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Permatasari, Lina
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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QUALITATIVE AND QUANTITATIVE ANALYSIS OF MEDICINAL CHEMICALS OF “ JAMU REMATIK DAN PEGAL LINU “ IN MAGELANG REGION Haresmita, Perdana Priya; Wardani, Arief Kusuma; Pradani, Missya Putri Kurnia; Permatasari, Lina
Jurnal Ilmu Kesehatan Vol 11 No 2 (2023): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v11i2.3829

Abstract

Jamu for rheumatism and "pegal linu" are two of the most commonly used traditional medicine products in the community, so it is a type of traditional medicine preparation that is prone to the addition of medicinal chemicals. Any type of medicinal chemical should not be added to herbal preparations. The purpose of this study was to determine is there any medicinal chemicals in traditional medicine samples for "pegal linu" and rheumatism in the Magelang area. The total number of samples used is nine. Thin layer chromatography was used to analyze medicinal chemicals in traditional medicine, and preliminary organoleptic test was performed. The next step is a quantitative analysis using the UV-Visible spectrophotometric method. Prednisone, mefenamic acid, and ibuprofen were used as standards. The stationary phase was silica gel 60 F254, and the mobile phase was ethyl acetate: chloroform (4:1) for the prednisone standard, chloroform:methanol (9:1) for the mefenamic acid standard, and chloroform:ethanol (8:1) for the ibuprofen standard. Thin layer chromatography analysis showed that three of the nine traditional medicine samples tested positive for prednisone, but none contained mefenamic acid or ibuprofen. Herbs A, D, and E contained prednisone in their samples. Prednisone concentrations in the three samples were 0,252%; 0.754%, and 2,005%, respectively.
Eksplorasi Aktivitas Antioksidan Biji Kepundung (Baccaurea racemosa) Dan Korelasinya Dengan Kandungan Fenolik Total Permatasari, Lina; Rohman, Abdul; Riyanto, Sugeng; Priya Haresmita, Perdana
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.443

Abstract

Dalam dekade terakhir, radikal bebas dapat menyebabkan banyak penyakit, misalnya kanker. Antioksidan merupakan senyawa yang mampu menghambat aktivitas radikal bebas. Indonesia memiliki kekayaan sumber daya alam yang bisa dieksplor aktivitas antioksidannya. Salah satu tumbuhan Indonesia yang potensial yaitu kepundung (Baccaurea racemosa). Bagian daun, batang, buah, kulit buah, dan kulit batang kepundung dilaporkan memiliki aktivitas antioksidan yang tergolong sedang sampai sangat kuat. Namun, aktivitas antioksidan biji kepundung belum pernah dilaporkan. Oleh karena itu, penelitian ini bertujuan untuk mengekplorasi aktivitas antioksidan biji kepundung dan korelasinya dengan kandungan fenolik totalnya. Biji buah kepundung diekstraksi dengan metode maserasi bertingkat diawali dengan pelarut petroleum eter kemudian dilanjutkan dengan kloroform lalu etil asetat. Ekstrak petroleum eter, ekstrak kloroform, dan ekstrak etil asetat biji kepundung dianalisis aktivitas antioksidannya menggunakan metode penangkapan radikal bebas 2,2’-diphenil-1-picrylhydrazil (DPPH). Sementara itu, kandungan fenolik total diuji menggunakan metode Folin-Ciocalteu. Korelasi antara aktivitas antioksidan dan kandungan fenolik total dianalisis menggunakan Person correlation test. Hasil menunjukkan bahwa ekstrak petroleum eter, ekstrak kloroform, dan ekstrak etil asetat secara berurutan memiliki persen penghambatan radikal DPPH sebesar 6,35 ± 0,97 %; 28,84 ± 5,48 %; dan 50,78 ± 1,18 %. Sementara itu, kandungan fenolik total ekstrak petroleum eter, ekstrak kloroform, dan ekstrak etil asetat secara berurutan yaitu 0,10 ± 0,01; 15,12 ± 0,52; dan 30,62 ± 0,87 mg ekuivalen asam galat/ gram ekstrak (mg EAG/g). Senyawa fenolik ekstrak biji kepundung berkorelasi positif dan signifikan dengan aktivitas antioksidannya. Senyawa fenolik berkonstribusi sebesar 98,9% terhadap aktivitas antioksidan biji kepundung. Biji kepundung dapat dikembangkan lebih lanjut sebagai antioksidan alami.
Comparative Analysis of a Secondary Metabolite Profile from Leaves, Peel and Bulbs of Allium sativum L. by GC-MS Hafizah, Gina Tasya Rizka; Hidayati, Agriana Rosmalina; Permatasari, Lina
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7058

Abstract

Garlic is a herbal plant that is widely used as a medicinal ingredient, because it contains secondary metabolite compounds such as alkaloids, flavonoids, tannins, phenols, terpenoids and saponins. The secondary metabolite content of plants is influenced by genetic, ontogenic, morphogenetic and environmental factors that can influence the biosynthesis and accumulation of secondary metabolites. Garlic is generally only used for the bulbs, while other parts such as the leaves and skin are still not widely used. This study aims to identify the secondary metabolite profile of ethanol extract of garlic leaves, bulbs and peels using the gas chromatography mass spectrometry (GC-MS) method. Identification of secondary metabolite compounds contained in each 70% ethanol extract was analyzed using the tube test, thin layer chromatography (TLC) and GC-MS methods. The results of analysis of secondary metabolite content using the tube test and TLC method showed that the ethanol extract of garlic leaves, skin and bulbs positively contained flavonoids, tannins, phenols and saponins. The results of secondary metabolite profile analysis using the GC-MS method from the ethanol extract of garlic skin and bulbs showed that 5 compounds were obtained with the main compound being 3,4-Dihydroxyphenylacetic acid and 23 compounds with the main compound being 1,2-Benzenedicaboxylic acid and palmitic acid, while the leek extract white only detected 1 compound. The conclusion is that the ethanol extract of garlic leaves, skin and bulbs has secondary metabolites in the form of flavonoids, tannins, phenols and saponins. There are differences in the profile of secondary metabolite compounds in the ethanol extract of garlic leaves, skin and bulbs in terms of the results of GC-MS analysis.
Antioxidant Activity Testing of Fractions Resulting from Gravity Column Chromatography of Methanol Extract of Kepundung Leaves (Baccaurea racemosa) Using The DPPH Method Istiqamah, Juhratul; Permatasari, Lina; Hanifa, Nisa Isneni
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7404

Abstract

Free radicals are compounds that can cause various diseases and can be inhibited with antioxidant compounds. One of the antioxidant compounds that can be obtained from natural sources is the kepundung plant (Baccaurea racemosa). This research aims to determine the fraction that contains flavonoid compounds and determine the percent inhibition of the fraction resulting from gravity column chromatography from the methanol extract of kepundung leaves (Baccaurea racemosa) using the DPPH method. Extraction used the sonication method and continued with fractionation using gravity column chromatography. A UV-VIS spectrophotometer was then used to measure the antiradical activity and perform a qualitative flavonoid and antioxidant test using TLC. The study's findings demonstrated that the yield of a 96% methanol extract of kepundung leaves was 17%, and that there were 15 sets of fractions produced by gravity column chromatography. Positive results for flavonoids and antioxidants were shown by fractions B, G, H, K, L, and N. The fraction with the highest antiradical activity was fraction L with a % inhibition value of 79,94%.
The Sun Protection Factor (SPF) of Kepundung Leaf Methanol 96% Extract (Baccaurea racemosa) Using The In-Vitro Test Rosida, Naela; Permatasari, Lina; Hajrin, Wahida
Jurnal Biologi Tropis Vol. 24 No. 2b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i2b.7422

Abstract

Excessive sun exposure can reveal harmful effects on the skin. One way to prevent these effects is by using Kepundung (Baccaurea racemosa) a plant known for its antioxidant properties. Several studies have shown that the antioxidant activity of kepundung leaf extract has a very strong IC50 value, making it potentially a sunscreen. However, research on the Sun Protector Factor (SPF) value of kepundung leaf extract has not been reported. Therefore, this study will conduct to determine the SPF value of the extract. Compound extraction will carry out using the sonication method with methanol solvent. The extract obtained was analyzed for SPF value using UV-Vis spectrophotometry and the SPF value will calculated using the Mansur formula. The various concentration of kepundung leaves extract revealed various SPF from minimal and ultra protection. Kepundung leaves extract with concentation 500 ppm have ultra protection with SPF value 15.19. The Kepundung leaves can to be developed as natural SPF.
Analysis of Cholesterol Content, E. Coli Bacteria, and Organoleptic Value of Rarang Chicken Cooking Based on Slaughter Age Alfian G. M, Aji; Bulkaini, Bulkaini; Kisworo, Djoko; Ichsan, Ichsan; Rosyidi, A.; Yuliani, Enny; Permatasari, Lina
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7789

Abstract

Rarang chicken dish is a very special dish with a unique taste on Lombok Island. This research aims to determine the effect of slaughter age on cholesterol content, E.Coli and organoleptic value of Rarang chicken dishes. The materials used were 15 male chickens and a number of Rarang chicken cooking spices. The method used is an experimental method in the Animal Product Processing Technology Laboratory, Faculty of Animal Science, University of Mataram, which is designed based on a Completely Randomized Design in a one-way pattern with 3 treatments and 5 replications: namely P1 = 6 weeks of slaughter age, P1 = 7 weeks of slaughter age and P2 = 8 weeks of slaughter age. Research data such as cholesterol content, E.Coli and organoleptic values ​​were analyzed using analysis of variance followed by the Tukkey Honestly Different Test. The results of the research showed that the cholesterol content, E. Coli, and organoleptic value of Rarang chicken dishes based on age at slaughter were respectively: total cholesterol ranges from 32.18-45.30%; E.Coli content of 0.4 CFU/g, with organoleptic values ​​(color, aroma, taste and tenderness) accepted by consumers. Conclusion: Super village chicken which is processed into Rarang chicken dishes at 7 weeks of slaughter age can provide relatively low total cholesterol and E.Coli content, with organoleptic values (color and aroma) that consumers like, the taste is relatively delicious and Rarang chicken dishes are relatively tender.
Literature Review: Exploration of Bioactive Components of Avicennia marina and Its Biological Activities Budastra, Cintya; Ulya, Tuhfatul; Maulidya, Selvira Anandia Intan; Purnomo, Indra; Lisnasari, Baiq Risky Wahyu; Permatasari, Lina
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7987

Abstract

Indonesia, as a maritime nation, possesses numerous mangrove ecosystems that have significant potential for exploring their benefits. One species of mangrove that has attracted attention is Avicennia marina, which contains various bioactive compounds. This article aims to provide a comprehensive review of the bioactive components of the Avicennia marina plant and its biological activities, particularly its therapeutic potential and benefits in the pharmaceutical field. We conducted a literature search to find relevant articles in the PubMed, Scopus, and Google Scholar databases using the keywords: plant identification + Avicennia marina; compound identification + Avicennia marina; biological activity + Avicennia marina. The bioactive content from the leaves, fruits, stems, and roots of Avicennia marina has been shown to exhibit antioxidant, antimicrobial, anticancer, and anti-inflammatory effects. This effect is strongly correlated to the presence of active metabolites of triterpenes, terpene alcohols, diterpenes, tannins, dodecanoic acid, octadecanoic acid, phenolic compound, flavonoid, squalene, and phytol. This indicates that Avicennia marina is a promising natural source for further research in the development of a new drug. Our finding further the notion of Avicennia marina as a potential medicinal plant.
DPPH Radical Capture Test of Sumbawa Oil and Identification of Compound Content Using GC-MS Wardani, Ray Haerul; Permatasari, Lina; Hidayati, Agriana Rosmalina; Hanifa, Nisa Isneni
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8468

Abstract

Free radicals are reactive fragments that can trigger a variety of chronic diseases. Antioxidant compounds are needed to counteract the attack of free radicals. Sumbawa oil is one of the natural traditional remedies that has the potential to be a natural antioxidant because it contains compounds such as lauric acid, palmitic acid, linoleic acid, stearic acid, and methyl palmitate. The study aimed to determine the metabolite compounds contained in the Sumbawa oil brand “Rimba” and their activity to capture the DPPH free radical. The Sumbawa oil determined their metabolite compounds using Gass Chromatography-Mass Spectrometry (GC-MS). The antioxidant activity of Sumbawa oil was analyzed using the DPPH radical capture method. The GC spectra showed the 5 compounds detected in the Sumbawa oil. In addition, the MS spectra showed these 5 compounds were delta-3-carene, trans-caryophyllene, palmitic acid, palmitoleic acid, and stearic acid. The antioxidant activity of Sumbawa oil was found to be very weak with an IC50 value of 13.49 ± 0.34 mg/mL. Therefore, Palmitoleic acid and palmitic acid were reported to have potential antioxidant activity. These compounds were lipophilic antioxidants that did not properly detect their antioxidant activity using the DPPH method. So, the antioxidant activity of Sumbawa oil was recommended to be analyzed using the β-carotene bleaching method.
Review artikel: analisis validasi metode penetapan kadar logam timbal (Pb) dalam kosmetik menggunakan berbagai instrumen Razkianita, Haulya; Permatasari, Lina
Sasambo Journal of Pharmacy Vol. 6 No. 2 (2025): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i2.589

Abstract

Lead (Pb) is one of the most commonly found heavy metal contaminants in cosmetic products. Continuous exposure to lead (Pb) can cause pathological changes in body organs and may lead to cancer. Therefore, it is essential to measure the concentration of lead in cosmetics to ensure safety and prevent potential side effects. This article aims to determine the most effective method for analyzing lead (Pb) content in cosmetic preparations using various instruments, including UV-Vis Spectrophotometry and Atomic Absorption Spectrophotometry (AAS). This study was conducted by comparing the validation results of both instruments. The results showed that the lead (Pb) content in most cosmetic preparations was below the safety limit set by the Badan Pengawas Obat dan Makanan (BPOM) Indonesian, which is <20 ppm. Atomic Absorption Spectrophotometry (AAS) was selected as the most optimal method, as it met all validation parameters with high accuracy and precision. It also demonstrated higher sensitivity, with lower LOD (Limit of Detection) and LOQ (Limit of Quantification) values compared to UV-Vis Spectrophotometry. Therefore, AAS is superior in detecting and quantifying lead in cosmetic preparations
Review artikel: validasi metode analisis kafein dalam minuman kemasan menggunakan berbagai instrumen Maesarah, Siti; Permatasari, Lina
Sasambo Journal of Pharmacy Vol. 6 No. 2 (2025): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i2.598

Abstract

Caffeine is a central nervous system stimulant that is commonly found in packaged beverages. While moderate consumption provides cognitive and physical benefits, excessive intake may cause adverse health effects, including anxiety disorders, insomnia, cardiovascular diseases, and renal dysfunction. Consequently, accurate and validated analytical methods are essential for determining caffeine levels in commercial beverages. This review evaluates analytical instruments and techniques for caffeine quantification, drawing on national and international studies published between 2015 and 2025. The methods examined include UV-Visible Spectrophotometry, High-Performance Liquid Chromatography (HPLC), Gas Chromatography–Mass Spectrometry (GC–MS), Ultra-Performance Liquid Chromatography (UPLC), and High-Performance Thin-Layer Chromatography (HPTLC). Validation was assessed using parameters such as limit of detection (LOD), limit of quantification (LOQ), precision, accuracy, and linearity. The findings indicate that all methods meet acceptable validation criteria. Among them, UPLC demonstrated the highest sensitivity, while HPTLC provided advantages in speed and operational efficiency. Therefore, the choice of method for caffeine determination should be guided by analytical objectives, laboratory resources, and required sensitivity.
Co-Authors Abdul Rohman Aditya Astarika, Yolanda Afriza Faishal, Imam Agrijanti, Agrijanti Aini, Dinatul Alfian G. M, Aji Ali, Baiq Aulia Alya, Ainun Amalia, Marshanda Fitri Anandia Intan Maulidya, Selvira Ananta, Muhammad Naufal Farras Anindiya, Naya Wahyu Annas, Zulfiana Fitrianingrum Ari Khusuma Attaya, Kalisa Aulia Rahmah, Diyani Azariani, Wiwin Budastra, Cintya Bulkaini (Bulkaini) Bulkis, Nanda Cintya Ganes Budastra, Wayan Deccati, Rizqa Fersiyana Dewi, Lale Budi Kusuma Djoko Kisworo Enny Yuliani Farhaini, Azizatul Farobbi, Muhammad Iqbal Fatihatussir, Layla Febrianingsih, Karlina Dwi Fersiyana Deccati, Rizqa Fitriani, Risma Guban Juniarza, A'yuni Hafizah, Gina Tasya Rizka Hafizah, Qori'atul Hajrin, Wahida Haryanto, Wahyu Hayyatun Nufus, Fadirah Hidayati, Agriana Rosmalina Ichsan Ichsan Isnaini, Nisa Istiqamah, Juhratul Junaida, Alfini Juniarza, A'yuni Guban Kabir, Mila Mayanti Lisnasari, Baiq Risky Wahyu M. Rifqi Azami S, Lalu Maesarah, Siti Magfira Nurmalasanti, Nadia Maulidya, Selvira Maulidya, Selvira Anandia Intan Maziya, Raehanul Muchlishah, Neneng Rachmalia Izzatul Mukhlishah, Neneng Rachmalia Izzatul Muliasari, Handa Mustika, Mitha Juliana Ni Made Amelia Ratnata Dewi Ningrum, Linda Tuanida Nirmala, Annisa Rizka Nisa Isneni Hanifa Ocktaviana Saputri, Legis Patya Putri, Hudaynu Perdana Priya Haresmita, Perdana Priya Pradani, Missya Putri Kurnia Priya Haresmita, Perdana Purnomo, Indra Putra, Bayu Karunia Putri, Fawwaz Aqila Putri, Hudaynu Patya Rachmalia Izzatul Mukhlishah, Neneng Rahmayanti, Wulan Desi Razkianita, Haulya Rizqullah, Rifqi Rosida, Naela Rosyidi, A. Sammanta, Rahula Vijja Saputra, Yoga Dwi Sasvania, Anisa Sugeng Riyanto Sulthanah Ahmad, Dzakiyyah Susi Rahayu Sutanti, Baiq Novia Rahmadita Tasya Kamila, Afifah Tunggal Arya Rezky, Noval Ulya, Tuhfatul Ussarwan, M Ihya Wardani, Arief Kusuma Wardani, Ray Haerul Zaneta, Nabila Destia Zanuba, Anisa