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All Journal Biology, Medicine, & Natural Product Chemistry The Indonesian Biomedical Journal Jurnal Biologi Tropis Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Window of Health : Jurnal Kesehatan Journal of Health Policy and Management JURNAL PENDIDIKAN TAMBUSAI Poltekita : Jurnal Ilmu Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ilmiah Profesi Pendidikan Window of Community Dedication Journal Jurnal Kesehatan Tambusai JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal Wal'afiat Hospital Journal INDONESIAN JOURNAL OF HEALTH YASIN: Jurnal Pendidikan dan Sosial Budaya jpki Innovative: Journal Of Social Science Research WAL'AFIAT HOSPITAL JOURNAL Malahayati International Journal of Nursing and Health Science
Makmun, Armanto
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Karakteristik Penggunaan Obat Herbal pada Pasien Rawat Inap di RSP Ibnu Sina Makassar Nurdin, Abbas Zavey; Yusril, Moh.; Makmun, Armanto; Syamsu, Rachmat
Jurnal Pendidikan Tambusai Vol. 8 No. 1 (2024): April 2024
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jptam.v8i1.14026

Abstract

WHO melaporkan bahwa pada tahun 2008, lebih dari 80% penduduk di beberapa negara Asia dan Afrika memilih pengobatan tradisional untuk menjaga kesehatannya. Penilitian ini bertujuan untuk mengetahui Karakteristik penggunaan obat herbal pada pasien rawat inap RSP Ibnu Sina Makassar. Metode penitilian ini bersifat deskriptif kuantitatif yang dilakukan di RSP Ibnu Sina Makassar. Hasil penelitian ini berjumlah 123 responden. Dengan usia pasien 41-60 tahun sebanyak 51 responden (41.5%). Responden perempuan sebanyak 79 orang (64.2%). Pekerjaan pasien sebanyak 42 responden (34.1%) sebagai ibu rumah tangga. Suku pasien sebanyak 49 responden (39.8%) suku Makassar. Pendidikan terakhir Sarjana sebanyak 44 responden (35.8%). Penyakit yang diderita sebanyak 29 responden (23.6%) penyakit tumor, Responden yang menggunakan herbal sebanyak 78 responden (63.4%). Sebanyak (21.1%) responden menggunakan jahe sebesar 69,2%, Jenis obat herbal sebesar 71.8% responden memilih bukan salah satu dari jenis obat herbal yang diketahui. Hasil penelitian tingkat kepercayaan sebesar 92.3% responden. Didapatkan kesimpulan populasi responden yang berusia 41-60 tahun, terutama perempuan, dengan latar belakang suku Makassar dan pendidikan tinggi, terdapat tingkat penerimaan dan kepercayaan yang tinggi terhadap penggunaan herbal jahe.
LAPORAN KASUS : ANALISIS KASUS FRAKTUR DALAM PERSPEKTIF MEDIS, BIOETIK DAN ISLAM Wardayani, Wardayani; Putra, Fadil Mula; Mappaware, Nasrudin Andi; Rijal, Syamsu; Mokhtar, Shulhana; Makmun, Armanto; Syamsu, Rachmat Faisal
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.26918

Abstract

Fraktur adalah kerusakan kontinuitas susunan tulang yang terjadi karena trauma, stres berulang dan kelemahan abnormal pada tulang (fraktur patologis). Dalam kaidah dasar bioetik diketahui terdapat 4 aspek, yaitu: Beneficence, non-maleficence, autonomy, dan justice. Dalam perspektif islam yaitu surah Al- Qasas ayat 77, surah Asy-Su'ara ayat 80, surah Al-Maidah ayat 2, dan H.R Bukhari. Maqasid  Al Shariat mengandung 5 nilai yaitu Hifz ad din, Hifz an nafs, Hifz al maal, hifz al nasl dan hifz al aql. Dalam  perspektif  ilmu  fiqih  terdiri  atas  lima  kaidah  yaitu Al-Umuru  Bi  Maqashida,  La  Dharar  wala Dhirara,  Al-Masyaqqah  Tajlibut  Tasyir,  Al-Yaqinu  La  yuzalu  bi  syak  dan  Al-Adatu  Muhakkamah Laporan kasus ini adalah laki laki usia 21 tahun dengan sulit berjalan akibat terjatuh dari tangga saat memasang lampu sekitar 3 bulan yang lalu. Pemeriksaan fisik d regio femur dextra tampak deformitas (+), edema (-), bone exposure (-), nyeri tenderness (-),  ROM terbatas, sensibilitas baik, pulsasi arteri radialis dan ulnaris teraba, CRT < 2 detik. Pada pemeriksaan foto polos femur dextra didapatkan kesan Fraktur transversa nonunion 1/3 proksimal os femur dextra dengan displacement fragmen proksimal ke anterior. Untuk itu pasien di diagnosis fraktur femur non union. Untuk tatalaksana pada pasien, dilakukan Tindakan ORIF. Dalam perspektif kaidah dasar bioetik autonomy  dan beneficence, serta  memenuhi  nilai  Maqasid  Al  Shariat  yaitu Hifz  an  nafs serta  kaidah fiqih La Dharar wala Dhirara. Kesimpulan dari kasus ini bahwa seorang laki laki dengan fraktur femur non union, dilakukan tindakan sesuai indikasi medis, memenuhi kaidah dasar bioetik, etika klinik dan kaidah fiqih.
LITERATURE REVIEW : POST TRAUMATIC STRESS DISORDER PASCA COVID-19 Yani, Siti Nurindah; RiJal, Syamsul; Mappaware, Nasrudin Andi; Mokhtar, Sulhana; Makmun, Armanto; Syamsul, Racmat Faisal
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.27372

Abstract

Pandemi COVID-19 telah menyebabkan dampak psikologis yang signifikan di seluruh dunia, dengan potensi untuk meningkatkan risiko gangguan stres pasca trauma (PTSD) pada individu yang terkena dampaknya. Dalam tinjauan literatur ini, kami menyelidiki implikasi klinis dari PTSD setelah pandemi COVID-19, dengan fokus pada faktor risiko, gejala, dan pendekatan terapeutik yang relevan. Kami menemukan bahwa faktor risiko utama untuk PTSD pasca COVID-19 mencakup pengalaman langsung dengan penyakit, kehilangan sosial, isolasi, dan stres ekonomi. Gejala yang muncul mungkin meliputi reaksi psikologis yang intens terhadap pengalaman trauma, seperti flashbacks, insomnia, dan peningkatan kecemasan. Selain itu, kami menguraikan berbagai pendekatan terapeutik yang dapat digunakan untuk mengatasi PTSD pasca COVID-19, termasuk terapi kognitif-perilaku, terapi eksposur, dan intervensi berbasis dukungan sosial. Pemahaman yang lebih baik tentang kompleksitas PTSD pasca COVID-19 penting untuk mendukung upaya pencegahan, deteksi, dan intervensi yang tepat waktu. Implikasi klinis dari penelitian ini dapat membantu memandu praktisi kesehatan mental dalam memberikan perawatan yang efektif dan mendukung pemulihan bagi individu yang terkena dampaknya.
The Effectiveness of Olive Oil in Preventing Atherosclerosis: A Literature Review Syamsu, Rachmat Faisal; Thahira, Yugni Maula; Nasruddin, Hermiaty; Dahlia, Dahlia; Indarwati, Rezky Putri; Palloge, Salahuddin Andi; Nurdin, Abbas Zavey; Makmun, Armanto; Bahar, Burhanuddin
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3532

Abstract

Olive oil is a rich source of oleic acid and polyphenols. Extra virgin olive oil is rich in phenolic compounds which are known to have anti-inflammatory, anti-cancer, and antioxidant effects. Olive oil has been used for thousands of years as a food source and is reported to have beneficial effects on cardiovascular disease. This review aims to provide a comprehensive overview of the current literature on the use of olive oil in the prevention and treatment of cardiovascular diseases and prevention of atherosclerosis. The methodology is employed by searching the article at Google Scholar, PubMed, Semantic Scholar, teaching materials, and research gate. Studies included the consumption of olive oil, by using qualitative and quantitative methodologies, were published in journals between 2013 and 2024 to obtain the latest information and relevant contents of the articles as well as the empirical data that indicate the effectiveness of olive oil. This research has a varying result, such as the high level of cholesterol and low-density lipoprotein cholesterol (LDL-C). Olive oil polyphenols also increase HDL particle size increase HDL stability by producing a triglyceride-poor core, and improve HDL antioxidant status by increasing the olive oil polyphenol metabolite content of lipoproteins, and it can intake of several foods also positively modulates platelet reactivity and may be the basis for the reduced cardiovascular risk reported in individuals on diets that increase the intake of plant foods, such as the Mediterranean diet. The olive oil which contains MUFA in the form of oleic acid and polyphenols has anti-atherogenic properties to prevent cardiovascular disease.
Black Rice Extract Reduces Body Weight, Waist Circumference, Body Mass Index and Lipopolysaccharide in Obese Subjects: A Preliminary Study Makmun, Armanto; Bukhari, Agussalim; Taslim, Nurpudji Astuti; Aminuddin, Aminuddin; Sandra, Ferry
The Indonesian Biomedical Journal Vol 16, No 5 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i5.3250

Abstract

BACKGROUND: The prevalence of obesity, or an excessive fat accumulation, is keep increasing. In obesity, inflammation can be induced by leaky gut due to the intestinal tight junction barrier dysfunction. Zonula occludens-1 (ZO-1) plays a role in developing intestinal tight junction barrier dysfunction and gut microbiota imbalance, thus promote the translocation of bacterial endotoxin characterized by lipopolysaccharide (LPS) into circulation. Black rice extract (BRE) has been known to have anti-inflammatory property. This study was conducted to investigate the effect of BRE on body weight (BW), waist circumference (WC), body mass index (BMI), ZO-1 and LPS of obese patients.METHODS: Twenty-three male subjects were divided into non-obese group (NOG), obese group (COG) and BRE-obese group (BOG). Subjects in BOG received a daily dose of 5.6 g/day BRE for 4 weeks. BW, WC and BMI, serum ZO-1 and LPS were measured before and after treatment.RESULTS: BRE was prepared successfully and free from microbial contamination. Treatment of BRE for 4 weeks reduce BW (95.40±5.78 vs. 94.59±6.00 kg, p=0.043), WC (109.25±3.55 vs. 107.50±3.46 cm, p=0.000) BMI (32.65±1.86 vs. 32.18±1.80, p=0.000) and LPS (222.27±38.63 vs. 131.63±9.70 ng/mL, p=0.020) of obese subjects. The pre-post ZO-1 levels in all groups were not significantly different (p>0.05).CONCLUSION: Treatment of 5.6 gr BRE daily for four weeks can reduce BW, WC, BMI and serum LPS, but not serum ZO-1 in obese patients. Therefore, BRE may reduce inflammation in obesity.KEYWORDS: black rice, obesity, BW, WC, BMI, LPS, ZO-1
Pengaruh Anemia dan Preeklampsia terhadap Kejadian Bayi Berat Lahir Rendah (BBLR) Cahyani, Pramesty Regita; Dahliah, Dahliah; Makmun, Armanto; Kamaluddin, Irna Diyana Kartika; Darma, Sidrah
Wal'afiat Hospital Journal Vol 5 No 1 (2024): Wal'afiat Hospital Journal
Publisher : Rumah Sakit Ibnu Sina, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/whj.v5i1.131

Abstract

Anemia and preeclampsia during pregnancy contribute significantly to the risk of low birth weight (LBW) in neonates. Anemia, characterized by hemoglobin levels below 11 g/dL in the first and third trimesters, and below 10 g/dL in the second trimester, and preeclampsia, which involves hypertension and organ dysfunction after 20 weeks of pregnancy, can interfere with the supply of oxygen and nutrients to the fetus, causing LBW. The study conducted a Literature Review of 840 articles, and found that anemia increased the risk of LBW by about 1.49 times, while preeclampsia also had a significant association with LBW. These findings suggest the importance of early detection and treatment of anemia and preeclampsia to improve neonatal health outcomes. Further research is needed to develop more effective interventions to address these conditions.
Laporan Kasus: Analisis Kasus Hipoalbuminemia Pada Congestive Heart Failure (CHF) Dalam Perspektif Medis, Bioetik Dan Islam Palo, Nurul Aisyah; Rachmat, Rizqah Aulyna; Mappaware, Nasrudin Andi; Royani, Ida; Mokhtar, Shulhana; Makmun, Armanto; Syamsu, Rachmat Faisal; Latief, Shofiyah
Innovative: Journal Of Social Science Research Vol. 4 No. 5 (2024): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v4i5.13827

Abstract

Albumin merupakan protein utama yang memiliki beberapa peran fisiologis. Hipoalbuminemia adalah kadar albumin darah yang kurang dari normal yaitu kurang dari 3,5 g/dl. Dalam kaidah dasar bioetik diketahui terdapat 4 aspek, yaitu: Beneficence, non-maleficence, autonomy, dan justice. Dalam perspektif islam yaitu surah Al- Rum ayat 41, surah Al-Isra ayat 82, H.R Bukhari dan H.R Muslim. Laporan kasus ini adalah perempuan 48 tahun, datang ke Poli Interna RSUD Tenriawaru Bone dengan keluhan keluhan bengkak diseluruh badan sejak > 6 bulan yang lalu. Pemeriksaan fisik didapatkan kesadaran composmentis, tanda tanda vital didapatkan tekanan darah 184/84 mmHg dan suhu 37,5oC. Status generalis konjungtiva anemis (+/+),  bibir pucat (+), bunyi napas tambahan rhonki -/+, pada abdomen tampak cembung, timpani (+), pada ekstremitas edema (+) ekstremitas atas dan bawah (tangan dan kaki). Pada pemeriksaan laboratorium didapatkan kolesterol total 364mg/dL, glukosa sewaktu 364 mg/dL, albumin 2.2g/dL, natrium 133 mmol/l, kalsium 108 mmol/l dan pH urin 5.0. Untuk itu pasien di diagnosis hipoalbuminemia. Untuk tatalaksana pada pasien, dilakukan tindakan cairan dan farmakologi. Dalam perspektif kaidah dasar bioetik autonomy  dan beneficence. Kesimpulan dari kasus ini bahwa seorang perempuan dengan hipoalbuminemia, dilakukan tindakan sesuai indikasi medis, memenuhi kaidah dasar bioetik dan etika klinik
Pengaruh Puasa Terhadap Kadar Kolesterol Pada Hewan Mencit (Mus Musculus) Hiperkolesterolemia Isman, Thalhah Bin; Makmun, Armanto; Ningsih, Iin Widya; Mukhtar, Shulhana; Murfat, Zulfitriani
MAHESA : Malahayati Health Student Journal Vol 4, No 5 (2024): Volume 4 Nomor 5 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i5.14574

Abstract

ABSTRACT Cholesterol is an important fat component for the body. But if excessive, cholesterol can cause hypercholesterolemia. Hypercholesterolemia can form atherosclerotic plaque. This is the main cause of increasing deaths in Indonesia every year. This condition is often caused by an unhealthy lifestyle. On the other hand, Muslims have a worship service called fasting. This study aims to examine the effect of fasting on hypercholesterolemia in mice. Mice were chosen because this animal's genome is very similar to humans. Using true experimental research with a Pre-Test and Post-Test Control Group Design research design. The total number of mice used was 30 mice. Before treatment, mice will be given food and drink twice a day (morning and evening) with the same type of food and drink for 1 week. The feed in question is high cholesterol feed consisting of 100g of PTU medication, 100g of beef brain and 100g of quail egg yolk. After one week, the mice were divided into three groups. The first group fasted for 12 hours during the day. The second group fasted 12 hours at night. The third group does not fast. All mice were given high-cholesterol feed orally or fed every two days. Measurement of cholesterol levels in mice was carried out before and after treatment. As a result, research shows that fasting for 12 hours day and night has a significant effect on reducing weight and cholesterol levels in mice. The mice's total cholesterol levels dropped drastically in the second week of fasting intervention. This indicates the effectiveness of fasting on these health indicators. Thus, it can be concluded that fasting is an effective solution for reducing cholesterol levels in the body.  Keywords: Mice, Fasting, Hypercholesterolemia  ABSTRAK Kolesterol merupakan komponen lemak yang penting bagi tubuh. Tetapi jika berlebihan, kolesterol dapat menimbulkan hiperkolesterolemia. Hiperkolesterolemia bisa membentuk plak aterosklerosis. Ini adalah penyebab utama peningkatan kematian di Indonesia setiap tahunnya. Kondisi ini banyak disebabkan karena gaya hidup yang tidak sehat. Di sisi lain, umat muslim memiliki ibadah yang disebut puasa atau shaum. Penelitian ini bertujuan untuk meneliti pengaruh puasa terhadap kondisi hiperkolesterolemia pada mencit. Mencit dipilih karena genome hewan ini sangat mirip dengan manusia.  Menggunakan penelitian true experimental dengan desain penelitian Pre-Test and Post-Test Control Group Design. Total mencit yang digunakan adalah 30 ekor. Sebelum perlakuan, mencit akan diberikan makan dan minum 2 kali sehari (pagi dan sore) dengan jenis makanan dan minuman yang sama selama 1 minggu. Pakan yang dimaksud adalah pakan tinggi kolesterol yang terdiri dari obat PTU 100gr, 100gr otak sapi dan 100rg kuning telur puyuh. Setelah satu minggu, mencit dibagi menjadi tiga kelompok. Kelompok pertama puasa 12 jam di siang hari. Kelompok kedua puasa 12 jam di malam hari. Kelompok ketiga tidak berpuasa. Seluruh mencit diberikan pakan tinggi kolesterol secara oral atau disonde setiap dua hari sekali. Pengukuran kadar kolesterol pada mencit dilakukan sebelum dan setelah diberi perlakuan. Hasilnya, penelitian menunjukkan puasa 12 jam siang dan malam berpengaruh signifikan terhadap penurunan berat badan dan kadar kolesterol mencit. Kadar kolesterol total mencit turun drastis di minggu kedua intervensi puasa. Ini menandakan efektivitas puasa terhadap indikator kesehatan tersebut. Dengan demikian, bisa diambil kesimpulan bahwa puasa merupakan salah satu solusi yang efektif untuk menurunkan tingkat kolesterol di dalam tubuh. Kata Kunci: Mencit, Puasa, Hiperkolesterolemia
Pengaruh Puasa 12 Jam Terhadap Kadar Asam Urat pada Mencit (Mus Musculus) Hiperurisemia Fakhirah, Muthiah Raghdah; Makmun, Armanto; Ningsih, Iin Widya; Kartika K, Irna Diyana; Murfat, Zulfitriani
MAHESA : Malahayati Health Student Journal Vol 4, No 7 (2024): Volume 4 Nomor 7 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i7.14700

Abstract

ABSTRACT Gout is one condition that is categorized as a metabolic disease and is rather common in both developed and developing nations. Uric acid can accumulate in tissues and blood due to gout, a common inflammatory disease. The term hyperuricemia refers to the state in which an individual has an excess of uric acid in their blood, surpassing the upper limit of normal, which is 6.8 mg/dl. If the uric acid level in a man is more than 7 mg/dl, and more than 6 mg/dl in a woman, it is considered hyperuricemia. One of the religious practices that Muslims follow at Allah SWT's command is fasting. Blood levels of uric acid, cholesterol, and glucose can all be lowered by fasting. According to the research's results the patient had a uric acid level of 7.7 mg/dl prior to fasting, whereas men's normal uric acid levels are less than 7 mg/dl. It turned out that the same person's uric acid dropped to 6.6 mg/dl in the first ten days. The 21st day saw another drop in his uric acid level to 6.2 mg/dl. It was not specified, though, what kind of fasting was done based on this research. Thus, more thorough research is required to determine the best kind of fasting to lower blood levels of uric acid. Mice (Mus musculus) are mammals and are polyestrus animals, which means that over a period of one year there is a repeated reproductive cycle. Mice (Mus musculus) from their external shape are more practical and efficient for research in the laboratory. Analyze and determine the effect of 12 hours of fasting for 14 days on uric acid levels in hyperuricemic mice (Mus musculus). This type of research is true experimental research with a Pre-Test and Post-Test Control Group Design research design. Measurement of uric acid levels in mice (Mus musculus) was carried out before and after treatment. The population in this study were mice (Mus musculus) aged 6 - 8 weeks with a body weight of 20 - 40 grams. All mice were given food and drink twice a day with the same food and drink for 1 week. Then the mice were induced with potassium oxonate at a dose of 300 mg/kgBW or 6 mg/20gBW in the intravenous area. Mice were divided into 3 groups. Group 1 (Control), namely mice that did not fast 12 hours for 14 days. The second group, namely mice, fasted 12 hours during the day for 14 days. The third group, namely mice, fasted 12 hours at night for 14 days. This treatment was carried out for 14 days by providing the same type of food and drink. Mice uric acid levels were measured after being induced by potassium oxonate and on the last day of fasting. Mice blood was collected from the tail vein using a blood lancet. From the research results, it was found that there were insignificant changes in the control group of mice and significant changes in the group of mice with nighttime fasting intervention. The results of the study also showed a significant relationship in the three groups of mice after treatment. Then the group of mice that fasted at night was the group of mice that experienced the most significant changes in uric acid levels. From this research, the results showed that there were significant changes in the uric acid levels of mice before and after fasting for 12 hours at night for 14 days.  Keywords: Fasting, Gout, Mice, Research  ABSTRAK Salah satu penyakit yang memiliki prevalensi cukup tinggi di Negara berkembang bahkan di Negara maju yang tergolong kedalam penyakit metabolik adalah penyakit gout. Gout merupakan penyakit inflamasi yang umum terjadi dan memungkinkan terjadinya penumpukan asam urat dalam darah dan jaringan. Kondisi ini disebut dengan hiperurisemia yaitu kondisi seseorang yang mengalami kelebihan asam urat di dalam darah, yang mana asam uratnya melampaui batas atas normal yaitu 6,8 mg/dl. Pada laki-laki dikatakan hiperurisemia apabila kadar asam uratnya > 7 mg/dl dan pada perempuan apabila kadarnya > 6 mg/dl. Puasa adalah salah satu ibadah yang dilakukan oleh orang islam atas perintah Allah SWT. Puasa dapat menurunkan kadar glukosa, kolesterol, dan asam urat dalam darah. Berdasarkan hasil penelitian, sebelum puasa kadar asam urat pada pasien sebesar 7,7 mg/dl dimana nilai normal dari kadar asam urat untuk laki-laki yaitu dibawah 7 mg/dl. Ternyata dalam 10 hari pertama pada orang yang sama, asam uratnya mengalami penurunan menjadi 6,6 mg/dl. Pada hari ke-21, asam uratnya turun lagi menjadi 6,2 mg/dl. Namun, berdasarkan penelitian tersebut tidak disebutkan jenis puasa yang dilakukan. Oleh karena itu, diperlukan penelitian yang lebih mendalam terkait jenis puasa yang tepat untuk menurunkan kadar asam urat dalam darah. Mencit (Mus musculus) merupakan hewan mamalia dan termasuk hewan poliestrus yang artinya dalam periode satu tahun terjadi siklus reproduksi yang berulang-ulang. Mencit (Mus musculus) dari bentuk luarnya lebih praktis dan efisien untuk penelitian di laboratorium. Menganalisis dan mengetahui pengaruh puasa 12 jam selama 14 hari terhadap kadar asam urat pada mencit (Mus musculus) hiperurisemia. Jenis penelitian ini adalah penelitian true experimental dengan desain penelitian Pre-Test and Post-Test Control Group Design. Pengukuran kadar asam urat pada mencit (Mus musculus) dilakukan sebelum dan setelah diberikan perlakuan. Populasi pada penelitian ini adalah mencit (Mus musculus) yang berusia 6 - 8 minggu dengan berat badan 20 – 40 gram. Semua mencit diberikan makan dan minum dua kali sehari dengan makanan dan minuman yang sama selama 1 pekan. Kemudian mencit diinduksikan dengan kalium oksonat dosis 300 mg/kgBB atau 6 mg/20gBB di daerah intravena. Mencit dibagi menjadi 3 kelompok. Kelompok 1 (Kontrol), yakni mencit yang tidak berpuasa 12 jam selama 14 hari. Kelompok kedua, yakni mencit yang berpuasa 12 jam siang hari selama 14 hari. Kelompok ketiga, yakni mencit yang berpuasa 12 jam malam hari selama 14 hari. Perlakuan ini dilakukan selama 14 hari dengan memberikan jenis makanan dan minuman yang sama. Pengukuran kadar asam urat mencit dilakukan setelah diinduksi kalium oksonat dan hari terakhir dipuasakan. Pengambilan darah mencit dilakukan pada pembuluh darah bagian ekornya dengan menggunakan blood lancet. Dari hasil penelitian didapatkan bahwa terdapat perubahan yang tidak signifikan pada kelompok mencit kontrol dan perubahan signifikan pada kelompok mencit dengan intervensi puasa malam hari. Hasil penelitian juga menunjukkan hubungan yang signifikan pada ketiga kelompok mencit setelah perlakuan. Kemudian kelompok mencit pada puasa malam hari merupakan kelompok mencit yang mengalami perubahan kadar asam urat paling signifikan. Dari penelitian tersebut didapatkan hasil bahwa terdapat perubahan signifikan pada kadar asam urat dari mencit sebelum dan sesudah berbuasa 12 jam di malam hari selama 14 hari. Kata Kunci: Puasa, Asam Urat, Mencit, Penelitian
Polypharmacy Profile in Geriatric Patients Rifa'at, Syahrul; Makmun, Armanto; Nurmadilla, Nesyana; Liaury, Kristian; Sommeng, Faisal; DK, Indah Lestari
Journal La Medihealtico Vol. 6 No. 5 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i5.2636

Abstract

Polypharmacy is a common phenomenon in geriatric patients and is strongly associated with aging and the presence of multiple comorbidities. In the elderly population, the simultaneous use of several medications increases the risk of negative outcomes, including higher healthcare costs, adverse drug reactions, drug–drug interactions, poor medication adherence, functional decline, and geriatric syndromes. Older adults are particularly prone to polypharmacy, which considerably heightens the risk of drug interactions, especially among those with multiple chronic conditions. The probability of drug–drug interactions escalates in direct proportion to the number of medications prescribed, as geriatric patients generally receive more prescriptions compared to younger populations. This study employed a Literature Review approach with a Narrative Review design. Polypharmacy is highly prevalent among geriatric patients and is significantly linked to disease burden, adverse effects, drug interactions, and increased treatment costs. Elderly patients with multiple comorbidities taking several medications concurrently are at heightened risk of harmful drug interactions, with the likelihood rising alongside the number of medications consumed. Geriatric patients are particularly vulnerable to polypharmacy, which substantially increases the risk of drug–drug interactions. The greater the number of medications prescribed, the higher the potential for adverse outcomes.
Co-Authors Abdillah, Andi Rachmat Afrayani, Wirna Ahyar, Muammar Aisyah, Windi Nurul Akbar, A. Muh. Alamanda Irwan, Andi Aminuddin Aminuddin Andi Mappaware, Nasrudin Anugrah, Iqra Ardiansar, Abdul Mubdi Arifuddin, Andi Tenri Sanna Arsa, Sri Asmawati Aryanti Aryanti Ashlihati, Munifah Asmi, Muh. Nurul Avisha, Mirah Awalia, Awalia Bamahry, Aryanti Bamahry, Aryanti R. Basalamah, Putri Azimah Fauzi Bazith, Akhmad Bukhari, Agussalim Burhanuddin Bahar Cahyani, Nafila Cahyani, Pramesty Regita Daeng Kanang, Indah Lestari Dahlia Dahlia Dahlia Dahliah, Dahliah Darma, Sidrah Dase, Jerny Dewi M, Anna Sari DK, Indah Lestari El Firman, Andi Mappaita Faisal Syamsu, Rachmat Fakhirah, Muthiah Raghdah fatimah Fatimah Ferry Sandra Gani, Azis Beru Hadi, Santriani Hamsah, Hamsah Hamsah, Muhammad Hamzah, Firmansyah Hamzah, Pratiwi Nasir Harahap, Muhammad Wirawan Hilman, Feisal Husen, Siti Hajar Abdul Ida Royani Indarwati, Rezky Putri Isman, Thalhah Bin Kamaluddin, Irna Diyana Kartika Kamaruddin, M Yusril Karim, Marzelina Kartika K, Irna Diyana Kartika, Andy Visi Khoirunnisa, Nur Kurniyanti, Novia Latief, Shofiyah Liaury, Kristian M, Nasrudin A M. Yogi Riyantama Isjoni Mangarengi, Yusriani Mappaware, Nasrudin Andi Mathius, Denny Mayo, Abbas Ali Mochtar, Shulhana Mokhtar, Shulhana Mokhtar, Sulhana Muhammad Irsan Muhammad Jabal Nur, Muhammad Jabal Mukhtar, Shulhana Mulyadi, Farah Ekawati Mulyadi, Melan Septiany Mursyid, Muhammad MW. Pettawali, Sitti Ainun Nasruddin, Hermiaty Nesyana, Nesyana Ningsi, Iin Widya Ningsih, Iin Widya Nirwana, Nirwana Nissatuljannah, Syarifah Fatimah Novriansyah, Zulfikri Khalil Nur Intan, Nur Nurdin, Abbas Zavery Nurdin, Abbas Zavey Nurfadhilah, Nadiyah Nurmadilla, Nesyana Nurwahyuni Ode Arli, Rosmelidian Safari Palloge, Salahuddin Andi Palo, Nurul Aisyah Parningan, Zherant Paulus Paulus Pratama, Arhmad Ardhani Prema Hapsari Purnama, Indah Dian Putra, Fadil Mula Rachmat Faisal Syamsu, Rachmat Faisal Rachmat, Rizqah Aulyna Rasfayanah, Rasfayanah Rianti, Riska Rifa'at, Syahrul Riyanti, Nabilah Sabir, Nurani Islami Satria, Anna Shamad, Muhammad Ishaq Siti Rahma Solly Aryza Sommeng, Faisal Sri Vitayani Sudirman, Farah Zhafirah Sulvita Karsa, Nevi Sumarni Sumarni Surdam, Zulfiyah Syamsu Rijal Syamsu, Rachmat Syamsul Rijal Syamsul, Racmat Faisal Syatirah, Andi Bau Taslim, Nurpudji Astuti Thahir, Ilyas Thahira, Yugni Maula Trika Irianta Ulfa, Nura Usmiah Musa, Amelia Utami, Nurfika Wardayani Wardayani, Wardayani Waskito, Farah Nadhilla Ramadhani Wijaya, Fanny Yani, Siti Nurindah Yanti, A Kartini Eka Yasid, Nurul Wahidah Yuniar, Andi Irma Yusriani, Yusriani Yusril, Moh. Yusuf, Andini Zahiyah, Azzah Zahra Nizrina, Alfiyya Zulfa, Atria Putri Zulfahmidah, Zulfahmidah Zulfitriani Murfat