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Chiuman, Linda
Universitas Prima Indonesia
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Efektivitas Ekstrak Bawang Putih Tunggal Terhadap Gambaran Histopatologi Ginjal Dan Kadar Ureum Kreatinin Rattus Novergicus Yang Mengalami Dislipidemia Rambe, Natasya Septiana; Suandy, Suandy; Chiuman, Linda
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62239

Abstract

Heart disease and kidney failure are both increased by dyslipidemia. There are a lot of antioxidant and nephroprotective chemicals in just one clove of garlic (Allium sativum L.), including allicin, flavonoids, and organosulfur compounds. This study set out to examine the effects of a single garlic extract on the urea, creatinine, and uric acid levels in rats with dyslipidemia (Rattus norvegicus). There was an examination of the renal histopathology picture as well. This research used an experimental tack by using a control group design with pre- and post-tests. Each of the four groups consisted of 24 male Wistar rats' tails: the control group (aquades), the experimental group (simvastatin 2.1 mg/kgBB), the garlic extract alone group (200 mg/kgBB), and the highest dose (400 mg/kgBB). Each group followed a high-fat diet for a full month. Both the 200 mg/kgBB and 400 mg/kgBB doses of garlic extract significantly decreased the levels of ureum, creatinine, and uric acid (p<0.05) as compared to the negative control group. Kidney histopathology also revealed improvement, with less congestion, necrosis, and cell death. The positive control and the 400 mg/kgBB group showed similar effects after delivery. Rats with dyslipidemia showed improvements in renal histology and decreased levels of ureum, creatinine, and uric acid after administration of a single garlic extract.
HUBUNGAN AKTIVITAS FISIK TERHADAP PERUBAHAN KARDIORESPIRASI PADA MAHASISWA KEDOKTERAN UNIVERSITAS PRIMA INDONESIA Sagala, Agasy Gideon Admiral; Rusip, Gusbakti; Chiuman, Linda
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.31517

Abstract

Penelitian ini bertujuan untuk mengetahui hubungan aktivitas fisik dengan perubahan fungsi kardiorespirasi pada mahasiswa kedokteran Universitas Prima Indonesia. Penelitian ini menggunakan pendekatan eksperimen semu dengan desain one-group pre-and post-test untuk menguji hubungan tersebut. Purposive sampling dengan rumus Federer digunakan untuk memilih sampel yang berjumlah 32 orang mahasiswa kedokteran Universitas Prima Indonesia. Queen's College Step Test digunakan untuk mengukur kebugaran kardiorespirasi dan aktivitas fisik dalam data yang dikumpulkan. Analisis data memakai SPSS versi 27 serta Uji Wilcoxon digunakan untuk analisis statistik, dengan ambang signifikansi P <0,05. Temuan penelitian menunjukkan bahwa di kalangan mahasiswa kedokteran Universitas Prima Indonesia, aktivitas fisik dan perubahan fungsi kardiorespirasi berhubungan (P=0,005). Dari tiga puluh dua orang mahasiswa kedokteran Universitas Prima Indonesia didapati Delapan orang mahasiswa kedokteran Universitas Prima Indonesia semuanya mengalami perubahan pada sistem kardiorespirasi mereka sebelum dan sesudah melakukan aktivitas fisik (4,50). Artinya Terdapat hubungan aktivitas fisik dengan perubahan fungsi kardiorespirasi pada mahasiswa kedokteran Universitas Prima Indonesia.
Formulation and Effectiveness Testing of Moringa Leaf (Moringa Oleifera) Ethanol Extract Lotion as A Skin Moisturizer Nasution, Isna Gita Amalia; Ginting, Chrismis Novalinda; Chiuman, Linda
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3477

Abstract

This study delves into the formulation of a lotion using different concentrations (0.5%, 2%, and 5%) of Moringa oleifera leaf ethanol extract, aiming to address the constant exposure of the skin to a prooxidant environment. In Indonesia, the rising interest in exploring natural plants for traditional skincare formulations is attributed to their perceived lower side effects compared to chemical substances. Employing an experimental research approach with a pre-test and post-test control group design, the study focuses on observing and controlling the formulation and effectiveness of Moringa oleifera leaf extract lotion in various skin-enhancing aspects.The research findings reveal that the formulated lotions exhibit distinctive aroma, soft texture, ease of spread, and semi-solid or gel consistency without stickiness. Physical homogeneity suggests a well-blended composition, and the pH values (6.32 for 0.5%, 6.30 for 2%, and 6.28 for 5%) fall within the ideal range, ensuring skin compatibility. Spreadability tests show the 5% concentration has the highest spreadability, while adhesive strength analysis indicates all concentrations meet the criteria for good cream adhesive strength.Furthermore, the efficacy of the lotion is assessed for moisturizing, smoothing, pore-shrinking, wrinkle-reducing, and collagen fiber density-increasing properties. Results indicate the 5% concentration is the most effective across these parameters.In conclusion, the ethanol extract lotion formulated from Moringa oleifera leaves holds promise for enhancing skin health, with the 5% concentration demonstrating the highest efficacy. This research contributes valuable insights to the development of natural skincare products with potential applications in dermatology and cosmetology, aligning with the growing interest in sustainable and effective skincare solutions.
Analisis Akar Masalah dan Waktu Tunggu Pelayanan Obat di Instalasi Farmasi Rawat Jalan Pinem, Sabriela Br; Ginting, Chrismis Novalinda; Chiuman, Linda
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 8 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i8.4594

Abstract

Waktu tunggu pelayanan farmasi merupakan indikator penting dalam penilaian mutu pelayanan kesehatan di rumah sakit. Penelitian ini bertujuan menganalisis akar masalah dan waktu tunggu yang dibutuhkan untuk mendapatkan obat di instalasi farmasi rawat jalan RSU Royal Prima Medan. Metode penelitian menggunakan pendekatan deskriptif kualitatif dengan teknik wawancara mendalam kepada 5 informan manajemen dan observasi terhadap 50 pasien rawat jalan. Analisis data dilakukan melalui reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan akar masalah utama meliputi kurangnya SDM di instalasi farmasi, kelengkapan berkas pasien yang belum terpenuhi, ketersediaan obat yang terbatas, penggunaan sistem resep elektronik dan manual secara bersamaan, banyaknya resep di luar formularium nasional, tingginya permintaan obat racikan, dan kesulitan membaca tulisan dokter. Waktu tunggu rata-rata untuk obat non racikan adalah 24,8 menit dan obat racikan 49,44 menit, yang masih sesuai dengan Standar Pelayanan Minimal (SPM). Meskipun demikian, terdapat 8 dari 50 pasien yang mengalami waktu tunggu melebihi SPM. Penelitian ini memberikan kontribusi penting dalam identifikasi faktor-faktor yang mempengaruhi efisiensi pelayanan farmasi dan dapat menjadi dasar pengembangan strategi perbaikan sistem pelayanan.
Effectiveness Test of Ethanol Extract of Red Betel Leaves (Piper Crocatum Ruiz & Pav) Against Histopathological Features of The Pancreas and Blood Sugar Levels of Alloxan-Induced Male Mice (Mus Musculus L) Sembiring, Mahral Effendi; Nasution, Ali Napiah; Chiuman, Linda
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes Mellitus induces hyperglycemia. Low insulin production causes insulin resistance and altered protein, fat, and carbohydrate metabolism. Much research has shown that traditional herbal treatments can treat diabetes. Diabetes increases free radical production. Secondary metabolic plants include antioxidants that treat extreme illnesses like diabetes. This study examines the efficacy of ethanol extract from red betel leaves (EERBL) in lowering blood glucose levels in vivo, the optimal dose, secondary metabolite content based on phytochemical screening, and alloxan-induced pancreatic hyperglycemia histopathology. Mouse. Six 20-30 gram groups of mice were treated. Group III got 0.65 mg/kgBW glibenclamide, and Groups IV, V, and VI received oral gavage EERBL 100, 300, and 500 mg/kgBW. Group I was in standard control without alloxan, and Group II was in alloxan control. Hyperglycemic mice received 150 mg/kg BW intraperitoneal alloxan. Red betel is 96% ethanol-macerated. Oral red betel leaf extract was given for 21 days to monitor blood glucose and pancreatic function. Splitting red betel leaves to male mice significantly altered blood glucose and pancreatic histology. Red betel goes low cuts close and pancreatic histology by 58.4%. Blood glucose readings were Kruskal-Wallis significant at 0.004 or 0.05. Red betel leaf extract reduced blood glucose and enhanced pancreatic histology in male mice.
Hospital Preparedness and Resilience in Public Health Emergencies at Royal Prima Medan Hospital Aulia, Rumi; Ginting, Chrismis Novalinda; Chiuman, Linda
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.1787

Abstract

Hospitals have a very important role in public health, because hospitals are places where people can get maximum health services to support the health of these patients. With the importance of the role of hospitals for the community, it is necessary to have preparedness and resilience on the part of the hospital to always be ready to receive emergencies that come from the community, such as when a disaster occurs where the role of the hospital is very important in helping victims affected by disasters. . The aim of this research is to determine the preparedness and resilience of hospitals in public health emergencies at RSU Royal Prima Medan. This type of research is quantitative research with a cross sectional approach. The population in this study was all medical and non-medical employees at RSU Royal Prima Medan, totaling 822. The sampling method used in this research was systematic sampling. The sampling technique in this research used Proportional Random Sampling so that the number of samples in this research was 134 samples. Data analysis in this study used univariate analysis. The results showed that the majority of respondents in this study were aged 36-45 years, 73 people, the majority were female, 91 people, the majority had worked < 5 years, 74 people and the majority worked as nurses, 50 people. The preparedness of RSU Royal Prima Medan in facing public health emergencies is good, the resilience of RSU Royal Prima Medan in facing public health emergencies is good.
Hypolipidemic and Hypoglycemic Potentials of Garlic Extract in High-Fat Diet and Streptozotocin-Induced Wistar Rats Veronica, Veronica; Girsang, Ermi; Chiuman, Linda
Jurnal Kesehatan Vol 16 No 2 (2025): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v16i2.5003

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels and often associated with hypercholesterolemia. Garlic (Allium sativum Linn.), rich in bioactive compounds such as allicin, saponins, and flavonoids, has been widely reported to possess lipid- and glucose-lowering properties. This study aimed to evaluate the hypolipidemic and hypoglycemic effects of garlic extract in Wistar rats subjected to a high-fat diet and streptozotocin (STZ) induction. A laboratory experimental design with a post-test-only control group was employed. For cholesterol assessment, hypercholesterolemic rats were administered garlic extract at doses of 0.05, 0.10, and 0.20g/head/day, while diabetic rats induced with STZ received doses of 100, 250, and 500 mg/kg body weight per day, with corresponding control groups. Garlic extract significantly reduced mean cholesterol levels in a dose-dependent manner (130.60mg/dL, 121.80mg/dL, and 112.00mg/dL for 0.05, 0.10, and 0.20g/head/day, respectively). In contrast, mean blood glucose levels showed a marginal decrease with increasing doses (282.80 mg/dL, 271.20mg/dL, and 269.27mg/dL at 100, 250, and 500mg/kgBW/day, respectively). However, no statistically significant differences were observed among groups (p=0.706, one-way ANOVA). These findings suggest that garlic extract exhibits a potent cholesterol-lowering effect in hypercholesterolemic rats but has a limited impact on blood glucose reduction under the tested conditions. Further studies are warranted to determine the optimal dosage and underlying mechanisms of action. 
Efek Ekstrak Kunyit Putih (Curcuma Zedoaria) Sebagai Nefroprotektor Pada Tikus Putih Jantan Galur Wistar yang Diinduksi Tembaga Wardhani, Fiska Maya; Chiuman, Linda; Ginting, Chrismis Novalinda; Ginting, Sahna Ferdinand; Nasution, Ali Napiah
Majalah Kedokteran Indonesia Vol 69 No 8 (2019): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.69.8-2019-186

Abstract

Background: Metal pollution increases along with increasing industrial development. Exposure to copper in large quantities can cause kidney and liver damage. Curcuma zedoaria has benefits as an antioxidant, anti-inflammatory, antiproliferation, anticancer, and antimicrobial. Curcumin which contained in white turmeric rhizomes in previous studies was used as a nephroprotective variation. Objective: This study is used to know wether white turmeric rhizome (Curcuma zedoaria had a nephroprotective effect with exposure to CuSO4 pentahydrate. Methods: This is an experimental study by designing post test only control group design. The sampling is using simple random sampling technique. Male white wistar rats are divided into six groups; normal control, control of white turmeric (45 mg / 200 g), control of CuSO4 pentahydrate, and co-treatment group (curcumin for 14 days followed by CuSO4 for 5 days).Results: Data were analyzed using One Way test. For group 4 (preventive group) serum urea creatinine level was not different from group 1 and 2 (p greater than 0.05) with mild histological structure damage. However, differences were obtained (p less than 0.05) in Groups 3, 5, and 6. Conclusion: The dose of 45 mg / 200 g white turmeric extract showed a percentage decrease in serum creatinine urea level and mild histological damage to kidney tissue.
Effectiveness of Earthworm Extract on the Lipid Profile of Diabetic Wistar Rats Suandy, Suandy; Chiuman, Linda; Halim, Angel Jonathane
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.3

Abstract

Various metabolic diseases, such as diabetes mellitus, are characterized by hyperglycemia, stemming from decreased insulin action, secretion, or both. The use of chemical medicines for diabetes mellitus, especially acarbose, involves regulating the digestion and absorption of complex carbohydrates. However, acarbose may disrupt liver function, prompting exploration into alternative sources for treatment, such as earthworm extract. The purpose of this study was to identify the effectiveness of ethanol extract and coelomic fluid from earthworms (E. eugeniae) on the lipid profile of male diabetic wistar rats (R. norvegicus) in vivo. The research hypothesis is that earthworm extracts could effectively lower the lipid profile of diabetic Wistar rats. This research is experimental research with pre-test and post-test control study group design, using an in vivo method. The results of the one-way ANOVA test of HDL were p=0.441; p=0.441; p=0.000; for LDL were p=0.691; p=0.101; p=0.049; for total cholesterol were p=0.107; p=0.347; p=0.486; and for triglycerides were p=0.028; p=0.926; p=0.553 on days 0, 7, and 14, respectively. Based on the research data, both ethanol extract and a combination of ethanol extract and coelomic fluid were able to reduce lipid profile levels on the 7th and 14th days. Earthworm extract has the potential to promote repair of β cells and is anti-inflammatory which can be used to reduce lipid profile levels.
Dermapen Treatments for Healing Pockmarked Skin in Male Wistar Rats (Rattus norvegicus): A Study Comparing Platelet-Rich Plasma with Salmon DNA Serum Chiuman, Linda; Hestina; Ongko, Nicolas Xavier; Tarigan, Setia Budi
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.6000

Abstract

Skin issues like deep acne scars (pockmarks) are routinely addressed. Dermaroller and Dermapen face skin care help cure this issue. Researchers believe plasma from platelets (PRP) and salmon DNA serum dermapens work similarly on pockmarked skin. White Wistar mice were tested to confirm this suspicion. This is a lab study or an experiment. The study employed a post-test only with a control group design on 16 white Wistar rats (Rattus norvegicus) divided into two groups of eight rats each: Group I received platelet plasma dermapen (PRP) and Group II received salmon DNA serum dermapen. The collected data was tested for normalcy using SPSS. The data normality test showed a significance value of 0.20 > 0.05, indicating normal distribution. The homogeneity test is 0.224. The significant probability value is greater than 0.05, indicating that the PRP dermapen group and the salmon serum DNA dermapen group have similar variances. The t-test rejects H0 or shows a significant difference in wound healing between groups if the significance value is 0.00 or less than 0.05. The study found that PRP and salmon DNA serum promote wound healing. Healing was faster in the PRP than in the salmon DNA serum group. This is possible because PRP includes bioactive molecules that act as tissue growth factors to enhance proliferation. PRP contains various growth factors that aid wound healing.
Co-Authors Adrian Adrian Adrian Adrian Afina, Lubna Akalili, Cory Cintia Alexander Simanjuntak Alexander, Rico Amir, Widya Pasca Anditha, Arie Tika Anggraeni, Wenti Arif, Maria Nisaul Aulia, Rumi Azah, Yunita Wannur Bagas Dwi Sanjaya Bangun, Chrismas Gideon Bangun, Primta Binarwan Halim Br Ginting, Lois Eprillia Bukit, Christin Debora Chairun, Ryeo Ramadhan Chintya Darma, Gladys Chiuman, Veranyca Claudia Tanamal Colin, Vito Coray Carolyn Ruth Pardede, Eifel Datitha Alodia Br Kaban, Karina DEWI SARTIKA Dhillon, Jessyca Manishwer Kaur Dhillon, Neha Amar Dika Suranda Dwi Puspitasari Edy Fachrial Erika Erika Ermi Girsang Fahlevy, Ridho Fazwiansyah Darlin Muniro Febriani Simanjuntak, Lorena Felix, Jesslyn Fentia, Lia Ferdinand, Sahna Fiska Maya Wardhani gan, claris cyntha deninta Ginting, Astriani Natalia Br Ginting, Chirmis Novalinda Ginting, Chrismis Novalina Ginting, Chrismis Novalinda Ginting, Sahna Ferdinand Girsang, Ermi Gozali, Juliana Grandis, Lexandria Gusbakti Gusbakti Rusip hafizha, Shalli Haicha Pritama, Irza Halim, Angel Jonathane Halim, Michael Halim, Valencia Angelina Handayani, Rr. Anisa Siwianti hardiansyah siregar Harmileni Hasya, Muhammad Nawal Hestina Hidayatti, Mustika Iksen, Iksen Indriani, Vidya Intan Hasibuan, Febria Nurul Irwan Irwan irza Haicha Pratama Janice Janice Jannah, Ratu Mutiara Raudhatul Kosasih, Michaela Kotsasi, Fransisca Krishna, Priyanka Kurniawan, Gracella Verren Leony, Catherine Levinna, Levinna Liena, Liena lister , Clarissa Lister, Gilbert Lumbantobing, Christina J. R. Esmaralda Marfitania, Taranipa Maswarni Maulidza, Citra Puan Mawarni, Evi Michael Michael MICHELLE HENDRIANI DJUANG Mukti, Ade Indra Muna Soraya Putri Nadapdap, Thomson Nadia, Felanda A Nasution, Ali Napiah Nasution, Atika Rimalda Nasution, Isna Gita Amalia Nurlaela, Lia Olivia Laurent Ong, Gabriella Fransisca Ongko, Nicolas Xavier Pardianto, Gede Pasaribu, Jelita Pebriani Patriyuni, Tri Permata Khaira, Azzuhra Pinem, Sabriela Br Rambe, Natasya Septiana Razoki, Razoki Rizki, Kartika Sari Sagala, Agasy Gideon Admiral Sahna Ferdinand Ginting Saragih, Reyini Namora L. Sebayang, Dwi Putri Agita Sembiring, Mahral Effendi Sihombing, Bungaran Simarmata, Hans Pangestu Siti Hardianti, Siti Sitorus, Josua Panangian Stanliko, Stanliko Suandy, Suandy SUHARTOMI . Sulistijanto, Eddy Suyono, Tan Syahputra, Fahmi Syahputra, Hariyadi Dharmawan Tambunan, Andika Z Tambunan, Andika Zayani Tambunan, Ridhona Tanamal, Claudia Tandiono, Michelle Tarigan, Elviyanti Tarigan, Setia Budi Tengku Rachmi Hidayani, Tengku Rachmi Theresia, Yohani Tia Triyanti Tjendera, Mariaman Utami, Sherlinda Putri Utomo, Wilbert Waldo Varerina, Ria Br Perangin-angin Vera Estefania Kaban vera vera, vera VERONICA VERONICA Virgoh, Livia WAHYU WIDOWATI Wardhani, Fiska Maya Wijaya, Johanna Fransiska Wijaya, Linda Leonando Winda Sari Yosefa, Stephanie Renata Yuliansyah, Jeri Yulita, Emi Yusmaini, Yusmaini Zendrato, Ronauli Muliani