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FORMULATION AND PHYSICAL QUALITY TESTS HAIR FERTILIZER PREPARATIONS FROM LEMONGRASS (Chrysopogon zizanioides L.) AND VCO (VIRGIN COCONUT OIL) Junia Fitri Hayani; Gabena Indrayani Dalimunthe; Minda Sari Lubis; Rapita Yuniarti
FORTE JOURNAL Vol 4 No 1 (2024): Edisi Januari 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v4i1.789

Abstract

Hair loss is the shedding of hair from the skin. The factor that causes hair loss is a lack of nutrition for hair growth. Pure coconut oil (VCO) and citronella oil contain saturated fatty acids with short and medium chains of carbon atoms, especially octanoic acid and decanoic acid and essential oils which can be used to nourish hair. The aim of this research is to determine the effectiveness of the combination of citronella oil and VCO oil as a hair-fertilizing oil. This research was carried out using experimental methods including collecting and identifying samples, evaluating oil preparations, then testing hair-fertilizing oil preparations on 3 rabbits which were divided into 6 groups, namely positive control, negative control, formula 1, formula 2, formula 3 and formula 4. Data on the percentage of hair growth length were analyzed using the ANOVA (Analysis of Variance) method using the SPSS (Statistical Program for the Social Sciences) program. The results of the preparation evaluation showed that the oil preparation was stable during storage. The results showed that hair growth on day 28 with the positive control was 8.3 mm, negative control 4.17 mm, F1 4.83 mm, F2 5.17 mm, F3 6.33 mm and F4 7.83 mm. Duncan's test on day 28 showed that the positive control was not significantly different from formula 4, but was significantly different from formula 1, formula 2 and formula 3.
Foot Gel Mask from Aloe Vera Leaf Flesh (Aloe vera (L.) Burm.f.): Formulation and Evaluation Nurfadilla, Kiki; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani; Yuniarti, Rafita
Indonesian Journal of Science and Pharmacy Vol. 2 No. 2 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i2.81

Abstract

Formulation and evaluation of a gel foot mask preparation from aloe vera leaf flesh (Aloe vera (L.) Burm.f.) have been carried out. The secondary metabolite content of aloe vera leaf flesh was identified through phytochemical screening. The formulation of the gel foot mask was carried out by varying the concentration of aloe vera leaf flesh by 2.5%, 5%, and 10%. Evaluation of the physical quality of the gel mask preparation included organoleptic, homogeneity, pH of the preparation, spreadability, adhesiveness, drying time of the preparation, viscosity, and exfoliation test. The results of phytochemical screening showed that aloe vera leaf flesh contains flavonoids, glycosides, tannins, saponins, and steroids. Evaluation of physical quality showed that the gel mask has characteristics and meets the standards of a good gel mask preparation. The exfoliation test of the gel mask showed a good effect on the skin, namely increased skin moisture and good skin elasticity after using a gel foot mask from aloe vera leaf flesh with an effective increase in the 10% formulation. The higher the concentration of the preparation, the better the exfoliator effectiveness.
Translucent Solid Soap Preparation from Turmeric Rhizome Juice (Curcuma domestica Val.): Formulation and Physical Characterization Aulia, Meisyah; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani; Yuniarti, Rafita
Indonesian Journal of Science and Pharmacy Vol. 2 No. 2 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i2.82

Abstract

The formulation and physical characterization of translucent solid soap preparations from turmeric rhizome juice (Curcuma domestica Val.) have been carried out. The manufacture of translucent soap was carried out by varying the concentration of turmeric rhizome juice from 0%, 2%, 4%, and 6% into the soap formula. The multi-physical tests of translucent soap preparations included organoleptic tests, pH tests, water content tests, foam stability height tests, irritation tests and preference tests. The obtained turmeric rhizome squeezed translucent soap had good characteristics and met the requirements as translucent soap because it had good hardness, appropriate water content, pH between 9-11, and good foam stability. The results of the skin irritation test of soap preparations of all concentration variations did not find any side effects in the form of redness, itching and roughness on the volunteer's skin so that all soap preparations with various comparisons were safe to use. The results of the preference test which included color, translucency, texture and aroma showed that on average the panelists liked the soap preparation with a turmeric rhizome juice concentration of 2%.
Pembuatan Permen Sehat Ginger Candy dengan Penambahan Pewarna Alami untuk Meningkatkan Imunitas Tubuh Rani, Zulmai; Dalimunthe, Gabena Indrayani; Nasution, Haris Munandar; Yuniarti, Rafita; Lubis, Minda Sari; Utami, Dinda Sari; Fitri, Raissa; Fitri, Aulia; Miswanda, Dikki; Sani, Sulwiyatul Kamariyah
Jurnal Bakti Nusantara Vol. 2 No. 2 (2024): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jbn.v2i2.77

Abstract

Telah dilaksanakan pengadian kepada masyarakat Desa Kolam, Kecamatan Percut Sei Tuan, Deli Serdang Sumatera Utara berupa pelatihan pembuatan permen sehat ginger candy dengan penambahan pewarna alami untuk meningkatkan imunitas tubuh. Metode yang digunakan dalam kegiatan ini adalah penerapan teknologi tepat guna dalam membuat permen sehat. Evaluasi kegiatan pengabdian yang dilakukan dengan memberikan tes awal dan tes akhir menunjukkan kegiatan pembuatan permen sehat ginger candy dengan penambahan pewarna alami pandan di Desa Kolam telah berhasil dilakukan yang dibuktikan dengan terjadinya peningkatan pemahaman peserta kegiatan. Peningkatan pemahaman peserta dapat dilihat dari nilai tes kuisioner. Rata-rata terjadi peningkatan sebesar 75% dari rata-rata nilai tes awal sebesar 4,60 menjadi 7,96 pada tes akhir. Dari Tabel 1 diketahui beberapa peserta kegiatan meningkat hingga 100% pemahamannya setelah diberikan pelatihan. Dengan demikian kegiatan pengabdian telah efektif meningkatkan pemahaman masyarakat mitra dalam memanfaatkan jahe dan pandan menjadi permen sehat yang dapat meningkatkan imunitas tubuh.
ANALISIS PENGGUNAAN OBAT KEMOTERAPI KANKER PARU-PARU DI RSUD DR. PIRNGADI KOTA MEDAN Nasution, Vevi Sarah; Sri Wahyuni; Dalimunthe, Gabena Indrayani; Lubis, Minda Sari
FARMASAINKES: JURNAL FARMASI, SAINS, dan KESEHATAN Vol. 4 No. 2 (2025): FARMASAINKES: JURNAL FARMASI, SAINS dan KESEHATAN
Publisher : Fakultas Farmasi Universitas Muslim Nusantara Al Washliyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/farmasainkes.v4i2.3708

Abstract

Kanker paru-paru terjadi karena pertumbuhan sel kanker yang tidak terkendali dalam jaringan paru. Di indonesia kanker paru menduduki urutan ketiga dengan jumlah kejadian 34.783 kasus. Kemoterapi merupakan pengobatan anti kanker yang dapat menghancurkan sel tumor dengan cara mengganggu fungsi sel. Pengobatan kemoterapi pada pasien kanker paru beragam dilakukan berdasarkan stadiumnya, yaitu dengan pembedahan, radioterapi dan kemoterapi, sesuai dengan standar dari National Comprehensive Cancer Network (NCCN), Food and drug Administration (FDA), European Medicines Agency (EMA) dan European Society for Medical Oncology (ESMO). Kemoterapi ini diberikan dalam beberapa tahap biasanya 4-6 siklus dan bahkan ada yang seumur hidup. Pemberian kemoterapi ini dengan setiap 21 hari agar mendapatkan efek yang diharapkan dengan efek samping yang masih wajar dan dapat diterima. Penelitian ini merupakan penelitian deskriptif yang dilakukan dengan pendekatan cross section secara retrospektif. Pengumpulan obat pasien kanker paru-paru diambil dari rekam medis pasien periode bulan Januari-Desember 2023. Sampel pada penelitian ini terdiri dari 42 pasien yang memenuhi kriteria inklusi. Hasil penelitian menunjukkan bahwa obat yang digunakan oleh 42 pasien kanker paru-paru di RSUD Dr. Pirngadi Kota Medan periode Januari-Desember 2023 adalah vinorelbine 52 obat (32,7%), karboblatin 43 obat (27%), gefitinib 25 obat (15,7%), paclitaxel 12 obat (7,5%), cisplatin 7 obat (4,4%), docetaxel 7 obat (4,4%), pemetrexed 7 obat (4,4%), giotrif 6 obat (3,8%). Dapat disimpulkan bahwa obat paling banyak digunakan oleh pasien kanker paru-paru di RSUD Dr. Pirngadi Kota Medan adalah vinorelbine dan karboplatin. Kata Kunci: Kanker paru-paru, kemoterapi, obat kemoterapi, pengobatan kanker paru-paru.
FORMULASI DAN UJI AKTIVITAS DEODORANT STICK EKSTRAK ETANOL DAUN SIRIH MERAH (Piper ornantum N.E.BR ) TERHADAP BAKTERI staphylococcus epidermidis Fitri, Nurul; Rani, Zulmai; Lubis, Minda Sari; Nasution, Haris Munandar
FARMASAINKES: JURNAL FARMASI, SAINS, dan KESEHATAN Vol. 4 No. 2 (2025): FARMASAINKES: JURNAL FARMASI, SAINS dan KESEHATAN
Publisher : Fakultas Farmasi Universitas Muslim Nusantara Al Washliyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/farmasainkes.v4i2.4163

Abstract

Red betel leaf (Piper ornatum N.E.Br) is one of several plants that have antibacterial properties so that it can be selected as an active ingredient in deodorants because of its effectiveness as an antibacterial. Red betel leaf contains secondary metabolites, namely alkaloids, flavonoids, tannins and essential oils. The purpose of this study was to determine the formulation of ethanol extract of red betel leaf (Piper ornatum N.E.Br) made in the form of a deodorant stick preparation with good characteristics and to determine the concentration of the deodorant stick preparation in inhibiting Staphylococcus epidermidis bacteria. The study was conducted experimentally including the manufacture of extracts by the maceration method. In this study, ethanol extract of red betel leaf with concentration variations of 1, 2 and 3%. The preparation was tested for organoleptic, homogeneity, pH, melting time, melting point, and antibacterial activity. The content of the phytochemical screening results of the ethanol extract of red betel leaf showed that there were flavonoids, alkaloids, tannins, saponins, and triterpenoids so that they have the potential to inhibit bacteria. The resulting deodorant stick meets the requirements of pH test, melting time test, melting point test and has bacterial inhibitory activity. At a concentration of 1% it is categorized as moderate with an inhibition zone of 6-10 while for a concentration of 2% and 3% it is categorized as strong with an inhibition zone of 10-20 mm.
FORMULASI, EVALUASI, DAN AKTIVITAS ANTIBAKTERI SABUN PADAT NANOEKSTRAK BONGGOL NANAS (Ananas comosus (L.) Merr) TERHADAP Staphylococcus aureus Widya, Rizka; Lubis, Minda Sari; Zulmai Rani; Nasution, Haris Munandar
FARMASAINKES: JURNAL FARMASI, SAINS, dan KESEHATAN Vol. 4 No. 2 (2025): FARMASAINKES: JURNAL FARMASI, SAINS dan KESEHATAN
Publisher : Fakultas Farmasi Universitas Muslim Nusantara Al Washliyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/farmasainkes.v4i2.4164

Abstract

Nanopartikel merupakan salah satu hasil dari teknologi nano yang berkembang pesat. Sabun dapat digunakan untuk mengatasi penyakit, seperti penyakit kulit yang disebabkan oleh bakteri dan jamur. Tujuan dari penelitian ini adalah untuk memutus ikatan protein pada bakteri sehingga dapat menghambat pertumbuhan dan aktivitas antibakteri sediaan sabun padat terhadap Staphylococcus aureus. Penelitian ini menggunakan rancangan True Experimental Design. Tahapan penelitian meliputi pembuatan ekstrak, pembuatan nano ekstrak, skrining fitokimia, pembuatan sabun padat, dan evaluasi mutu fisik sabun padat yang terdiri dari uji organoleptik, uji pH, uji stabilitas, uji kekerasan, dan uji daya bersih. Serta uji aktivitas antibakteri sabun padat terhadap Staphylococcus aureus dengan masing-masing konsentrasi yaitu F1 (Blanko), F2 (1,25%), dan F3 (12,5%). Hasil penelitian menunjukkan bahwa ekstrak mahkota nanas mengandung senyawa kimia berupa alkaloid, flavonoid, tanin, saponin, steroid, dan glikosida. Hasil pengujian ukuran partikel menunjukkan bahwa nano ekstrak memiliki ukuran 76 nm. Aktivitas antibakteri sabun padat terhadap Staphylococcus aureus menunjukkan bahwa pada konsentrasi F1 memiliki efektivitas yang kuat dengan diameter zona hambat sebesar 13,61 mm; pada konsentrasi F2 juga menunjukkan efektivitas yang kuat dengan diameter zona hambat sebesar 16,46 mm; dan pada konsentrasi F3 menunjukkan efektivitas yang kuat dengan diameter zona hambat sebesar 19,38 mm dalam menghambat pertumbuhan Staphylococcus aureus. Kata kunci: Nano ekstrak, Mahkota Nanas, Antibakteri, Sabun Padat
PENENTUAN NILAI SPF (Sun Protection Factor) SEDIAAN LOTION EKSTRAK ETANOL KULIT ALPUKAT (Persea americana Mill.) DENGAN METODE SPEKTROFOTOMETRI UV Sri Murni; Rafita Yuniarti; Minda Sari Lubis; Anny Sartika Daulay
Jurnal Kesehatan Vol. 3 No. 2 (2025): Februari
Publisher : CV. ADIBA AISHA AMIRA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tabir surya merupakan sediaan kosmetika yang digunakan untuk melindungi kulit dari paparan sinar matahari, sehingga mencegah terjadinya gangguan kulit karena terpapar sinar matahari. Tujuan untuk mengetahui mutu simplisia, metabolit sekunder, ekstrak etanol kulit alpukat, karektristis sedian lotion serta aktifitas tabir suraya ekstrak kulit alpukat dan lotion ekstrak etanol kuliat alpukat melalu pemantaun mutu nilai SPF. Metode yang digunakan pada penelitian ini metode eksperimental. Pada ekstrak etanol kulit alpukat dan lotion ekstrak etanol ditentukan nilai SPF dengan spektrofotometri UV. Yang diukur pada panjang gelombang 290-390nm dengan interval 5 nm evaluasi mutu fisik dilakukan terhadap uji organoleptis, homogenitas, pH, viskositas, daya sebar dan daya lekat. Hasil penelitian menunjukkan bahwa simplisia kulit alpukat memiliki kadar air 4,7%kadar sari larut dalam air 25,5% kadar sari larut dalam etanol 22,6 % kadar abu total 3,55%, kadar abu tidak larut asam 0,5 % secara keseluruhan memenuhi standar MMI, dengan kandungan senyawa kimia berupa golongan flavonoid, saponin, dan triterpenoid. Uji SPF sediaan lotion ekstrak etanol kulit alpukat dibuat pada konsentrasi 0,3%; 0,36%; 0,48% dengan hasil berturut-turut 9,974; 9,934; 18,8. Organoleptis sediaan lotion secara keseluruhan memiliki bentuk kental dengan warna kecoklatan serta aroma mawar, pH homogen 6, viskositas lotion 1000ppm: 7740Cp; 3000ppm: 2310Cp; 4000ppm: 5890Cp; 5000ppm: 8770 daya sebar lotion dari konsentrasi 3000ppm: 4cm; 4000ppm: 6cm; 5000ppm: 7cm, daya lekat lotion dari konsentrasi 3000ppm: 4,12 dtk; 4000pm: 4,39 dtk; 5000ppm: 4,48 dtk.
Skrining Fitokimia, Formulasi, dan Karakteristik Fisik Sediaan Soothing Gel Daging Daun Lidah Buaya (Aloe vera (L.) Burm.f.) Sinaga, Rosalinda Mahdalena; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani; Rahayu, Yayuk Putri
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p81-88

Abstract

Aloe vera (Aloe vera (L.) Burm.f.) can make the skin not dry quickly and feel moisturised. Soothing gel works effectively to restore skin moisture, provide comfort and a cooling effect on red and irritated skin so that the skin condition returns to normal, and prevents skin dryness. The aim of the study was to determine the various secondary metabolites in aloe vera leaf extract to determine differences in concentrations of aloe vera leaf extract in soothing gel preparations on the physical characteristics of the preparations and to determine physical changes before and after stability tests were carried out using the cycling test method. The research method was used experimental, with the independent variables varying the concentration of aloe vera leaf extract 0% (blank), 1%, 2%, and 3%, the dependent variable secondary metabolites and physical characteristics. The sample preparation method is wet sorting and other methods used are phytochemical screening, viscometry, and cycling tests. The results of the phytochemical screening showed that aloe vera leaf extract contains secondary metabolites of flavonoids, glycosides, tannins, saponins, and steroids.
Formulasi Sabun Transparan Sari Wortel (Daucus carota L.) Sebagai Pelembab Kulit Miranza, Nona; Yuniarti, Rafita; Lubis , Minda Sari; Daulay, Anny Sartika
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.834

Abstract

Transparent soap is a type of soap that appears clear and attractive, with a finer foam. Carrots are one of the plants that contain compounds that can naturally moisturize the skin. The chemical compounds in carrots that can be used as skin moisturizers are present in high amounts. The aim of this study is to formulate transparent soap using carrot Juice as a skin moisturizer. The transparent soap formulation was made using carrot Juice at concentrations of 4%, 6%, and 8%. The evaluation of the transparent soap formulation included organoleptic testing, moisture content testing, foam height testing, pH testing, irritation testing, and hedonic testing. The results showed that the 8% concentration had the highest moisture content, at 14.45%. The highest foam height measurement was also observed at the 8% concentration, with an average of 8.3. The highest pH level was recorded at 8% concentration, with a value of 9.34. Skin analyzer testing indicated that the highest skin moisture level was achieved at 8% concentration, reaching 48%. The transparent carrot Juice soap met the standards set by the Indonesian National Standard (SNI) in terms of organoleptic properties, moisture content, foam height, pH, skin analyzer results, irritation testing, and hedonic testing. The conclusion of this study is that carrot Juice can be formulated into transparent soap that meets SNI requirements.
Co-Authors A'dilah, Nur Adani, Bazlina Adela Octi Dwiyani Adjelie, Tiara Afifah, Puan Ibni Alfi Wahyudi Nasution Alma Dhita Shafira Amaliana, Amaliana Andjelie, Tiara Anggraini, Dea Puspa Anny Sartika Daulay Anugrah, Bayu Ariandi Arianti, Sellin Arina Aulia Fitri, Aulia Aulia, Meisyah Ayuningrum, Annisa Bambang Hermanto Chairina Milda Cindy Marlina Tambunan Cut Dian Mala Luthfia D Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D.Elysa Putri Mambang Debi Meilani Dena, Mutia Denni Bahari Dewa, Fasca Dewi, Sri Harti Dikki Miswanda Dinda Sari Utami Efendi, Tania Tiara Ellyza, Chella Emmy Wiriandini Fauziah Zain Fithri Pulungan, Ainil Fitri Febriani Fitri, Nurul Fitri, Raissa Gabena Indrayani Dalimunthe Haris Munandar Nasution Hasibuan , Fika Miah Sasmitha Hendraputra, Hardy Handoko Heru Adha Prayogo Husna, Miftahul Hutagalung , Septi Ratna Cempaka Hutagalung, Riris Br Ika Fitriani Indah Nasution Inna Myesha Junia Fitri Hayani Juwita, Sukma Karismawati Karlina Butar Butar Khoyrill Muttiin Kiki Rawitri Krisna Juniharta Napitupulu Lestari, Seri Lestari, Sri Indah Linda, Rosa Lisda Mayanti Lubis, Nadya Frestika Lubis, Nurazizah Lubis, Zulkifli Ismail M. Arya Wiguna Madani Sirait maghfirah, Suci Mambang, D Elysa Putri Matondang , Fikriyah Hafni Maulana Putri, Yasinta Meutia, Cut Meylisa Pratami Br Sinaga Miftahul Jannah Milwani Harahap Miranza, Nona Misna Rosalinda Hutabarat Mohd. Bilal Muhammad Amin Nasution Muhammad Tegar Tri Rizky Nadia Salsabilla Nasution , Muhammad Amin Nasution, M Pandapotan Nasution, M. Pandapotan Nasution, Vevi Sarah Nia Novranda Pertiwi Ningtias, Anggitha Novi Yuliandari Novita Sari, Helsa Novriani Putri Santia Nur Asia, Nur Nuratika, Eli Nurfadilla, Kiki Nurul Salsa Abya Ritonga Nurwijayanti Pulungan, Anili Fithri Purba , Intan Sabila Putri Purba, Juvantri Fablo Puteri, Cut Intan Annisa Putri , Adilla Rafita Yuliarti Rafita Yuniarti Rafita Yuniarti Rafita Yuniarti Rahma Maulidia Fitri Rahmi, Sofia Ramadhan , Yusril Rambe, Sitiapsah Rapita Yuniarti Rati , Yuliandini Rati Satri Situmorang Rezky , Deswita Ina Riani, Nur Aslin Ridwan Taher Lubis Ridwanto Ridwanto Ritonga , Nur Sakina Ritonga , Septi Ani Ritonga, Oktavia Rohmah, Roihanah Rosalinda Mahdalena Sinaga Rosalinda Mahdalena Sinaga Safitri , Nurhaliza Sagita Marina Simatupang Sandika, M Teguh Sari, Syilvi Rinda Savika, Anggraini Selvicahyani, Selvicahyani Shinta Mida Ariani Harahap Sihotang, Laura Indah Restu silalahi, zahra salsabila Sinaga, Rosalinda Mahdalena Sindi, Sindi Siregar , Misbah Siregar , Runisya Maugin Utami Siregar, Hikmatussabaria Siregar, Rina Paramitha Siti Aisyah Jamil Siti Anisa Sitinjak, Iyustri Ririn Slamet Indarjo Sri Harti Sri Mulia Ningsih Siregar Sri Murni Sri Ria Ranti Sri Wahyuni Sulwiyatul K Sani Supiyani, Supiyani Surendro, Yasmeen Nazhifah Amani Syafa Nadira Ashiilah Syafira, Nona Syafirna, Nada Tia Nazilla Titin Agustina Trisha Wulan Erja Ummu Safura Sirait Vera Kristiana Wan Dian Safina Widya, Rizka Wilda Septia Winda Aulia Yadi, Hervi Yayuk Putri Rahayu Yayuk Putri Rahayu Yayuk Yuliana Yuni Sartika Yuniarti , Rafita Yuniarti, Rafita Yuniarti, Rapita Zahara, Fitria Siti Zahira Ahmad, Madani Zannah , Muhamad Ziza Putri Aisyia Fauzi Zulhij, Fizrya Zulmai Rani