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Yodha, Agung Wibawa Mahatva
Politeknik Bina Husada Kendari
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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

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Isolation of Secondary Metabolite Compounds from the Soft Coral Isis sp., Antimicrobial Testing and Molecular Docking Studies Imran; Amalia, Fajri Fitra; Sahidin; Yodha, Agung Wibawa Mahatva; Nohong; Sutapa, I Wayan; Azis, Thamrin
Jurnal Penelitian Pendidikan IPA Vol 11 No 7 (2025): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i7.10830

Abstract

Soft coral Isis sp. is a type of soft coral that contains many chemical compounds with various benefits that have not been widely studied. This study aims to identify and isolate secondary metabolite compounds contained in the ethyl acetate extract fraction of Isis sp. soft coral, determine of antimicrobial activity, and molecular docking study. Compound separation was carried out by maceration followed by fractionation using Liquid Vacuum Chromatography (LVC). The fractions obtained were identified by Liquid Chromatography Tandem-Mass Spectrometry (LC-MS/MS) technique. Four compounds were successfully identified through LC-MS/MS analysis namely Deoxyadenosine (C10H13N5O3), Spinasterol (C29H48O), Pseudoionone (C11H16O) and Isosalsoline (C11H15NO2). Antimicrobial activity test was conducted against Staphylococcus aureus, and Escherichia coli. The results of the antimicrobial activity test showed strong activity against S.aureus bacteria and E. coli bacteria with the same MIC value of 2 µg/mL. Based on molecular docking analysis can be predicted that compounds isolated from soft coral Isis sp., namely pseudoinone compounds have a role as anti-bacterial S. aureus (PDB: 6KVS). This compound also shows a strong ability as an anti- gram positive bacteria than gram negative. Isosalsoline compounds have a role as anti-bacterial E. coli (PDB: 5BNM). This compound also shows a strong ability as an anti-gram negative bacteria rather than gram positive.
Co-Authors Adryan Fristiohadi Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Agustini Amalia, Fajri Fitra Andini Sundowo Andini Sundowo Andini Sundowo Angriani Fusvita Arba, Muhammad Arfan Arfan Arfan Arfan Arfan Asasutjarit, Rathapon Asnani Asnani Astrid Indalifiany Austin Tee, Selfyana Azdar Setiawan, Muh. Badia, Esti Bafadal, Mentarry Baharum, Syarul Nataqain Baru Sadarun Baru Sadarun Budipramana, Krisyanti Daud, Nur Saadah Dian Munasari Elfahmi Elfahmi, Elfahmi Eny Nurhikma Esti Badia Esti Badia Fadhliyah Malik Fauziah, Yulianti Firasmi Sangadji Firdayanti, Firdayanti Fitrawan, La Ode Muhammad Frangky Sangande Fristiohady, Adryan Fusvita, Angriani Gusti Ayu Kade Sutariati Gusti Ray Sadimantara Harnita, Wa Ode Haruna, Lidya Agriningsih Haslianti Haslianti, Haslianti I Sahidin I Wayan Sutapa I. Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Idin, Sahidin Ilyas Y, Muhammad Imran Irnawati Irnawati Irvan Anwar Jumadil Junli Hong Karmilah Karmilah Karmilah Karmilah Karmilah, Karmilah La Ode Muh. Fitrawan La Ode Muhammad Julian Purnama Lisa Wulansari Siregar Loly Subhiaty Idrus Malaka, Muh. Hajrul Malaka, Muhammad Hajrul Malaka, Muhammad Hajrul Muamar Abdillah Muh. Arnas Muh. Azdar Setiawan Muhammad Azdar Setiawan Muhammad Azhar Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Israwan Azis Murtafia Murtafia Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah Musdalipah, Musdalipah Nirwati Rusli Nohong Nur Saadah Daud Nur Saadah Daud Nur Syifa Rahmatika Nur Syifa Rahmatika Nurcahyani, Fitria Nurpajriani, Nurpajriani Nurramadhani A. Sida Nursaadah Daud Pascayantri, Asniar Purnama, La Ode Muh. Julian Purnama, La Ode Muhammad Julian Rahmat Muliadi Randa Wulaisfan Reymon Reymon Rina Andryani Rini Hamsidi Rissyelly Rissyelly Sahidin Sahidin . Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin, Idin Santi Oktaviani, Santi Saripuddin Selfyana Austin Tee Sernita Sernita Setiawan, Muh. Azdar Sitti Raodah Nurul Jannah Solo, Dian Munasari Sukrasno Sukrasno Syaikhul Aziz Syamsu Alam Syarul Nataqain Baharum Tee, Selfyana Austin THAMRIN AZIS WAHYUNI Wahyuni Wahyuni Wahyuni Wahyuni wahyuni wahyuni Yulianti Fauziah