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Formulation and Evaluation of Pharmaceutical Suspensions Using Hemicellulose Extracted from Oil Palm Empty Fruit Bunches Savika, Anggraini; Miswanda, Dikki; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani
Indonesian Journal of Science and Pharmacy Vol. 3 No. 1 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v3i1.113

Abstract

Oil palm empty fruit bunches (OPEFB), a major solid waste from palm oil processing, represent a rich source of lignocellulosic biomass that can be valorized into high-value bioproducts. This study aimed to isolate hemicellulose from OPEFB and evaluate its potential as a natural suspending agent in pharmaceutical suspension formulations, either alone or in combination with sodium carboxymethyl cellulose (CMC-Na). A series of formulations (F0–F5) were prepared and characterized for organoleptic properties, pH, density, viscosity, sedimentation volume, and redispersibility over seven days of storage. The results showed that suspensions containing OPEFB hemicellulose exhibited acceptable sensory characteristics, stable pH values (5–7), and densities above 1.00 g/mL. The addition of hemicellulose and CMC-Na significantly increased viscosity (up to 683.5 cP) and improved sedimentation stability, with sedimentation volumes reaching 0.22 and redispersibility up to 90% in formulations F2 and F3. These findings indicate a synergistic effect between hemicellulose and CMC-Na, enhancing suspension uniformity and preventing particle aggregation without compromising flowability. In conclusion, OPEFB-derived hemicellulose demonstrates excellent potential as a biodegradable and eco-friendly suspending agent for pharmaceutical suspensions. Its use not only improves formulation stability but also promotes the sustainable utilization of palm oil industry waste in green pharmaceutical product development. Oil palm empty fruit bunches (OPEFB), a major solid waste from palm oil processing, represent a rich source of lignocellulosic biomass that can be valorized into high-value bioproducts. This study aimed to isolate hemicellulose from OPEFB and evaluate its potential as a natural suspending agent in pharmaceutical suspension formulations, either alone or in combination with sodium carboxymethyl cellulose (CMC-Na). A series of formulations (F0–F5) were prepared and characterized for organoleptic properties, pH, density, viscosity, sedimentation volume, and redispersibility over seven days of storage. The results showed that suspensions containing OPEFB hemicellulose exhibited acceptable sensory characteristics, stable pH values (5–7), and densities above 1.00 g/mL. The addition of hemicellulose and CMC-Na significantly increased viscosity (up to 683.5 cP) and improved sedimentation stability, with sedimentation volumes reaching 0.22 and redispersibility up to 90% in formulations F2 and F3. These findings indicate a synergistic effect between hemicellulose and CMC-Na, enhancing suspension uniformity and preventing particle aggregation without compromising flowability. In conclusion, OPEFB-derived hemicellulose demonstrates excellent potential as a biodegradable and eco-friendly suspending agent for pharmaceutical suspensions. Its use not only improves formulation stability but also promotes the sustainable utilization of palm oil industry waste in green pharmaceutical product development.
Antioxidant and Antibacterial Activity of Ethanol Extract of Butterfly Leaf (Bauhinia Purpurea L.) with Maceration Extraction Method Surendro, Yasmeen Nazhifah Amani; Nasution , Muhammad Amin; Lubis, Minda Sari; Pulungan, Anili Fithri
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7963

Abstract

The butterfly plant (Bauhinia purpurea L.) is a plant widely used in traditional medicine to treat various ailments. The butterfly plant's leaves have medicinal properties. The leaves of butterfly plants contain bioactive chemicals that can be employed as natural antibacterial and antioxidant agents. The purpose of this study was to evaluate the ethanol extract of butterfly leaves' antibacterial and antioxidant properties. Butterfly leaf extract was obtained using a maceration process with 96% ethanol solvent. Antioxidant activity was measured using the DPPH (1,1-diphenyl-2-picryhydrazyl) and FRAP (Ferric Reducing Antioxidant Power) techniques, with ascorbic acid as a comparator. The disc paper diffusion method was used to test the antibacterial activity against Streptococcus mutans bacteria. The DPPH method has an IC50 value of 27.5484 µg/ml with a very strong category, while the FRAP method has an IC50 value of 72.9311 µg/ml with a strong category. Butterfly leaf extract showed antibacterial efficacy against Streptococcus mutans bacteria at all doses, with maximum inhibition seen at an extract concentration of 50% (inhibition zone diameter: 16.3 mm ± 0.81). The study's findings suggest that butterfly leaf extract works well as a natural antibacterial and antioxidant.
Antibacterial Activity of Foot Spray Preparations Extract of Jeruk Purut Leaves (Citrus Hystrix) and Robusta Coffee Leaves (Coffea canephora) Against Staphylococcus epidermidis Lestari, Seri; Nasution, Muhammad Amin; Dalimunthe, Gabena indrayani; Lubis, Minda Sari
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8736

Abstract

A problem that is often found in Indonesia, especially on the feet and causes many people to lack self-confidence, is smelly feet. This odor is caused by bacteria on the skin and inside shoes. Bacteria like Staphylococcus epidermidis produce an unpleasant smell by degrading leucine from sweat, leading to the formation of isovaleric acid, which emits a foul odor. This issue can be addressed using plant materials such as jeruk purut leaves (Citrus hystrix) and robusta coffee leaves (Coffea canephora). This research uses an experimental method. Jeruk purut leaves and robusta coffee leaves are extracted through maceration and then formulated into a foot spray with extract concentrations of 1.5%, 2%, and 2.5%. The evaluation results indicate that the foot spray formulation meets the stability test parameters, including organoleptic properties and pH. In terms of hedonic testing, panelists preferred Formula 1, and no formula caused skin irritation. Antibacterial testing of all formulations showed strong antibacterial activity, with inhibition zone diameters of 11.9 mm for Formula 1 (1.5% concentration), 12.4 mm for Formula 2 (2% concentration), and 12.8 mm for Formula 3 (2.5% concentration) against Staphylococcus epidermidis. Statistical analysis using One-Way ANOVA showed that the antibacterial activity of the foot spray in inhibiting bacterial growth was significant at a 0.005 level, with a probability value (significance) of 0.00 < 0.05, indicating that the antibacterial activity of the foot spray can affect the growth of Staphylococcus epidermidis.
KAJIAN INTERAKSI OBAT PASIEN GAGAL GINJAL KRONIS DI RUMAH SAKIT X SUMATERA UTARA Karismawati; Sari, Syilvi Rinda; Lubis, Minda Sari; Yuniarti, Rafita
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.32326

Abstract

Tujuan penelitian ini adalah sebagai berikut: Pertama, untuk mengidentifikasi adanya kejadian interaksi obat pada pasien gagal ginjal kronis yang dirawat inap di rumah sakit X. Kedua, untuk mengevaluasi dampak interaksi obat terhadap jumlah obat yang diresepkan kepada pasien tersebut. Ketiga, untuk mengklasifikasikan jenis kategori interaksi obat yang terjadi pada pasien gagal ginjal kronis yang dirawat inap di rumah sakit X. Penelitian ini adalah penelitian observasional non-eksperimental yang menganalisis data sekunder rekam medis pasien gagal ginjal kronis yang dirawat inap di rumah sakit X pada tahun 2023. Penelitian dilakukan secara retrospektif dengan mengakses arsip rekam medis dari Februari hingga Maret 2024. Teknik pengambilan sampel menggunakan total sampling, melibatkan semua pasien yang memenuhi kriteria inklusi. Data dikumpulkan dan dicatat, lalu dianalisis secara univariat untuk menggambarkan karakteristik pasien, termasuk informasi identitas, usia, jenis kelamin, penyakit penyerta, dan terapi obat. Analisis bertujuan mengidentifikasi potensi interaksi obat selama perawatan inap. Berdasarkan hasil penelitian mengenai interaksi obat pada pasien gagal ginjal kronis di rumah sakit X, ditemukan beberapa temuan penting. Pertama, terdeteksi adanya kejadian interaksi obat pada pasien tersebut. Untuk menangani masalah ini, disarankan agar dokter dan apoteker saling berkoordinasi dan saling mengingatkan tentang potensi interaksi obat. Selain itu, jika terdapat perkembangan terbaru mengenai obat, evaluasi ulang terhadap penggunaan obat yang diberikan perlu dilakukan. Kedua, analisis terhadap jumlah obat yang diresepkan menunjukkan bahwa semakin banyak obat yang diresepkan, semakin tinggi kemungkinan terjadinya interaksi obat. Ketiga, dalam kategori interaksi obat yang terjadi pada pasien gagal ginjal kronis, sebagian besar pasien berada dalam kategori keparahan moderat dengan persentase mencapai 61,76%. Berdasarkan mekanisme kerja obat, interaksi farmakodinamik mendominasi dengan persentase sebesar 57,14%.
Pemanfaatan Ekstrak Bahan Alam Pada Sabun Cuci Piring di Desa Sidomulyo Kecamatan Biru-Biru, Deli Serdang Yuniarti, Rafita; Sari Lubis, Minda; Munandar Nasution, Haris; Rani, Zulmai; Linda, Rosa; Adjelie, Tiara
Jukeshum: Jurnal Pengabdian Masyarakat Vol. 4 No. 2 (2024): Edisi Juli 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/jukeshum.v4i2.933

Abstract

Salah satu penyakit yang masih banyak terdapat di Masyarakat Indonesia adalah penyakit infeksi, yang dapat disebabkan oleh bakteri ataupun virus. Penyakit infeksi yang disebabkan oleh bakteri dapat diatasi dengan antibakteri, sedangkan infeksi yang disebabkan oleh virus dapat diatasi dengan menggunakan antivirus. Salah satu penyebab sering munculnya penyakit infeksi adalah karena hygiene dan sanitasi yang buruk. Penggunaan antibakteri dari bahan alam merupakan salah satu cara yang aman dalam mengatasi masalah tersebut. Tujuan: meningkatkan pengetahuan Masyarakat tentang bahan alam yang berkhasiat sebagai antibakteri dan pemanfaatan bahan alam dalam sediaan perbekalan Kesehatan rumah tangga (PKRT). Metode: penyuluhan tentang tumbuhan yang berkhasiat sebagai antibakteri dan pembuatan sabun cuci piring menggunakan ekstrak daun jeruk kuok (Citrus nobilis). Hasil: pada penyuluhan tentang tumbuhan yang digunakan sebagai antibakteri diperoleh Tingkat pengetahuan sebesar 61% dan setelah kegiatan diperoleh hasil Tingkat pengetahuan sebesar 82% sedangkan pada kegiatan pembuatan sabun cair dengan bahan alam sebagai antibakteri diperoleh hasil 58% dan setelah kegiatan sebesar 93%. Kesimpulan: Terjadi peningkatan pengetahuan tentang tumbuhan yang berkhasiat sebagai antibakteri sebesar 21% dan peningkatan pengetahuan tentang pembuatan sabun cuci piring dengan bahan alam sebesar 35%.
Penentuan Kadar Vitamin C Pada Sediaan Krim Pemutih Wajah yang Beredar di Pasar Online Dengan Metode Titrasi 2,6-Diklorophenol Indophenol Anugrah, Bayu; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani; Daulay, Anny Sartika
Journal of Health and Medical Science Volume 3 Nomor 1 Januari 2024
Publisher : CV. Pusdikra Mitra Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/jhms.v3i1.1963

Abstract

Krim pemutih wajah merupakan produk yang tersusun dari beberapa bahan kimia atau bahan lainnya yang mampu memutihkan wajah dalam waktu yang singkat. Untuk mengetahui kadar Vitamin C yang terdapat pada sediaan krim wajah yang beredar di pasar online diuji dengan metode analisis kuantitatif. Tujuan penelitian ini adalah untuk mengetahui kadar Vitamin C pada sediaan krim pemutih wajah yang beredar di pasar online. Tujuan penggunaannya dalam jangka waktu lama agar dapat mengurangi hiperpegmentasi pada kulit. Tetapi penggunaan yang terus-menerus justru akan menimbulkan pigmentasi dengan efek permanen. Metode yang digunakan dalam penelitian ini adalah metode 2,6-Diklorophenol Indophenol. Metode ini merupakan metode yang paling baik digunakan pada penetapan kadar Vitamin C karena spesifik sehingga tidak dipengaruhi oleh senyawa lainnya. Kelebihan metode ini yaitu reaksi yang terjadi secara kauntitatif sehingga dapat diketahui jumlah atau kadarnya. Dari hasil penelitian menunjukkan kadar Vitamin C pada sampel kosmetik pemutih wajah yaitu Amos Siang dan Amos Malam, Collagen Siang dan Collagen Malam, Walet Siang dan Walet Malam, Temulawak Siang dan Temulawak Malam. Perolehan kadar Vitamin C pada Amos Siang 0,0298% sedangkan kadar Vitamin C pada Amos Malam 0,0245% kadar Vitamin C pada Collagen Siang 0,0355% kadar Vitamin C pada Collagen Malam 0,0350% kadar Vitamin C pada Walet Siang 0,0298% kadar Vitamin C pada Walet Malam 0,0528% kadar Vitamin C pada Temulawak Siang 0,023% kadar Vitamin C pada Temulawak Malam 0,023%.
Sintesis Nanopartikel Perak Menggunakan Ekstrak Daun Bidara Ziziphus Spina-Christi Dan Uji Aktivitas Antibakteri Terhadap Bakteri Staphylococcus Aureus Cut Dian Mala Luthfia; Dikki Miswanda; Haris Munandar Nasution; Minda Sari Lubis
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 1 (2024): Januari : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i1.168

Abstract

Nanotechnology is currently growing rapidly due to its broad application in science and technology. Nanotechnology itself is a science based on nanoparticles, so a more environmentally friendly method is being developed, namely the "green synthesis" method using plant extracts as a bioreductor. Silver nanoparticles have been synthesized using extracts of bidara leaf as a reducing agent. The objective of this research was was to determine the synthesis of silver nanoparticles using bioreductors and their application as antibacterial agents using bidara leaf extract against Staphylococcus aureus bacteria. This research used the green synthesis method to produce silver nanoparticles. The bidara leaf extract used was divided into several concentrations, namely 1 mM, 2 mM, 3 mM and 4 mM. To characterize silver nanoparticles, UV-Vis and PSA spectrophotometers were used. Furthermore, the Kirby-Bauer method was used to test the antibacterial properties of silver nanoparticles against Staphylococcus aureus bacteria. The results of research that has been done show that the formation of silver nanoparticles is characterized by the emergence of maximum absorbance peaks in the wavelength range of 400-450 nm, while the PSA results at concentrations of 3 and 4µm showed nanoparticle sizes of 185 nm. Silver nanoparticles of bidara leaf extract with various concentrations of 1 mM, 2 mM, 3 mM and 4 mM have antibacterial activity that can inhibit the growth of Staphylococcus aureus bacteria with an average inhibition zone diameter of 13.0617 mm, 11.7333 mm, 9.05 mm and 13.19 mm. This shows that silver nanoparticles with bidara leaf extract have antibacterial properties.
Uji Aktivitas Antibakteri Sabun Transparan Putik Saffron (Crocus sativus L) terhadap Bakteri Staphylococcus aureus Emmy Wiriandini; Gabena Indrayani Dalimunthe; Minda Sari Lubis; Haris Munandar Nasution
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 2 (2024): March : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i2.343

Abstract

Transparent soap is a variation of solid bar soap that not only functions to clean dirt but also has a scrubbing function. Transparent solid soap is one of the soap innovations that has become an attractive soap. Saffron also has antibacterial properties due to the presence of flavonoids, tannins and saponins. Flavonoids are compounds that can have anti-inflammatory, anticancer and antioxidant effects, because they can inhibit the formation of free radicals. It has been used traditionally to treat various ailments including depression, cardiovascular disease, menstrual disorders, asthma, insomnia, digestive ailments, bone pain and several other ailments. Saffron pistil juice is made by dissolving in CO₂-free distilled water. Phytochemical screening was carried out on saffron pistil extract. Saffron pistil juice is made in various soap formulas, namely formula I, formula II and formula III. The positive control used was chloramphenicol antibiotic and the negative control was DMSO. There were several tests carried out on Saffron pistil extract in addition to phytochemical screening, namely antibacterial testing on transparent soap with Saffron pistil extract as a soap additive. The results of phytochemical screening showed that the pistil of saffron (Crocus sativus L) contained secondary metabolites, namely: flavonoids, alkaloids, tannins, and saponins. And for the results of the antibacterial activity research also showed that the Saffron pistil extract against transparent soap which can be used as a soap additive, the antibacterial results had a strong inhibition at the average value of formula III which was 20.5 and formula II was 18.4 mm and formula I 16.1 mm, against Staphylococcus aureus bacteria.
Produksi Protein Sel Tunggal dari Kultur Saccharomyces cerevisiae dengan Medium Limbah Kulit Nanas (Ananas comosus L. MERR) Krisna Juniharta Napitupulu; Yayuk Putri Rahayu; Haris Munandar Nasution; Minda Sari Lubis
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 2 (2024): March : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i2.346

Abstract

Single cell protein is the term used for peoteins derived from microbes such as fungi. Pineapple waste is one of the alternative media that has easiest source of carbohydrates to obtain, so it has the potential for the growth of Saccharomyces cerevisiae. The purpose of this study was to determine wether pineapple waste could produce single cell protein production by adding nutrients to the fermentation medium. The research used in this research is experimental research. To determine the relationship between the independent variable and the dependent variable. Where the independent variables are the addition of nutrients and fermentation time on days 0,2,4,6 to see the dependant variable, namely the analysis of protein content, dry weight analysis of cells, analysis of glucose levels, pH and temperature analysis. The results of this study showed that the highest protein content was obtained in H4 fermentation by MFKN2, namely 0,43%, cell dry weight 0,851 grams, glucose content 1,3402%, ph 4,5, temperature 27,1 ⁰C. Meanwile, MFKN1 showed the highest protein content in H6 fermentation, namely 0,38%, cell dry weight 0,817 grams, glucose content 1,3397%, pH 4, temperature 26,2 ⁰C. The yield of glucose and pH tended to decrease as the fermentation process progressed until the last day of fermentation. The results of the temperature analysis tend to be stable as the fermentation process progresses until the last day of fermentation. The conclusion of this study is that pineapple waste can produced single cell protein from Saccharomyces cerevisiae culture and has different protein production with the addition of nutrients in the fermentation medium.
Drug Formulasi paper soap ekstrak etanol dedak padi (Oryza sativa L.) dan uji aktivitas antibakteri terhadap bakteri Escherichia coli dan Staphylococcus aureus Zannah , Muhamad; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.229

Abstract

Paper soap is soap in the form of thin sheets resembling paper. Rice bran from rice milling waste contains antibacterial compounds. The aim of this research was to formulate paper soap from rice bran ethanol extract and to determine its antibacterial activity. This research is a type of experimental research carried out in a laboratory. Includes steps such as taking and identifying samples, preparing and making ethanol extract of rice bran (Oryza sativa L.), and testing antibacterial activity against Escherichia coli using the Disc Disc method, where the inhibition zone of the ethanol extract of rice bran and the paper soap preparation is containing rice bran extract (Oryza sativa L.) was observed and measured as a result of the antibacterial activity test. The results of this research show that the ethanol extract of rice bran contains chemical compounds, namely alkaloids, flavonoids, saponins, tannins, triterpenoids/steroids and glycosides. Rice bran ethanol extract has characteristics in accordance with the 1989 MMI requirements. The results of determining the antibacterial activity of rice bran ethanol extract produce an inhibition zone against Escherechia coli bacteria ranging from 5mm - 12.5mm and Staphylococcus aureus ranging from 5.5 mm-16.67 mm. The results of the paper soap evaluation test, organoleptic examination, thickness examination, weight uniformity test, stability test, foam power test met the requirements and in the irritation tests F0, F1, F2 and F3 did not irritate the skin, in the hedonic test the most preferred formula was F1. The results of determining the antibacterial activity of paper soap produced an inhibition zone for Escherechia coli bacteria ranging from 8.16mm - 12.5mm and Staphylococcus aureus ranging from 15mm-14.83mm. From the research results it can be concluded that rice bran ethanol extract can be formulated into paper soap and has antibacterial activity.
Co-Authors A'dilah, Nur Adani, Bazlina Adela Octi Dwiyani Adjelie, Tiara Afifah, Puan Ibni Alfi Wahyudi Nasution Alma Dhita Shafira Amaliana, Amaliana Andjelie, Tiara Angelina Maghvira Ananda Anggraini, Dea Puspa Anny Sartika Daulay Anugrah, Bayu Ariandi Arianti, Sellin Arina Arifna Luthfianida Aulia Fitri, Aulia Aulia, Meisyah Ayuningrum, Annisa Bambang Hermanto Chairina Milda Chairunnisa Rkt Cikal Azura Cindy Marlina Tambunan Cut Dian Mala Luthfia Cut Intan Annisa Putri D Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D.Elysa Putri Mambang Dama Yanti, Fradilla Debi Meilani Dena, Mutia Denni Bahari Dewa, Fasca Dewi, Sri Harti Dikki Miswanda Dinda Dila Puspita Dinda Sari Utami Efendi, Tania Tiara Ellyza, Chella Elmi Sariani Hasibuan Emmy Wiriandini Fanny Anggreany Santosa fatimah Fauziah Zain Fithri Pulungan, Ainil Fitri Febriani Fitri, Nurul Fitri, Raissa Gabena Indrayani Dalimunte Gabena Indrayani Dalimunthe Gabena Indrayani Dalimunthe Gabena Indrayani Dalimunthe Haris Munandar Nasution Haris Munandar Nasution Hasibuan , Fika Miah Sasmitha Hendraputra, Hardy Handoko Heru Adha Prayogo Hindri Syahputri Husna, Miftahul husna, nadiatul Hutagalung , Septi Ratna Cempaka Hutagalung, Riris Br Hutagalung, Victor H Ika Fitriani Indah Nasution Inna Myesha Intan Sabila Putri Purba Juliana Metami Sihombing Junia Fitri Hayani Juwita, Sukma Karismawati Karlina Butar Butar Khoyrill Muttiin Kiki Rawitri Krisna Juniharta Napitupulu Latifah Hanum Lestari, Seri Lestari, Sri Indah Lilik Septiana Linda, Rosa Lisda Mayanti Lubis, Asira Lubis, Nadya Frestika Lubis, Nurazizah Lubis, Zulkifli Ismail M Rayhan Ulmi M. Arya Wiguna Madani Sirait maghfirah, Suci Mambang, D Elysa Putri Matondang , Fikriyah Hafni Maulana Putri, Yasinta Metami Sihombing, Juliana Meutia, Cut Meylisa Pratami Br Sinaga Miftahul Jannah Milwani Harahap Miranza, Nona Misbah Siregar Misna Rosalinda Hutabarat Mohd. Bilal Muhammad Amin Nasution Muhammad Tegar Tri Rizky Nadia Salsabilla Nasri Nasri, Nasri Nasution , Muhammad Amin Nasution, M Pandapotan Nasution, M. Pandapotan Nasution, Vevi Sarah Nia Novranda Pertiwi Ningtias, Anggitha Novi Yuliandari Novita Sari, Helsa Novriani Putri Santia Nur Asia, Nur Nuratika, Eli Nurfadilla, Kiki Nurhaliza Safitri Nurul Arafah Nurul Salsa Abya Ritonga Nurwijayanti Oktavia, Zela Oneayu One Pulungan, Anili Fithri Purba, Juvantri Fablo Puspita, Dinda Dila Puteri, Cut Intan Annisa Putri , Adilla Rafita Yuliarti Rafita Yuniarti Rafita Yuniarti Rafita Yuniarti Rafita Yuniarti Rahma Maulidia Fitri Rahmadani Rahmadani Rahmadani Rahmadani Rahmi, Sofia Ramadhan , Yusril Rambe, Sitiapsah Rapita Yuniarti Rati , Yuliandini Rati Satri Situmorang Rezky , Deswita Ina Riani, Nur Aslin Ridwan Taher Lubis Ridwanto Ridwanto Rifqi, M. Ainur Ritonga , Nur Sakina Ritonga , Septi Ani Ritonga, Oktavia rizka Rohmah, Roihanah Rosalinda Mahdalena Sinaga Rosalinda Mahdalena Sinaga Safina, Wan Dian Sagita Marina Simatupang Sandika, M Teguh Sari, Syilvi Rinda Savika, Anggraini Selvicahyani, Selvicahyani Shinta Mida Ariani Harahap Sihotang, Laura Indah Restu silalahi, zahra salsabila Sinaga, Rosalinda Mahdalena Sindi, Sindi Siregar , Runisya Maugin Utami Siregar, Hikmatussabaria Siregar, Rina Paramitha Siti Aisyah Jamil Siti Anisa Sitinjak, Iyustri Ririn Slamet Indarjo Sri Harti Sri Mulia Ningsih Siregar Sri Murni Sri Murni Sri Ria Ranti Sri Wahyuni Sri Wahyuni Sulaiman Sulaiman Sulwiyatul K Sani Supiyani Supiyani Supiyani Supiyani Supiyani, Supiyani Surendro, Yasmeen Nazhifah Amani Syafa Nadira Ashiilah Syafira, Nona Syafirna, Nada Syofyan Syofyan Tia Nazilla Titin Agustina Trisha Wulan Erja Ulmi, M Rayhan Ummu Safura Sirait Vera Estefania Kaban Vera Kristiana Wanda Elvia Putri Widya, Rizka Wilda Septia Winda Aulia Winda Kesuma Yadi, Hervi Yayuk Putri Rahayu Yayuk Putri Rahayu Yayuk Yuliana Yayuk Yufri Aldi Yuliawati Yuni Sartika Yuniarti , Rafita Yuniarti, Rafita Yuniarti, Rapita Zahara, Fitria Siti Zahira Ahmad, Madani Zannah , Muhamad Ziza Putri Aisyia Fauzi Zulhij, Fizrya Zulmai Rani