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All Journal JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Journal of Islamic Pharmacy JOURNAL OF INFORMATICS AND TELECOMMUNICATION ENGINEERING Jambura Journal of Sports Coaching JURNAL FARMASIMED (JFM) Jurnal Dunia Farmasi Jurnal Keperawatan Priority JURNAL PENELITIAN PERAWAT PROFESIONAL Journal of Islamic Law Jurnal Indah Sains dan Klinis Mejuajua JURNAL KIMIA SAINTEK DAN PENDIDIKAN Jurnal Mahasiswa Mengabdi (JIMAWAbdi) Journal of Applied Community Engagement (JACE) Jurnal Pengmas Kestra (JPK) Jurnal Indah Sains dan Klinis Pineleng Theological Review Journal of Critical Ecology Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Geosfera Indonesia
Suprianto Suprianto
Institut Kesehatan Medistra Lubuk Pakam
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Journal : Journal of Islamic Pharmacy

 1 
Formulasi Krim Pelembab Kombinasi Ekstrak Lidah Buaya (Aloe vera) dan Ekstrak Kulit Manggis (Garcinia mangostana L.) Leny Leny; Indra Ginting; Rachel Anastasia R Hutabarat; Suprianto Suprianto; Benni Iskandar
Journal of Islamic Pharmacy Vol 7, No 1 (2022): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v7i1.14093

Abstract

Aloe vera contains flavonol compounds, saponins such as kaempeferol, quercetin and merycetin as much as 257.7, 94.80 and 1283.50 mg/kg, respectively. Saponins contained in aloe vera gel are able to clean the dirt from skin. Vitamin E in aloe vera is also able to soften, moisturize and increase smoothness of the skin. Mangosteen peel waste contains higher xanthones  compared to the mangosteen fruit itself. In 100 grams of mangosteen peel, there are 107.76 mg of xanthones which are an extraordinary nutritions for the skin because they act as antioxidants and antiaging. This study aims to formulate a combination of aloe vera flesh extract and mangosteen peel extract into a cream dosage form and observe the effect in moisturizing the skin of volunteers within 3 months of treatment.The research was initiated by making extracts of aloe vera and mangosteen peel by using the maceration method. Then the extract was formulated into cream preparations with varies concentrations of each cream A (0%:20%), cream B (5%:15%), cream C (10%:10%), cream D (15%:5% ), cream E (20%:0%). The preparations were evaluated for their physical characteristics, namely homogeneity test, pH test, organoleptic test, dispersibility test, stability test, irritation test and its effectiveness in moisturizing volunteers skin using a moisture checker.The results showed that the combination extract of aloe vera flesh and mangosteen peel can be formulated in cream preparation that is homogeneous, does not change color, and remains stable in 12 weeks of storage with a pH between 6.0-6.6. The best cream formula in increasing moisture of skin are found in cream with a combination of 15% aloe vera flesh extract with 5% mangosteen peel extract by an uplifting until 92.5%.Lidah buaya atau aloe vera mengandung senyawa flavonol, saponin seperti kaempeferol, quercetin dan merycetin masing-masing sebanyak 257,7, 94,80 dan 1283,50 mg/kg. Kandungan saponin yang terdapat dalam gel lidah buaya dapat membersihkan kotoran dari kulit. Vitamin E pada aloe vera juga mampu melembutkan, melembabkan dan menambah kehalusan kulit. Limbah kulit manggis mengandung xanthone yang lebih tinggi daripada dalam daging buah manggis. Dalam 100 gram kulit manggis terdapat  xanthone sebesar 107,76 mg dan memiliki khasiat yang luar biasa untuk kulit karena berperan sebagai antioksidan dan antiaging. Penelitian ini bertujuan untuk memformulasikan kombinasi ekstrak daging lidah buaya dan ekstrak kulit buah manggis ke dalam bentuk sediaan krim dan mengamati efek kelembaban pada kulit sukarelawan selama 3 bulan perawatan.Penelitian diawali dengan membuat ekstrak lidah buaya dan kulit manggis yang diperoleh dengan menggunakan metode maserasi. Kemudian ekstrak diformulasikan menjadi sediaan krim dengan variasi konsentrasi masing-masing krim A (0%:20%), krim B (5%:15%), krim C (10%:10%), krim D (15%:5%), krim E (20%:0%). Sediaan dievaluasi untuk karakteristik fisiknya yaitu uji homogenitas, uji pH, uji organoleptis, uji daya sebar, uji stabilitas, uji iritasi dan uji kelembaban pada sukarelawan dengan menggunakan moisture checker.Hasil penelitian menunjukkan bahwa ekstrak daging lidah buaya dan kombinasi kulit buah manggis dapat di formulasikan dalam sediaan krim pelembab yang homogen, tidak berubah warna, dan tetap stabil dalam penyimpanan 12 minggu dengan pH 6,0-6,6. Formula krim terbaik yang memberikan efek peningkatan kadar air tertinggi adalah krim dengan kombinasi ekstrak daging lidah buaya 15% dengan ekstrak kulit manggis 5% dengan peningkatan hingga 92,5%.
Co-Authors Abdul Rahim Abrori, Abrori Adek Chan Adinda Seftia Afriadi Afriadi Agus Kristina Ahmad Hafizullah Ritonga Alam Suhada Alam Suhada Alizha Aisyah Ananda Sri Devy Ancel Mus Silaban Andilala Andraini, Galuh Andy Febriadi Anita Anita Anjur Falden Lingga Annas Reza Annas Reza Ardina Ardina Ardina Pakpahan Arinri Misnangin Sritala Ramadani Arinri Misnangin Sritala Ramadani Atika, Nur Azzahra, Innayah BENNI ISKANDAR Cahyono, Bowo Eko Chan, Adek Chandra Pranata Chusnul Chotimah Cut Fatimah Cut Fatimah Cyndi Veronica Damianus Pongoh De Lux Putra, Effendy Debi Meilani Debi Melani Derlina . Devi Purnama Sari Dewi Kartika Dewi Sartika Munthe Dharma Wijaya, Indra Dian Zulkarnain Lubis Dikari Harita Dwi Setio Purnomo Edy Dharma Putra Duhe Effendy De Lux Putra Elok Nur Hamdana Elvy Oktima Elvy Oktima Endang Subekti Endang Subekti Enny Fitriani Febriady, Andy Fesri Damai Riang Laia Fesri Damai Riang Laia Fina Dheny Lantika Fitri Mayang Sari Fitriani Nasution Fitriani, Enny Fridelly Mairani Apt Hasrat Masa Harefa Hendrawan, M. Afif Hendri Faisal Herliana Herlina H Herlina Herlina Hermansyah . Hetty Wahyuni Ihsanul Hafiz Indra Ginting Izudin, Ahmad Jakub Tarigan Jakub Tarigan Jelly Syahfitri Johannes Johannes Joko Wibowo Kurniawansyah, Kurniawansyah Kusjono, Gatot Kusumastuti, Melati Yulia Leny, Leny Lestari, Wita Lidiya Sasmaita Sihotang Lili Nurmaliza Lisa Syafrida Lukmanul Hakim M. Deddy Harfiansyah Maelani, Mia Mandike Ginting Mandike Ginting Marbun, Intan Coni Caroline Maya Annisa Lubis Maya Sartika Maya Sartika Melati Yulia Kusumastuti Melati Yulia Kusumastuti Mochamad Alfan Rosid Mohammad Ridwan Muhammad Gunawan Muhammad Gunawan Muhammad Hafizh Fattah Nasution, Lely Fitri Handayani Nilsya Febrika Zebua, Nilsya Febrika Nur Aisyah Pitri Nur Asni Arti Nur Asni Arti Nurasyah Nurasyah Nurkhoiroh Nurkhoiroh Nurlela Petra Saragih Nur’Adina Nur’Adina Nur’Adina Octaviani, Linggar Ayu Peri Aisyah Zubaidi Permata, Yade Metri Pramana Yoga Saputra Pranata, Chandra Prihanto, Yusep Putri Addina Rachel Anastasia R Hutabarat Risma Yeni Rotua Sumihar Sitorus Ruseni Ruth Mayana Rumanti Ruth Mayana Rumanti Sahrita Sahrita Samran, Samran Saragih, Safitri Sefryantonius Lase Sertin Prilda Sari Sandoro Sertin Prilda Sari Sandoro Shofian Syarifuddin Sindy Andriani Siregar, Riwandi Siregar, Suci Rahmadani Siti Fatimah Hanum Siti Nurbaya Siti Nurbaya Sri Handayani SRI RAHAYU Sri Rahayu Sriharini Sucihati, Roos Nana Sudiyarti, Nining Suhendra Tawarnate Sukma Aji Sumardi Sumardi Sumardi . Syamsul, Darwin Tambubolon, Regina Elianda Triatmojo, Muhammad Ikbal Nur Dian Ucok Hasian Refeiater Vivi Eulis Diana Vivi Eulis Diana Wafi, Moh. Abduh Wandani, Elliza Rizki Wilda Rizwani Winata, Hanafis Sastra Zai, Arifin Putra Zebua, Nilsya Febrika Zebua