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All Journal Jurnal Biologi Tropis Window of Health : Jurnal Kesehatan Jurnal Pengabdian Magister Pendidikan IPA Jurnal Dunia Farmasi Indonesian Journal of Pharmaceutical and Clinical Research Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) FORTE JOURNAL Sciences of Pharmacy Jurnal Bakti Nusantara Jurnal Sains dan Kesehatan
Ziza Putri Aisyia Fauzi
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Antibacterial Activity of Formulated Guava Leaf Extract (Psidium Guajava L.) Hand Wash Soap on Staphylococcus Aureus Puteri, Cut Intan Annisa; Rani, Zulmai; Fauzi, Ziza Putri Aisyia; Ningtias, Anggitha; Dalimunthe, Gabena Indrayani
Journal of Pharmaceutical and Health Research Vol 6 No 2 (2025): June 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i2.5709

Abstract

During the Covid-19 pandemic, the use of hand-washing soap increased. Hand-washing soap using natural ingredients as active ingredients is still not widely developed. One plant that has been proven to inhibit the growth of bacteria is guava leaves. This research aimed to formulate and test the antiseptic activity of liquid hand-washing soap from guava leaf extract. The research method used was laboratory experimental, with stages including; preparation of guava leaf extract, liquid soap formulation with a preparation concentration of FI 5%, FII 6%, FIII 7%, FIV 8%, then the physical properties of the soap will be tested to determine its quality and quality. Apart from the physical test, an antibacterial activity test was also carried out to determine the antibacterial effectiveness of the liquid hand wash soap formulation using the disc diffusion method to determine the diameter of inhibition or area of the inhibition zone. The preparation formula of 7% to 8% concentration of the preparation can inhibit growthStaphylococcus aureus. The diameter of the inhibition zone formed is included in the strong category. Based on research, it can be concluded that guava leaves have the potential to inhibit bacteria S. aureus, and evaluation of the preparations of all formulas shows stability and good characteristics. Each concentration has a good antibacterial effect, where the higher the extract concentration, the greater the diameter of the bacterial growth inhibition zones. aureusresulting from.
Liquid Soap with Pineapple Hump Extract and Nanoformulation Against Staphylococcus aureus Lubis, Minda Sari; Fauzi, Ziza Putri Aisyia; Dewi, Sri Harti; Rani, Zulmai; Yuniarti, Rafita
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403348

Abstract

Staphylococcus aureus is a Gram-positive bacterium that frequently causes skin infections and can become resistant to various antibiotics. Pineapple (Ananas comosus) waste, particularly the hump, contains active compounds such as bromelain, saponins, and flavonoids with known antibacterial properties. This study aimed to determine the antibacterial potential of liquid soap formulated with extract and nanoextract of pineapple hump against S. aureus. The pineapple hump was extracted using maceration with 96% ethanol, followed by nanoparticle formulation using a high-speed homogenization method. Liquid soap was made with three formulas, one formula contains a concentration of 12.5% extract and two formulas contain 1.25% nanoextract of pineapple hump. Antibacterial activity was evaluated using the disc diffusion method, and the diameter of the inhibition zones was measured. Results showed that all tested concentrations produced antibacterial activity, with the 12.5% concentration (Formula 1) exhibiting the highest inhibition zone (23.2 mm), followed by 1.25% nanoextract nano liquid soap (18.41 mm) (Formula 3) and 1.25% nanoextract liquid soap (14.53 mm) (Formula 2). The positive control (Dettol Handwash) produced a larger inhibition zone (20.08 mm). Data analysis using one-way ANOVA revealed significant differences for each formula, with a p-value of less than 0.05. These findings indicate that nanoextract of pineapple hump formulated in liquid soap has potential as a natural antibacterial agent against S. aureus.
Gerakan Masyarakat Cerdas Obat (GMCO): Upaya Pencegahan Self-Medication yang Tidak Rasional di Kalangan Masyarakat Kota Medan Fauzi, Ziza Putri Aisyia; Puteri, Cut Intan Annisa
Jurnal Pengabdian Magister Pendidikan IPA Vol 8 No 3 (2025): Juli-September 2025
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v8i3.11914

Abstract

Self-medication is a common practice in the community, but it is high risk if done irrationally. Medan City as a big city with easy access to over-the-counter drugs faces challenges in increasing public literacy about the correct use of drugs. This community service program aims to improve public knowledge and attitudes towards self-medication through a community-based educational approach. The activity was carried out in the form of the Smart Drug Community Movement (GMCO) with interactive lecture methods, discussions, leaflet distribution, and pre-post tests at Sanggar Sungai Deli, Sei Mati Village, Medan Maimun District, Medan City. The evaluation results showed a significant increase in knowledge scores and changes in public attitudes towards drug use. GMCO can be a model of community pharmacy education that is worthy of being developed more widely in urban areas.
ASSESSING THE ANTIBACTERIAL EFFICACY OF ETHANOL EXTRACT FROM PEPPERMINT LEAVES (Mentha piperita L.) IN HAND SOAP GEL AGAINST Staphylococcus epidermidis: UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN HAND SOAP GEL EKSTRAK ETANOL DAUN PEPPERMINT (Mentha piperita L.) TERHADAP Staphylococcus epidermidis Candrika, Candrika; Anita Naibaho, Tri; Rinanda Silitonga, Desni; putri aisyia fauzi, Ziza
FORTE JOURNAL Vol 5 No 2 (2025): Edisi Juli 2025
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v5i2.1828

Abstract

In traditional medicine, peppermint leaves (Mentha piperita L.) have been empirically used to treat of illnesses, including cholesterol, gout, hypertension. Peppermint leaves are known to contain a variety of secondary metabolites, including alkaloids, flavonoids, tannins, steroids, saponins, their antibacterial properties have been demonstrated experimentally. It is well known that these substances actively prevent the growth and development of germs. The aim of this study was to evaluate the stability of the formulation of hand soap gel including peppermint leaf ethanol extract, as well as the antibacterial activity of the extract against Staphylococcus epidermidis.Using a 70% ethanol solvent, peppermint leaf ethanol extract was produced by maceration. Diffusion agar method was then used to assess the peppermint leaf ethanol extract's antibacterial activity against Staphylococcus epidermidis. Then, different amounts of 3,6,9% of peppermint leaf ethanol extract were added to Hand Soap gel formulations. the final formulations were examined for preparation properties such as homogeneity, spreadability, foaming power, physical stability at various temperatures, organoleptic testing. The study's findings demonstrated that peppermint leaf ethanol extract can stop Staphylococcus epidermidis bacteria growing. This resulted in an inhibition zone diameter of 17.1 mm at 50% concentration, 16.3 mm at 40%, 15.8 mm at 30%, 14.5 mm at 20%, 13.5 mm at 10% and 6.9 mm at the lowest concentration of 1%. The test profile demonstrates that the diameter of the inhibition zone generated increases with concentration. The Hand Soap Gel formulation satisfied the criteria for evaluating and demonstrated consistent physical stability throughout a 4-week storage period.
Formulation of Tembelekan Leaf Hand Sanitizer (Lantana camara L.) and Antibacterial Activity Test Against Escherichia coli and Staphylococcus aureus Fauzi, Ziza Putri Aisyia; Putri, Cut Intan Annisa; Aska, Nawalul; Utami, Dinda Sari
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7595

Abstract

Disease-causing microorganisms stick to hands every day through physical contact with the environment. One of the easiest and most appropriate ways to clean them is to wash hands with soap and clean water. This study aims to determine the formulation of tembelekan leaf hand sanitizer (Lantana camara L.) and test its antibacterial activity against Escherichia coli and Staphylococcus aureus. Assessment of the arrangements acquired incorporates organoleptic tests with libertine tests, homogeneity, pH, spreadability, dependability, bothering to chip in skin, and antibacterial movement against Staphylococcus aureus and Escherichia coli by agar dispersion utilizing poke holes. The outcomes showed that the hand sanitizer readiness containing 10% tembelekan leaf remove was the best planning since it was liked by specialists, stable when put away at room temperature for a very long time, didn't cause bothering, and had solid antibacterial movement so that the tembelekan leaf gel planning utilized as a characteristic natural substance can be utilized to clean hands from microscopic organisms that is simple, reasonable and protected to use without utilizing water.
The Analgesic Activity Study of Ethanol Extract of Plantago Major L. in Mice (Mus Musculus L.) using Writhing Test Method Puteri, Cut Intan Annisa; Simahate, Sadjnah; Ningtias, Anggitha; Fauzi, Ziza Putri Aisyia; Karo-Karo, Sry Ulina; Andry, Muhammad
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7650

Abstract

Plantago major L. are known as weeds on plantations. Plantago major L. is effective to overcome pain because they contain secondary flavonoid metabolites that have the potential as pain relievers. The purpose of the experiment was to determine the analgesic effect of ethanol extract on Plantago major L. plant on male white mice. The experiment, phytochemical screening of ethanol and powder extracts from Plantago major L. plant, powder of simplicia characterization examination and analgesic effect using writhing test were carried out. As a pain inducer, 0.5% acetic acid is used intraperitoneally injected the lower abdomen of the mice and the amount of stretching is calculated with an interval of 5 minutes for 1 hour. The suspension of ethanol extract of Plantago major L. was given at a dose of 500, 1000 and 2000 mg / kg BW, 2% methampyron suspension as a positive control and 0.5% CMC suspension as a negative control. Pharmacological test results based on ANOVA test found that the amount of stretching between treatment groups was significantly different (p <0.05). The results of the analgesic effectiveness percentage obtained that the EEPM (Ethanol Extract of Plantago Major L.) suspension dose 500, 1000 and 2000 mg / kg BW had the highest analgesic power at a dose of 2000 mg / kg BW of 85.84%, EEPM suspension group 1000 mg / kg BW of 74.96 % and in the EETDS suspension group 500 mg / kg BW 62.37%.
Uji Efektivitas Ekstrak Jamur Susu Harimau (Lignosus rhinocerus) Sebagai Antioksidan dengan Metode DPPH: Test of the Effectiveness of Tiger Milk Fungus (Lignosus rhinocerus) Extract as an Antioxidant by DPPH Method Rambe, Robiatun; Rani, Zulmai; Ginting, Ovalina Sylvia Br; Fauzi, Ziza Putri Aisyia
Jurnal Sains dan Kesehatan Vol. 6 No. 3 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i3.2117

Abstract

Chemicals including alkaloids, flavonoids, tannins, saponins, and steroids are present in tigers milk mushrooms (Lignosus rhinocerus). This work compares the IC50 value of tiger milk mushrooms and assesses the antioxidant activity of ethanol extract. This study employed maceration as the extraction technique, utilizing a 1:10 ratio of 96% ethanol solvent. The antioxidant activity was assessed using the DPPH free radical reduction technique. Based on antioxidant activity studies, the tiger milk mushroom ethanol extract's IC50 value was 149.26 ppm, while vitamin C's was 3,238 ppm. Antioxidant activity was detected in the ethanol extract of tiger milk mushrooms, with an IC50 value of 19,206 ppm and an IC50 value of 3,238 ppm, suggesting that the antioxidant activity was in the middle range. But compared to the ethanol extract of tiger milk mushrooms, the vitamin C IC50 value was greater. Keywords:          Lignosus rhinocerus, Antioxidant activity, DPPH method   Abstrak Jamur susu harimau (Lignosus rhinocerus) memiliki kandungan kimia seperti alkaloid, flavonid, tanin, saponin dan steroid. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak etanol serta perbandingan nilai IC50 dari jamur susu harimau. Metode Ekstraksi yang digunakan dalam penelitian ini adalah maserasi menggunakan pelarut etanol 96% dengan perbandingan 1:10. Pengujian aktivitas antioksidan menggunakan metode peredaman radikal bebas DPPH. Dari hasil pengukuran aktivitas antioksidan diperoleh nilai IC50 ekstrak etanol jamur susu harimau sebesar 149,26 ppm dan vitamin C sebesar 3,238 ppm. Aktivitas antioksidan dari ekstrak etanol jamur susu harimau diperoleh dengan nilai IC50 ekstrak etanol jamur susu harimau sebesar 19,206 ppm dan vitamin C sebesar 3,238 ppm dimana aktivitas antioksidan tergolong kategori sedang, tetapi nilai IC50 vitamin C lebih baik dibandingkan ekstrak etanol jamur susu harimau. Kata Kunci:         Lignosus rhinocerus, Aktivitas antioksidan, Metode DPPH
Antimicrobial Activity Test of Ethanol Extract of Senggani Leaves (Melastoma malabraticum L) Against Propionibacterium Acnes and Staphylococcus Epidermidis Nasution, Haris Munandar; Rani, Zulmai; Fauzi, Ziza Putri Aisyia; Ridho, Ahmad Rasyid
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.2208

Abstract

Senggani leaves are a plant that can be found in Indonesia, including hilly locations. The people of Marendal, Patumbak subdistrict, believe that senggani leaves may heal minor skin wounds. The goal of this study was to identify the class of secondary metabolite chemical compounds and their antibacterial efficacy against the microorganisms Propionibacterium acnes and Staphylococcus epidermidis at 5, 10, and 20% concentrations. The ethanol extract of senggani leaves contains secondary metabolite compounds with antibacterial activity. According to the antibacterial test results, a 20% ethanol extract of senggani leaves is effective against Propionibacterium with a diameter of 10.7 mm, a 10% in the medium category with a diameter of 9.27 mm, and a 5% in the medium category with a diameter of 8.8 mm. Meanwhile, the diameter of Staphylococcus epidermidis at a 20% was 8.77 mm in the medium category, 8.37 mm at 10%, and 8.6 mm at a 5% concentration.   Keywords:          Propionibacterium acnes, Senggani leaves, Staphylococcus epidermidis
Antibacterial Activity Test of Malacca Leaf Extract (Phyllanthus emblica) Against Staphylococcus aureus and Staphylococcus epidermidis Bacteria Ridwanto, Ridwanto; Aprilia, Hijjatun; Rani, Zulmai; Putri Aisyia Fauzi, Ziza; Kaban, Vera Estefania; Nasri, Nasri
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.17912

Abstract

Antibacterials are substances that can interfere with the growth or even kill bacteria and have the side effect of antibacterial resistance. One effort to reduce resistance is choosing to use natural bacterial ingredients. One plant that can potentially contain antibacterial activity is malacca leaves (Phyllanthus emblica). The contents of this plant include flavonoids, alkaloids, tannins, saponins, and steroids/triterpenoids. This research aimed to prove the antibacterial activity test of malacca leaf extract. The stages in this research included phytochemical screening and testing the antibacterial activity of ethanol extract from Malacca leaves for Staphylococcus aureus and Staphylococcus epidermidis bacteria using the diffusion method using paper discs. The characteristics of malacca leaf simplicia obtained were water content of 4.6%, water-soluble content of 28%, ethanol-soluble essence content of 23.33%, total ash content of 2.00%, and insoluble ash content of 0.5%. The results of phytochemical screening showed the presence of flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. The antibacterial test results of malacca leaf extract at concentrations of 500 mg/ml, 400 mg/ml, 300 mg/ml, and 200 mg/ml have an antibacterial effect against Staphylococcus aureus and Staphylococcus epidermidis, and there is no difference in the effectiveness of the inhibitor against gram-positive and negative grams.
Edukasi Dan Pelatihan Pembuatan Minyak Rambut Herbal Berbahan Kemiri Untuk Pencegahan Rambut Rontok Di Kelurahan Paya Mabar, Kecamatan Stabat, Kabupaten Langkat Hartini, Putri Tri; Lubis, Syahnan Aly; Nabila; Sry Ulina Karo-karo; Ziza Putri Aisyia Fauzi
Jurnal Pengabdian Magister Pendidikan IPA Vol 8 No 4 (2025): Oktober-Desember 2025
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v8i4.13040

Abstract

Hair loss is a common problem that impacts appearance and self-confidence, so a safe and effective natural solution is needed. Candlenut oil (Aleurites moluccanus) contains essential fatty acids and vitamin E which are beneficial in strengthening the hair and nourishing the scalp. This community service program was carried out in Paya Mabar Village, Stabat District, Langkat Regency, with the aim of increasing community knowledge and skills in making herbal hair oil made from candlenut. A total of 35 participants participated in the activity through counseling, demonstration, and hands-on practice, accompanied by evaluation using pre-test and post-test. The results showed an average knowledge increase of 38%, and 80% of participants succeeded in producing good quality hazelnut oil despite facing constraints on temperature regulation. This program proved effective in improving hair health literacy, natural ingredient processing skills, and opening up entrepreneurial opportunities based on local herbal products.
Co-Authors Ahmad Rasyid Ridho Anita Naibaho, Tri Aprilia, Hijjatun Arifin, Khairil Fikri Aska, Nawalul Aulia Fitri Candrika, Candrika Chandra, Putra Denny Satria Dewi, Sri Harti Dinda Sari Utami Gabena Indrayani Dalimunthe Ginting, Ovalina Sylvia Br Ginting, Ovalina Sylvia Br. Hari Purnomo Haris Munandar Nasution Hartini, Putri Tri Hindri Syahputri Karo-Karo, Sry Ulina Lestari, Amanda Putri Lubis, Minda Sari Lubis, Syahnan Aly Muhammad Amin Nasution Muhammad Andry Muhammad Yunus Nabila Nasri Nasri, Nasri Nasution, Melvi Ariati Nia Novranda Pertiwi Nindya Indah Damayanti Ningtias, Anggitha Puteri, Cut Intan Annisa Putri, Cut Intan Annisa Rafita Yuniarti Rambe, Robiatun Rawitri, Kiki Ridho, Ahmad Rasyid Ridwanto Ridwanto Rinanda Silitonga, Desni Rinda Sari, Sylvi Robiatun Rambe Rukmana, Siti Samran, Samran Sari, Syilvi Rinda Simahate, Sadjnah Siti Anisa Sry Ulina Karo-karo Syukur Berkat Waruwu Urip Harahap Vera Estefania Kaban Yuandani Yuniarti, Rafita Zulmai Rani