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AKUMULASI LIPID HATI DAN PROFIL LIPID DARAH TIKUS Sprague Dawley YANG DIINTERVENSI MINYAK SUPER OLEIN DAN OLEIN Nurdin, Naufal Muharam; Rimbawan, Rimbawan; Marliyati, Sri Anna; Martianto, Drajat; Subangkit, Mawar
Jurnal Gizi dan Pangan Vol. 11 No. 1 (2016)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (971.804 KB) | DOI: 10.25182/jgp.2016.11.1.%p

Abstract

The objective of this research was to analyze the effect of olein and super olein palm oil on blood lipid profile (total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride) and fatty liver condition of Sprague Dawley rats. The design used was pre and post test with control group design. The intervention run for 8 weeks using 20 rats which were divided into four treatments i.e: (1) standard-low fat feed and water (negative control/KN), (2) standard-low fat feed and dried egg yolk (positive control/KP), (3)standard-low fat feed and olein palm oil (B), and (4) standard-low fat feed and super olein palm oil (A). Results showed that blood lipid profile of rats at baseline were not different among treatment groups, while at midline super olein group has total cholesterol, triglyceride, and indirect LDL cholesterol lower than olein group. At endline, HDL and indirect LDL cholesterol of super olein group were different compared to olein group, while total cholesterol and triglyceride were not different between both groups. Super olein group had HDL cholesterol higher and indirect LDL cholesterol lower than olein group. Based on histopathology, lipid accumulation in the liver of Sprague Dawley rats in super olein group were lower than in olein group. The data showed that percentage of lipid droplet in super olein group (A) was 22.01%, while in olein group (B) was 40.43%.Keywords: blood lipid profile, fatty liver, palm oil, rats 
Potensi selada air (Nasturtium officinale R. Br) sebagai antioksidan dan agen anti proliferasi terhadap sel MCF-7 secara in vitro Rahman, Dewi Rahmayani; Rimbawan, Rimbawan; Madanijah, Siti; Purwaningsih, Sri
Jurnal Gizi dan Pangan Vol. 12 No. 3 (2017)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (488.893 KB) | DOI: 10.25182/jgp.2017.12.3.217-224

Abstract

This study aimed to determine the potential of watercress extract as an antioxidant and antiproliferation against cancer cells in vitro. Cells used in this study were breast cancer culture cells (MCF-7) and vero cells. Watercress was extracted using water solvent and 70% ethanol. Phytochemical test was performed on both types of extract. Toxicity test was measured using BSLT method, assessment of antioxidant activity was measured using DPPH method and inhibitory proliferation in cancer cell was measured using MTT Assay method. Analysis of the data using ANOVA, if there is a significant difference between treatments will be followed up with Duncan test. The results of phytochemical tests showed that watercress extracts had bioactive content namely flavonoids, tannins, saponins, and steroids. The result of BSLT test showed that the strongest extract toxicity was 70% ethanol extract with LC50 value of 406.02 ppm and had the highest antioxidant activity with IC50 value of 102.26 ppm, while proliferation inhibitory test found in MCF-7 breast cancer cells had IC50 value of 1.696 μg / ml and not toxic to vero cells. Result showed that the ethanolic extract of Nasturtium Officinale gave a significant effect on MCF-7 breast cancer cells inhibition (p=0,015) at concentration 50, 400, 800 and 1000 ppm. The mechanism of proliferative inhibition was associated with phytochemical content present in watercress. 
POTENSI NUTRASETIKAL SEBAGAI TERAPI PENDAMPING KANKER PAYUDARA: TELAAH SISTEMATIS Putri, Sefanadia; Siregar, Mukhlidah Hanun; Suryana, Suryana; Rimbawan, Rimbawan
Tirtayasa Medical Journal Vol 4, No 2 (2025): May
Publisher : Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/tmj.v4i2.29475

Abstract

Globally, breast cancer stands as the most common cancer and the leading cause of death for women. Currently, breast cancer treatment strategies focus more on the evaluation of clinical and pathological parameters rather than gene expression criteria. With advances in medical science and nutrition, great attention is being paid to foods and natural products that can improve health. Bioactive nutrients that provide protective benefits against breast cancer include polyphenols, retinoids, and polyunsaturated fatty acids (PUFAs). These compounds possess antioxidant, anti-inflammatory, immunomodulatory, and antitumor properties. Specific substances such as resveratrol, epigallocatechin 3-gallate, retinoids, and omega-3 PUFAs influence the characteristics of breast cancer and are involved in various cancer processes, including cell growth inhibition, inflammation, and angiogenesis.
Pengaruh Substitusi Tempe, Penambahan Puree Wortel dan Puree Daun Kelor terhadap Kandungan Protein, Serat Pangan, Zat Besi, dan Bioassesibilitas Zat Besi Sosis Sapi: Effect of Tempeh Substitution, Addition of Carrot Puree and Moringa Leaf Puree on Protein, Fiber, Iron Content, and Iron Bioaccessibility of Beef Sausage Azizi, Elsa Carla; Rimbawan, Rimbawan; Marliyati, Sri Anna
Amerta Nutrition Vol. 9 No. 1 (2025): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i1.2025.14-19

Abstract

Background: Cases of iron deficiency anemia among adolescent girls in Indonesia remain high. To address this issue, there is a need to formulate an inexpensive sausage product with relatively high protein, iron, and fiber content. Objectives: This research was conducted to analyze the effect of tempeh substitution, carrot puree addition, and moringa leaf puree addition on the protein content, dietary fiber, iron, and Fe bioaccessibility in beef sausages. Methods: This study employed a true experimental design to develop sausage formulations and analyze their protein content, dietary fiber, iron content, and iron bioaccessibility. A 3-factor factorial design was used, with factors including tempeh substitution, carrot puree addition, and moringa leaf puree addition. Results: The protein content in the sausages was not influenced by any individual factor or interaction between factors, with values ranging from 6.27% to 6.91%. Fiber content was only affected by tempeh substitution, ranging from 11.89 to 13.84 mg/100 g. Iron bioaccessibility was influenced by both tempeh substitution and moringa leaf puree addition, with bioaccessibility values ranging from 84.3% to 87.1%. The highest bioaccessibility was observed with 40% tempeh substitution, 20% carrot puree addition, and 6% moringa leaf puree addition. Conclusions: Tempeh substitution significantly affected fiber content, iron content, and iron bioaccessibility. Carrot puree addition had no effect on any parameter, while moringa leaf puree addition influenced only iron bioaccessibility.
Status Gizi, Pola Konsumsi, Aktivitas Fisik, Riwayat Kesehatan dan Fenotip Wanita Muda Obese di Kota Bandung: Nutritional Status, Eating Patterns, Physical Activity, Health and Phenotype History of Obese Young Women in Bandung City Novitasari, Putri; Rimbawan, Rimbawan; Hardinsyah, Hardinsyah; Riyadi, Hadi
Amerta Nutrition Vol. 9 No. 1 (2025): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i1.2025.109-118

Abstract

Background: The incidence of obesity in Bandung City is rising. The prevalence of obesity among women surpasses that of men, with a notable rise observed in the young adult demographic. Objectives: This study assessed the nutritional status, dietary habits, physical activity, health history, and phenotype of young obese women in Bandung City. Methods: This mixed-method design involved 88 obese individuals (body fat percentage >35%) aged 18-25 years of Sundanese ethnicity. The research was carried out from August to November 2023. The obtained data encompassed general subject characteristics, anthropometric measurements, body composition, dietary intake and physical activity information, health history, and phenotypic data. Comprehensive interviews were performed concerning dietary habits, physical activity, phenotypic history, nutritional status, and health history. Results: The participants' average age and body weight were 20.3 years and 81.5 kilograms, respectively. The average total fat percentage (%BF) was 38.3%. Occupation (p-value=0.033), weight (p-value=0.001), body mass index (p-value=0.001), waist circumference (p-value=0.001), hip circumference (p-value=0.001), visceral fat (p-value=0.001), resting metabolism (p-value=0.001), and energy (p-value=0.009), fat (p-value=0.043), and carbohydrate (p-value=0.021) intake were associated with total body fat. Conversely, the subject's physical activity, personal and familial history of chronic diseases, development of obesity, and parental obesity history exhibited no correlation with the subject's total body fat (p-value≥0.05). Conclusions: The subject’s occupation, body weight, body mass index, waist and hip circumference, visceral fat, resting metabolism, energy, fat, and carbohydrate intake were correlated with the subject's total body fat.
POTENSI NUTRASETIKAL SEBAGAI TERAPI PENDAMPING KANKER PAYUDARA: TELAAH SISTEMATIS Putri, Sefanadia; Siregar, Mukhlidah Hanun; Suryana, Suryana; Rimbawan, Rimbawan
Tirtayasa Medical Journal Vol 4, No 2 (2025): May
Publisher : Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/tmj.v4i2.29475

Abstract

Globally, breast cancer stands as the most common cancer and the leading cause of death for women. Currently, breast cancer treatment strategies focus more on the evaluation of clinical and pathological parameters rather than gene expression criteria. With advances in medical science and nutrition, great attention is being paid to foods and natural products that can improve health. Bioactive nutrients that provide protective benefits against breast cancer include polyphenols, retinoids, and polyunsaturated fatty acids (PUFAs). These compounds possess antioxidant, anti-inflammatory, immunomodulatory, and antitumor properties. Specific substances such as resveratrol, epigallocatechin 3-gallate, retinoids, and omega-3 PUFAs influence the characteristics of breast cancer and are involved in various cancer processes, including cell growth inhibition, inflammation, and angiogenesis.
FTO rs9939609 Genotypes: Impact on Body Composition and Inflammatory Markers Related to Cardiovascular Risk Novitasari, Putri; Rimbawan, Rimbawan; Hardinsyah, Hardinsyah; Riyadi, Hadi
Mulawarman International Conference on Tropical Public Health Vol. 1 No. 1 (2025): The 3rd MICTOPH
Publisher : Faculty of Public Health Mulawarman University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background : Obesity is a significant global health issue, contributing to the prevalence of chronic diseases. Genetic factors such as the Fat-Mass Obesity-Associated (FTO) gene, particularly the rs9939609 variant, have been linked to increased susceptibility to obesity. Objective : This study examines the relationship between FTO rs9939609 genotypes (TT and AA/TA) and body composition, as well as markers of inflammation, in obese individuals. Research Methods/ Implementation Methods : Using a cross-sectional design, 38 obese young women aged 18-25 years from Bandung City were included. Anthropometric measurements were taken, and blood samples were analyzed for interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and adiponectin (ADP) levels. Results : The findings indicate that the AA/TA variant group showed lower mean values for weight, body mass index, waist and hip circumferences, visceral fat, fat percentage, resting metabolic rate, and subcutaneous fat than the TT group; however, these differences were not statistically significant. Additionally, the AA/TA group displayed slightly higher waist-to-hip ratios and skeletal muscle percentages, although these differences were also non-significant. These results contrast with previous studies, suggesting the influence of the FTO gene on obesity may vary based on population and other contributing factors. No significant differences in body composition or biochemical markers were observed between the FTO rs9939609 genotypes. Conclusion/Lesson Learned : The limited sample size and focus on a single demographic may have impacted the findings. Future research should involve a larger and more diverse sample, including individuals with various nutritional statuses, to enhance comparison and increase the reliability of the results.
The intervention of banana peel smoothies products to lower blood pressure in prehypertensive patients Khairina, Dini Nur; Dewi, Mira; Rimbawan, Rimbawan
AcTion: Aceh Nutrition Journal Vol 10, No 3 (2025): September
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i3.2053

Abstract

The incidence of hypertension in Indonesia is increasing, affecting not only the elderly population but also young adults aged 18–39 years. Prehypertension is an early indicator of hypertension; however, the application of fruit-based interventions remains limited. Bananas, particularly their peels, are abundant in nutrients and bioactive compounds that may mitigate hypertension. This study aimed to assess the impact of banana peel smoothing on blood pressure in individuals with prehypertension. A quasi-experimental pre-post-test design was employed. Thirty-two participants were screened and equally divided into two groups: one receiving banana fruit smoothies, and the other receiving banana peel smoothies. The study was conducted from February to March 2024 at the Faculty of Agriculture, Siliwangi University, Tasikmalaya, West Java. Blood pressure measurements were obtained before and after the intervention, and the data were analyzed using a paired t-test. Both banana fruit and banana peel smoothies significantly reduced blood pressure (p= 0,000) in both interventions. In conclusion, banana peel smoothies exhibited greater efficacy in lowering blood pressure in prehypertensive individuals than banana fruit. Banana peel smoothies represent an effective intervention for reducing blood pressure in prehypertensive individuals, offering a promising and nutrient-rich approach for hypertension management.
Sun Exposure on the Incidence of Allergies in Adult Women Pertiwi, Fenti Dewi; Damayanthi, Evy; Rimbawan, Rimbawan
Jurnal Kesehatan Masyarakat Vol. 20 No. 4 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i4.31230

Abstract

Exposure to UVB rays in humans largely affects vitamin D synthesis, and approximately 90%–95% of vitamin D is produced in the skin. Allergic diseases have a significant impact on the health of the affected individuals. This study aimed to determine the relationship between sun exposure and the incidence of allergies in adult women. This research used a quantitative cross-sectional design. This research was conducted in Bogor from August to November 2023. The population investigated consisted of the entire adult female population living in the city of Bogor. This study used simple random sampling to select representative respondents. The data were collected using a questionnaire. The study sample comprised of 395 people. The inclusion criteria were women aged between 19 and 49 years who permanently resided in Bogor City. The exclusion criteria are women who are pregnant, breastfeeding, experiencing menopause, using hormonal contraception, and diagnosed with diabetes or other infectious or non-communicable diseases. Bivariate data was analyzed using the chi-square test to determine the relationship between sun exposure and the incidence of allergies in women in Bogor City. Processed shellfish foods and products are a common cause of allergies in women in Bogor. The frequency of sunbathing and the use of sunscreen have a significant effect on allergies. Sunbathing 2 times/week reduces allergies, whereas never sunbathing causes allergies. Sunscreen use increases allergies, and more research is needed to develop effective prevention strategies.
Potensi Asam Amino pada Tempe untuk Memperbaiki Profil Lipid dan Diabetes Mellitus Utari, Diah M.; Rimbawan, Rimbawan; Riyadi, Hadi; Muhilal, Muhilal; Purwantyastuti, Purwantyastuti
Kesmas Vol. 5, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Prevalensi penyakit degeneratif dari tahun ke tahun meningkat akibat perubahan gaya hidup, khususnya perubahan pola makan. Walaupun tempe sebagai makanan tradisional Indonesia yang banyak dikonsumsi masyarakat karena mudah diperoleh dan harga terjangkau, tidak banyak yang mengetahui manfaat tempe bagi kesehatan. Tempe lama dikenal sebagai sumber protein yang dikonsumsi oleh kalangan masyarakat berpenghasilan rendah. Kajian lebih mendalam mengenai kandungan gizi dan manfaat tempe dan bagi kesehatan, khusus sebagai pencegah penyakit degeneratif perlu dilakukan. Proses fermentasi kedelai menjadi tempe mengakibatkan perubahan zat gizi dan non gizi yang mengakibatkan manfaat tempe jauh lebih baik dibandingkan kedelai. Protein tempe lebih mudah di cerna tubuh, sedangkan asam amino arginin yang meningkat hampir dua kali lipat pada tempe, sangat tinggi manfaatnya bagi kesehatan terutama dalam memperbaiki profil lipid dan diabetes mellitus. Mempertimbangkan hal tersebut tempe dapat dipertimbangkan sebagai pangan fungsional yang bermanfaat bagi kesehatan. Degenerative diseases prevalence had been arining over years. One of the causes is the life style changes including eating pattern. Tempeh, an Indonesian soybean traditionally fermented food, was known and consumed by almost all Indonesian people. However, only a few know the health benefit of tempeh. Tempeh was also well known and cheap protein source food affordable for the poor. Hence, there is a need to explore the nutritious content of tempeh and health benefit of it deeper such as in preventing degenerative diseases. Fermentation process of soybean to become tempeh had improved nutrient and non-nutrient contents that make tempeh better than soybean. Tempeh protein is more digestible than soybean and the arginine content increases twice, that could improve lipid profile and diabetes mellitus. Tempeh could be considered as functional food having health benefit.
Co-Authors Adi Teruna Efendi Adi Teruna Effendi Adi Teruna Effendi Adi Winarto Agustino Agustino Ahmad Sulaeman Ainia Herminiati Ainia Herminiati Ainia Herminiati Ali Khomsan Angga Rizqiawan Anna Vipta Resti Mauludyani Aprinia Dian Nurhayati Ascobat, Purwantyastuti Asep Rusyana Aslis Wirda Hayati Astuti Lamid Aya Yuriestia Arifin, Aya Yuriestia Azizi, Elsa Carla Bambang P. Priosoeryanto Bambang Pontjo Priosoeryanto Betty Yosephin Simanjuntak Bibi Ahmad Chahyanto Bohari Bohari Budi Setiawan Budi Setiawan Budi Setiawan Budi Setiawan Budi Setiawan Cassandra Permata Nusa Cesilia M Dwiriani Clara M. Kusharto Clara Meliyanti Kusharto Dadan Rohdiana Dadang Sukandar Damayanti, Rinda Daus, Firdaus Firdaus Deddy Muchtadi Deddy Muchtadi Deni Elnovriza DEWI APRI ASTUTI Dewi Kusumawati Dewi Kusumawati Diah M. Utari Diah M. Utari Diffah Hanim Dijaya, Rendy Dionysius Subali Dodik Briawan Drajat Martianto Egayanti, Yusra Ekowati Handharyani Elisa Diana Julianti Emma S Wirakusumah Ennita Fahriza Eny Palupi Eva Susanti Evi Damayanthi Evy Damayanthi Faisal Anwar Fajriaty, Deannisa Febrina Sulistiawati Fifi Retiaty Firdaus Firdaus Firdaus Firdaus Fitrah Ernawati Fitrah Ernawati Fivi Melva Diana, Fivi Melva Gifari, Nazhif Hadi Riyadi Haerati, Nur Hardiansyah, Angga Hardinsyah Harianti, Rini Harianti, Rini Hidayat Syarief Hidayat Syarief Himarwan, Aditya I Gusti Bagus Wiksuana I MADE ARTIKA I.Wayan T.Wibawan, I.Wayan Ika Heri Kustanti Ikeu Ekayanti Ikeu Tanziha Ikue Ekayanti Ilmi Dewi Astuti Ilmi, Ibnu Malkan Bakhrul Indhira Shagti Iswahyudi Iswahyudi ITA DJUWITA Katrin Roosita Khaerul Fadly Khairina, Dini Nur Kharisma Tamimi Kresandra, Anastasha Laeli Nur Hasanah Latifah Darusman Latifah K Darusman Latifah K. Darusman Leily Amalia Leily Amalia Furqon Lidwina Lidwina Lilik Kustiyah Linar Zalinar Udin Lubis, Anwar M. Muslim MADE ASTAWAN MARIA BINTANG Mauludiya, Putri Nur Mira Dewi Mohamad Rafi Muhamad Rizal Martua Damanik Muhammad Aries Muhilal ., Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Mukhlidah Hanun Siregar Mulya Agustina Mury Kuswari Muti'ah Mustaqimatusy Syahadah Nasir, Syifa Qolbiyah Nasution, Zuraidah Naufal Muharam Nurdin Ni Ketut Sutiari Ni'ma Hilyatin Noviana, Astrid Novitasari, Putri Nunung Nurjanah Nur Indrawaty Lipoeto Nurhidayati, Nuzuliyati Nuri Andarwulan Pertiwi, Fenti Dewi Picauly, Intje Pipih Suptijah Purwantyastuti Ascobat Purwantyastuti Purwantyastuti Purwantyastuti Purwantyastuti Puspo Edi Giriwono Putra, Felicia Kartawidjaja Putri Puncak Anjani Rahman, Dewi Rahmayani Rakhmawati FKR Ratu Diah Koerniawati Reisi Nurdiani, Reisi Resita Nurbayani Restu Pertiwi Rian Adi Pamungkas Riana, Nidya Ulfah Rini Kurniasih, Rini Rizal M Damanik, Rizal M Roosita, Kartin Rosyanne Kushargina Rusyda, Akifa Laila Safitri, Debby Endayani Sari, Eny Kurnia Seprianto, Seprianto Simbolon, Martina Siti Madanijah Sri Anna Marliyati Sri Hartati R. Suradijono Sri Nur Amalia Sri Purwaningsih Sri Sumarmi Sri Wahyu Angga Dewi Subangkit, Mawar Sudjana Sibarani Suryana, Suryana Susi Desminarti Susi Nurohmi Susilawati, Esih Sutrisna, Aang SYAHRIAL SYAHRIAL Syartiwidya, Syartiwidya Tande, Ribka TATI NURHAYATI Tresnanda, Muhammad Nawaf Trini Suryowati, Trini Tunggul Waloya Umam, Hafizul V Prihananto Vetnizah Juniantito Warisanti, Dira Wiwin Winarsih Yunianto, Andi Eka Zakiudin Munasir Zakiudin Munasir