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All Journal Jurnal Biologi Tropis Window of Health : Jurnal Kesehatan JOPS (Journal Of Pharmacy and Science) Jurnal Pengabdian Magister Pendidikan IPA Jurnal Dunia Farmasi Indonesian Journal of Pharmaceutical and Clinical Research Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) FORTE JOURNAL Jurnal Pengabdian Masyarakat PEMA: Jurnal Pendidikan dan Pengabdian Kepada Masyarakat Sciences of Pharmacy Mestaka: Jurnal Pengabdian Kepada Masyarakat Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Bakti Nusantara Jurnal Sains dan Kesehatan Journal of Pharmascience Fundamental and Applied Research in Medicine and Allied Sciences Indonesia
Ziza Putri Aisyia Fauzi
Faculty Of Pharmacy, Universitas Muslim Nusantara Al-Washliyah, Medan, 20147, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Other

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Edukasi Pemasaran Digital Untuk Meningkatkan UMKM Desa Kuala Tanjung Ananda, Dea; Azzuhra, Dara Nabilah; Mutia, Mutia; Safitri, Tria; Fadhilah, Rika; Aisyia Fauzi, Ziza Putri
PEMA Vol. 5 No. 3 (2025)
Publisher : Perkumpulan Manajer Pendidikan Islam Indonesia (PERMAPENDIS) Prov. Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56832/pema.v5i3.1945

Abstract

Pentingnya pemasaran digital bagi Usaha Mikro, Kecil, dan Menengah (UMKM) di Desa Kuala Tanjung dalam era digitalisasi saat ini menjadi elemen yang sangat penting dalam mengembangkan bisnis. Masalah yang dihadapi oleh UMKM terkait kurangnya pengetahuan dan keterampilan dalam pemasaran produk secara online. Pendampingan ini bertujuan untuk memberikan pemahaman dan pengalaman kepada UMKM tentang bagaimana cara agar jangkauan pemasaran produk lebih luas . Pendampingan meliputi praktek langsung kepada para pelaku UMKM. Sebelum pelaksanaan kegiatan, dilakukan survei terhadap UMKM di Desa Kuala Tanjung untuk mengidentifikasi permasalahan yang mereka hadapi terkait pemasaran produk UMKM. Selama pendampingan, peserta diberikan pengetahuan tentang pentingnya pemasaran digital, kemudian mereka terlibat dalam praktek pembuatan toko online dengan bimbingan. Hasil dan pembahasan dari kegiatan ini menunjukkan pentingnya pemasaran digital bagi UMKM Desa Kuala Tanjung dan masalah yang dihadapi terkait kurangnya pengetahuan dan keterampilan dalam pemasaran secara online yang kurang luas.
Total Flavonoid Content, Antibacterial Activity and In Silico Toxicity Prediction of Ethanolic Extract from Murraya koenigii Leaves against Streptococcus mutans Haris Munandar Nasution; Nasri Nasri; Ziza Putri Aisyia Fauzi; Zulmai Rani; Ainil Fithri Pulungan; Vera Estefania Kaban
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22436

Abstract

Dental caries is a chronic disease exclusive to humans and remains one of the most prevalent oral health problems worldwide. The increasing emergence of antibiotic resistance and the adverse effects associated with conventional antimicrobials have encouraged the exploration of natural plant-derived compounds for caries prevention. Murraya koenigii leaves are widely used as a culinary ingredient and are known to possess various therapeutic properties, including antioxidant, antibacterial, anti-inflammatory, and hepatoprotective activities. This study aimed to evaluate the total flavonoid content, antibacterial activity, and in silico toxicity profile of the ethanolic extract of M. koenigii leaves against Streptococcus mutans, a primary cariogenic pathogen. Total flavonoid content was determined using the aluminum chloride colorimetric method, while antibacterial activity was assessed using the agar disk diffusion assay. The toxicity profile of major flavonoid constituents was further analyzed using in silico ADMET prediction tools. The results showed that the ethanolic extract of M. koenigii leaves contained a high total flavonoid content (281.83 ± 10.23 mg QE/g extract) and exhibited strong antibacterial activity against Streptococcus mutans, producing inhibition zones ranging from 14.4 to 19.4 mm in a concentration-dependent manner. In silico analysis indicated that the major flavonoid constituents possessed favorable pharmacokinetic characteristics with low predicted toxicity risks. These findings suggest that the ethanolic extract of M. koenigii leaves is rich in flavonoids and demonstrates significant antibacterial potential, supporting its promise as a natural antibacterial agent for oral health applications. Further studies focusing on compound isolation, formulation development, and in vivo validation are recommended.
Gel Pembersih Wajah Berbasis Ekstrak Daun Sengani: Inovasi Herbal untuk Terapi Anti-Jerawat yang Menargetkan Cutibacterium acnes Candrika Candrika; Ziza Putri Aisyia Fauzi; Cut Intan Annisa Puteri; Ferina Septiani Damanik; Dinda Sari Utami; Putri Tri Hartini
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1454

Abstract

Senggani is a traditional Asian plant commonly used as an alternative medicine, particularly in Indonesia. The leaves of the senggani plant contain secondary metabolites, including tannins, alkaloids, flavonoids, and saponins. Among these, tannins and flavonoids are believed to have antibacterial properties. This study investigates whether a facial wash gel made from the ethanol extract of senggani leaves possesses stable properties and meets established standards. Additionally, the study aims to evaluate its antibacterial activity against Cutibacterium acnes, the bacteria responsible for acne. A maceration method with 70% ethanol was used to prepare the ethanol extract from senggani leaves. This extract was then formulated into a facial wash gel using carbopol polymer at 5%, 7.5%, and 10%, followed by tests to assess its antibacterial activity. The antibacterial activity was determined using the disc diffusion method at the same concentrations. The results indicated that the diameter of the bacterial inhibition zone was 9.93 mm at 5%, 11.66 mm at 7.5%, and 13.93 mm at 10%. The gel preparation of the ethanol extract from senggani leaves demonstrated stable properties, with physical stability evaluations confirming compliance with the quality standards for facial washes set by Indonesian national regulations. Furthermore, the senggani leaf ethanol extract gel effectively inhibited the growth of Cutibacterium acnes, indicating its potential as an effective face wash.
Perbandingan Efektivitas Antibakteri Ekstrak dan Sediaan Hand Soap Gel Daun Peppermint (Mentha piperita L.) Terhadap Bakteri Staphylococcus aureus Penyebab Infeksi Kulit Candrika Candrika; Nufadila Nazmi; Halimah Raina Nasution; Ziza Putri Aisyia Fauzi; Khaira Banu; Lusi Mardika Ariyanti; Hardiyanti Rukmana
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1479

Abstract

Background: Peppermint leaves (Mentha piperita L.) contain various secondary metabolites, including flavonoids, alkaloids, tannins, and steroids, which exhibit antibacterial activity. The development of peppermint extract into a hand soap gel requires evaluation of its physical stability and antibacterial effectiveness. Aim: This study aimed to formulate a hand soap gel from peppermint leaf ethanol extract and evaluate its physical characteristics, stability, and antibacterial activity against Staphylococcus aureus. Methods: Peppermint leaves were extracted by maceration using 70% ethanol. Hand soap gel formulations containing 3%, 6%, and 9% extract concentrations were prepared and evaluated through organoleptic, homogeneity, spreadability, foam height, pH, viscosity, and stability tests under different storage temperatures. Antibacterial activity was determined against Staphylococcus aureus using the agar diffusion method. Results: The ethanol extract demonstrated antibacterial activity with a maximum inhibition zone of 17.1 mm at 50% concentration. All hand soap gel formulations showed good physical characteristics and stability under various storage temperatures. The antibacterial activity of the formulations increased with extract concentration, producing inhibition zones ranging from 20.8 to 21.1 mm, categorized as very strong activity. Statistical analysis using one-way ANOVA showed significant differences among treatment groups (p < 0.05). Conclusion: Peppermint leaf ethanol extract can be successfully formulated into a stable hand soap gel preparation with very strong antibacterial activity against Staphylococcus aureus.
Sosialisasi Pemakaian Obat untuk Perawatan Luka Pasca Sunat di MI Raudhathussolihin, Medan Johor: Pengabdian Rahmadani Rahmadani; Minda Sari Lubis; Lilik Septiana; Ziza Putri Aisyia Fauzi; Hindri Syahputri
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 4 (2026): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 4 April - Juni
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i4.6873

Abstract

Sunat merupakan tindakan medis yang memerlukan perawatan luka yang tepat untuk mempercepat penyembuhan dan mencegah infeksi. Perawatan yang kurang baik dapat menyebabkan infeksi, perdarahan, iritasi, nyeri berkepanjangan, dan keterlambatan penyembuhan. Selain itu, rendahnya pemahaman masyarakat tentang penggunaan obat yang tepat turut memengaruhi keberhasilan perawatan. Kegiatan pengabdian masyarakat ini bertujuan meningkatkan pengetahuan peserta mengenai penggunaan obat pada perawatan luka pasca sunat di MI Raudhathussolihin, Medan Johor. Kegiatan dilakukan melalui sosialisasi dan edukasi kesehatan dengan metode ceramah, diskusi, demonstrasi, dan pembagian leaflet. Materi mencakup kebersihan luka, jenis dan cara penggunaan obat, waktu penggantian perban, serta tanda-tanda infeksi. Peserta terdiri atas anak pasca sunat dan orang tua atau wali. Hasil kegiatan menunjukkan peningkatan pengetahuan peserta tentang perawatan luka, penggunaan obat yang benar, dan pencegahan infeksi. Antusiasme peserta juga terlihat dari keaktifan dalam diskusi dan tanya jawab. Kegiatan ini diharapkan dapat meningkatkan kesadaran masyarakat sehingga proses penyembuhan luka pasca sunat lebih optimal dan risiko komplikasi dapat diminimalkan.
Peran Farmasi Klinis Dalam Edukasi Masyarakat Sebagai Strategi Promotif dan Preventif Penyakit ISPA Kiki Rawitri; Syilvi Rinda Sari; Cut Intan Annisa Puteri; Ziza Putri Aisyia Fauzi; Ferina Septiani Damanik
Jurnal Bakti Nusantara Vol. 3 No. 3 (2026): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jutira.v3i3.170

Abstract

Infeksi Saluran Pernapasan Akut (ISPA) masih menjadi masalah kesehatan masyarakat yang signifikan, dengan tingginya angka kejadian yang tidak hanya dipengaruhi oleh rendahnya literasi kesehatan, tetapi juga oleh praktik penggunaan obat yang kurang rasional di masyarakat. Dalam konteks farmasi klinis, peran farmasis menjadi krusial dalam memberikan edukasi terkait deteksi dini, pencegahan, serta penggunaan obat yang tepat untuk menghindari komplikasi dan resistensi, khususnya akibat swamedikasi yang tidak rasional. Temuan awal di Puskesmas Teladan Kota Medan menunjukkan bahwa masyarakat belum mampu mengenali gejala awal ISPA secara tepat dan cenderung melakukan swamedikasi tanpa informasi yang memadai. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk mengoptimalkan edukasi berbasis farmasi klinis sebagai intervensi promotif dan preventif dalam meningkatkan pengetahuan masyarakat terkait deteksi dini, pencegahan, dan penggunaan obat yang rasional pada ISPA. Metode yang digunakan adalah penyuluhan dan edukasi interaktif dengan desain quasi-eksperimental one group pre-test–post-test terhadap 17 responden. Materi edukasi mencakup pengenalan ISPA, tanda dan gejala, faktor risiko, pencegahan berbasis Perilaku Hidup Bersih dan Sehat (PHBS), serta prinsip penggunaan obat yang rasional. Hasil menunjukkan peningkatan signifikan tingkat pengetahuan (p<0,05), dengan peningkatan kategori pengetahuan baik dari 11,76% menjadi 52,94% dan penurunan kategori kurang dari 58,82% menjadi 11,76%. Temuan ini mengindikasikan bahwa edukasi berbasis farmasi klinis efektif dalam menunjang upaya promotif dan preventif sekaligus meningkatkan rasionalitas penggunaan obat dalam pengendalian ISPA di masyarakat.
Pemberdayaan Ibu Balita dalam Penatalaksanaan Diare dan Pencegahan Dehidrasi Berbasis Edukasi Kesehatan Ziza Putri Aisyia Fauzi; Cut Intan Annisa Puteri; Rahmadani; Kiki Rawitri
Jurnal Pengabdian Magister Pendidikan IPA Vol 9 No 2 (2026): April-Juni 2026
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v9i2.15767

Abstract

Diare masih menjadi salah satu penyebab utama morbiditas dan mortalitas pada balita, terutama akibat komplikasi dehidrasi. Rendahnya pengetahuan ibu mengenai penatalaksanaan diare yang tepat, penggunaan oralit dan zinc, serta pengenalan tanda bahaya menjadi faktor yang berkontribusi terhadap tingginya risiko komplikasi. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan ibu balita dalam penatalaksanaan diare dan pencegahan dehidrasi melalui edukasi kesehatan. Kegiatan dilaksanakan pada bulan Maret 2026 di UPT Puskesmas Teladan, Kelurahan Teladan Barat, Kota Medan, dengan melibatkan 35 ibu balita sebagai peserta. Metode yang digunakan meliputi penyuluhan interaktif, demonstrasi pembuatan oralit, simulasi identifikasi tanda dehidrasi, serta evaluasi menggunakan desain pre-test dan post-test. Media edukasi yang digunakan berupa presentasi, leaflet, dan booklet. Hasil evaluasi menunjukkan adanya peningkatan rata-rata skor pengetahuan peserta dari 58,6 ± 12,4 pada pre-test menjadi 84,7 ± 9,8 pada post-test. Sebanyak 88,6% peserta mampu menjelaskan tanda-tanda dehidrasi dan 91,4% peserta mampu menyiapkan oralit dengan benar setelah kegiatan. Kegiatan ini terbukti efektif dalam meningkatkan literasi kesehatan ibu balita terkait penatalaksanaan diare dan pencegahan dehidrasi. Program edukasi kesehatan secara berkelanjutan perlu dilakukan melalui kolaborasi dengan kader posyandu dan puskesmas untuk meningkatkan kemampuan keluarga dalam penanganan awal diare pada balita.
Evaluation of the Hepatoprotective Effects of the Flavonoid-Containing Ethyl Acetate Fraction Obtained after n-Hexane Defatting of Matoa (Pometia pinnata) Fruit Peel on a DMN-Induced Hepatic Fibrosis Model in Rats: A Histopathological and Serum Biomarker Approach Emma Jayanti Besan; Atun Qowiyyah; Korinus Suweni; Yunita Kristina; Ziza Putri Aisyia Fauzi
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 2 (2025): November, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i2.389

Abstract

Liver fibrosis is a progressive liver disorder and a major global health concern, prompting increasing interest in natural products with antifibrotic potential. Pometia pinnata, traditionally used to treat liver disorders, lacks sufficient experimental evidence supporting its hepatoprotective effects. This study evaluated the hepatoprotective and antifibrotic activity of a flavonoid-containing ethyl acetate fraction obtained after n-hexane defatting of Pometia pinnata fruit peel in a dimethylnitrosamine (DMN)-induced hepatic fibrosis rat model. Male rats were divided into six groups: normal control, DMN control, three treatment groups receiving the flavonoid fraction at doses of 50, 100, and 200 mg/kg body weight, and a silymarin-treated group (100 mg/kg). Dose selection was based on preliminary toxicity data and previous studies on flavonoid-rich extracts. Liver injury was assessed using serum biochemical markers (ALT, AST, ALP, and bilirubin), histopathological examination, and fibrosis scoring with Masson’s Trichrome staining. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test (p < 0.05). DMN significantly induced hepatic injury and fibrosis, while flavonoid fraction treatment improved liver function and histological features in a dose-dependent manner. The highest dose showed effects comparable to silymarin and significantly reduced fibrosis scores (r = −0.91, p < 0.001). These findings indicate that Pometia pinnata fruit peel exhibits promising hepatoprotective and antifibrotic potential.
Optimization of Dengue-EDIII – Hepatitis B-VLP Fusion Antigen Protein Expression in Mammalian Cell Systems and Preliminary Immunogenicity Testing in Mice Ziza Putri Aisyia Fauzi; Eka Nur Fatmawati; Putri Tri Hartini; Yuneka Saristiana; Husnunnisa
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 2 (2025): November, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i2.430

Abstract

The development of a safe and effective dengue vaccine remains challenging due to the risk of antibody-dependent enhancement (ADE) associated with imbalanced immune responses. This study aimed to optimize the expression of a dengue virus envelope domain III (EDIII) fusion antigen displayed on Hepatitis B core antigen virus-like particles (VLPs) and to evaluate its preliminary immunogenicity in a murine model. Optimization of antigen design and expression conditions resulted in a substantial increase in VLP production compared with the non-optimized construct. The purified VLPs showed uniform size, proper particle assembly, and preserved antigenic integrity. Immunization of mice induced high titers of EDIII-specific IgG and strong serotype-specific neutralizing antibodies against dengue virus serotype 2, while no antibody-dependent enhancement was detected in vitro. These findings indicate that the optimized EDIII–HBcAg VLP platform is highly immunogenic and demonstrates a favorable safety profile, supporting its potential as a promising subunit vaccine candidate for dengue virus.
Formulation and Characterization of PEGylated Liposomes as a Targeted Delivery System for the Chemotherapy Drug Doxorubicin putri tri hartini; Arbayah; Ziza Putri Aisyia Fauzi; Fendy Prasetyawa; Revan Busriano Putra
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 1 (2026): May, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i1.526

Abstract

Doxorubicin (DOX) is an effective anticancer agent, but its clinical use is limited by severe systemic toxicity. This study developed and optimized PEGylated liposomes containing DOX to improve therapeutic efficacy and safety. Liposomes were prepared using thin-film hydration and active loading via an ammonium sulfate gradient, and optimized using a Box-Behnken Design. The optimized formulation showed a particle size of ~112 nm, high encapsulation efficiency (94.7%), good stability, and pH-responsive drug release, with greater release under acidic conditions. In vitro studies demonstrated enhanced cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells compared to free DOX. The formulation also remained stable for 6 months under ICH conditions. Overall, DOX-loaded PEGylated liposomes exhibited favorable physicochemical characteristics, improved anticancer activity, and strong potential as a targeted nanocarrier for breast cancer therapy.
Co-Authors Ahmad Rasyid Ridho Ananda, Dea Anggitha Ningtias Anita Naibaho, Tri Anny Sartika Daulay Aprilia, Hijjatun Arbayah Arifin, Khairil Fikri Aska, Nawalul Atun Qowiyyah Aulia Fitri Azzuhra, Dara Nabilah Chandra, Putra Darwin Syamsul Denny Satria, Denny Devira Zahara Dewi, Sri Harti Dinda Sari Utami Dinda Sari Utami Dinda Sari Utami Eka Nur Fatmawati Emma Jayanti Besan Fadhilah, Rika Fendy Prasetyawa Ferina Septiani Damanik Fithri Pulungan, Ainil Gabena Indrayani Dalimunthe Ginting, Ovalina Sylvia Br Ginting, Ovalina Sylvia Br. Halimah Raina Nasution Hardiyanti Rukmana HARI PURNOMO Haris Munandar Nasution Haris Munandar Nasution Harry Agoestaf Asroel Hartini, Putri Tri Helni Maulida Hindri Syahputri Husnunnisa Karo-Karo, Sry Ulina Khaira Banu Kiki Rawitri Korinus Suweni Lestari, Amanda Putri Lilik Septiana Lilik Septiana Lubis, Minda Sari Lusi Mardika Ariyanti Melati Yulia Kusumastuti Muhammad Amin Nasution Muhammad Andry Muhammad Yunus Mutia Mutia, Mutia Nabila Nasri Nasri Nasri Nasri, Nasri Nasution, Melvi Ariati Nia Novranda Pertiwi Nindya Indah Damayanti Ningtias, Anggitha Nufadila Nazmi Puteri, Cut Intan Annisa Putri Tri Hartini putri tri hartini Putri, Cut Intan Annisa Rahmadani Rahmadani Rahmadani Rahmadani Rahmadani Rambe, Robiatun Revan Busriano Putra Ridho, Ahmad Rasyid Ridwanto Ridwanto Rinanda Silitonga, Desni Rinda Sari, Sylvi Robiatun Rambe Rukmana, Siti Safitri, Tria Samran, Samran Sari, Febia Sari, Syilvi Rinda Simahate, Sadjnah Siswahyudianto Siti Anisa Sri Wahyuni Sri Wahyuni Sry Ulina Karo-karo Syahnan Aly Lubis Syarifah Nadia Syukur Berkat Waruwu Urip Harahap Vera Estefania Kaban Vera Estefania Kaban Yuandani Yuneka Saristiana Yuniarti, Rafita Yunita Kristina Zihazia Leumita Zulmai Rani