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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Brawijaya Indonesian Journal of Urology MEDISAINS Indonesian Journal of Obstetrics & Gynecology Science Jurnal Teknik Informatika UNIKA Santo Thomas Majalah Patologi Indonesia Indonesian Journal of Global Health research Jurnal Pendidikan, Sains, Geologi, dan Geofisika (GeoScienceEd Journal) MEDIC MEdical Dedication Medical Scope Journal (MSJ) Afeksi: Jurnal Penelitian dan Evaluasi Pendidikan Arus Jurnal Sosial dan Humaniora Almufi Jurnal Pengabdian kepada Masyarakat Jurnal Teknik Informatika Unika Santo Thomas (JTIUST) Jurnal Ekonomi Syariah dan Bisnis Jurnal Karya Abdi Masyarakat Sciences of Pharmacy Electronic Journal Scientific of Environmental Health And Diseases Journal of Economics and Social Sciences Jurnal Adijaya Multidisiplin Health Research Journal of Indonesia Journal of Social Knowledge Education (JSKE) Journal of Medical Studies Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan ZIJEc: Zabags International Journal of Economy ENDLESS : International Journal of Future Studies International Journal Of Health And Social Behavior Journal of Pharmacy Tiara Bunda
dewi, hasna
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Journal : medisains

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Antifertility effect of betel nut (Areca catechu L) in male rat Rahman, Ave Olivia; Purwakanthi, Anati; Dewi, Hasna
MEDISAINS Vol 18, No 2 (2020)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v18i2.7588

Abstract

Background: Betel nut (Areca catechu L) are traditional beverages in Jambi. Betel nut high dose has a cytotoxic effect on testis and other organs—limited data about the effect of betel nut as male antifertility.Purposes:  This study aimed to determine the effect of infertility on betel nut use at a dose of 50 mg/kg body weight (BW) in male rats.   Methods: Ten male Sprague Dawney rats that had passed the fertility test, aged 2-3 months and weighing 150-200 grams ware used in this study. The rat was grouped into two groups randomly. Group 1, as the negative control, were received aqua dest, and group 2 was treated by betel nut with dose 50 mg/kg BW for 35 days. When terminated, testis weight weighed using micro scales. Blood collected for measuring testosterone levels. Histopathology assessment of testis used Hematoxylin Eosin Staining and sperm counting from cauda epididymis.Results: The weight of testis in the group received betel nut was lower than the control group. The histopathology of testis showed shrunk, reduced the diameter of seminiferous tubules, and like cytolytic lesions in the germinal layer—the total sperm number and progressive sperms also lower than the control group (p<0.05). There was no abnormality in Leydig cell and interstitium tissue.  Male rats after treatment could not impregnate the female rats.Conclusion: Betel nut at dose 50 mg/kg BW have antifertility activity in male rats.
Antidiabetic effect of Psychotria malayana Jack in induced type 1 diabetic rat Fairuz, Fairuz; Dewi, Hasna; Humaryanto, Humaryanto
MEDISAINS Vol 18, No 1 (2020)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v18i1.6909

Abstract

Background: Therapies for hyperglycemic treatment, including insulin and oral diabetes medications, have been confirmed to cause several side effects. Thus, finding new drugs with fewer side effects is of high importance. Salung leaf herb (Psychotria malayana Jack) reported used in traditional societies as a treatment for diabetes. However, the scientific proof of this plant for diabetes treatment is still lacking.Objective: To evaluate the antidiabetic effect of the P. malayana jack in induced type 1 diabetic rats by assessing blood glucose level and pancreatic cells in white rats.Methods: Alloxan used to induce type I diabetes. Rats randomly divided into six groups. A Group P1 received 250 mg/kg BW; group P2 received 500 mg/kg BW, group P3 received 1000 mg/kg BW. While group 4 basal received no treatment, group 5 received distilled water as a negative control, and group 6 received glibenclamide as a positive control. Medications are given for six days. Glucose levels were measured, and observation of pancreatic Langerhans cell damages.Results:  A decrease in blood glucose levels observed in all treatment groups. The most significant reduction (49.76%; 1000 mg/kg BW) occurred in the P3 group. Morphological features of pancreatic Langerhans cell damage were slightly high in the P1 group.Conclusion: P. malayana Jack can consider having an antidiabetic effect in a type 1 diabetic rat by reducing blood glucose levels.
Co-Authors A Syamsi Abdul Hadi Hassan, Abdul Hadi Ade Irma Suryani Adrian, Adek Afryandes, Amelya Agustiansyah, Lukidita Ahmad Hidayat Ahmad Syauqy Ahmad Syauqy Al Hadad, Ahmad Masyuri Amdely, Easti Vishiara Anati Purwakanthi, Anati Anggelia Puspasari Arjmand, Reza ATTIYA ISTARINI Ave Olivia Rahman Bethy Suryawati Hernowo Budi Justitia Cantika Dwi Daru Ikhwan Maulana Daud Daud, Daud Dian Andini Ekaputri, Tia Wida Elisma Elisma Enis, Rina N. Erisca Utami Erny Kusdiyah Erwina Kartika Devi Esa Indah Ayu, Esa Indah Fairuz Quzwain Fairuz, Fairuz Fauzan, Randy Febrianto, Heri Fitriyanti Fitriyanti Geniro, Billi Brian Gita Mayani Hanina Hanina, Hanina Hanina, Hanina Hanum Chaira Bahri Aeswarani Hashim, Emilda Hendra Kasmi Herlambang Herlambang Humaryanto Humaryanto Humaryanto Humaryanto, Humaryanto Humaryanto, Humaryanto Husman, Lipinwati Inne Fioren Monica Irawan Anasta Putra, Irawan Anasta Iskandar, Mirna Marhami Ismiyanti, Anissa Juniati, Rianita Kadarsih , Sri Kartika Devi, Erwina Kemal, Amir Kurniawan Kurniawan Kurniawan Lailan Lailan Lestari, Nur Afni Lipinwati ., Lipinwati Lola’ Tulak Rerung M. Arif Musthofa Mahrunnisa Rienti Sepestian Mara Imam Taufiq Siregar Maslaini Masyanto Miftahurrahma Miftahurrahma Miftahurrahma Miftahurrahmah Miftahurrahmah, Miftahurrahmah Miranda, Melly Muharramah, Delvia Mun'amah, Anatun Nisa Munamah , Anatun Nisa Munip, Al Mursalin, Adhywira Musthofa , M Arif Niati Ambarsari Nisak, Sayida Khoiratun Nur Afni Lestari Nuriyah Nuriyah Nuriyah, Nuriyah Nurjali Nurul Safitri Nyimas Natasha Ayu Shafira Oktaviani, Milla Patrick William Gading Periadi, Ardiansyah Pitri, Alisyah Puji astuti, Fuji Lestari Puteri, Vanya Gita Putri Sari Wulandari Putri, Hesti Amelia Quzwain, Fairuz Chatib Quzwain, Suhair Rahayu, Della Putri Raihanah Suzan Ramadhan, Ghozi F. Rina Nofri Enis Rina Nofrienis Rini Kartika Riska Marvelia Romadiani, Inaya Sani K, Fathnur Sapriandi Saputra, Ahmad Edi Sari, Rahayu Mustika Saryanti, Saryanti Siti Fatimah Sukiawati, Indah Sunarti, Zeni Teuku Mahmud Tia Wida Ekaputri Utami, Erisca Ayu Vonna Riasari Wargo Wargo, Wargo Wati, Besse Mirna Wendi Rachman Widyanita Artha Uli Br Simamora Wulandari, Triyana Wulansari, Nadia Yatima, Khusnul Yuliawati Zaenal Abidin Zahra Frizki Asty Zilzikridini Wijayanti Zulfi