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All Journal Jurnal Biologi Tropis Jurnal Kreativitas PKM AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT JURNAL FARMASIMED (JFM) Jurnal Ilmiah Manusia dan Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat ad-Dawaa : Journal of Pharmaceutical Sciences Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Aisyah : Jurnal Ilmu Kesehatan JURMA : Jurnal Program Mahasiswa Kreatif Jurnal Ilmiah Pharmacy Jurnal Kesehatan Tambusai Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Buana Farma JUKESHUM: Jurnal Pengabdian Masyarakat Jurnal EduHealth FORTE JOURNAL Bulletin of Community Engagement Jurnal Farmanesia Jurnal Farmasi Etam Journal of Health and Medical Science International Journal of Health and Pharmaceutical (IJHP) Jurnal Farmasi Klinik dan Sains Sciences of Pharmacy All Fields of Science Journal Liaison Academia and Sosiety Cross-border FARMASAINKES Journal of Pharmaceutical and Sciences. JK Jurnal Kesehatan Medic Nutricia : Jurnal Ilmu Kesehatan Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Indonesian Journal of Science and Pharmacy Jurnal Bakti Nusantara Jurnal Sains dan Kesehatan
Lubis, Minda Sari
Universitas Muslim Nusantara Al-washliyah
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Pembuatan nanoekstrak dari kulit buah jeruk kasturi (Citrus microcarpa) dan formulasinya sebagai pasta gigi Hasibuan , Fika Miah Sasmitha; Dalimunthe, Gabena Indrayani; Lubis , Minda Sari; Rani, Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.694

Abstract

Dental caries is a common oral health problem among the Indonesian population, and its primary cause is the bacterium Streptococcus mutans. The peel of the Kasturi orange (Citrus microcarpa) fruit has been known to contain antibacterial properties, which may help prevent the occurrence of dental caries. This study aims to evaluate the toothpaste formulation with the active ingredient of nano-extract from kasturi orange peel (Citrus microcarpa). The extract of Kasturi orange peel was obtained through a maceration method, followed by phytochemical screening that identified the presence of flavonoids, steroids, alkaloids, saponins, glycosides, and essential oils. The extract was then processed into a nano-extract, and its particle size was measured using a Particle Size Analyzer (PSA) with a dynamic light scattering technique. The nano-extract was formulated into toothpaste at concentrations of 7.5%, 10%, and 12.5%, and its antibacterial activity was tested. Physical evaluations showed that the toothpaste maintained its shape, color, odor, and taste during storage, was homogeneous, had a pH within the acceptable range (4.5–10.5), viscosity within the required range (20,000–50,000 cps), and passed organoleptic testing (color, aroma, taste, and texture) on respondents.
Formulasi eyeshadow kombinasi umbi bit (Beta vulgaris L.) dan rimpang kunyit (Curcuma longa L.) dalam perbandingan ekstrak dan nanoekstrak Sihotang, Laura Indah Restu; Dalimunthe, Gabena Indrayani; Lubis , Minda Sari; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.723

Abstract

Eyeshadow is an eye cosmetic that contains coloring agents to color effects and change the appearance. Some eyeshadow products use synthetic dyes that have a negative impact, so it is important to use safe dyes such as beetroot to produce a red color and turmeric rhizome to produce a yellow color. Turmeric rhizome yellow color. Nanoparticle-based cosmetics have advantages and can penetrate cell walls more effectively. This study aims to determine whether beetroot and turmeric rhizome extracts meet the requirements of nano extracts. Nano extracts determine the color difference at each concentration in the extracts and nano extracts as colorants for eyeshadow preparations, and choose the color of the extracts and nano extracts in eyeshadow preparations with certain concentrations that can meet the physical quality and favored by panels. This research method is True Experimental, and the research design used is a post-test-only control group design. The research design used was a post-test-only control group design. Independent variables are variations in the concentration of the combination of extracts and nano extracts of beetroot and turmeric rhizomes and eyeshadow formulations of various concentrations. Turmeric rhizome and eyeshadow formulations of multiple concentrations. The dependent variables are simplicity characteristics, phytochemical screening, particle uniformity characteristics, nano extract, and various tests. Nano extracts and various physical quality inspection tests of eyeshadow. The results showed that the beetroot and turmeric rhizome extracts met the requirements of nanoextracts with a particle size of beetroot 261 nm and turmeric rhizome 203 nm. Eyeshadow preparations containing a combination of beetroot and turmeric rhizomes in extracts and nano extracts have different colors: F1 is pink, F2 is light brown, F3 is Salem peach, F4 is peach pink, F5 is brown, and F6 is Salem pink. All eyeshadow preparation formulas meet the physical quality requirements, and F5 and F6 are the most preferred formulas for volunteers because they provide attractive colors.
Formulasi orally disintegrating tablet dari serbuk kembang kol (Brassica oleracea var. botrytis L.) dengan variasi konsentrasi sari tapai sebagai disintegrant Lestari, Sri Indah; Dalimunthe, Gabena Indrayani; Lubis, Minda Sari; Nasution, Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.773

Abstract

Cauliflower (Brassica oleracea var. botrytis L.) has a nutritional content consisting of calcium, magnesium, potassium, phosphorus, and low saturated fat. It has vitamin C, which helps increase body immunity. Orally Disintegrating Tablet preparations can dissolve quickly when placed on the tongue, formulated for ease of use of drugs for patients who have difficulty swallowing. Therefore, disintegrants are very important in ODT preparations. Tapai extract has a sweet, slightly sour taste and disintegrates immediately when placed on the tongue. This research aimed to determine whether cauliflower powder with tapai extract disintegrants can be formulated into ODT preparations and which formulation is the best.  This research included characterization of simplicia, making pre-formulation by mixing all ingredients, evaluating pre-formulation, and tablet printing by direct compression method. Then, the tablet evaluation was carried out. The disintegrant was tapai extract with 5%, 7.5%, and 10% concentrations. Data were analyzed using the One Way ANOVA method. The results of the formulation evaluation, the flow time test obtained <10 seconds, which is easy to flow; the angle of repose test obtained 26˚, the category is very good; and the compressibility test obtained 18-20%, which is quite good. The results of the tablet evaluation in the organoleptic test obtained round tablets, sweet taste, brownish-white color, and distinctive odor. The weight uniformity test on all formulas did not have any deviating weights; the size uniformity test met the requirements, the hardness test obtained 1-3 kg, the friability test obtained 0.4-0.7%, the petri dish disintegration time test obtained 44.07-52.48 seconds, and the mouth disintegration time test obtained 53.07-57.78 seconds and the wetting time test obtained 53.21-54.87 seconds. The best formula is formula 3, with a 10% tapai extract concentration.
Potensi Antioksidan Dari Ekstrak Etanol Kulit Buah Asam Jawa (Tamarandus Indica L.) sebagai Anti Aging Dalam Sediaan Kosmetik Gel Lubis, Minda Sari; Yuniarti, Rafita; Rani, Zulmai; Andjelie, Tiara; Zulhij, Fizrya
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.17992

Abstract

Skin aging can be caused by intrinsic factors which are aging processes that take place naturally and extrinsic factors caused by environmental influences such as sunlight, air, chemicals and the surrounding environment. Prevention of premature aging can be done by giving anti-oxidants, especially herbal skin care products and anti-oxidant cosmetic preparations. plants and spices. One plant that functions as an anti-oxidant is tamarind fruit (Tamarindus indica L.) is a plant with the family Mimosaceae. The method used in this study is a preparation made based on the standard formula of Na-CMC gel base according to Muttiin (2021), a gel standard formula based on Sodium Carboxymethyl cellulose (Na-CMC) based on % w/w. The results of research on the physical characteristics of gel preparations concluded that the gel preparation of Java Tamarind Fruit Skin Ethanol Extract (Tamarindus Indica L.) has met the physical quality standards of facial gel preparations. Gel preparation of Java Tamarind Fruit Skin Ethanol Extract (Tamarindus Indica L.) can provide anti-aging effects which can improve skin condition in the first week.
Optimasi Dan Formulasi Minuman Instan Granul Bunga Kecombrang (Etlingera Elatior (Jack) R.M.Sm) Dengan Kombinasi Xylitol, Madu Dan Sukrosa Zulhij, Fizrya; Lubis, Minda Sari; Yuniarti, Rafita; Rani, Zulmai
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18034

Abstract

Kecombrang merupakan tumbuhan dari keluarga Zingiberaceae, tumbuh di banyak tempat di Indonesia. Tujuan penelitian ini adalah untuk mengetahui hasil formula optimum granul instan serbuk bunga kecombrang (Etlingera elatior) dengan kombinasi Xylitol, Madu dan Sukrosa dari Simplex Lattice Design, untuk mengetahui hasil sediaan granul instan yang dilihat dari persyaratan sebagai granul instan. Metode yang digunakan adalah eksperimental. Granul instan diolah menggunakan simplex lattice design melalui aplikasi Design Expert® versi 13, selanjutnya run formula yang didapat dari aplikasi dan diuji karakteristik fisiknya. Data yang diperoleh kemudian di input kedalam aplikasi dan di dapatkan prediksi formula optimum dari aplikasi, selanjutnya prediksi formula optimum di formulasi lalu dibandingkan antara prediksi software Design Expert® versi 13 dengan menggunakan Uji-t one sample pada software SPSS®. Hasil penelitian menunjukkan granul dengan kombinasi Xylitol, Madu dan Sukrosa pada granul instan serbuk bunga kecombrang (Etlingera elatior) mendapatkan hasil formula yang optimum menggunakan metode simplex lattice design dengan konsentrasi Xylitol (9.6%), Madu (6%) dan Sukrosa (5.4%). Sediaan granul serbuk bunga kecombrang tidak memenuhi persyaratan sebagai granul instan yang dimana pada uji waktu alir mendapatkan hasil t>4-10 gr/detik, kelembaban granul MC>4%.
OPTIMASI DAN FORMULASI GRANUL DAUN SINGKONG (Manihot esculenta Crantz) DENGAN KOMBINASI MANITOL, SUKROSA DAN MADU silalahi, zahra salsabila; Lubis, Minda Sari; Yuniarti, Rafita; Rani, Zulmai
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18035

Abstract

Tanaman daun singkong (Manihot esculenta Crantz) merupakan salah satu tumbuhan obat yang digunakan secara turun temurun. Secara farmakologi daun singkong mempunyai aktivitas sebagai antiinflamasi, antibakteri, antioksidan. Pada penelitian ini metode yang digunakan adalah eksperimental. Formula granul diolah menggunakan simplex lattice design melalui aplikasi Design Expert® versi 13, selanjutnya run formula yang didapat dari aplikasi di formulasi secara konvensional dan diuji karakteristik fisiknya. Hasil penelitian ini menunjukkan bahwa formula optimum granul yang diperoleh yaitu dengan konsentrasi manitol 14%, sukrosa 5,4% dan madu 2,6%. Hasil uji evaluasi yang diperoleh indeks tap 10%, waktu alir 3.58 detik dan sudut diam 24.42o. Hasil pengujian menggunakan Uji-t one sample pada software SPSS Statistic® didapati bahwa nilai p>0,05 sehingga data dinyatakan tidak berbeda signifikan .Hasil pengujian antibakteri menunjukkan bahwa formula optimum memiliki daya hambat yang kuat.
Formulasi, Evaluasi dan Aktivitas Antioksidan Sabun Padat Serbuk Nano Teh Celup Bekas Siregar , Misbah; Lubis , Minda Sari; Yuniarti , Rafita; Rani, Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1055

Abstract

Background: Ideal soap should not only cleanse the skin but also contain substances that protect it from adverse effects, including those of free radicals, which can accelerate aging and cause other skin problems. Antioxidant compounds are needed to counteract free radicals. Used tea bags are a waste product that still contains antioxidant compounds. The use of nanotechnology is expected to enhance the stability and long-term effectiveness of cosmetic formulations, including soap. Objective: This study aimed to formulate a solid soap containing used nano tea bag powder, evaluate the physical characteristics of the soap, and test its antioxidant activity. Method: This research used a True Experimental method with a Post Test Only Control Group Design. The used tea bag powder sample was processed into nano powder using a Ball Mill. Solid soap was formulated in three variations: F0 (control without powder), F1 (containing 1.4% used tea bag powder), and F2 (containing 1.4% used nano tea bag powder). The soap preparations were then evaluated for their physical characteristics (organoleptic, pH, foam stability, hardness, cleaning power) and tested for antioxidant activity using the DPPH method. Results: The used tea bag powder was successfully converted into nano powder with an average particle size of 684.35 nm. Phytochemical screening results showed that both the powder and nano powder contained alkaloids, steroids, flavonoids, saponins, and tannins. Evaluation of the solid soap showed that all formulas (F0, F1, F2) met the physical quality requirements. The antioxidant activity test yielded IC50 values for F0, F1, and F2 of 975.2861 µg/ml (very weak), 211.3533 µg/ml (very weak), and 168.3053 µg/ml (weak), respectively. Conclusion: It can be concluded that the used tea bag powder meets the characteristics of nano powder. The solid soap formulation containing used nano tea bag powder meets physical quality requirements and demonstrates antioxidant activity, albeit in the weak category. The F2 formula (nano powder) showed better antioxidant activity than F1 (coarse powder) and F0 (control).
Analisis Kadar Nikotin dan Identifikasi Senyawa Bioaktif pada Ekstrak Daun Tembakau Asal Gayo (Nicotiana tabacum L.) Menggunakan GC–MS dan Titrasi Purba , Intan Sabila Putri; Supiyani, Supiyani; Nasution, Haris munandar; Lubis , Minda Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1161

Abstract

Gayo-origin tobacco leaves (Nicotiana tabacum L.) are a locally cultivated tobacco variety widely grown in Central Aceh, Indonesia. Tobacco leaves are known to contain nicotine, a bioactive compound with various pharmacological and economic potentials. This study aimed to identify the nicotine content and phytochemical profile of Gayo tobacco leaf extract. The research procedures included sample collection, macroscopic and microscopic examinations, simplicia preparation, characterization of the simplicia and extract, phytochemical screening, quantitative nicotine determination using acidimetry titration, and qualitative analysis using Gas Chromatography–Mass Spectrometry (GC–MS). Macroscopic examination showed that the leaves were oval to round in shape, broad-surfaced, green in color, with a characteristic odor and a bitter taste. Microscopic observation revealed the presence of vascular bundles, covering trichomes, and glandular hairs in the leaf fragments. The titrimetric test showed nicotine levels of 0.95 ± 0.3% in the simplicia powder and 1.87 ± 0.45% in the ethanol extract. GC–MS analysis identified several major compounds, including nicotine (20.99%) and Labda-8(20),13-dien-15-oic acid (29.85%) as dominant components, along with minor compounds such as Quinolin, 8-amino-6-hydroxy-Quinazoline (2.39%). These findings indicate that the Gayo tobacco leaf extract contains a relatively high level of nicotine and is dominated by alkaloid and diterpenoid acid derivatives, suggesting its potential for further phytochemical and pharmacological exploration.
FORMULASI SEDIAAN MINUMAN SERBUK JELI LIDAH BUAYA (Aloe vera (L.) Burm.f.) Sari lubis, Minda
Jurnal Farmasi Etam (JFE) Vol 4 No 1 (2024): Juni
Publisher : Unit Penelitian dan Pengabdian Kepada Masyarakat (UPPM) STIKES Dirgahayu Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52841/jfe.v4i1.293

Abstract

Lidah buaya (Aloe vera (L.) Burm.f.) salah satu jenis tumbuhan yang mudah sekali kita temukan dan banyak manfaatnya. Sejumlah penelitian diseluruh dunia, lidah buaya membantu mencegah berbagai jenis penyakit. Jenis lidah buaya yang dipakai untuk pembuatan herbal lidah buaya adalah jenis Barbadensis yang mengandung zat untuk kebutuhan manusia, seperti Vitamin A, B1, B2, B6, B12, Vitamin E dan Vitamin C. Tanaman ini dapat juga menyembuhkan penyakit diabetes jantung,dan penyakit lainnya. Lidah buaya dapat diformulasikan menjadi minuman serbuk karena dapat memberikan rasa yang menyegarkan. Tujuan penelitian ini adalah untuk membuat formulasi baru dari lidah buaya (Aloe vera (L.) Burm.f.) sebagai minuman serbuk dengan komposisi maltodekstrin yang berbeda.Penelitian ini menggunakan metode eksperimental. Pada penelitian ini lidah buaya diformulasikan dalam bentuk minuman serbuk. Evaluasi fisik yang dilakukan meliputi uji kadar air, uji kadar abu, uji waktu alir, uji sudut diam dan uji waktu larut, uji organoleptis serta uji hedonik. Berdasarkan hasil penelitian dapat diketahui bahwa evaluasi mutu fisik uji kadar air sediaan berada pada rentang 2,93%-4,73 %,kadar abu 0,12%-0,23%, waktu alir 4,23-6,20 gram/detik, sudut diam 21,95°-29,92o, dan waktu larut berada pada rentang 1,03-2,90 menit. Pada uji hedonik formula yang paling disukai adalah F3 baik dari segi rasa,aroma dan warna. Kesimpulan penelitian ini yaitu bahwa minuman serbuk lidah buaya memenuhi eveluasi mutu fisik dan memiliki rasa yang disukai oleh para panelis.
Co-Authors A'dilah, Nur Adani, Bazlina Adela Octi Dwiyani Adjelie, Tiara Afifah, Puan Ibni Alfi Wahyudi Nasution Alma Dhita Shafira Amaliana, Amaliana Andjelie, Tiara Anggraini, Dea Puspa Anny Sartika Daulay Anugrah, Bayu Ariandi Arianti, Sellin Arina Aulia Fitri, Aulia Aulia, Meisyah Ayuningrum, Annisa Bambang Hermanto Chairina Milda Cindy Marlina Tambunan Cut Dian Mala Luthfia D Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D.Elysa Putri Mambang Debi Meilani Dena, Mutia Denni Bahari Dewa, Fasca Dewi, Sri Harti Dikki Miswanda Dinda Sari Utami Efendi, Tania Tiara Ellyza, Chella Emmy Wiriandini Fauziah Zain Fithri Pulungan, Ainil Fitri Febriani Fitri, Nurul Fitri, Raissa Gabena Indrayani Dalimunthe Haris Munandar Nasution Hasibuan , Fika Miah Sasmitha Hendraputra, Hardy Handoko Heru Adha Prayogo Husna, Miftahul Hutagalung , Septi Ratna Cempaka Hutagalung, Riris Br Ika Fitriani Indah Nasution Inna Myesha Junia Fitri Hayani Juwita, Sukma Karismawati Karlina Butar Butar Khoyrill Muttiin Kiki Rawitri Krisna Juniharta Napitupulu Lestari, Seri Lestari, Sri Indah Linda, Rosa Lisda Mayanti Lubis, Nadya Frestika Lubis, Nurazizah Lubis, Zulkifli Ismail M. Arya Wiguna Madani Sirait maghfirah, Suci Mambang, D Elysa Putri Matondang , Fikriyah Hafni Maulana Putri, Yasinta Meutia, Cut Meylisa Pratami Br Sinaga Miftahul Jannah Milwani Harahap Miranza, Nona Misna Rosalinda Hutabarat Mohd. Bilal Muhammad Amin Nasution Muhammad Tegar Tri Rizky Nadia Salsabilla Nasution , Muhammad Amin Nasution, M Pandapotan Nasution, M. Pandapotan Nasution, Vevi Sarah Nia Novranda Pertiwi Ningtias, Anggitha Novi Yuliandari Novita Sari, Helsa Novriani Putri Santia Nur Asia, Nur Nuratika, Eli Nurfadilla, Kiki Nurul Salsa Abya Ritonga Nurwijayanti Pulungan, Anili Fithri Purba , Intan Sabila Putri Purba, Juvantri Fablo Puteri, Cut Intan Annisa Putri , Adilla Rafita Yuliarti Rafita Yuniarti Rafita Yuniarti Rafita Yuniarti Rahma Maulidia Fitri Rahmi, Sofia Ramadhan , Yusril Rambe, Sitiapsah Rapita Yuniarti Rati , Yuliandini Rati Satri Situmorang Rezky , Deswita Ina Riani, Nur Aslin Ridwan Taher Lubis Ridwanto Ridwanto Ritonga , Nur Sakina Ritonga , Septi Ani Ritonga, Oktavia Rohmah, Roihanah Rosalinda Mahdalena Sinaga Rosalinda Mahdalena Sinaga Safitri , Nurhaliza Sagita Marina Simatupang Sandika, M Teguh Sari, Syilvi Rinda Savika, Anggraini Selvicahyani, Selvicahyani Shinta Mida Ariani Harahap Sihotang, Laura Indah Restu silalahi, zahra salsabila Sinaga, Rosalinda Mahdalena Sindi, Sindi Siregar , Misbah Siregar , Runisya Maugin Utami Siregar, Hikmatussabaria Siregar, Rina Paramitha Siti Aisyah Jamil Siti Anisa Sitinjak, Iyustri Ririn Slamet Indarjo Sri Harti Sri Mulia Ningsih Siregar Sri Murni Sri Ria Ranti Sri Wahyuni Sulwiyatul K Sani Supiyani, Supiyani Surendro, Yasmeen Nazhifah Amani Syafa Nadira Ashiilah Syafira, Nona Syafirna, Nada Tia Nazilla Titin Agustina Trisha Wulan Erja Ummu Safura Sirait Vera Kristiana Wan Dian Safina Widya, Rizka Wilda Septia Winda Aulia Yadi, Hervi Yayuk Putri Rahayu Yayuk Putri Rahayu Yayuk Yuliana Yuni Sartika Yuniarti , Rafita Yuniarti, Rafita Yuniarti, Rapita Zahara, Fitria Siti Zahira Ahmad, Madani Zannah , Muhamad Ziza Putri Aisyia Fauzi Zulhij, Fizrya Zulmai Rani