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Lubis, Minda Sari
Universitas Muslim Nusantara Al-washliyah
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Toxicity and Antioxidant Activity of Teabags of Mangrove Lenggadai (Bruguiera parviflora) and Stevia (Stevia rbaudiana Bertoni) Leaves Andjelie, Tiara; Lubis, Minda Sari; Nasution, Haris Munandar; Rani, Zulmai
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.52548

Abstract

Introduction: Mangrove plants are known to have a lot of potential as medicine. One of the most commonly found mangroves is the lenggadai mangrove (Bruguiera parviflora).  Utilization of herbal drinks is made to prevent the onset of various diseases. The mixed teabag of mangrove lenggadai leaves and stevia leaves (Stevia rbaudiana bertoni) is named Mangrove Lenggadai Stevia (MLS) teabag. Aims: the purpose of this study is to see which MLS teabag formulation has good antioxidant activity and toxicity activity. Methods: The research conducted was experimental in nature. The data collected are quantitative and qualitative data which are taken from the results of sample collection, physical characteristics of MLS teabag quality, phytochemical screening of simplisia, antioxidant activity test using DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method, toxicity test using Brine Shrimp Lethality Test (BSLT) method on Artemia salina Leach shrimp larvae, stability and hedonic level Result: MLS teabags have characteristics according to the quality requirements of SNI 4324:2014. The results of determining the antioxidant activity of MLS teabags obtained an IC50 value of 13.38 µg/mL. The results of the toxicity test of MLS teabags obtained an LC50 value of 8.74 µg/mL. Conclusion: MLS tea bags have physical quality characteristics that meet the requirements of SNI 4324: 2014 and have the potential as antioxidants and toxicity activity against Artemia salina Leach.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BUAH KERANJI (Dialium indum L.) DALAM KEBOCORAN DNA DAN PROTEIN BAKTERI Escherichia coli Ellyza, Chella; Ningtias, Anggitha; Nasution, Haris Munandar; Lubis, Minda Sari
JURNAL FARMASI, SAINS, dan KESEHATAN Vol. 5 No. 1 (2025): FARMASAINKES: JURNAL FARMASI, SAINS dan KESEHATAN
Publisher : Fakultas Farmasi Universitas Muslim Nusantara Al Washliyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/farmasainkes.v5i1.5022

Abstract

Buah asam keranji (Dialium indum L.) memiliki banyak kegunaan, termasuk sebagai bahan pangan, pakan ternak, dan obat tradisional untuk diare. Buah ini mengandung antioksidan dan nutrisi yang berpotensi sebagai agen antibakteri, terutama terhadap Escherichia coli. Penelitian ini bertujuan mengevaluasi aktivitas antibakteri ekstrak etanol buah keranji dengan mengukur kebocoran DNA dan protein bakteri, yang menunjukkan kerusakan membran sel. Penelitian menggunakan ekstrak etanol buah keranji sebagai variabel bebas, sedangkan variabel terikat meliputi senyawa metabolit sekunder, kadar flavonoid total, gugus fungsi (FTIR), nilai KHM, KBM, dan kebocoran DNA serta protein yang diukur menggunakan spektrofotometer UV-Vis. Hasil menunjukkan ekstrak etanol buah keranji mengandung alkaloid, flavonoid, saponin, tanin, triterpenoid, dan glikosida. Analisis FTIR mendeteksi gugus fungsi seperti O–H, C–H, C=O, C=C, C–O, dan N–H yang mengonfirmasi keberadaan senyawa bioaktif. Kadar flavonoid total sebesar 28,16 ± 1,21 mgQE/g. Ekstrak etanol buah keranji menunjukkan KHM pada konsentrasi 35% dan KBM pada konsentrasi 45%. Zona hambat pada konsentrasi 35%, 40%, 45%, dan 50% berturut-turut sebesar 8,3; 9,0; 10,0; dan 11,8 mm. Absorbansi pada 260 nm (DNA) dan 280 nm (protein) tertinggi pada konsentrasi 50%, yang menandakan adanya kerusakan membran sel bakteri. Kesimpulannya, ekstrak etanol buah keranji efektif menghambat Escherichia coli dengan mekanisme merusak membran sel.
FORMULASI DAN EVALUASI MASKER GEL PEEL-OFF NANOEKSTRAK BONGGOL NANAS (Ananas comosus (L.) Merr) SEBAGAI ANTI-AGING Husna, Miftahul; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani; Zulmai Rani
JURNAL FARMASI, SAINS, dan KESEHATAN Vol. 5 No. 1 (2025): FARMASAINKES: JURNAL FARMASI, SAINS dan KESEHATAN
Publisher : Fakultas Farmasi Universitas Muslim Nusantara Al Washliyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/farmasainkes.v5i1.5080

Abstract

Bonggol nanas mempunyai kandungan flavonoid yang berfungsi sebagai antioksidan, sehingga dapat melindungi kulit dari penuaan dini. Masker gel peel-off mampu meningkatkan kelembapan kulit dan mudah digunakan. Penelitian ini bertujuan untuk mengetahui apakah variasi pengolahan ekstrak dan nanoekstrak bonggol nanas dapat diolah menjadi masker gel peel-off serta untuk mengevaluasi aktivitas anti-aging dari produk tersebut. Jenis penelitian yang dilakukan adalah eksperimental. Dalam studi ini, bonggol nanas diekstraksi menggunakan metode maserasi dan diubah menjadi nanoekstrak, kemudian beberapa pengujian dilakukan, termasuk karakterisasi simplisia, skrining fitokimia pada ekstrak dan nanoekstrak bonggol nanas, pengujian aktivitas antioksidan dengan metode DPPH, serta evaluasi masker gel peel-off yang meliputi uji homogenitas, pH, waktu pengeringan, daya sebar, dan daya lekat. Efektivitas anti-aging diuji menggunakan alat skin analyzer dengan parameter kadar air, elastisitas, dan warna kulit. Hasil dari karakterisasi simplisia bonggol nanas menunjukkan bahwa ia memenuhi kriteria simplisia yang baik. Ekstrak dan nanoekstrak dari bonggol nanas mengandung senyawa metabolit sekunder. Nilai IC50 pada ekstrak bonggol nanas tercatat sebesar 5. 804,72 µg/mL, sedangkan masker gel peel-off dari ekstrak bonggol nanas memiliki warna coklat muda hingga coklat pucat, aroma khas, homogen, pH stabil, dengan waktu pengeringan 15-30 menit dan daya sebar 5-6 cm. Hasil uji aktivitas antioksidan dari sediaan menunjukkan nilai IC50 masing-masing yaitu (F0) 171,4434 µg/mL, (F1) 137,7746 µg/mL, (F2) 155,1636 µg/mL, dan (F3) 146,9484 µg/mL, dengan hasil terbaik diperoleh dari F3. Pengujian statistik dengan One Way Anova menunjukkan hasil yang signifikan.
ISOLASI HEMISELULOSA DARI TANDAN KOSONG KELAPA SAWIT (Elaeis guineensis Jacq.) SEBAGAI EMULGATOR DALAM SEDIAAN EMULSI MINYAK IKAN Syafirna, Nada; Dikki Miswanda; Lubis, Minda Sari; Yuniarti, Rafita
JURNAL FARMASI, SAINS, dan KESEHATAN Vol. 5 No. 1 (2025): FARMASAINKES: JURNAL FARMASI, SAINS dan KESEHATAN
Publisher : Fakultas Farmasi Universitas Muslim Nusantara Al Washliyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/farmasainkes.v5i1.5192

Abstract

Tandan kosong kelapa sawit (TKKS) merupakan limbah padat yang dihasilkan dari industri pengolahan kelapa sawit. Diketahui TKKS mengandung hemiselulosa yang dapat dimanfaatkan dalam bidang farmasi. Tujuan penelitian ini untuk mengisolasi hemiselulosa dari TKKS dan memformulasikan sebagai emulgator pada sediaan emulsi minyak ikan. Penelitian ini dilakukan dengan metode eksperimental dengan tahapan meliputi isolasi hemiselulosa TKKS dengan menggunakan metode ekstraksi alkali dengan NaOH 0,05N, 0,1N, 0,2N, 0,3N, 0,5N, kemudian karakterisasi hemiselulosa meliputi uji organoleptis, uji kelarutan, uji FTIR (Fourier Transform Infra Red) dan uji SEM (Scanning Elektron Microscope). Hemiselulosa yang telah diperoleh digunakan sebagai emulgator dalam sediaan emulsi, kemudian dilakukan uji evaluasi sediaan seperti uji organoleptis, uji homogenitas, uji pH, uji tipe emulsi, uji redispersi, dan uji viskositas. Hasil dari isolasi hemiselulosa TKKS mendapatkan hasil terbaik pada konsentrasi NaOH 0,5N menghasilkan randemen 12,84%. Hasil formula sediaan emulsi kombinasi hemiselulosa yang terbaik adalah F5 dengan perbandingan gom arab : hemiselulosa (2:1). Sediaan emulsi homogen, hasil uji pH formula F1 dan F5 memenuhi syarat pH emulsi oral pada rentang 5-7,5. Hasil uji tipe emulsi yaitu A/M, hasil uji viskositas F1, F3, F4, F5 sudah memenuhi syarat sesuai SNI yaitu 2000-50.000 cPs. Hemiselulosa TKKS dapat menjadi emulgator pada emulsi minyak ikan pada formula kombinasi.
Liquid Soap with Pineapple Hump Extract and Nanoformulation Against Staphylococcus aureus Lubis, Minda Sari; Fauzi, Ziza Putri Aisyia; Dewi, Sri Harti; Rani, Zulmai; Yuniarti, Rafita
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403348

Abstract

Staphylococcus aureus is a Gram-positive bacterium that frequently causes skin infections and can become resistant to various antibiotics. Pineapple (Ananas comosus) waste, particularly the hump, contains active compounds such as bromelain, saponins, and flavonoids with known antibacterial properties. This study aimed to determine the antibacterial potential of liquid soap formulated with extract and nanoextract of pineapple hump against S. aureus. The pineapple hump was extracted using maceration with 96% ethanol, followed by nanoparticle formulation using a high-speed homogenization method. Liquid soap was made with three formulas, one formula contains a concentration of 12.5% extract and two formulas contain 1.25% nanoextract of pineapple hump. Antibacterial activity was evaluated using the disc diffusion method, and the diameter of the inhibition zones was measured. Results showed that all tested concentrations produced antibacterial activity, with the 12.5% concentration (Formula 1) exhibiting the highest inhibition zone (23.2 mm), followed by 1.25% nanoextract nano liquid soap (18.41 mm) (Formula 3) and 1.25% nanoextract liquid soap (14.53 mm) (Formula 2). The positive control (Dettol Handwash) produced a larger inhibition zone (20.08 mm). Data analysis using one-way ANOVA revealed significant differences for each formula, with a p-value of less than 0.05. These findings indicate that nanoextract of pineapple hump formulated in liquid soap has potential as a natural antibacterial agent against S. aureus.
Penetapan Kadar Nikotin Tembakau Gayo (Nicotiana tabacum L) Menggunakan Metode Titrasi Asidimetri dan GC-MS. Rezky , Deswita Ina; Supiyani, Supiyani; Daulay, Anny Sartika; Lubis , Minda Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.909

Abstract

Background: Gayo tobacco (Nicotiana tabacum L.) is known for its distinctive quality and is highly sought after, particularly among young adults. This tobacco contains nicotine, a compound that plays a significant role in influencing human behavior, acting both as a stimulant and as a raw material for cigarette production. Understanding the nicotine content in Gayo tobacco is crucial for assessing its potential industrial applications and its impact on health. Objective: This study aimed to determine the nicotine content in Gayo tobacco leaves and analyze it using acidimetric titration and GC-MS methods to obtain more accurate results. Methods: This research employed two analytical methods: acidimetric titration for quantitative nicotine determination and Gas Chromatography-Mass Spectrometry (GC-MS) for qualitative analysis of other chemical compounds in the Gayo tobacco leaf extract. The tobacco leaf samples were obtained from the Gayo region of Aceh and extracted using 96% ethanol. Results: The study revealed that the nicotine content in Gayo tobacco leaves was 1,3% based on acidimetric titration, while the ethanol extract showed a higher nicotine concentration of 2.5%. GC-MS analysis identified various other compounds, including piperidine derivatives, terpenoids, and aromatic compounds, which have potential pharmaceutical and industrial applications. Conclusion: This study successfully determined the nicotine content in Gayo tobacco leaves using acidimetric titration and GC-MS. The findings provide a comprehensive overview of the chemical composition of Gayo tobacco, serving as a foundation for further research into its applications in pharmaceuticals and other industries.
Formulasi Dan Karakteristik Fisik Deodorant Stick Dari Ekstrak Etanol Daun Beluntas (Pluchea indica (L.) Less.) Hutagalung, Riris Br; Yuniarti, Rafita; Nasution, Haris Munandar; Lubis, Minda Sari
Journal of Health and Medical Science Volume 4 Nomor 3 Juli 2025
Publisher : CV. Pusdikra Mitra Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/jhms.v4i3.2818

Abstract

Indonesia merupakan negara tropis yang memiliki suhu udara rata-rata yaitu ± 22-32°C yang menyebabkan tubuh berkeringat memicu bau badan yang menggangu. Deodorant sintetis berbahan aluminium dan Paraben kerap dihubungkan dengan iritasi bahkan risiko kanker payudara, sehingga diperlukan alternatif berbahan alam. Daun beluntas (Pluchea indica (L.) Less.) ,kaya flavonoid, dipilih sebagai kandidat senyawa aktif. Penelitian ini bertujuan memformulasikan dan mengetahui karakteristik fisik deodorant stick dari ekstrak etanol daun beluntas (Pluchea indica (L.) Less.) Penelitian eksperimental dimulai dengan pengumpulan, identifikasi, simplisia daun beluntas, serta diikuti ekstraksi,secara maserasi, menggunakan etanol 96% selama lima hari. Ekstrak kental kemudian dimasukkan kedalam empat formula deodorant stick: FO (0%),F1 (1%),F2 (2%), dan F3 (3%). Basis padat terdiri atas Cera Alba, vaselin album, cetyl alcohol, propilen glikol, dan oleum citri. Evaluasi mutu fisik meliputi uji organoleptis, homogenitas, pH, titik lebur, waktu leleh, serta uji iritasi metode open- test pada enam sukarelawan. Hasil uji sediaan deodorant berbentuk padat, berwarna hijau muda sampai hijau tua, mempunyai aroma yang khas, homogen, mempunyai pH kurang lebih 6,3-64 ,titik lebur kurang lebih 67,3-67,8°C, waktu leleh 23-25 menit serta aman digunakan karena tidak menyebabkan iritasi. Dengan demikian, sediaan deodorant stick ekstrak etanol daun beluntas telah memenuhi syarat karakteristik mutu fisik dan dinyatakan aman digunakan sebagai deodorant berbahan alam.
PHENOLIC, FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY WITH SUN PROTECTION FACTOR VALUE OF RED BETEL LEAF ETHANOL EXTRACT (Piper ornatum N. E. Br) Yuniarti, Rafita; Rani, Zulmai; Ridwanto, Ridwanto; Lubis, Minda Sari
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 2 (2025): September
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i2.3149

Abstract

Red betel leaf is a plant that is rich in benefits, one of which is as an antioxidant. The benefits as an antioxidant in plants are due to the content of phenolic and flavonoid compounds. Phenolic compounds also function as protection against UV-B rays, this ability can be seen from the SPF value. The purpose of this study was to determine the amount of phenolic and flavonoid compounds and the antioxidant and sunscreen activity of ethanol extract from red betel leaves. Phenolic content was determined using 10% Follin Ciocalteu reagent and 20% Na2CO3. In contrast, flavonoid content used AlCl3 and CH3COONa solutions, and the determination of antioxidant activity was carried out using DPPH. In contrast, the ability a protect against sunlight (sunscreen) was carried out by determining the sun protection factor (SPF) value. After measurements were carried out using a UV-visible spectrophotometer, the results obtained were a phenolic content of 257.56 mg GAE/g and flavonoids of 46.8008 mg QE/g. They had a very strong antioxidant activity with an IC50 value of 38.9338 ppm and had sunscreen activity with an SPF value of 5, 17, 28, 36, and 38 at concentrations of 100, 300, 500, 700, and 1000 ppm respectively.
Formulasi dan Evaluasi Mutu Fisik Serta Uji Aktivitas Antiinflamasi Sediaan Balsem Stik Ekstrak Etanol Daun Bakung (Crinum asiaticum L.) Ramadhan , Yusril; Yuniarti , Rafita; Lubis , Minda Sari; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.892

Abstract

Background: Spider lily leaves (Crinum asiaticum L.) contain bioactive compounds, such as flavonoids, which are known for their anti-inflammatory properties. Developing a convenient topical formulation like a stick balm could provide an effective and practical alternative for treating inflammation. Objective: This study aimed to formulate a stick balm containing ethanol extract of spider lily leaves (EESL) and evaluate its physical quality and anti-inflammatory activity. Methods: The extract was obtained by macerating the leaves in 96% ethanol. Stick balm formulations were prepared with varying concentrations of EESL: F0 (base), F1 (1%), F2 (3%), and F3 (5%). The physical quality of the formulations (homogeneity, pH, spreadability, melting point) was evaluated. Anti-inflammatory activity was tested on 24 male white rats induced with carrageenan. The rats were divided into six groups: negative control (induced only), positive control (commercial Geliga balm), F0, F1, F2, and F3. Paw edema volume was measured every hour for 6 hours. Results: All stick balm formulations met the physical quality standards. The anti-inflammatory test showed that the F3 formulation (5% EESL) exhibited the highest activity, with an edema reduction of 0.007 mm, which was equivalent to the positive control group (0.007 mm). The anti-inflammatory effect was concentration-dependent, with lower efficacy observed in the F2 and F1 groups. Conclusion: The ethanol extract of Crinum asiaticum L. leaves can be successfully formulated into a stable stick balm. The 5% EESL stick balm demonstrated significant anti-inflammatory activity that was comparable to a commercial product, making it a promising natural alternative for topical anti-inflammatory therapy.
Uji Aktivitas Antibakteri Sediaan Mouthwash Dari Ekstrak Daun Peppermint ( Mentha piperita L.) dan Daun Jarak Cina ( Jatropha multifida L.) Terhadap Streptococcus mutans Putri , Adilla; Nasution, Muhammad Amin; Lubis , Minda Sari; Nasution, Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.917

Abstract

Background: Mouthwash is a liquid preparation that plays an important role in maintaining oral health. An ideal formulation should possess antibacterial effectiveness, physicochemical stability, and acceptable organoleptic properties. Streptococcus mutans is the primary pathogenic bacterium responsible for halitosis and dental caries. Peppermint (Mentha piperita L.) and physic nut (Jatropha multifida L.) leaves are known to contain bioactive compounds such as flavonoids, saponins, and tannins, which have potential antibacterial activity. Objective: This study aimed to formulate peppermint and physic nut leaf extracts into a stable mouthwash preparation and evaluate its antibacterial activity against Streptococcus mutans. Methods: The extracts were prepared using maceration with ethanol as a solvent. The mouthwash formulations were developed with three variations of extract concentrations (2%, 2.5%, and 3%). The preparations were then evaluated for their physical stability (organoleptic properties and pH) and tested for antibacterial activity against S. mutans using the Kirby-Bauer disc diffusion method. Inhibition zone data were statistically analyzed using ANOVA and Duncan’s test. Results: Physicochemical evaluation showed that all formulations remained stable over 28 days of observation, with a pH of 6, which is compatible with the oral cavity. Antibacterial testing demonstrated an increase in inhibition zone diameter with higher extract concentrations: 10.33 mm (2%), 11.1 mm (2.5%), and 11.9 mm (3%). These results were comparable to the positive control, Betadine gargle (11.95 mm). The negative control showed no inhibition zone. Statistical analysis revealed significant differences (p < 0.05) among the concentrations. Conclusion: The combination mouthwash containing peppermint and physic nut leaf extracts at a concentration of 3% was found to be the most stable formulation and exhibited the strongest antibacterial activity, comparable to the commercial reference product. Thus, this combination extract has potential to be developed as a natural antibacterial agent for oral health.
Co-Authors A'dilah, Nur Adani, Bazlina Adela Octi Dwiyani Adjelie, Tiara Afifah, Puan Ibni Alfi Wahyudi Nasution Alma Dhita Shafira Amaliana, Amaliana Andjelie, Tiara Anggraini, Dea Puspa Anny Sartika Daulay Anugrah, Bayu Ariandi Arianti, Sellin Arina Aulia Fitri, Aulia Aulia, Meisyah Ayuningrum, Annisa Bambang Hermanto Chairina Milda Cindy Marlina Tambunan Cut Dian Mala Luthfia D Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D.Elysa Putri Mambang Debi Meilani Dena, Mutia Denni Bahari Dewa, Fasca Dewi, Sri Harti Dikki Miswanda Dinda Sari Utami Efendi, Tania Tiara Ellyza, Chella Emmy Wiriandini Fauziah Zain Fithri Pulungan, Ainil Fitri Febriani Fitri, Nurul Fitri, Raissa Gabena Indrayani Dalimunthe Haris Munandar Nasution Hasibuan , Fika Miah Sasmitha Hendraputra, Hardy Handoko Heru Adha Prayogo Husna, Miftahul Hutagalung , Septi Ratna Cempaka Hutagalung, Riris Br Ika Fitriani Indah Nasution Inna Myesha Junia Fitri Hayani Juwita, Sukma Karismawati Karlina Butar Butar Khoyrill Muttiin Kiki Rawitri Krisna Juniharta Napitupulu Lestari, Seri Lestari, Sri Indah Linda, Rosa Lisda Mayanti Lubis, Nadya Frestika Lubis, Nurazizah Lubis, Zulkifli Ismail M. Arya Wiguna Madani Sirait maghfirah, Suci Mambang, D Elysa Putri Matondang , Fikriyah Hafni Maulana Putri, Yasinta Meutia, Cut Meylisa Pratami Br Sinaga Miftahul Jannah Milwani Harahap Miranza, Nona Misna Rosalinda Hutabarat Mohd. Bilal Muhammad Amin Nasution Muhammad Tegar Tri Rizky Nadia Salsabilla Nasution , Muhammad Amin Nasution, M Pandapotan Nasution, M. Pandapotan Nasution, Vevi Sarah Nia Novranda Pertiwi Ningtias, Anggitha Novi Yuliandari Novita Sari, Helsa Novriani Putri Santia Nur Asia, Nur Nuratika, Eli Nurfadilla, Kiki Nurul Salsa Abya Ritonga Nurwijayanti Pulungan, Anili Fithri Purba , Intan Sabila Putri Purba, Juvantri Fablo Puteri, Cut Intan Annisa Putri , Adilla Rafita Yuliarti Rafita Yuniarti Rafita Yuniarti Rafita Yuniarti Rahma Maulidia Fitri Rahmi, Sofia Ramadhan , Yusril Rambe, Sitiapsah Rapita Yuniarti Rati , Yuliandini Rati Satri Situmorang Rezky , Deswita Ina Riani, Nur Aslin Ridwan Taher Lubis Ridwanto Ridwanto Ritonga , Nur Sakina Ritonga , Septi Ani Ritonga, Oktavia Rohmah, Roihanah Rosalinda Mahdalena Sinaga Rosalinda Mahdalena Sinaga Safitri , Nurhaliza Sagita Marina Simatupang Sandika, M Teguh Sari, Syilvi Rinda Savika, Anggraini Selvicahyani, Selvicahyani Shinta Mida Ariani Harahap Sihotang, Laura Indah Restu silalahi, zahra salsabila Sinaga, Rosalinda Mahdalena Sindi, Sindi Siregar , Misbah Siregar , Runisya Maugin Utami Siregar, Hikmatussabaria Siregar, Rina Paramitha Siti Aisyah Jamil Siti Anisa Sitinjak, Iyustri Ririn Slamet Indarjo Sri Harti Sri Mulia Ningsih Siregar Sri Murni Sri Ria Ranti Sri Wahyuni Sulwiyatul K Sani Supiyani, Supiyani Surendro, Yasmeen Nazhifah Amani Syafa Nadira Ashiilah Syafira, Nona Syafirna, Nada Tia Nazilla Titin Agustina Trisha Wulan Erja Ummu Safura Sirait Vera Kristiana Wan Dian Safina Widya, Rizka Wilda Septia Winda Aulia Yadi, Hervi Yayuk Putri Rahayu Yayuk Putri Rahayu Yayuk Yuliana Yuni Sartika Yuniarti , Rafita Yuniarti, Rafita Yuniarti, Rapita Zahara, Fitria Siti Zahira Ahmad, Madani Zannah , Muhamad Ziza Putri Aisyia Fauzi Zulhij, Fizrya Zulmai Rani