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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

Determination Of Total Flavonoid Content In Bangle Plant (Zingiber Montanum)Extraction Results Pulukadang, Sri Hastuti Virgianti; Rahmawati, Sitti; Santoso, Tri; Fatimah, Siti; Aminah, Sitti; Ningsih, Purnama; Magfirah
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.7893

Abstract

The bangle plant (Zingiber montanum) is a plant that has been used traditionally as a medicinal ingredient, both for prevention and treatment by the community. Parts of the bangle plant contain active compounds that act as antioxidants, one of which is flavonoids. This research aims to determine the total flavonoid content in bangle plants from the extraction results measured using a UV-Vis spectrophotometer. The method for separating flavonoid levels used is maceration. The research results showed that positive test results were obtained for flavonoid compounds in bangle rhizomes as evidenced by qualitative test results which produced a red color in the sample extract and the average total flavonoid content in bangle rhizomes from the extraction results measured using a UV-Vis spectrophotometer was 23. 1mg/100g.
Potential of Beluntas Leaf Extract (Pluchea indica L) as a basic ingredient for Making Liquid Anti-Mosquito Repellent Rahmawati, Sitti; Winarsih; Santoso, Tri; Ahmar, Dewi Satria; Magfirah; Suherman
Jurnal Penelitian Pendidikan IPA Vol 10 No 7 (2024): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i7.8331

Abstract

The herbaceous Belugas leaves (Pluchea indica L.) belong to the Asteraceae family and are commonly utilized as food and hedges. They typically grow wild. Alkaloids, saponins, flavonoids, tannins, triterpenes, and steroids are among the substances found in belugas leaves that may have insecticidal properties. The purpose of this study is to use the leaf extract of Beluntas (Pluchea indica L.) as a foundational component for liquid mosquito repellant. In order to produce a thick extract of beluntas leaves, this study used an extraction process that involved evaporating 96% ethanol solvent. Several concentrations of the thick extract were diluted, including 15%, 25%, 35%, 45%, and 55%. The collected data, which was mosquito mortality, was subjected to a One-Way Anova test with a significance level of p = 0.000 <0.05, and then the Duncan test.  The findings demonstrated that the number of mosquitoes that perished varied depending on the concentration fluctuations of beluntas leaf extract, with the highest concentration of beluntas leaf extract killing mosquitoes at a rate of 55% and a mosquito mortality percentage of 98.4%.
Acute Toxicity Test of Gastroretentive Mucoadhesive Granule Preparation of Earthworm Flour (Lumbricus rubellus) Magfirah; Merue, Novalia; Tandi, Joni; Islamiati, Utami
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8952

Abstract

Earthworms (Lumbricus rubellus) contain the compound lumbricin, which is beneficial for treatment, and its use is still simple, leading to the innovation of gastroretentive mucoadhesive granule formulations. However, its security has not yet been fully supported by research. This research aims to determine the toxic effects caused by earthworm granule preparations in terms of toxicity symptoms and the determination of the LD50 value. This research used 20 male white rats that were randomly divided into 4 groups. One control group was given Aquadest, and three treatment groups were given earthworm granules at doses of 500 mg/kgBB (P1), 2000 mg/kgBB (P2), and 5000 mg/kgBB (P3) with a single oral administration. The research results indicate that the preparation of earthworm granules (Lumbricus rubellus) causes toxic symptoms such as decreased locomotor activity, piloerection, and increased grooming frequency in line with the increase in dosage, but does not result in the death of the test animals. (LD50). Based on the research findings, it can be concluded that the LD50 value of the earthworm granules (Lumbricus rubellus) is >5000 mg/kgBB and falls into the practically non-toxic category with an LD50 range of 5–15 g/kgBB
Test of the Effectiveness of Earthworm Flour (Lumbricus rubellus) Gastroretentive Mucoadhesive Granule Formulation on Male White Rats (Rattus norvegicus) Infected with Salmonella typhi Magfirah; Bengkati, Stely Gracia; Tandi, Joni; Anggi, Viani
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8953

Abstract

Lumbricus rubellus contains lumbricin which is efficacious for treating typhoid fever. The aim of the research was to determine the effectiveness of gastroretentive mucoadhesive granule preparations from earthworm flour. This study used 30 male Wistar rats which were divided into 6 groups which were given orally, the normal and negative control groups were given Na-CMC, the positive control group was given chloramphenicol, and the treatment group was given doses of 200 mg/kgBW, 400 mg/kgBW and 800 mg/kgBW. mg/kgBB gastroretentive mucoadhesive granules earthworm flour. The results of body temperature measurements, on day 7 the control group obtained results of ±37.08, ±39.00 and ±38.09 respectively, and the treatment group obtained results of ±38.09, ±38.09 and ±38.07 respectively. On day 21, the control group obtained results of ±37.08, ±39.00 and ±38.09, respectively, and the treatment group obtained results of ±38.09, ±38.09 and ±38.07, respectively. The Widal test results on the 7th day were positive and after 14 days of administering the preparation on the 21st day the results were negative. It was concluded that the effective dose for typhoid fever therapy was a dose of 400 mg/kgBW.
The Effectiveness of Bougainvillea (Bougainvillea spectabilis willd) Extract on Reducing Blood Glucose in Hypercholesterolaemia White Rats Hardani, Muhammad Fakhrul; Hamzah, Baharuddin; Hardani, Ririen; Magfirah; Rahmawati, Sitti; Ningsih, Purnama
Jurnal Penelitian Pendidikan IPA Vol 11 No 1 (2025): January
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i1.9762

Abstract

Bougainvillea leaves are often used by the public as a treatment by drinking boiled water, but their use as a blood sugar-lowering agent is not supported by scientific data. The purpose of this study was to determine the effect of reducing blood glucose levels and to determine the dose of extract that is effective in in white rats. The plant's herbal extract was prepared using the reflux method with 90% ethanol solvent. This study uses a laboratory experimental method to compare blood glucose levels in white rats before and after administration of herb extract at doses of 100, 200, and 300 mg/kg BW orally using high-fat feed induction and streptozotocin. Blood glucose levels were measured using a glucometer, and mice were declared positive for diabetes with fasting blood sugar levels above 126 mg/dL. The number of test animals used in this study was 30 mice, divided into 6 groups. A randomized block design was used as the research design. The study's findings revealed that administering Bougainville spectabilis willd herb extract at doses of 100, 200, and 300 mg/kg BW can reduce blood glucose in test animals with an effective dose of 200 mg/kg BW
Co-Authors Abd. Rajab Abdul Rahim Abdul Rajab Abdullah, Hasrianah ABUTE, ERNIWATI LA Ady DJ, Arifhan Afdal, Faidil Agus Nasir Ahmad K Ahmar, Ansari Saleh Ahyuna Ainun, Nurfadilah Aisyah Akbar Azis Amri Amal Andrew Ridow Johanis M Anggi, Viani Anis Anshari Mas'ud Anis Anshari Mas'ud Annisa Arham Arifin Arifin, Suci Ramadhani Arwansyah Asrianti Safitri Muchtar Asyraf, Ammar Ayu Andira Ayu Rahayu Azzajjad, Muhammad Fath Badirun Basir Baharuddin Hamzah Baharuddin Paloloang Bahtiar Bengkati, Stely Gracia Dahliah Damayanti, Alfina Debora Rislianti Lakiu Dewa, Nurfadillah Y.A Dewi Satria Ahmar Dian Rahmayanti Rivai Edy Saputra Erni Marlina, Erni Erwin Faizal Ficiyarni Firdayanti Fitry Rahmah Haeruddin Hafid Hafizah Hardani, Muhammad Fakhrul Harun Haslina, Welsi Hasritawati Hasyrif SY Herman Heriadi Idwar Ijirana Ilimu, Edi Indah Kurnia Utami Intan Novita Sari Islamiati, Utami Ita Novianti Joni Tandi, Joni Khaerunnisa Khalil Gibran Lanapu, Saira Luluk Musfiroh Mahfud Radi Mambuhu, Ilham Mangindara, Mutmainnah Markus Bamba, Pampang Arruan Merue, Novalia Miftah Chairani Hairuddin Moingo, Moh. Taufik Muh. Erwinto Imran Muhammad Nabil Muhammad Shaleh Z MUHAMMAD YUSUF Muhaymin, Safar Mujirin M. Yamin Musdalifah, Uci Nabil , Muhammad Nazily Haryati Niluh Puspita Dewi Ningsih, Fitria Wahyu Nur Fitriani Nur Isramawati Nurdiansah Nurhafida Nurmasita, Endah Nurpadillah Nursyam Anwar Nurvita Nurwahyuni Oktavia Putri Hamidah Oktaviani, Dhea Oktavianus, Michael Pajri, Nur Polakitan, Grace Prasetio, Budi Purnama Ningsih Purniawan, Didin Rahmat Ghazali Rasmiyanti, Ni Kadek Evy Ridhayani Adiningsih Rio Akbar Ririen Hardani Rusdi, Nur Risma Siti Fatimah Siti Rahmah Sitti Aminah Sitti Rahmawati Sri Hastuti Virgianti Pulukadang Suherman Sumarsih SURYANI Suryani Syamsuddin Syafika Alaydrus Syam, Asrul Syamsuadi, Ahmad Tamaulina Br Sembiring Tien, Tien Wahyu Handayani Tri Santoso Tri Santoso Ulpa, Nur Aulia Utami, Indah Kurnia Wahdaniah Wahyu Maulid Adha WAHYUNI Wahyuni Zumara Wali Ara Wati , Caecilia Henny Setya WINARSIH Y.A. Dewa, Nurfadillah. Yana Novika R Yusnani