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Lumbricus Rubellus Earthworm Extract Hydrogel for Treatment of Diabetic Ulcer Wounds Diana Tri Lestari; Muhamad Jauhar; Eko Retnowati
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22880

Abstract

A diabetic ulcer is a complication that requires serious treatment because it is the highest cause of amputation. This condition has an impact on the morbidity, mortality, and socioeconomics of people with diabetes. Therefore, accuracy is needed in managing diabetic ulcers, one of which is natural ingredients that have potential as topical ulcer medicines, namely the Lumbricus rubellus earthworm. This study aims to find out the most effective formula for the treatment of diabetic ulcer wounds. The formula for this drug candidate is made using the hydrogel preparation formulation using an HPMC 940 base with variations in the active ingredient of lumbricus worm extract of 20%, 50%, and 80% to obtain the desired hydrogel preparation. The candidate drug will be tested, namely physical tests including organoleptic tests, homogeneity tests, pH tests, viscosity tests, spreadability tests, and adhesive tests. After that in vivo trial using Wistar rat experiments. The results of the organoleptic test showed that the three formulas were in gel form with a distinctive extract odor, but the three preparations showed different colors, namely brownish yellow, dark brown, and blackish brown. The three formulations appear homogeneous, having a pH between 4.36 and 4.44 and a viscosity between 5,376 cp and 5,894 cp. The spreading power in formulas 2 and 3 is good, and formula 2 has good adhesion. The results of this study demonstrate that the group treated with 50% L. rubellus topical extract experienced the most significant and rapid wound healing among all intervention groups. L. rubellus extract can be used as a topical gel preparation for wound care, with the best formulation at a concentration of 50%.
Psychometric Evaluation of the Stakeholder Support Questionnaire for Integrated Primary Care: Evidence of a Multidimensional and Hierarchical Construct in Indonesia Wiwin Wiarsih; Utami Rachmawati; Muhamad Jauhar; Megah Andriany; Endang Triyanto; Lita Heni Kusumawardani; Maula Mar'atus Solikhah; Umi Hani; Kinantika Nur Dewanti; M.Agung Akbar
An Idea Health Journal Vol 6 No 02 (2026)
Publisher : PT.Mantaya Idea Batara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53690/ihj.v6i02.638

Abstract

Background: Integrated primary care (IPC) is recognized as essential for strengthening health systems. However, Indonesia currently lacks a validated instrument to assess stakeholder support, which is a critical determinant of successful IPC implementation. This study evaluated the content validity, internal structure, and reliability of the newly developed Stakeholder Support Questionnaire for Integrated Primary Care (SSQ-IPC), grounded in Freeman’s Stakeholder Theory. Methods: A cross-sectional psychometric validation was conducted with 570 primary healthcare nurses recruited through stratified random sampling across Indonesia. The initial 18-item instrument, encompassing four constructs, underwent content validation by a panel of seven experts. Data analysis included calculating the Content Validity Index (CVI), conducting exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and second-order CFA. Model fit was assessed using multiple fit indices, while construct validity and reliability were evaluated through factor loadings, Average Variance Extracted (AVE), Cronbach’s alpha, and McDonald’s omega. Results: EFA supported a four-factor structure. First-order CFA indicated acceptable model fit (CFI = 0.933, TLI = 0.921, SRMR = 0.037), with all factor loadings statistically significant (p<.001) and strong indicator reliability. Convergent validity was established with AVE values ranging from 0.650 to 0.869, and internal consistency was high across constructs (α= 0.877–0.978; ω = 0.884–0.973). Second-order CFA supported a hierarchical model, with all four constructs significantly loading onto a higher-order factor. Conclusion: The SSQ-IPC demonstrates strong evidence of validity and reliability, supporting its multidimensional and hierarchical structure. This instrument provides a robust tool for research and practice, facilitating.
Stigma, Health Literacy, and Treatment-Seeking Behavior among Caregivers of Stunting Toddlers in Rural Areas Adella Risma Triwijayanti; Indanah Indanah; Muhamad Jauhar
Journal of Bionursing Vol 8 No 2 (2026): Journal of Bionursing
Publisher : Fakultas Ilmu-ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.job.2026.8.2.15854

Abstract

Stunting is a health problem that threatens human quality and the competitiveness of the nation. This condition has an impact on the physical, mental, and cognitive development of toddlers and increases the risk of disease. There are still many toddlers who are diagnosed with stunting but do not receive treatment. Treatment-seeking behavior is influenced by knowledge, attitudes, stigma, and community beliefs. This research aims to analyze the relationship between stigma and health literacy with treatment-seeking behavior. The research design uses a correlational analytical approach that is cross-sectional. The independent variables are stigma and health literacy, while the dependent variable is treatment-seeking behavior. This research was conducted in the Keling II Community Health Center Working Area, Jepara Regency, in January 2025. The research sample was 100 caregivers of stunted toddlers and was taken using techniques of purposive sampling. The research instrument includes a stigma questionnaire using (SSCI-8), a questionnaire on health literacy using (HLS-EU-Q16), and a questionnaire on treatment-seeking behavior using (GHSQ). Data analysis using chi-square tests. The results of this study show that there is a significant relationship between stigma (p=0.002; r=0.394) and health literacy (p=0.000; r=0.448) with treatment-seeking behavior in caregivers of stunted toddlers. Stigma and health literacy play a role in shaping behavior in seeking health assistance, especially among caregivers of toddlers with stunting in rural areas. There needs to be intervention to reduce negative stigma and increase health literacy so that caregivers of stunted toddlers have the awareness to carry out screening and treat stunting in health service facilities.
Duration, Compliance, and Value of Interdialytic Weight Gain in Chronic Kidney Disease Patients Undergoing Hemodialysis Muhamad Jauhar; Muhammad Adi Saseno; Umi Faridah
Journal of Bionursing Vol 8 No 2 (2026): Journal of Bionursing
Publisher : Fakultas Ilmu-ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.job.2026.8.2.15881

Abstract

Background: Chronic Kidney Disease (CKD) is a life-threatening problem. CKD patients who require hemodialysis therapy experience a significant increase; one of the important indicators in hemodialysis therapy is interdialytic weight gain (IDWG). In practice, there are still cases where patients experience high IDWG, which is suspected to be due to non-compliance with the schedule or length of hemodialysis sessions. Objectives: This study aimed to determine the relationship between frequency and compliance with the value of IDWG in CKD patients undergoing hemodialysis. Methods: This quantitative study uses a correlative analytical research method with a cross-sectional approach. The population was 47 chronic kidney failure patients undergoing hemodialysis at the Muhammadiyah Mayong Hospital, Jepara. The instruments used were weight scales, patient medical records, and End-Stage Renal Disease Adherence Questionnaire (ESRD-AQ) questionnaires. Bivariate analysis in this study used the Spearman Rho test. Results: The results of this study are that most respondents have undergone hemodialysis for more than 12 months, as many as 20 respondents (42.6%); respondents who are compliant with hemodialysis are 25 respondents (53.2%); and most respondents experienced a mild weight gain category of 16 respondents (34%). There is a relationship between the length of time (p-value = 0.001, r= 0,762) and hemodialysis compliance (p-value = 0.003, r= 0,578) with the interdialytic weight gain value in chronic kidney disease patients undergoing hemodialysis at the hospital. Conclusion: Frequency and compliance have a relationship with the value of IDWG in CKD patients undergoing hemodialysis. The correlation between two variables are direct and positive means that the more compliant with HD, the value of IDWG is lower.
Knowledge, Stress, and Treatment Compliance among Hypertension Clients in Rural Areas Lisa Tiyansi; Dewi Hartinah; Muhamad Jauhar; Novi Tiara
Journal of Bionursing Vol 8 No 2 (2026): Journal of Bionursing
Publisher : Fakultas Ilmu-ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.job.2026.8.2.17367

Abstract

Hypertension is a major risk factor for increasing mortality and morbidity rates. This is supported by the increasing prevalence of hypertension cases every year worldwide. If blood pressure cannot be controlled, it will lead to complications such as stroke, retinopathy, heart failure, heart attack, kidney failure, and disability. Therefore, adherence to treatment is crucial to prevent these complications. However, in the treatment of long-term diseases such as hypertension, which require lifelong treatment, barriers to medication adherence often occur. The purpose of this study was to analyze the relationship between knowledge and stress with medication adherence in hypertension patients in rural areas. The study design used correlation analysis with a cross-sectional approach. The independent variables were knowledge and stress, while the dependent variable was medication adherence. This study was conducted in two villages in Kudus Regency, which is the locus of hypertension, in April 2025. The study sample consisted of 97 respondents selected through a cross-sectional approach through purposive sampling based on inclusion and exclusion criteria. The instruments used include the Hill-Bone Compliance to High Blood Pressure Therapy Scale, the Hypertension Knowledge-Level Scale, and the Perceived Stress Scale (PSS-10). Data analysis using the chi-square test. The results of the study showed a significant relationship between knowledge (p=0.000) and stress (p=0.000) with medication adherence. Knowledge and stress are associated with medication adherence in hypertensive clients. Community health centers need to implement innovative programs to improve medication adherence through structured health education and stress management.
Health Literacy and Early Detection Skills of Dengue Hemorrhagic Fever in Adolescents Ilham Syarochman Putra; Dewi Hartinah; Muhamad Jauhar
Jurnal Keperawatan Priority Vol. 8 No. 1 (2025)
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jukep.v8i1.5981

Abstract

Dengue hemorrhagic fever (DHF) is a significant public health problem in Indonesia, especially in tropical areas such as Jepara Regency. The increase in DHF cases in adolescents is caused by low health literacy and a lack of confidence in early detection skills that play an important role in preventing DHF. The impact is the occurrence of complications to the economic impact of the community in the treatment phase. This study aims to analyze the relationship between health literacy with early detection skills for DHF in adolescents. This study aims to analyze the relationship between health literacy and health beliefs with early detection skills of DHF in adolescent groups at SMAN 1 Tahunan, Jepara Regency. This study used a correlational analytical design with a cross-sectional approach. Independent variables are health literacy Dependent variables are early detection skills of DHF. This study was conducted in November at SMAN 1 Tahunan, the number of samples was 93 students selected using purposive sampling techniques. The research instrument used health literacy instruments (HLS-12Q),), and early detection behavioral skills of DHF. Data analysis was carried out using the chi-square test. The results of the study showed that there was a significant relationship between health literacy and early detection skills of DHF with a p-value = 0.000, health literacy is related to early detection skills. With this, schools and health centers can collaborate in improve health literacy, skills and early detection of DHF.
The Effect Of Brisk Walking Exercise On Blood Pressure In Elderly Hypertension In The Working Area Of The Gajah Ii Community Health Center Cherlina Pramushinta; Dewi Hartinah; Muhamad Jauhar
International Journal of Health Engineering and Technology Vol. 5 No. 2 (2026): Vol 5. No. 2 JULY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i2.907

Abstract

Hypertension is a non-communicable disease that often occurs in the elderly and can cause serious complications if not properly controlled. One non-pharmacological therapy that can be done is brisk walking exercise. This study aims to determine the effect of brisk walking exercise on blood pressure in elderly people with hypertension in the Gajah II Community Health Center work area. The study used a quasi-experimental design with a pretest-posttest approach with a control group. The study sample consisted of 36 respondents who were divided into an intervention group and a control group using a total sampling technique. The intervention group was given brisk walking exercise for 20–30 minutes three times a week for two weeks, while the control group was only given health education. Blood pressure was measured using a digital sphygmomanometer before and after the intervention. Data analysis used a paired sample t-test and an independent sample t-test. The results showed that the average systolic blood pressure in the intervention group decreased from 174.06 mmHg to 128.67 mmHg and diastolic from 101.39 mmHg to 83.11 mmHg. Statistical tests showed a significant effect of brisk walking exercise on reducing blood pressure, with a p-value of 0.001 for systolic and 0.011 for diastolic blood pressure. It was concluded that brisk walking exercise is effective as a non-pharmacological therapy to help control blood pressure in elderly hypertensive patients.
PREDICTORS OF THE INCIDENCE OF PREECLAMPSIA IN PREGNANT WOMEN Yasinta Anugrah Heni; Noor Hidayah; Muhamad Jauhar
(IJP) Indonesia Jurnal Perawat Vol 11, No 1 (2026): (IJP) INDONESIA JURNAL PERAWAT
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijp.v11i1.3403

Abstract

Background: Preeclampsia is one of the leading causes of maternal morbidity and mortality in Indonesia, characterized by increased blood pressure and proteinuria after 20 weeks of gestation. Risk factors that often play a role in the incidence of preeclampsia include pre-pregnancy weight (obesity), family history of hypertension, and twin pregnancies.Objective: This study aims to determine the relationship between pre-pregnancy weight, family history of hypertension, and twin pregnancies with the incidence of preeclampsia at Sunan Kudus Hospital.Methods: This study used a quantitative design with a cross-sectional retrospective case control approach. Independent variables are pre-pregnancy BB, family history of hypertension and twin pregnancies while dependent on the incidence of preeclampsia. This research was conducted at RSI Sunan Kudus in August 2025. The sample of 252 pregnant women in 2024 through total sampling, consisting of 63 mothers with preeclampsia (cases) and 189 mothers without preeclampsia (control). Data were obtained from medical records and analyzed using the Chi-Square test.Results: showed a significant association between prepregnancy weight and the incidence of preeclampsia (p = 0.001; OR = 49.6; CI 95%: 14.29–172.12) and a significant association between family history of hypertension and the incidence of preeclampsia (p = 0.001; OR = 16.75; 95% CI: 9.67–28.99). However, there was no significant association between twin pregnancies and preeclampsia (p = 0.718; OR = 0.58; 95% CI: 0.16–2.07).Conclusions: There was a significant association between pre-pregnancy weight and family history of hypertension and the incidence of preeclampsia, however twin pregnancies were not significantly associated. It is recommended that health workers increase early detection and education for pregnant women with high risk factors to reduce the incidence of preeclampsia.      
HEALTH LITERACY AND HEALTH BELIEF AS A DETERMINANTS OF HEALTH-SEEKING BEHAVIOR IN THE ELDERLY WITH DEMENTIA Novi Tiara; Muhamad Jauhar; Noor Eswanti; Faridha Alfiyatur Rohmaniah
(IJP) Indonesia Jurnal Perawat Vol 11, No 1 (2026): (IJP) INDONESIA JURNAL PERAWAT
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijp.v11i1.3422

Abstract

Peningkatan jumlah lansia di Indonesia diikuti oleh meningkatnya prevalensi demensia yang belum diimbangi dengan perilaku pencarian layanan kesehatan yang optimal. Banyak lansia dengan demensia tidak terdeteksi dan terlambat mendapatkan penanganan akibat rendahnya health literacy dan keyakinan kesehatan yang keliru, seperti anggapan bahwa demensia merupakan proses penuaan normal. Kondisi ini memperlebar treatment gap dan meningkatkan beban keluarga serta sistem kesehatan. Penelitian ini menjadi urgen untuk mengidentifikasi peran health literacy dan health belief terhadap health seeking behavior sebagai dasar pengembangan intervensi keperawatan komunitas yang efektif dan berbasis bukti. Tujuan dari penelitian ini yaitu menganalisis hubungan health literacy dan health belief dengan health seeking behaviour pada lansia dengan demensia. Metode penelitian menggunakan desain penelitian yaitu deskriptif analisis korelasi dengan pendekatan cross sectional. Variabel independen yaitu health literacy dan health belief serta variabel dependen yaitu health seeking behaviour. Penelitian dilakukan pada Bulan Januari 2025 di UPTD Puskesmas Dawe Kabupaten Kudus. Sampel penelitian sebanyak 106 lansia dengan Teknik purposive sampling. Kriteria Inklusi penelitian ini lansia yang berusia lebih dari 60 tahun, bisa membaca dan menulis, mampu berkomunikasi, dan tinggal di wilayah UPT Puskesmas Dawe. Kriteria Eksklusi, tidak mempunyai komplikasi penyakit berat, tidak disabilitas dan memiliki gangguan kognitif. Instrumen penelitian menggunakan kuesioner health literacy 12, keyakinan Kesehatan HBM, dan perilaku pencarian bantuan kesehatan HCSBQ. Analisis data menggunakan uji chi square. Hasil Penelitian ini menunjukkan ada hubungan antara health literacy dan health belief dengan health seeking behavior dengan nilai p value p=0,01 (p0,05).
DETERMINATION OF FAMILY SUPPORT FOR SELF-MANAGEMENT OF HYPERTENSION PATIENTS Noor Eswanti; Muhamad Jauhar; Novi Tiara; Lasmini Lasmini
(IJP) Indonesia Jurnal Perawat Vol 11, No 1 (2026): (IJP) INDONESIA JURNAL PERAWAT
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijp.v11i1.3303

Abstract

Hypertension is a chronic disease that requires long-term management through optimal self-management behavior. However, many hypertensive clients are still unable to consistently perform self-management behavior. One factor suspected of playing a role in improving self-management behavior is family support. This study aims to determine the relationship between family support and self-management behavior in hypertensive clients. This study used a quantitative design with a cross-sectional approach. The study sample consisted of hypertensive clients in the Dawe Community Health Center area, selected using a purposive sampling technique. The instruments used included a standardized family questionnaire containing family support sourced from (Nursalam, 2017) with a Cronbach Alpha value of 0.628 and the Hypertension Self-Management Behavior Questionnaire (HSMBQ) to measure self-management behavior. The data collection procedure was carried out by filling out the questionnaire directly. Data analysis was performed using the Spearman rho statistical test with a significance level of 0.05. The results of the study showed a significant relationship between family support and self-management behavior in hypertensive clients with a p-value of 0.000 and a correlation coefficient of 0.333, indicating a positive relationship with weak to moderate strength. It can be concluded that family support plays a role in improving self-management behavior in hypertensive clients. Therefore, nurses are expected to actively involve families in nursing care through family-based education and interventions to improve optimal hypertension management.
Co-Authors A Nur Anna AS Adella Risma Triwijayanti Aeni, Linda Nur Agustiani, widya Ahmad Suriyadi Muslim Alfiatur Rochma Amarilla Melati Anggara Dwi Sulistiyanto Anny Fauziyah Anny Rosiana Mashitoh Anny Rosiana Masithoh Anny Rosiana Masithoh Ardiansyah, Diki Arina Novitasari Ariyanto, Andhika Arwani Arwani Ashri Maulida Rahmawati Astuti Yuni Nursasi Astuti, Verra Widhi Aulia Chusna, Arda Auliya, Arida Balqis Fashila Catur Ririn Indarsih Cherlina Pramushinta Choiruna, Hasby Pri Ckancer Bela Romantis D. Eka Harsanto Darmawati, Laesa Desak Parwati Dewi Hartinah Dewi Murti Sari Dewi, Risah Wati Diah Irawati Diah Widowati Diana Tri Lestari Diana Tri Lestari Dina Indrati Dwi Astuti Dwi Febryanto Dwi Mei Anggraini Edi Wibowo Suwandi Edita Pusparatri Edy Soesanto Eko Retnowati Elisa Elisa Endang Triyanto Endang Triyanto Erni Setiyowati Eswanti, Noor Etikasari, Ria Eva Luthfiati Putri Fajar Surachmi Fajar Surachmi Fajar Surahmi Fajar Surahmi, Fajar Fania Nurul Khoirunnisa Fania Nurul Khoirunnisa Faridha Alfiatur Rohmaniah Faridha Alfiyatur Rohmaniah Fatihatul Husna Fery Nanik Handayani Fitriana Kartikasari Futkhatin Nasikhah Gandi Siwitri Gunardi Pome Gunardi Pome Heny Siswanti I Gusti Ayu Putu Desy Rohana Iffah Hanifah Iis Sriningsih Iis Sriningsih Ike Puspitaningrum Ike Puspitaningrum Ilham Syarochman Putra Ilyana Sari Inayah Alviorizka Pujanti Indah Risnawati Indanah Intan Idiasari Ismail, Wan Ismahanisa Isna Nailil Hana Iswatun Qasanah Iza, Ifa Nailatul Jelita, Monica Artha Kanan, Thanalechumy Kinantika Nur Dewanti Kumalasari, Novy Kurniasaria, Intan Endyka Kurniati Puji Lestari Kurniati Puji Lestari kusumawardani, lita heni Laesa Darmawati Lasmini Lasmini Lasmini Lasmini Lasmini Lasmini, Lasmini Lestari, Rizka Puji Lisa Tiyansi Lita Heni Kusumawardani Lita Heni Kusumawardani Lita Heni Kusumawardani Lita Heni Kusumawardani Lita Heni Kusumawardani M.Agung Akbar Maksuk Marendra, Irvan Maulana Masayu Hartina Ulfa Masithoh, Anny Rosisana Maula Mar'atus Solikhah Maulana, Bonnix Hedy Mauludina, Ibtasama Megah Andriany Misga, Nesdania Mohamad Khafidh Rio Irwansyah Mohammad Sholahudin Mugi Hartoyo Muhammad Adi Saseno Muhammad Hasan Burhanudin Muhammad Niko Bagus Saputro Muhammad Purnomo Muhammad Purnomo Nadya Tiara Sabila Nanda Arum Widya Warapsari Nasriyah Nasriyah Nerlita Yogi Rizki Rulloh Nikmah, Mauliana Nurlaila Nisa Herlina Puspitasari Noor Eswanti Noor Eswanti Noor Hidayah Noor Hidayah Novi Tiara Nur Ulisetiani Okta Yosiana Dewi Padad, A. Tenri Putra, Ilham Syarochman Putra, M. Adib Jaharii Dwi Putri Intan Rosita Dewi Rachmawati, Utami Rahmasari, Lutfir Fitri Rasdiyanah, Rasdiyanah Retno Dewi Wulandari Ririn Navita Sari Ririn Widyasari Riza Yanti Rizka Himawan Rohana, I Gusti Ayu Putu Desy Roisul Fahmi Ilyas Rusnoto Rusnoto rusnoto rusnoto Salma Adilanisa Sari, Etik Nila Sarwo Edi, Sarwo Sekar Ayuningtyas Septyani, Ima Aulia Setyasih, Pingki Agit Sheva Jusuf Az Zahra Shobirun Shobirun Shobirun Shobirun Sholikhah, Shafa Artamevia Siti Rukhaniyah Siti Wahyuni Sofiana Nur Mardhiyah Sri Karyati Sri Widiyati Sugih Wijayati Sugih Wijayati Sugih Wijayati Sugih Wijayati, Sugih Sukarmin Sukarmin Sukarmin Sukesih Sukesih Sukesih Sukesih Sukesih Sukesih, Sukesih Sukoharjanti, Bintari Tri Susanti, Sofy Norma Taftazani Ghazi Pratama Tassya Yanurifsa Ameilia Theresia Avila Kurnia Tiara, Novi Trianita Siwi Utami Udin, Berkah Afif Umi Faridah Umi Faridah Umi Hani Unsa, Annisa Laila Usamah Jundullah Verra Widhi Astuti Wardani, Ema Saputri Kusuma Widara, Jihan Zinnia widya Agustiani Widyatuti Wisdom Rudiyana Wiwik Dewi Mulyani Wiwin Wiarsih Yasinta Anugrah Heni Yasmina Izzat Yayuk Mundriyastutik Yuliastuti, Fitri Zaenal Fanani