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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Penelitian Pendidikan IPA (JPPIPA) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JPSCR : Journal of Pharmaceutical Science and Clinical Research Journal of Pharmaceutical and Medicinal Sciences JPBIO (Jurnal Pendidikan Biologi) Jurnal Mandala Pharmacon Indonesia Health Information : Jurnal Penelitian Archives Pharmacia Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Pengabdian Mandiri Pharmaceutical Reports Journal of Noncommunicable Diseases (JOND) jpki Jurnal Katalisator Sahabat Sosial: Jurnal Pengabdian Masyarakat International Journal of Health Sciences E-Amal: Jurnal Pengabdian Kepada Masyarakat Jurnal Sains dan Kesehatan
Yuri Pratiwi Utami
Universitas Mega Buana Palopo
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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TOTAL FLAVONOID LEVELS AND ANTIOXIDANT ACTIVITY OF KERSEN LEAF EXTRACT (muntingia calabura L.) L A, Hamdayani; Fitriyanti Jumaetri Sami; Yuri Pratiwi Utami
JURNAL KATALISATOR Vol. 9 No. 1 (2024): Jurnal Katalisator Volume 9 No.1, April 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i1.2831

Abstract

Kersen leaves (Muntingia calabura L.) are plants that contain many secondary metabolites, one of which is flavonoids that can act as antioxidants. This study aims to determine the total content of flavonoids which also have the potential as antioxidants in cherry leaves using the DPPH method (2,2-diphenyl-1-picrylhidrazyl) with various filters, namely 70% ethanol, ethyl acetate and n-hexan. Testing of total flavonoid content was carried out using AlCl3 reagent and measured using spectrophotometry at a wavelength of 422 nm. Antioxidant activity testing was measured at an absorption wavelength of 516 nm. The results showed the total flavonoid content of 70% ethanol filter leaf extract as much as 8.13 (mgQE/g), ethyl acetate as much as 8.32 (mgQE/g) and n-hexan as much as 18.96 (mgQE/g). antioxidant activity of cherry leaves using DPPH method (2,2-diphenyl-1-picrylhidrazyl) with filter variations. 70% ethanol extract of cherry leaves has an IC50 value of 7.56 μg/mL, ethyl acetate extract with an IC50 value of 36.05 μg/mL, and n-hexan extract with an IC50 value of 21.33 μg/mL. From the results obtained it can be concluded that the highest antioxidant activity is contained in 70% ethanol extract of 7.56 μg/mL.
ANTIBACTERIA ACTIVITY ETHANOL EXTRACT OF ACHRAS ZAPOTA L. FRUIT AND LAGENARIA SICERARIA (MOLINA) STANDL. AGAINST SALMONELLA TYPHI Saldi Hapiwaty; Yuri Pratiwi Utami; Imrawati; Mahfuzun Bone; Nurjannah Bachri; Rahmah Mustarin; Ainun Jariah; Zahira Amody; Benedikta Winne Angela
JURNAL KATALISATOR Vol. 9 No. 2 (2024): Jurnal Katalisator Volume 9 No.2, Oktober 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i2.3103

Abstract

The Synergistic of antibacterial is an interaction of two antibacterial agents that produces a greater inhibitory effect on bacteria, compared to the individual antibacterial effects of the two agents. The purpose of this study was to determine the synergistic effect of anti-bacterial extract of sapodilla fruit (Achras zapota L.) and water gourd (Lagenaria siceraria (Molina) Standl.) extract against Salmonella typhi bacteria. Extraction of sapodilla fruit and water gourd fruit was carried out by maceration method using 96% ethanol (1:10). Determination of the value of the minimum inhibitory concentration (MIC) of anti-bacterial sapodilla manila fruit and water gourd fruit was carried out by the checkerboard assay method using a 96 wells microplate by calculating the Fractional Inhibition Concentration Index (FICI) value. The results showed that the single MIC value of sapodilla manila fruit and water gourd fruit respectively are 50 mg/mL and 100 mg/mL. The interaction between the two is expressed as a Fractional Inhibitory Concentration Index (FICI) with a value of 1.5. The FICI values ​​indicate different antibacterial effects of the combination of sapodilla fruit and water gourd fruit against Salmonella typhi. Keywords: Synergistic, Salmonella typhi, Achras zapota L., Lagenaria siceraria (Molina) Standl., FICI
ANTI-AGING ACTIVITY WITH TYROSINASE INHIBITORS AND ANTIOXIDANTS FROM BADUY OUTER TRIBE PLANTS AS COSMETICS: REVIEW Yuri Pratiwi Utami; Anto Apriyanto; Nurhayani; Agus Firmansyah; Firdaus
JURNAL KATALISATOR Vol. 10 No. 1 (2025): Jurnal Katalisator ( On Progres)
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i1.3439

Abstract

Aging is an unavoidable physiological process. The process of premature aging is prevented using natural anti-aging cosmetics derived from plants. Cosmetics can be used as anti-aging products. Therefore, plants can be used as substitutes for anti-aging chemicals with fewer side effects. There are many herbal plants that are empirically used by the Baduy community and have potential as anti-aging agents with tyrosinase inhibitory and antioxidant activities. Evidence of anti-aging activity can be obtained by testing the effects of each herbal plant, which has been conducted by several researchers previously. The purpose of this article is to provide information on which plants have the potential as anti-aging agents for cosmetic raw materials thru a literature review of journals in electronic databases. The results obtained from several plants such as Carica papaya L., Kaempferia galanga, Psidium guajava, Zingiber officinale var. Rubrum, Piper bettle, Caesalpinia sappan L, and Etlingera elatior (Jack) R.M. Sm have tyrosinase inhibitory activity. Orthosiphon stamineus B., Coleus scutellarioides (L.) Benth, and Imperata cylindrica (L) Beauv., the cogongrass plant, use an antioxidant approach as anti-aging. In conclusion, all herbal plants from the Baduy tribe have the potential as raw materials for anti-aging cosmetics
Variasi Waktu dan Suhu Penyimpanan Ekstrak Daun Andong Merah Cordyline fruticosa (L.) A. Cheval tehadap Kadar Total Antosianin: Variations in Storage Time and Temperature of Cordyline fruticosa (L.) A. Cheval Red Andong Leaf Extract on Total Anthocyanin Contents Utami, Yuri Pratiwi; Sarwati, Dewi
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.1971

Abstract

Cordyline fruticosa. (L.) A. Cheval plant is one of the traditional medicines which has been proven to have benefits including as a medicinal ingredient. This plant contains several chemical compounds including saponins, tannins, flavonoids, polyphenols and steroids. The aim of the research This was to determine the effect of temperature and storage time of red andong leaf extract on anthocyanin levels. Red andong leaves were extracted by maceration using 70% ethanol. The results showed total anthocyanin levels at temperatures of -20°C, 4°C, 25°C and 37°C for 7 days and 14 days. For the first week it was 7.81 mg/L, 8.41 mg/L, 7.29 mg/L, 6.19 mg/L and the 2nd week was 5.99 mg /L, 7.14 mg/L, 3.03 mg/L, 2.37 mg/L. Based on the research results, it was concluded that increasing temperature and storage time damaged the color of anthocyanins. The highest anthocyanin levels after storage were at 4°C of 8.41 mg/l in week 1 and 7.14 mg/L in week 2.   Keywords:          Cordyline fruticosa ( L.) A. Cheval, anthocyanin, Temperature and storage time   Abstrak Tumbuhan andong merah (Cordyline fruticosa. (L.) A. Cheval merupakan salah satu obat tradisional yang terbukti memiliki  manfaat diantaranya sebagai bahan obat. Tanaman ini mengandung beberapa senyawa kimia antara lain saponin, tanin, flavonoid, polifenol, dan steroid. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh suhu dan waktu penyimpanan ekstrak daun andong merah terhadap kadar antosianin. Daun andong merah diekstraksi dengan maserasi menggunakan etanol 70%. Hasil penelitian menunjukkan kadar antosianin total pada suhu -20°C, 4°C, 25°C dan 37°C selama 7 hari dan 14 hari. Untuk minggu pertama adalah 7,81 mg/L, 8,41 mg/L, 7,29 mg/L, 6,19 mg/L dan minggu ke-2 adalah 5,99 mg/L, 7,14 mg/L, 3,03 mg/L, 2,37 mg/L. Berdasarkan hasil penelitian disimpulkan bahwa peningkatan suhu dan lama penyimpanan merusak warna antosianin. Kadar antosianin tertinggi setelah penyimpanan berada pada suhu 4°C sebesar 8,41 mg/l pada minggu ke-1 dan 7,14 mg/L pada minggu ke-2.   Kata Kunci:         Andong merah, antosianin, lama dan waktu penyimpanan
Fraksi Daun Andong Merah (Cordyline fruticose (L.) A. Cheval) Berpotensi sebagai Sitotoksik Metode BSLT Utami, Yuri Pratiwi; Imrawati, Imrawati; Mus, Suwahyuni; Astri, Andi Astri Sri Nurul Fardila; Mustarin, Rahmah
JOURNAL OF NONCOMMUNICABLE DISEASES Vol 4, No 1 (2024): April 2024
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jond.v4i1.974

Abstract

Andong merah (Cordyline fruticosa (L.) A. Cheval) merupakan tanaman yang banyak digunakan sebagai obat tradisional. Kandungan senyawa yang ada pada tanaman andong merah berupa metabolit sekunder diantaranya polifenol, flavonoid, saponin, alkaloid, steroid dan triterpenoid sedangkan pada daun andong merah mengandung senyawa polifenol, tannin dan flavonoid. Tujuan dari penelitian ini yaitu untuk mengetahui sitotoksisitas fraksi daun andong merah (C. Fruticosa) terhadap larva udang Artemia salina Leach menggunakan metode BSLT. Ekstrak etanol 70% menghasilkan tiga fraksi yaitu fraksi n-heksan, fraksi etil asetat, dan fraksi etanol-air dengan teknik ekstraksi cair-cair (ECC) menggunakan tiga pelarut. Kemudian diuji sitotoksisitasnya dari seri konsentrasi 20 ppm, 40 ppm, 60 ppm, 80 ppm dan 100 ppm serta kontrol negatif. Hasil yang diperoleh dari penelitian ini berupa aktivitas sitotoksik fraksi dengan parameter nilai LC50 yaitu fraksi n-heksan 25,05 ppm ppm, fraksi etil aetat 85,21 ppm dan fraksi etanol-air 32,39 ppm. Kesimpulannya yakni fraksi dari daun andong merah (C. Fruticosa) termasuk dalam kategori sitotoksistas kuat. Cordyline fruticosa (L.) A. Cheval is a plant that is widely used as a traditional medicine. The compounds contained in the red oak plant are secondary metabolites including polyphenols, flavonoids, saponins, alkaloids, steroids and triterpenoids whereas in the leaves of the red andong contain compound polyphenol, tannins and flavanoids. The aim of the study was to determine the cytotoxicity of the C. fruticosa fraction to the larvae of the shrimp Artemia salina Leach using the BSLT method. The 70% ethanol extract produces three fractions namely the n-hexane fraction, the ethyl acetate fraction and the ethanole-water fraction using the liquid-liquid extraction technique (ECC) using three solvents. Then they tested their cytotoxicity from a series of concentrations of 20 ppm, 40 ppm and 60 ppm as well as negative controls. The results obtained from this study were fractional cytotoxic activity with LC50 parameters of 25.05 ppm n-hexane fraction, 85.21 ppm ethyl acetate fraction and 32.39 ppm ethanol-water fraction. The conclusion is that the fraction of the C. Fruticosa leaves belongs to the category of strong cytotoxists
Exploration of lactic acid bacteria from husk and black rice (Oryza sativa L) of toraja origin Hapiwaty, Saldi; Zainal, Tuti Handayani; Abidin, Hamdayani Lance; Utami, Yuri Pratiwi
JPBIO (Jurnal Pendidikan Biologi) Vol 10, No 2 (2025): November 2025
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v10i2.5529

Abstract

Lactic acid (LAB) is a bacteria involved in food fermentation and can be used as a probiotic to provide health benefits for those who consume it. This research aims to bring innovation and added value, and improve the community's utilization of probiotics (LAB) from husks and black rice from Toraja. The method used is collecting and processing samples, isolation and purification of LAB, microscopic and macroscopic identification, testing the activity/potential of LAB (Kirby Bauer), and molecular identification of 16S rRNA (sequencing). This study has confirmed that fermented rice has Lactococcus taiwanensis type lactic acid bacteria, while fermented husk is not a type of lactic acid bacteria. Lactococcus taiwanensis bacteria have probiotic potential and can produce antibacterial substances.
Α-GLUCOSIDASE ENZYME INHIBITOR ACTIVITY OF ETLINGERA ELATIOR LEAF EXTRACT WITH SOLVENT VARIATION Imrawati Imrawati; Yuri Pratiwi Utami; Yuniar Dwi Yanti; Tuti Handayani; Nurzadrina wahyuddin; Zahira Amody; Aulia Debby Pelu; Rahmah Mustarin; Indri Indri
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3462

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin production or utilization. The increasing prevalence of diabetes, especially type 2, is a global concern due to the risk of complications it poses. One approach in treating type 2 diabetes is to inhibit the α-glucosidase enzyme to slow down glucose absorption. This research aims to identify the potential of patikala leaf extract as an α-glucosidase enzyme inhibitor. Using an experimental method with patikala leaf samples collected from Mariri Hamlet, Banyuurip Village, Bone-bone District, North Luwu Regency. Extraction was performed using the maceration method with variations in solvents: 70% ethanol, ethyl acetate, and n-hexane. The α-glucosidase enzyme inhibition activity was measured using a microplate reader and analyzed to determine the IC50 value. From the percentage inhibition data, the IC50 values obtained for 30% ethanol extract of patikala leaves were 351.95 µg/mL, for 70% ethanol extract of patikala leaves were 444.83 µg/mL, for 96% ethanol extract of patikala leaves were 362.27 µg/mL, for ethyl acetate extract of patikala leaves were 163.59 µg/mL, and for n-hexane extract of patikala leaves were 294.90 µg/mL, indicating that patikala leaf extracts with variations in solvent or extraction method exhibited very weak α-glucosidase enzyme inhibition activity. In conclusion, based on the research results obtained, the extract with variations in the solvent or extractant. Patikala leaf extract has an inhibitory activity against the α-glucosidase enzyme, which is categorized as very weak because it has an IC50 value > 100 µg/mL. In comparison, the control (acarbose) is in the weak category with an IC50 value of 50-100 µg/mL.
Antibacterial Potential of Muntingia calabura L. Ethanol Extract Against MDR Escherichia coli Utami, Yuri Pratiwi; Latu, Saparuddin; Mustarin, Rahmah; Imrawati; Yudistira, Aditya; Rahmatia
Jurnal Penelitian Pendidikan IPA Vol 11 No 12 (2025): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i12.7765

Abstract

Kersen leaves (Muntingia calabura L.) have long been utilized as a traditional medicinal plant used for headaches, antiseptics, antioxidants, antimicrobials, anti-inflammatories, anti-diabetics, and anti-tumors. This study aims to determine the antibacterial activity and the concentration at which kersen leaf extract can inhibit the growth of Multi Drug Resistant (MDR) Escherichia coli bacteria. The type of research conducted is a laboratory-scale experimental study. The kersen leaves were extracted using the maceration method with a 70% ethanol solvent. The antibacterial activity was tested using the agar diffusion method with sensitive and MDR Escherichia coli bacteria at varying concentrations of 1.25%, 2.5%, 5%, and 10%, conducted in three replicates and incubated for 24 hours. Subsequently, the inhibition zones were measured and the data were statistically processed. Based on the research results, at a concentration of 1.25%, an inhibition zone of 7.86 mm was obtained, at 2.5% concentration 9.65 mm, at 5% and 10% concentrations 11.93 mm and 13.98 mm on sensitive Escherichia coli bacteria, while on MDR Escherichia coli bacteria at a concentration of 1.25%, an inhibition zone of 6.51 mm was obtained, at 2.5% concentration 6.61 mm, at 5% and 10% concentrations 6.68 mm and 6.98 mm. These findings suggest that kersen leaf extract possesses moderate antibacterial activity against both sensitive and MDR E. coli, particularly at higher concentrations.
Penyuluhan dan Edukasi Kosmetik yang Aman Bersama HIASKOS di SMKN 8 Makassar Jariah, Ainun; Utami, Yuri Pratiwi; Imrawati, Imrawati; Mustarin, Rahmah; AS, Indah Meilani; Wahyuddin, Nurzadrina; Yanti, Yuniar Dwi
Sahabat Sosial: Jurnal Pengabdian Masyarakat Vol. 4 No. 1 (2025): Sahabat Sosial: Jurnal Pengabdian Masyarakat (Desember)
Publisher : Asosiasi Guru dan Dosen Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59585/sosisabdimas.v4i1.967

Abstract

Cosmetics are substances or preparations used on the external parts of the human body (epidermis, hair, nails, lips, and external genital organs) primarily for cleansing, perfuming, altering appearance, or improving body odor, or for protecting or maintaining the body's health. Providing counselling and education on safe cosmetics to teenagers is not just about giving beauty tips; it's a crucial step in protecting their long-term health. Adolescents are in a phase of physical and hormonal transition that makes them very concerned about their appearance, but they often lack sufficient consumer literacy to distinguish between safe and harmful products. This counselling aims to educate students to be wiser in choosing safe cosmetics. The method used is direct socialization to students at SMKN 8 Makassar, providing counselling to assess the improvement in understanding after education, direct socialization, and socialization using leaflets. The results obtained show an increase in participants' knowledge of how to choose and use appropriate and safe daily cosmetics. The conclusion of this service activity is that the counselling on safe cosmetics is highly relevant and well-received by adolescents, and it is able to improve their understanding of safe cosmetics, so similar activities can be expanded to other locations.
Co-Authors Abd Rasyid Abd. Halim Umar Abdul Halim Umar Abidin, Hamdayani Lance Abubakar Betan Aditya Yudistira Afni, Fauza Agus Firmansyah Ainun Jariah Ainun Jariah Ainun Jariah Ainun Jariah Anto Apriyanto Aprilia Matelda Dwi Kristiyanti Arif Rachman Aripa, Lusyana AS, Indah Meilani Asril Asril Burhan Asril Burhan Astri, Andi Astri Sri Nurul Fardila Astuti Amin Aulia Debby Pelu Benedikta Winne Angela Besse Yuliana Bone, Mahfuzun Burhanuddin Taebe Dwi Yanti, Yuniar Erianto, Fatricia Fadel Ahmad Haris Fadhilla Maryam Fadillah Maryam Fadillah Maryam Fajriansyah Fajriansyah Fhahri Mubarak Firdaus Fitri Andriani, Fitri Fitriyanti Jumaetri Sami Gemini Alam Hamdayani L. A Hamdayani Lance Abidin Hapiwaty, Saldi Hardianti Hardianti, Hardianti HARDIANTO - Heldawati Heldawati Herlina Rante Hilal, Achmad Humang, Rezki Ihsan Imrawati Imrawati Imrawati Imrawati Imrawati Imrawati Imrawati Imrawati Imrawati, Imrawati Indah Kadullah Indri Indri Irmayanti Irmayanti, Irmayanti Khairuddin Khairuddin L A, Hamdayani Lusianawati, Hayu Mahfuzun Bone Mangosa, Grace Pretty Marwati Marwati Mar’atun Jannah, Imrawati, Muzakkir Baitz, Massolo, Selpi Muh Azwar AR Muhammad A.Y. Ardi Mus, Suwahyuni Mustarin, Rahmah Nasution, Ahmad Faisal Nur Aida Kubangun * Nurhayani Nurhedah, Nurhedah Nurhidaya Nurhidaya Nurjannah Bachri Nurjannah Bachri, Nurjannah Nurul Ainun Agustin Nurzadrina Wahyuddin Pannyiwi, Rahmat Prima Astuti Handayani Rahmad Aksa Rahmah Mustarin Rahmah Mustarin Rahman, Nur Fausia Rahmat, Rezqiqah Aulia Rahmatia Reny Syahruni Risfah Yulianty Rohana Rohana Rosadika Fatimah Rosdiana Rosdiana S, St. Mujahida Safidni, Elvira Saldi Hapiwaty Saparuddin Latu Sari, Lely Meriaya Sarwati, Dewi Sima, Yenny Sri Wahyuni Suhaera Suminar, Saka Surya, Sara Suwahyuni Mus Suwahyuni Mus Tuti Handayani Tuti Handayani Tuti Handayani Zainal Wahyu Hendrarti Wahyuddin Wahyuddin Wahyuddin Wahyuddin, Nurzadrina Yulia Yusrini Djabir Yuniar Dwi Yanti Zaenal Zaenal, Zaenal Zahira Amody Zainal, Tuti Handayani Zulfahmidah Zulfahmidah