival within host macrophages. Polymorphisms in the TLR-2 gene (e.g., rs3804099) have been associated with increased susceptibility and variable clinical outcomes in PTB. TLR-2 plays a paradoxical role in pulmonary tuberculosis by mediating both protective immunity and facilitating immune evasion by M.tb. Understanding the balance of TLR-2 signaling and genetic variation is crucial for developing immunomodulatory therapies and personalized interventions in TB management.
Analysis of Determinants of Type 2 Diabetes Mellitus: A Literature Review Adzkiya Safitri; Yuanita Windusari; Iche Andriyani Liberty
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.857

Abstract

Type 2 Diabetes Mellitus (T2DM) is a global health issue, with 537 million cases reported in 2021 and projected to increase to 783 million by 2045. Indonesia ranks fifth globally, with T2DM prevalence rising to 8.5% in 2018. The high number of cases and the risk of severe complications, such as heart disease, stroke, and kidney failure, underline the need for an in-depth study of risk factors to mitigate the disease's impact. Objective to further examine the determinants of Type 2 Diabetes Mellitus. This study employed a literature review approach using search engines such as Google Scholar, PubMed, ScienceDirect, and BMC with the keywords "Risk Factor" AND "T2DM." The reviewed articles are reputable and accredited, published within the last five years. From a total of 20 reviewed articles, the findings indicate that Type 2 Diabetes Mellitus is significantly associated with factors such as age, gender, hypertension, physical activity, family history of diabetes, obesity, smoking, cholesterol levels, fruit and vegetable consumption, and sweet food consumption. The determinants of Type 2 Diabetes Mellitus include physical activity, dietary patterns, family history of diabetes, BMI, smoking, age, gender, hypertension, and cholesterol levels.
Increasing Family Awareness of COVID-19 Transmission In Vulnerable Communities Iche Andriyani Liberty; Muhammad Zainal Fikri; Tri Hari Irfani; Pariyana Pariyana; Suryadi Tjekyan
International Journal Of Community Service Vol. 1 No. 2 (2021): August 2021 (Indonesia - Malaysia)
Publisher : CV. Inara in Colaboration with www.stie-sampit.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijcs.v1i2.17

Abstract

COVID-19 cases in Indonesia are still quite high. However, community mobility continues to increase. If in a family there is a vulnerable and / or comorbid age group, it will certainly be increasingly threatened when a productive family member leaves the house but is negligent in implementing health protocols. People who live in market areas, of course, are in direct contact with high economic activities and of course also indicate high mobility. The purpose of this activity is to increase family awareness of COVID-19 transmission in vulnerable communities with comorbidities. The target audience for this community service activity is 31 people who live in the Jakabaring Main Market area of ​​Palembang City. This community service activity results in an increase in knowledge about the importance of health protocols that are carried out in a disciplined and correct manner. This health protocol is carried out in order to protect each other starting from the family and for the community, especially for vulnerable communities. Apart from home visiting activities, the construction of hand washing facilities will also be used by the surrounding community and at the same time become a symbol to remind that washing hands with soap in running water is not only an obligation of the health protocol for preventing COVID-19 but will also save many lives from various threats of other infectious diseases.
Improving the Preparedness of Housewives to Deal with the Dynamics of the COVID-19 Pandemic Situation Iche Andriyani Liberty; Indri Seta Septadina; Emma Novita; Eddy Roflin; Pariyana; Abdusallam; Syifa Inanta Mulia Nasution
International Journal Of Community Service Vol. 1 No. 3 (2021): November 2021 (Indonesia - Malaysia)
Publisher : CV. Inara in Colaboration with www.stie-sampit.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijcs.v1i3.57

Abstract

COVID-19 (Coronavirus Disease-19) caused by the SARS-CoV-2 virus is known to attack all ages. Not only adults, it can also be dangerous for the elderly and children. On the other hand, offline schools have been planned to be carried out. Therefore, it is important for parents who have school-age children to know the impacts and situations that occur during the COVID-19 pandemic. The target subjects for this community service activity are 27 people who live in the Jakabaring, Palembang. This community service activity resulted in an increase in knowledge about the dynamics of the COVID-19 pandemic situation and the importance of health protocols to protect families, especially if the children attend offline school, as well as conducting periodic visits to see the development of the consistency of people's attitudes and behavior. This community service activity is also carried out in order to increase the participation of the community in the area to become the successor of information regarding the dynamics of the COVID-19 pandemic situation and the importance of health protocols to protect families, especially if the children who will attend offline school.
Education and Supplementary Food Provision for Tuberculosis Patients at the Merdeka Health Center, Palembang City Emma Novita Emma; Iche Andriyani Liberty; Mariana; Pariyana; Hanna Marsinta Uli; Afrida Yolanda Putri; Syafira Nofwanda
International Journal Of Community Service Vol. 1 No. 3 (2021): November 2021 (Indonesia - Malaysia)
Publisher : CV. Inara in Colaboration with www.stie-sampit.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijcs.v1i3.59

Abstract

The nutritional status of TB patients is very important because it is a simple clinical sign to see the success of TB therapy. Health education or counseling is one way to change a person's knowledge and attitudes about health and can indirectly affect nutritional status. The assessment method for community service is carried out using lecture and discussion methods. Community service will be held on November 3, 2021, at the Merdeka Health Center in Palembang. The population of this activity is TB patients and drug-taking supervisors (PMO) in the working area of the Merdeka Palembang Health Center. The number of participants is 22 people. The evaluation was carried out by conducting pre-test and post-test to assess the increase in knowledge before and after education/counseling about nutrition in TB patients. The results of community service activities showed that the provision of education significantly affected the knowledge of the nutritional status of patients (p-value <0.05) between patients before being given education and after being given education. Suggestions that can be given are the need for knowledge about the nutrition and diet of TB patients to improve their nutritional status so that treatment can be optimal.
The Role of BPJS Kesehatan in Improving Health Access Equity in Indonesia Lionardo Husin; Fachmi Idris; Iche Andriyani Liberty
Public Health Policy and Administration Journal Vol. 1 No. 1 (2025): June : Public Health Policy and Administration Journal
Publisher : CV.MEDINSIGHT PUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The implementation of BPJS Kesehatan has shown a significant increase in membership coverage. However, this achievement does not yet fully reflect success in realizing equitable access to healthcare services, as various challenges in healthcare delivery are still present. This study aims to describe the role of BPJS Kesehatan in improving health access equity in Indonesia.This literature review utilized the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method, with literature searches conducted through databases such as PubMed, Europe PMC, and Science Direct for the period 2020–2024. The keywords used were “Impact,” “Indonesia Social Health Insurance,” “BPJS Kesehatan,” and “Health Access Equity.” Articles were filtered based on relevance to the title, abstract, and full text, resulting in 11 articles considered relevant to the topic.Based on the literature review, BPJS Kesehatan has reached a large portion of the Indonesian population in terms of membership coverage. However, this has not yet reflected in equitable access to healthcare services for all, as barriers such as uneven healthcare infrastructure and a lack of understanding about the proper use of BPJS still exist.While BPJS Kesehatan’s membership coverage is relatively high, it does not guarantee equal and fair access to healthcare services across the population, as disparities in access remain.
Co-Authors ., Mariana Abdusallam Abdussalam Abdussalam Achmad Ridwan Adrina Esther Liaw Adzkiya Safitri Afrida Yolanda Putri Aldi Alfian Alisha Milenia Utami Ananda, Nadiya Andrina, Hana Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardesy Melizah Kurniati Argentina, Fiva aryani, Inda astri Bahrun Indawan kasim Chairil Anwar Chairil Anwar Dahlan, Kemas Dalilah Dalilah Dewi Rosariah Ayu Dwi Handayani Dwi Lisa Nuraini Eddy Roflin Eddy Roflin Eka Febri Zulissetiana Ellysa Carolinna Elvi Sunarsih Fachmi Idris Fachmi Idris Fadhyl Zuhry Lubis Faustina, Corinna Fifa Argentina Fitriani, Hidiyati Gita Dwi Prasasty Hamzah Hasyim Hanna Marsinta Uli Hari Kusnanto Josef Hertanti Indah Lestari, Hertanti Indah Indri Seta Septadina Irfannuddin Irfannuddin Irma Yunita Puspayani Irsan Irsan Jasmine Rana Sahirah Jihan Natra Shafira Jihan Natra Shafira Kesty, Cindy Kevin.S Kirana, Junneka Sarah Krisna Murti Krisna Murti Lionardo Husin Litania Leona Hidayat Lukman Waris M. Ammar Luthfi Kurniawan M. Farhan Fadhillah Machlery.AP Mariana Mariana Mariana Mariana Mariatul Fadilah Marta Hendry Maruf Agung Muhammad Amin Muhammad Aziz Muhammad Aziz Muhammad Aziz Muhammad Aziz Muhammad Farhan Muhammad Irsan Saleh Muhammad Totong Kamaluddin Muhammad Zainal Fikri Mulawan Umar Muradi, Akhmadu Nani Sari Murni Neubrina Raesuky Sukamto Novita, Emma Novrikasari Novrikasari, Novrikasari Nugraha Juliyanda Nur Alam Fajar Nurdin, Nugi Nurliyantika, Rizka Owen Hu Pariyana Pariyana Pariyana Pariyana Pariyana Pariyana Pariyana Pariyana Pariyana Pariyana Pariyana pariyana, Pariyana Peby Maulina Lestari, Peby Maulina Phey Liana Plorinda, Vanesha Pratama, Benny Putra Primadika Rubiansyah Pulungan, Rafiah Maharani Puspa Zuleika, Puspa Putri Mirani Qodir, Nur Radiyati Umi Partan, Radiyati Umi Rasyid, Riana Sari Puspita Ratu Ayu Dewi Sartika Ririn Puspita Risti, Sanely Rizal Zainal Rose Malfiana Saputra, Ricky Sari, Sagita Darma Septiandani, Randy Rakhmat Stevanny, Bella Subandrate Sudarto Sudarto Suryadi Tjekyan Susiwati Susiwati Syafira Nofwanda Syahranni, Dhanya Syakurah, Rizma Adila Syarif Husin Syarif Husin Syarif Husin Syarif Husin Syauki Ikhsan, Diyaz Syifa Inanta Mulia Nasution Tanzila, Raden Ayu Tjekyan, Suryadi Tri Hari Irfani Tungki Pratama Umar Utama, Meria Utami, Anissa Citra Utari, Sri Welly Salutondok Yuanita Windusari Yuanita Windusari Yudhie Tanta Yudianita Kesuma, Yudianita Yulia Farida Yahya Yusnilasari Yususf, Fahmi Jaka Zen Ahmad Zen Hafy Zulkarnain, Mohamad