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Lubis, Minda Sari
Universitas Muslim Nusantara Al-washliyah
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Formulation and Evaluation of Sustained-Release Tablets of Jatropha curcas L. Leaf Extract Using HPMC and Xanthan Gum Matrix for Antihypertensive Therapy Maghfirah, Suci; Puteri, Cut Intan Annisa; Dalimunthe, Gabena Indrayani; Lubis, Minda Sari
Indonesian Journal of Science and Pharmacy Vol. 3 No. 1 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v3i1.100

Abstract

The development of pharmaceutical technology has enabled the formulation of sustained-release tablets to improve therapeutic efficacy and patient compliance in antihypertensive therapy. This study aimed to evaluate the potential of Jatropha curcas L. leaf extract as an active ingredient in sustained-release tablets using hydroxypropyl methylcellulose (HPMC) and xanthan gum as matrix-forming polymers. The extract was obtained by maceration with 96% ethanol, and tablets were prepared using the wet granulation method. Granule flow properties and tablet physical characteristics (organoleptic properties, weight uniformity, size uniformity, hardness, friability, and disintegration time) were assessed, followed by dissolution studies in simulated gastric fluid (pH 1.2), intestinal fluid (pH 4.5), and intestinal fluid (pH 7.4). Results showed that all formulations met pharmacopeial requirements. Formula III, containing HPMC and xanthan gum in a 2:1 ratio, demonstrated the longest disintegration time (113 minutes) and the slowest drug release profile (54.80% within 480 minutes). These findings suggest that this formulation has the potential to serve as an optimal sustained-release tablet of Jatropha curcas L. extract for antihypertensive therapy.
Formulation and Evaluation of Pharmaceutical Suspensions Using Hemicellulose Extracted from Oil Palm Empty Fruit Bunches Savika, Anggraini; Miswanda, Dikki; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani
Indonesian Journal of Science and Pharmacy Vol. 3 No. 1 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v3i1.113

Abstract

Oil palm empty fruit bunches (OPEFB), a major solid waste from palm oil processing, represent a rich source of lignocellulosic biomass that can be valorized into high-value bioproducts. This study aimed to isolate hemicellulose from OPEFB and evaluate its potential as a natural suspending agent in pharmaceutical suspension formulations, either alone or in combination with sodium carboxymethyl cellulose (CMC-Na). A series of formulations (F0–F5) were prepared and characterized for organoleptic properties, pH, density, viscosity, sedimentation volume, and redispersibility over seven days of storage. The results showed that suspensions containing OPEFB hemicellulose exhibited acceptable sensory characteristics, stable pH values (5–7), and densities above 1.00 g/mL. The addition of hemicellulose and CMC-Na significantly increased viscosity (up to 683.5 cP) and improved sedimentation stability, with sedimentation volumes reaching 0.22 and redispersibility up to 90% in formulations F2 and F3. These findings indicate a synergistic effect between hemicellulose and CMC-Na, enhancing suspension uniformity and preventing particle aggregation without compromising flowability. In conclusion, OPEFB-derived hemicellulose demonstrates excellent potential as a biodegradable and eco-friendly suspending agent for pharmaceutical suspensions. Its use not only improves formulation stability but also promotes the sustainable utilization of palm oil industry waste in green pharmaceutical product development. Oil palm empty fruit bunches (OPEFB), a major solid waste from palm oil processing, represent a rich source of lignocellulosic biomass that can be valorized into high-value bioproducts. This study aimed to isolate hemicellulose from OPEFB and evaluate its potential as a natural suspending agent in pharmaceutical suspension formulations, either alone or in combination with sodium carboxymethyl cellulose (CMC-Na). A series of formulations (F0–F5) were prepared and characterized for organoleptic properties, pH, density, viscosity, sedimentation volume, and redispersibility over seven days of storage. The results showed that suspensions containing OPEFB hemicellulose exhibited acceptable sensory characteristics, stable pH values (5–7), and densities above 1.00 g/mL. The addition of hemicellulose and CMC-Na significantly increased viscosity (up to 683.5 cP) and improved sedimentation stability, with sedimentation volumes reaching 0.22 and redispersibility up to 90% in formulations F2 and F3. These findings indicate a synergistic effect between hemicellulose and CMC-Na, enhancing suspension uniformity and preventing particle aggregation without compromising flowability. In conclusion, OPEFB-derived hemicellulose demonstrates excellent potential as a biodegradable and eco-friendly suspending agent for pharmaceutical suspensions. Its use not only improves formulation stability but also promotes the sustainable utilization of palm oil industry waste in green pharmaceutical product development.
Evaluasi Mutu Fisik, Uji Kelembapan dan Potensi Aktivitas Tabir Surya Pelembab Bibir Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) Safitri , Nurhaliza; Yuniarti , Rafita; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1052

Abstract

Background: Lip balm is a cosmetic preparation containing key components such as waxes, fats, and oils—derived from either natural or synthetic extracts—to prevent lip dryness by enhancing moisture and protecting against harmful environmental factors. The red shoot plant (Syzygium myrtifolium Walp.) is commonly known as an ornamental plant but also contains beneficial chemical compounds. Objective: This study aims to formulate red shoot leaf ethanol extract into a lip balm with good physical quality, sun protection capability, and moisturizing effects. Methods: This research uses an experimental method with quantitative and qualitative data collection. The stages include simplicia characterization, secondary metabolite identification, extract preparation through maceration, lip balm formulation, and evaluation of physical quality (organoleptic test, homogeneity, pH, stability, irritation, melting point, and hedonic test), moisture test, and Sun Protection Factor (SPF) value determination. Results: The red shoot leaf extract was successfully formulated into a stick lip balm at concentrations of 5%, 7%, and 10%. The formulas demonstrated good physical quality in all tests, increased lip moisture and oil content (especially at 10% concentration), and high SPF values with ultra protection at the 10% concentration. Conclusion: Red shoot leaf extract (Syzygium myrtifolium Walp.) can be used as an active ingredient in lip balm, providing optimal physical quality, moisturizing effects, and UV radiation protection.
Antioxidant and Antibacterial Activity of Ethanol Extract of Butterfly Leaf (Bauhinia Purpurea L.) with Maceration Extraction Method Surendro, Yasmeen Nazhifah Amani; Nasution , Muhammad Amin; Lubis, Minda Sari; Pulungan, Anili Fithri
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7963

Abstract

The butterfly plant (Bauhinia purpurea L.) is a plant widely used in traditional medicine to treat various ailments. The butterfly plant's leaves have medicinal properties. The leaves of butterfly plants contain bioactive chemicals that can be employed as natural antibacterial and antioxidant agents. The purpose of this study was to evaluate the ethanol extract of butterfly leaves' antibacterial and antioxidant properties. Butterfly leaf extract was obtained using a maceration process with 96% ethanol solvent. Antioxidant activity was measured using the DPPH (1,1-diphenyl-2-picryhydrazyl) and FRAP (Ferric Reducing Antioxidant Power) techniques, with ascorbic acid as a comparator. The disc paper diffusion method was used to test the antibacterial activity against Streptococcus mutans bacteria. The DPPH method has an IC50 value of 27.5484 µg/ml with a very strong category, while the FRAP method has an IC50 value of 72.9311 µg/ml with a strong category. Butterfly leaf extract showed antibacterial efficacy against Streptococcus mutans bacteria at all doses, with maximum inhibition seen at an extract concentration of 50% (inhibition zone diameter: 16.3 mm ± 0.81). The study's findings suggest that butterfly leaf extract works well as a natural antibacterial and antioxidant.
Antibacterial Activity of Foot Spray Preparations Extract of Jeruk Purut Leaves (Citrus Hystrix) and Robusta Coffee Leaves (Coffea canephora) Against Staphylococcus epidermidis Lestari, Seri; Nasution, Muhammad Amin; Dalimunthe, Gabena indrayani; Lubis, Minda Sari
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8736

Abstract

A problem that is often found in Indonesia, especially on the feet and causes many people to lack self-confidence, is smelly feet. This odor is caused by bacteria on the skin and inside shoes. Bacteria like Staphylococcus epidermidis produce an unpleasant smell by degrading leucine from sweat, leading to the formation of isovaleric acid, which emits a foul odor. This issue can be addressed using plant materials such as jeruk purut leaves (Citrus hystrix) and robusta coffee leaves (Coffea canephora). This research uses an experimental method. Jeruk purut leaves and robusta coffee leaves are extracted through maceration and then formulated into a foot spray with extract concentrations of 1.5%, 2%, and 2.5%. The evaluation results indicate that the foot spray formulation meets the stability test parameters, including organoleptic properties and pH. In terms of hedonic testing, panelists preferred Formula 1, and no formula caused skin irritation. Antibacterial testing of all formulations showed strong antibacterial activity, with inhibition zone diameters of 11.9 mm for Formula 1 (1.5% concentration), 12.4 mm for Formula 2 (2% concentration), and 12.8 mm for Formula 3 (2.5% concentration) against Staphylococcus epidermidis. Statistical analysis using One-Way ANOVA showed that the antibacterial activity of the foot spray in inhibiting bacterial growth was significant at a 0.005 level, with a probability value (significance) of 0.00 < 0.05, indicating that the antibacterial activity of the foot spray can affect the growth of Staphylococcus epidermidis.
KAJIAN INTERAKSI OBAT PASIEN GAGAL GINJAL KRONIS DI RUMAH SAKIT X SUMATERA UTARA Karismawati; Sari, Syilvi Rinda; Lubis, Minda Sari; Yuniarti, Rafita
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.32326

Abstract

Tujuan penelitian ini adalah sebagai berikut: Pertama, untuk mengidentifikasi adanya kejadian interaksi obat pada pasien gagal ginjal kronis yang dirawat inap di rumah sakit X. Kedua, untuk mengevaluasi dampak interaksi obat terhadap jumlah obat yang diresepkan kepada pasien tersebut. Ketiga, untuk mengklasifikasikan jenis kategori interaksi obat yang terjadi pada pasien gagal ginjal kronis yang dirawat inap di rumah sakit X. Penelitian ini adalah penelitian observasional non-eksperimental yang menganalisis data sekunder rekam medis pasien gagal ginjal kronis yang dirawat inap di rumah sakit X pada tahun 2023. Penelitian dilakukan secara retrospektif dengan mengakses arsip rekam medis dari Februari hingga Maret 2024. Teknik pengambilan sampel menggunakan total sampling, melibatkan semua pasien yang memenuhi kriteria inklusi. Data dikumpulkan dan dicatat, lalu dianalisis secara univariat untuk menggambarkan karakteristik pasien, termasuk informasi identitas, usia, jenis kelamin, penyakit penyerta, dan terapi obat. Analisis bertujuan mengidentifikasi potensi interaksi obat selama perawatan inap. Berdasarkan hasil penelitian mengenai interaksi obat pada pasien gagal ginjal kronis di rumah sakit X, ditemukan beberapa temuan penting. Pertama, terdeteksi adanya kejadian interaksi obat pada pasien tersebut. Untuk menangani masalah ini, disarankan agar dokter dan apoteker saling berkoordinasi dan saling mengingatkan tentang potensi interaksi obat. Selain itu, jika terdapat perkembangan terbaru mengenai obat, evaluasi ulang terhadap penggunaan obat yang diberikan perlu dilakukan. Kedua, analisis terhadap jumlah obat yang diresepkan menunjukkan bahwa semakin banyak obat yang diresepkan, semakin tinggi kemungkinan terjadinya interaksi obat. Ketiga, dalam kategori interaksi obat yang terjadi pada pasien gagal ginjal kronis, sebagian besar pasien berada dalam kategori keparahan moderat dengan persentase mencapai 61,76%. Berdasarkan mekanisme kerja obat, interaksi farmakodinamik mendominasi dengan persentase sebesar 57,14%.
Pemanfaatan Ekstrak Bahan Alam Pada Sabun Cuci Piring di Desa Sidomulyo Kecamatan Biru-Biru, Deli Serdang Yuniarti, Rafita; Sari Lubis, Minda; Munandar Nasution, Haris; Rani, Zulmai; Linda, Rosa; Adjelie, Tiara
Jukeshum: Jurnal Pengabdian Masyarakat Vol. 4 No. 2 (2024): Edisi Juli 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/jukeshum.v4i2.933

Abstract

Salah satu penyakit yang masih banyak terdapat di Masyarakat Indonesia adalah penyakit infeksi, yang dapat disebabkan oleh bakteri ataupun virus. Penyakit infeksi yang disebabkan oleh bakteri dapat diatasi dengan antibakteri, sedangkan infeksi yang disebabkan oleh virus dapat diatasi dengan menggunakan antivirus. Salah satu penyebab sering munculnya penyakit infeksi adalah karena hygiene dan sanitasi yang buruk. Penggunaan antibakteri dari bahan alam merupakan salah satu cara yang aman dalam mengatasi masalah tersebut. Tujuan: meningkatkan pengetahuan Masyarakat tentang bahan alam yang berkhasiat sebagai antibakteri dan pemanfaatan bahan alam dalam sediaan perbekalan Kesehatan rumah tangga (PKRT). Metode: penyuluhan tentang tumbuhan yang berkhasiat sebagai antibakteri dan pembuatan sabun cuci piring menggunakan ekstrak daun jeruk kuok (Citrus nobilis). Hasil: pada penyuluhan tentang tumbuhan yang digunakan sebagai antibakteri diperoleh Tingkat pengetahuan sebesar 61% dan setelah kegiatan diperoleh hasil Tingkat pengetahuan sebesar 82% sedangkan pada kegiatan pembuatan sabun cair dengan bahan alam sebagai antibakteri diperoleh hasil 58% dan setelah kegiatan sebesar 93%. Kesimpulan: Terjadi peningkatan pengetahuan tentang tumbuhan yang berkhasiat sebagai antibakteri sebesar 21% dan peningkatan pengetahuan tentang pembuatan sabun cuci piring dengan bahan alam sebesar 35%.
Penentuan Kadar Vitamin C Pada Sediaan Krim Pemutih Wajah yang Beredar di Pasar Online Dengan Metode Titrasi 2,6-Diklorophenol Indophenol Anugrah, Bayu; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani; Daulay, Anny Sartika
Journal of Health and Medical Science Volume 3 Nomor 1 Januari 2024
Publisher : CV. Pusdikra Mitra Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/jhms.v3i1.1963

Abstract

Krim pemutih wajah merupakan produk yang tersusun dari beberapa bahan kimia atau bahan lainnya yang mampu memutihkan wajah dalam waktu yang singkat. Untuk mengetahui kadar Vitamin C yang terdapat pada sediaan krim wajah yang beredar di pasar online diuji dengan metode analisis kuantitatif. Tujuan penelitian ini adalah untuk mengetahui kadar Vitamin C pada sediaan krim pemutih wajah yang beredar di pasar online. Tujuan penggunaannya dalam jangka waktu lama agar dapat mengurangi hiperpegmentasi pada kulit. Tetapi penggunaan yang terus-menerus justru akan menimbulkan pigmentasi dengan efek permanen. Metode yang digunakan dalam penelitian ini adalah metode 2,6-Diklorophenol Indophenol. Metode ini merupakan metode yang paling baik digunakan pada penetapan kadar Vitamin C karena spesifik sehingga tidak dipengaruhi oleh senyawa lainnya. Kelebihan metode ini yaitu reaksi yang terjadi secara kauntitatif sehingga dapat diketahui jumlah atau kadarnya. Dari hasil penelitian menunjukkan kadar Vitamin C pada sampel kosmetik pemutih wajah yaitu Amos Siang dan Amos Malam, Collagen Siang dan Collagen Malam, Walet Siang dan Walet Malam, Temulawak Siang dan Temulawak Malam. Perolehan kadar Vitamin C pada Amos Siang 0,0298% sedangkan kadar Vitamin C pada Amos Malam 0,0245% kadar Vitamin C pada Collagen Siang 0,0355% kadar Vitamin C pada Collagen Malam 0,0350% kadar Vitamin C pada Walet Siang 0,0298% kadar Vitamin C pada Walet Malam 0,0528% kadar Vitamin C pada Temulawak Siang 0,023% kadar Vitamin C pada Temulawak Malam 0,023%.
Sintesis Nanopartikel Perak Menggunakan Ekstrak Daun Bidara Ziziphus Spina-Christi Dan Uji Aktivitas Antibakteri Terhadap Bakteri Staphylococcus Aureus Cut Dian Mala Luthfia; Dikki Miswanda; Haris Munandar Nasution; Minda Sari Lubis
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 1 (2024): Januari : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i1.168

Abstract

Nanotechnology is currently growing rapidly due to its broad application in science and technology. Nanotechnology itself is a science based on nanoparticles, so a more environmentally friendly method is being developed, namely the "green synthesis" method using plant extracts as a bioreductor. Silver nanoparticles have been synthesized using extracts of bidara leaf as a reducing agent. The objective of this research was was to determine the synthesis of silver nanoparticles using bioreductors and their application as antibacterial agents using bidara leaf extract against Staphylococcus aureus bacteria. This research used the green synthesis method to produce silver nanoparticles. The bidara leaf extract used was divided into several concentrations, namely 1 mM, 2 mM, 3 mM and 4 mM. To characterize silver nanoparticles, UV-Vis and PSA spectrophotometers were used. Furthermore, the Kirby-Bauer method was used to test the antibacterial properties of silver nanoparticles against Staphylococcus aureus bacteria. The results of research that has been done show that the formation of silver nanoparticles is characterized by the emergence of maximum absorbance peaks in the wavelength range of 400-450 nm, while the PSA results at concentrations of 3 and 4µm showed nanoparticle sizes of 185 nm. Silver nanoparticles of bidara leaf extract with various concentrations of 1 mM, 2 mM, 3 mM and 4 mM have antibacterial activity that can inhibit the growth of Staphylococcus aureus bacteria with an average inhibition zone diameter of 13.0617 mm, 11.7333 mm, 9.05 mm and 13.19 mm. This shows that silver nanoparticles with bidara leaf extract have antibacterial properties.
Uji Aktivitas Antibakteri Sabun Transparan Putik Saffron (Crocus sativus L) terhadap Bakteri Staphylococcus aureus Emmy Wiriandini; Gabena Indrayani Dalimunthe; Minda Sari Lubis; Haris Munandar Nasution
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 2 (2024): March : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i2.343

Abstract

Transparent soap is a variation of solid bar soap that not only functions to clean dirt but also has a scrubbing function. Transparent solid soap is one of the soap innovations that has become an attractive soap. Saffron also has antibacterial properties due to the presence of flavonoids, tannins and saponins. Flavonoids are compounds that can have anti-inflammatory, anticancer and antioxidant effects, because they can inhibit the formation of free radicals. It has been used traditionally to treat various ailments including depression, cardiovascular disease, menstrual disorders, asthma, insomnia, digestive ailments, bone pain and several other ailments. Saffron pistil juice is made by dissolving in CO₂-free distilled water. Phytochemical screening was carried out on saffron pistil extract. Saffron pistil juice is made in various soap formulas, namely formula I, formula II and formula III. The positive control used was chloramphenicol antibiotic and the negative control was DMSO. There were several tests carried out on Saffron pistil extract in addition to phytochemical screening, namely antibacterial testing on transparent soap with Saffron pistil extract as a soap additive. The results of phytochemical screening showed that the pistil of saffron (Crocus sativus L) contained secondary metabolites, namely: flavonoids, alkaloids, tannins, and saponins. And for the results of the antibacterial activity research also showed that the Saffron pistil extract against transparent soap which can be used as a soap additive, the antibacterial results had a strong inhibition at the average value of formula III which was 20.5 and formula II was 18.4 mm and formula I 16.1 mm, against Staphylococcus aureus bacteria.
Co-Authors A'dilah, Nur Adani, Bazlina Adela Octi Dwiyani Adjelie, Tiara Afifah, Puan Ibni Alfi Wahyudi Nasution Alma Dhita Shafira Amaliana, Amaliana Andjelie, Tiara Anggraini, Dea Puspa Anny Sartika Daulay Anugrah, Bayu Ariandi Arianti, Sellin Arina Aulia Fitri, Aulia Aulia, Meisyah Ayuningrum, Annisa Bambang Hermanto Bilal, Mohd. Chairina Milda Cindy Marlina Tambunan Cut Dian Mala Luthfia D Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D.Elysa Putri Mambang Dama Yanti, Fradilla Debi Meilani Dena, Mutia Denni Bahari Dewa, Fasca Dewi, Sri Harti Dikki Miswanda Dinda Sari Utami Efendi, Tania Tiara Ellyza, Chella Emmy Wiriandini Fauziah Zain Fithri Pulungan, Ainil Fitri Febriani Fitri, Nurul Fitri, Raissa Gabena Indrayani Dalimunthe Haris Munandar Nasution Hasibuan , Fika Miah Sasmitha Hendraputra, Hardy Handoko Heru Adha Prayogo Husna, Miftahul Hutagalung , Septi Ratna Cempaka Hutagalung, Riris Br Hutagalung, Victor H Ika Fitriani Indah Nasution Inna Myesha Junia Fitri Hayani Juwita, Sukma Karismawati Karlina Butar Butar Khoyrill Muttiin Kiki Rawitri Krisna Juniharta Napitupulu Lestari, Seri Lestari, Sri Indah Linda, Rosa Lisda Mayanti Lubis, Asira Lubis, Nadya Frestika Lubis, Nurazizah Lubis, Zulkifli Ismail M. Arya Wiguna Madani Sirait maghfirah, Suci Mambang, D Elysa Putri Matondang , Fikriyah Hafni Maulana Putri, Yasinta Metami Sihombing, Juliana Meutia, Cut Meylisa Pratami Br Sinaga Miftahul Jannah Milwani Harahap Miranza, Nona Misna Rosalinda Hutabarat Muhammad Amin Nasution Muhammad Tegar Tri Rizky Nadia Salsabilla Nasri Nasri, Nasri Nasution , Muhammad Amin Nasution, M Pandapotan Nasution, M. Pandapotan Nasution, Vevi Sarah Nia Novranda Pertiwi Ningtias, Anggitha Novi Yuliandari Novita Sari, Helsa Novriani Putri Santia Nur Asia, Nur Nuratika, Eli Nurfadilla, Kiki Nurul Salsa Abya Ritonga Nurwijayanti Oktavia, Zela Pulungan, Anili Fithri Purba , Intan Sabila Putri Purba, Juvantri Fablo Puspita, Dinda Dila Puteri, Cut Intan Annisa Putri , Adilla Putri Rahayu, Yayuk Rafita Yuliarti Rahma Maulidia Fitri Rahmi, Sofia Ramadhan , Yusril Rambe, Sitiapsah Rapita Yuniarti Rati , Yuliandini Rezky , Deswita Ina Riani, Nur Aslin Ridwan Taher Lubis Ridwanto Ridwanto Rifqi, M. Ainur Rinda Sari, Syilvi Ritonga , Nur Sakina Ritonga , Septi Ani Ritonga, Oktavia Rkt, Chairunnisa Rohmah, Roihanah Rosalinda Mahdalena Sinaga Rosalinda Mahdalena Sinaga Safitri , Nurhaliza Sagita Marina Simatupang Sandika, M Teguh Sari, Syilvi Rinda Satri Situmorang, Rati Savika, Anggraini Selvicahyani, Selvicahyani Shinta Mida Ariani Harahap Sihotang, Laura Indah Restu silalahi, zahra salsabila Sinaga, Rosalinda Mahdalena Sindi, Sindi Siregar , Misbah Siregar , Runisya Maugin Utami Siregar, Hikmatussabaria Siregar, Rina Paramitha Siti Aisyah Jamil Siti Anisa Sitinjak, Iyustri Ririn Slamet Indarjo Sri Harti Sri Mulia Ningsih Siregar Sri Murni Sri Ria Ranti Sri Wahyuni Sri Wahyuni Sulwiyatul K Sani Supiyani, Supiyani Surendro, Yasmeen Nazhifah Amani Syafa Nadira Ashiilah Syafira, Nona Syafirna, Nada Tia Nazilla Titin Agustina Trisha Wulan Erja Ulmi, M Rayhan Ummu Safura Sirait Vera Estefania Kaban Vera Kristiana Wan Dian Safina Widya, Rizka Wilda Septia Winda Aulia Yadi, Hervi Yayuk Putri Rahayu Yayuk Putri Rahayu Yayuk Yuliana Yuni Sartika Yuniarti , Rafita Yuniarti, Rafita Yuniarti, Rapita Zahara, Fitria Siti Zahira Ahmad, Madani Zannah , Muhamad Ziza Putri Aisyia Fauzi Zulhij, Fizrya Zulmai Rani