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All Journal Biospecies Jurnal Kedokteran Brawijaya JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) BERITA BIOLOGI The Indonesian Biomedical Journal Lantanida Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kesehatan Komunitas Window of Health : Jurnal Kesehatan Indonesian Journal of Medicine Jambura Journal of Health Sciences and Research Journal Health & Science : Gorontalo Journal Health and Science Community Jurnal Kesehatan Poltekita : Jurnal Ilmu Kesehatan Jurnal Keperawatan Priority Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains An-Nadaa: Jurnal Kesehatan Masyarakat AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Jurnal Inovasi Pendidikan dan Sains Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Jurnal Ilmiah METADATA Eureka Herba Indonesia Jurnal Kesehatan Tambusai MAHESA : Malahayati Health Student Journal Journal of Multidisciplinary Applied Natural Science Interdisciplinary Social Studies Jurnal EduHealth Journal of Current Health Sciences International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Jurnal Locus Penelitian dan Pengabdian Jurnal Sains dan Teknologi Buletin Kedokteran dan Kesehatan Prima Pharmaceutical Sciences and Research (PSR) International Journal of Health and Pharmaceutical (IJHP) International Journal of Science and Environment Eduvest - Journal of Universal Studies Journal of Pharmaceutical and Sciences. Blantika : Multidisciplinary Journal Malahayati International Journal of Nursing and Health Science
Chiuman, Linda
Universitas Prima Indonesia
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Formulation and Effectiveness Testing of Moringa Leaf (Moringa Oleifera) Ethanol Extract Lotion as A Skin Moisturizer Nasution, Isna Gita Amalia; Ginting, Chrismis Novalinda; Chiuman, Linda
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3477

Abstract

This study delves into the formulation of a lotion using different concentrations (0.5%, 2%, and 5%) of Moringa oleifera leaf ethanol extract, aiming to address the constant exposure of the skin to a prooxidant environment. In Indonesia, the rising interest in exploring natural plants for traditional skincare formulations is attributed to their perceived lower side effects compared to chemical substances. Employing an experimental research approach with a pre-test and post-test control group design, the study focuses on observing and controlling the formulation and effectiveness of Moringa oleifera leaf extract lotion in various skin-enhancing aspects.The research findings reveal that the formulated lotions exhibit distinctive aroma, soft texture, ease of spread, and semi-solid or gel consistency without stickiness. Physical homogeneity suggests a well-blended composition, and the pH values (6.32 for 0.5%, 6.30 for 2%, and 6.28 for 5%) fall within the ideal range, ensuring skin compatibility. Spreadability tests show the 5% concentration has the highest spreadability, while adhesive strength analysis indicates all concentrations meet the criteria for good cream adhesive strength.Furthermore, the efficacy of the lotion is assessed for moisturizing, smoothing, pore-shrinking, wrinkle-reducing, and collagen fiber density-increasing properties. Results indicate the 5% concentration is the most effective across these parameters.In conclusion, the ethanol extract lotion formulated from Moringa oleifera leaves holds promise for enhancing skin health, with the 5% concentration demonstrating the highest efficacy. This research contributes valuable insights to the development of natural skincare products with potential applications in dermatology and cosmetology, aligning with the growing interest in sustainable and effective skincare solutions.
Analisis Akar Masalah dan Waktu Tunggu Pelayanan Obat di Instalasi Farmasi Rawat Jalan Pinem, Sabriela Br; Ginting, Chrismis Novalinda; Chiuman, Linda
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 8 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i8.4594

Abstract

Waktu tunggu pelayanan farmasi merupakan indikator penting dalam penilaian mutu pelayanan kesehatan di rumah sakit. Penelitian ini bertujuan menganalisis akar masalah dan waktu tunggu yang dibutuhkan untuk mendapatkan obat di instalasi farmasi rawat jalan RSU Royal Prima Medan. Metode penelitian menggunakan pendekatan deskriptif kualitatif dengan teknik wawancara mendalam kepada 5 informan manajemen dan observasi terhadap 50 pasien rawat jalan. Analisis data dilakukan melalui reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan akar masalah utama meliputi kurangnya SDM di instalasi farmasi, kelengkapan berkas pasien yang belum terpenuhi, ketersediaan obat yang terbatas, penggunaan sistem resep elektronik dan manual secara bersamaan, banyaknya resep di luar formularium nasional, tingginya permintaan obat racikan, dan kesulitan membaca tulisan dokter. Waktu tunggu rata-rata untuk obat non racikan adalah 24,8 menit dan obat racikan 49,44 menit, yang masih sesuai dengan Standar Pelayanan Minimal (SPM). Meskipun demikian, terdapat 8 dari 50 pasien yang mengalami waktu tunggu melebihi SPM. Penelitian ini memberikan kontribusi penting dalam identifikasi faktor-faktor yang mempengaruhi efisiensi pelayanan farmasi dan dapat menjadi dasar pengembangan strategi perbaikan sistem pelayanan.
Effectiveness Test of Ethanol Extract of Red Betel Leaves (Piper Crocatum Ruiz & Pav) Against Histopathological Features of The Pancreas and Blood Sugar Levels of Alloxan-Induced Male Mice (Mus Musculus L) Sembiring, Mahral Effendi; Nasution, Ali Napiah; Chiuman, Linda
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes Mellitus induces hyperglycemia. Low insulin production causes insulin resistance and altered protein, fat, and carbohydrate metabolism. Much research has shown that traditional herbal treatments can treat diabetes. Diabetes increases free radical production. Secondary metabolic plants include antioxidants that treat extreme illnesses like diabetes. This study examines the efficacy of ethanol extract from red betel leaves (EERBL) in lowering blood glucose levels in vivo, the optimal dose, secondary metabolite content based on phytochemical screening, and alloxan-induced pancreatic hyperglycemia histopathology. Mouse. Six 20-30 gram groups of mice were treated. Group III got 0.65 mg/kgBW glibenclamide, and Groups IV, V, and VI received oral gavage EERBL 100, 300, and 500 mg/kgBW. Group I was in standard control without alloxan, and Group II was in alloxan control. Hyperglycemic mice received 150 mg/kg BW intraperitoneal alloxan. Red betel is 96% ethanol-macerated. Oral red betel leaf extract was given for 21 days to monitor blood glucose and pancreatic function. Splitting red betel leaves to male mice significantly altered blood glucose and pancreatic histology. Red betel goes low cuts close and pancreatic histology by 58.4%. Blood glucose readings were Kruskal-Wallis significant at 0.004 or 0.05. Red betel leaf extract reduced blood glucose and enhanced pancreatic histology in male mice.
Hospital Preparedness and Resilience in Public Health Emergencies at Royal Prima Medan Hospital Aulia, Rumi; Ginting, Chrismis Novalinda; Chiuman, Linda
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.1787

Abstract

Hospitals have a very important role in public health, because hospitals are places where people can get maximum health services to support the health of these patients. With the importance of the role of hospitals for the community, it is necessary to have preparedness and resilience on the part of the hospital to always be ready to receive emergencies that come from the community, such as when a disaster occurs where the role of the hospital is very important in helping victims affected by disasters. . The aim of this research is to determine the preparedness and resilience of hospitals in public health emergencies at RSU Royal Prima Medan. This type of research is quantitative research with a cross sectional approach. The population in this study was all medical and non-medical employees at RSU Royal Prima Medan, totaling 822. The sampling method used in this research was systematic sampling. The sampling technique in this research used Proportional Random Sampling so that the number of samples in this research was 134 samples. Data analysis in this study used univariate analysis. The results showed that the majority of respondents in this study were aged 36-45 years, 73 people, the majority were female, 91 people, the majority had worked < 5 years, 74 people and the majority worked as nurses, 50 people. The preparedness of RSU Royal Prima Medan in facing public health emergencies is good, the resilience of RSU Royal Prima Medan in facing public health emergencies is good.
Hypolipidemic and Hypoglycemic Potentials of Garlic Extract in High-Fat Diet and Streptozotocin-Induced Wistar Rats Lie, Veronica; Girsang, Ermi; Chiuman, Linda; Puspita, Sunny
Jurnal Kesehatan Vol 16 No 2 (2025): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v16i2.5003

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels and often associated with hypercholesterolemia. Garlic (Allium sativum Linn.), rich in bioactive compounds such as allicin, saponins, and flavonoids, has been widely reported to possess lipid- and glucose-lowering properties. This study aimed to evaluate the hypolipidemic and hypoglycemic effects of garlic extract in Wistar rats subjected to a high-fat diet and streptozotocin (STZ) induction. A laboratory experimental design with a post-test-only control group was employed. For cholesterol assessment, hypercholesterolemic rats were administered garlic extract at doses of 0.05, 0.10, and 0.20g/head/day, while diabetic rats induced with STZ received doses of 100, 250, and 500 mg/kg body weight per day, with corresponding control groups. Garlic extract significantly reduced mean cholesterol levels in a dose-dependent manner (130.60mg/dL, 121.80mg/dL, and 112.00mg/dL for 0.05, 0.10, and 0.20g/head/day, respectively). In contrast, mean blood glucose levels showed a marginal decrease with increasing doses (282.80 mg/dL, 271.20mg/dL, and 269.27mg/dL at 100, 250, and 500mg/kgBW/day, respectively). However, no statistically significant differences were observed among groups (p=0.706, one-way ANOVA). These findings suggest that garlic extract exhibits a potent cholesterol-lowering effect in hypercholesterolemic rats but has a limited impact on blood glucose reduction under the tested conditions. Further studies are warranted to determine the optimal dosage and underlying mechanisms of action. 
Efek Ekstrak Kunyit Putih (Curcuma Zedoaria) Sebagai Nefroprotektor Pada Tikus Putih Jantan Galur Wistar yang Diinduksi Tembaga Wardhani, Fiska Maya; Chiuman, Linda; Ginting, Chrismis Novalinda; Ginting, Sahna Ferdinand; Nasution, Ali Napiah
Majalah Kedokteran Indonesia Vol 69 No 8 (2019): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.69.8-2019-186

Abstract

Background: Metal pollution increases along with increasing industrial development. Exposure to copper in large quantities can cause kidney and liver damage. Curcuma zedoaria has benefits as an antioxidant, anti-inflammatory, antiproliferation, anticancer, and antimicrobial. Curcumin which contained in white turmeric rhizomes in previous studies was used as a nephroprotective variation. Objective: This study is used to know wether white turmeric rhizome (Curcuma zedoaria had a nephroprotective effect with exposure to CuSO4 pentahydrate. Methods: This is an experimental study by designing post test only control group design. The sampling is using simple random sampling technique. Male white wistar rats are divided into six groups; normal control, control of white turmeric (45 mg / 200 g), control of CuSO4 pentahydrate, and co-treatment group (curcumin for 14 days followed by CuSO4 for 5 days).Results: Data were analyzed using One Way test. For group 4 (preventive group) serum urea creatinine level was not different from group 1 and 2 (p greater than 0.05) with mild histological structure damage. However, differences were obtained (p less than 0.05) in Groups 3, 5, and 6. Conclusion: The dose of 45 mg / 200 g white turmeric extract showed a percentage decrease in serum creatinine urea level and mild histological damage to kidney tissue.
Effectiveness of Earthworm Extract on the Lipid Profile of Diabetic Wistar Rats Suandy, Suandy; Chiuman, Linda; Halim, Angel Jonathane
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.3

Abstract

Various metabolic diseases, such as diabetes mellitus, are characterized by hyperglycemia, stemming from decreased insulin action, secretion, or both. The use of chemical medicines for diabetes mellitus, especially acarbose, involves regulating the digestion and absorption of complex carbohydrates. However, acarbose may disrupt liver function, prompting exploration into alternative sources for treatment, such as earthworm extract. The purpose of this study was to identify the effectiveness of ethanol extract and coelomic fluid from earthworms (E. eugeniae) on the lipid profile of male diabetic wistar rats (R. norvegicus) in vivo. The research hypothesis is that earthworm extracts could effectively lower the lipid profile of diabetic Wistar rats. This research is experimental research with pre-test and post-test control study group design, using an in vivo method. The results of the one-way ANOVA test of HDL were p=0.441; p=0.441; p=0.000; for LDL were p=0.691; p=0.101; p=0.049; for total cholesterol were p=0.107; p=0.347; p=0.486; and for triglycerides were p=0.028; p=0.926; p=0.553 on days 0, 7, and 14, respectively. Based on the research data, both ethanol extract and a combination of ethanol extract and coelomic fluid were able to reduce lipid profile levels on the 7th and 14th days. Earthworm extract has the potential to promote repair of β cells and is anti-inflammatory which can be used to reduce lipid profile levels.
Dermapen Treatments for Healing Pockmarked Skin in Male Wistar Rats (Rattus norvegicus): A Study Comparing Platelet-Rich Plasma with Salmon DNA Serum Chiuman, Linda; Hestina; Ongko, Nicolas Xavier; Tarigan, Setia Budi
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.6000

Abstract

Skin issues like deep acne scars (pockmarks) are routinely addressed. Dermaroller and Dermapen face skin care help cure this issue. Researchers believe plasma from platelets (PRP) and salmon DNA serum dermapens work similarly on pockmarked skin. White Wistar mice were tested to confirm this suspicion. This is a lab study or an experiment. The study employed a post-test only with a control group design on 16 white Wistar rats (Rattus norvegicus) divided into two groups of eight rats each: Group I received platelet plasma dermapen (PRP) and Group II received salmon DNA serum dermapen. The collected data was tested for normalcy using SPSS. The data normality test showed a significance value of 0.20 > 0.05, indicating normal distribution. The homogeneity test is 0.224. The significant probability value is greater than 0.05, indicating that the PRP dermapen group and the salmon serum DNA dermapen group have similar variances. The t-test rejects H0 or shows a significant difference in wound healing between groups if the significance value is 0.00 or less than 0.05. The study found that PRP and salmon DNA serum promote wound healing. Healing was faster in the PRP than in the salmon DNA serum group. This is possible because PRP includes bioactive molecules that act as tissue growth factors to enhance proliferation. PRP contains various growth factors that aid wound healing.
Anti-inflammatory Activity of Lemon Pepper Nanoemulsion on Carrageenan-Induced Male Wistar Rat Chiuman, Linda; Sebayang, Dwi Putri Agita; Chiuman, Veranyca; Suhartomi, Suhartomi
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6292

Abstract

Lemon pepper does not only have a unique taste but also has some active compounds, which has anti-inflammatory activity. This study intended to investigate the anti-inflammatory effect of lemon pepper nanoemulsion on carrageenan-induced Wistar rats. This experimental study used Twenty-five male Wistar rats that were grouped into five different groups, including control, standard, lemon pepper nanoemulsion dose of 25, 50, and 75 mg/ kgBW. Initially, all rats received air injection in the back area for 5 days to form an air pouch. After that, all rats were injected with 1% carrageenan solution, and received treatment based on the groups for 48 hours via oral route. Then, it counted the number of white blood cells by Giemsa Stain that was expressed as a number of cells per High Power Field (HPF). The increasing of Lemon pepper nanoemulsion dose significantly decreased the number of leucocytes in the carrageenan aspiration after 48 hours of treatment (P-Value < 0.001). The lowest number of leucocytes was found in the Lemon Pepper Nanoemulsion dose of 75 mg/kgBW (2.40 leukocytes per HPF). Hence, it can be deducted that the lemon pepper nanoemulsion has an anti-inflammatory effect, especially at a dose of 50-75 mg/kgBW.
UV-Protection Effect of Nanoemulgel Formulation from Moringa oleifera Lam. Leaf Extracts in Rattus novergicus Anditha, Arie Tika; Chiuman, Linda; Ginting, Chrismis Novalinda
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8497

Abstract

Exposure to sunlight (UV radiation) can harm the skin, leading to cancer and tissue damage. The body’s natural defense involves activating hormones that stimulate melanin synthesis to reduce cellular damage. Moringa oleifera Lam. leaves, rich in flavonoids and phenolic compounds, are promising UV-protection agents. This study assessed the efficacy of nanoemulgel formulations containing M. oleifera leaf extract through in vitro and in vivo assays. Twenty-five rats were divided into five groups, including formulations with 2%, 3%, and 4% M. oleifera extract, a negative control, and a positive control with Azarine Sunscreen Gel SPF 45. The nanoemulsions had appropriate size and quality, with the highest SPF observed at 4% concentration (7.95±0.06). According to FDA classification, these formulations fall within the 'extra' SPF category (6<SPF<8). However, melanin scores in the nanoemulgel groups were comparable to the untreated control, and the 4% concentration (44.4±16.3) did not match the protection provided by commercial sunscreen (10.0±1.58). These findings suggest M. oleifera has potential for photoprotection, but further optimization is needed.
Co-Authors Adrian Adrian Adrian Adrian Afina, Lubna Agung Adha Witasa Dewana Akalili, Cory Cintia Alexander Simanjuntak Alexander, Rico AMALIA, TIARA Amir, Widya Pasca Andika Zayani Tambunan Anditha, Arie Tika Anggraeni, Wenti Arif, Maria Nisaul Aulia, Rumi Azah, Yunita Wannur Bagas Dwi Sanjaya Bangun, Chrismas Gideon Bangun, Primta Binarwan Halim Br Ginting, Lois Eprillia Bukit, Christin Debora Chairun, Ryeo Ramadhan Chintya Darma, Gladys Chiuman, Veranyca Claudia Tanamal Colin, Vito Coray Carolyn Ruth Pardede, Eifel Datitha Alodia Br Kaban, Karina DEWI SARTIKA Dhillon, Neha Amar Dika Suranda Dwi Puspitasari Dzil Fikri Edy Fachrial Erika Erika Ermi Girsang Fahlevy, Ridho Fazwiansyah Darlin Muniro Febriani Simanjuntak, Lorena Felix, Jesslyn Fentia, Lia Ferdinand, Sahna Fiska Maya Wardhani gan, claris cyntha deninta Ginting, Chirmis Novalinda Ginting, Chrismis Novalina Ginting, Chrismis Novalinda Ginting, Sahna Ferdinand Girsang, Ermi Gozali, Juliana Grandis, Lexandria Gusbakti Gusbakti Rusip hafizha, Shalli Haicha Pritama, Irza Halim, Angel Jonathane Halim, Michael Handayani, Rr. Anisa Siwianti hardiansyah siregar Harmileni Hasya, Muhammad Nawal Hestina Hidayatti, Mustika Ibnu, Syahroni Iksen, Iksen Indriani, Vidya Intan Hasibuan, Febria Nurul Ira Syaputri Irwan Irwan irza Haicha Pratama Iskandar, Ari Rahman Janice Janice Kosasih, Michaela Kotsasi, Fransisca Krishna, Priyanka Kurniawan, Gracella Verren Lawrence, Christopher Leony, Catherine Levinna, Levinna Lie, Veronica Liena, Liena lister , Clarissa Lister, Gilbert Lumbantobing, Christina J. R. Esmaralda Lumbantobing, Christina J.R Esmaralda Lumbantobing, Christina J.R.E. Marfitania, Taranipa Maswarni Mawarni, Evi Michael Michael MICHELLE HENDRIANI DJUANG Miranda Winda Sari Sitorus Mukti, Ade Indra Nadapdap, Thomson Nasution, Ali Napiah Nasution, Atika Rimalda Nasution, Isna Gita Amalia Novalinda, Chrismis Nurlaela, Lia Olivia Laurent Ong, Gabriella Fransisca Ongko, Nicolas Xavier Pardianto, Gede Pasaribu, Jelita Pebriani Patriyuni, Tri Permata Khaira, Azzuhra Pinem, Sabriela Br Puspita, Sunny Putri, Muna Soraya Rajagukguk, Samuel Joshua Hamonangan Tua Rambe, Natasya Septiana Razoki, Razoki Rizki, Kartika Sari Sagala, Agasy Gideon Admiral Sahna Ferdinand Ginting Saragih, Chanli Saragih, Reyini Namora L. Sebayang, Dwi Putri Agita Sembiring, Mahral Effendi Sihombing, Bungaran Simarmata, Hans Pangestu Siti Hardianti, Siti Sitorus, Josua Panangian Soekardi, Adi Stanliko, Stanliko Stefenie Suandy, Suandy Suhartomi Sulistijanto, Eddy Suyono, Tan Syahputra, Hariyadi Dharmawan Sylvana, Dhini Tambunan, Ridhona Tan Suyono Tanamal, Claudia Tandiono, Michelle Tarigan, Elviyanti Tarigan, Setia Budi Tengku Rachmi Hidayani, Tengku Rachmi Tia Triyanti Tjendera, Mariaman Utami, Sherlinda Putri Utomo, Wilbert Waldo Varerina, Ria Br Perangin-angin Vera Estefania Kaban vera vera, vera VERONICA VERONICA Virgoh, Livia WAHYU WIDOWATI Wardhani, Fiska Maya Wijaya, Johanna Fransiska Wijaya, Linda Leonando Winda Sari Yosefa, Stephanie Renata Yuliansyah, Jeri Yulita, Emi Yusmaini, Yusmaini Zendrato, Ronauli Muliani