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POTENSI NUTRASETIKAL SEBAGAI TERAPI PENDAMPING KANKER PAYUDARA: TELAAH SISTEMATIS Putri, Sefanadia; Siregar, Mukhlidah Hanun; Suryana, Suryana; Rimbawan, Rimbawan
Tirtayasa Medical Journal Vol 4, No 2 (2025): May
Publisher : Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/tmj.v4i2.29475

Abstract

Globally, breast cancer stands as the most common cancer and the leading cause of death for women. Currently, breast cancer treatment strategies focus more on the evaluation of clinical and pathological parameters rather than gene expression criteria. With advances in medical science and nutrition, great attention is being paid to foods and natural products that can improve health. Bioactive nutrients that provide protective benefits against breast cancer include polyphenols, retinoids, and polyunsaturated fatty acids (PUFAs). These compounds possess antioxidant, anti-inflammatory, immunomodulatory, and antitumor properties. Specific substances such as resveratrol, epigallocatechin 3-gallate, retinoids, and omega-3 PUFAs influence the characteristics of breast cancer and are involved in various cancer processes, including cell growth inhibition, inflammation, and angiogenesis.
FTO rs9939609 Genotypes: Impact on Body Composition and Inflammatory Markers Related to Cardiovascular Risk Novitasari, Putri; Rimbawan, Rimbawan; Hardinsyah, Hardinsyah; Riyadi, Hadi
Mulawarman International Conference on Tropical Public Health Vol. 1 No. 1 (2025): The 3th MICTOPH
Publisher : Faculty of Public Health Mulawarman University, Indonesia

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Abstract

Background : Obesity is a significant global health issue, contributing to the prevalence of chronic diseases. Genetic factors such as the Fat-Mass Obesity-Associated (FTO) gene, particularly the rs9939609 variant, have been linked to increased susceptibility to obesity. Objective : This study examines the relationship between FTO rs9939609 genotypes (TT and AA/TA) and body composition, as well as markers of inflammation, in obese individuals. Research Methods/ Implementation Methods : Using a cross-sectional design, 38 obese young women aged 18-25 years from Bandung City were included. Anthropometric measurements were taken, and blood samples were analyzed for interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and adiponectin (ADP) levels. Results : The findings indicate that the AA/TA variant group showed lower mean values for weight, body mass index, waist and hip circumferences, visceral fat, fat percentage, resting metabolic rate, and subcutaneous fat than the TT group; however, these differences were not statistically significant. Additionally, the AA/TA group displayed slightly higher waist-to-hip ratios and skeletal muscle percentages, although these differences were also non-significant. These results contrast with previous studies, suggesting the influence of the FTO gene on obesity may vary based on population and other contributing factors. No significant differences in body composition or biochemical markers were observed between the FTO rs9939609 genotypes. Conclusion/Lesson Learned : The limited sample size and focus on a single demographic may have impacted the findings. Future research should involve a larger and more diverse sample, including individuals with various nutritional statuses, to enhance comparison and increase the reliability of the results.
The intervention of banana peel smoothies products to lower blood pressure in prehypertensive patients Khairina, Dini Nur; Dewi, Mira; Rimbawan, Rimbawan
AcTion: Aceh Nutrition Journal Vol 10, No 3 (2025): September
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i3.2053

Abstract

The incidence of hypertension in Indonesia is increasing, affecting not only the elderly population but also young adults aged 18–39 years. Prehypertension is an early indicator of hypertension; however, the application of fruit-based interventions remains limited. Bananas, particularly their peels, are abundant in nutrients and bioactive compounds that may mitigate hypertension. This study aimed to assess the impact of banana peel smoothing on blood pressure in individuals with prehypertension. A quasi-experimental pre-post-test design was employed. Thirty-two participants were screened and equally divided into two groups: one receiving banana fruit smoothies, and the other receiving banana peel smoothies. The study was conducted from February to March 2024 at the Faculty of Agriculture, Siliwangi University, Tasikmalaya, West Java. Blood pressure measurements were obtained before and after the intervention, and the data were analyzed using a paired t-test. Both banana fruit and banana peel smoothies significantly reduced blood pressure (p= 0,000) in both interventions. In conclusion, banana peel smoothies exhibited greater efficacy in lowering blood pressure in prehypertensive individuals than banana fruit. Banana peel smoothies represent an effective intervention for reducing blood pressure in prehypertensive individuals, offering a promising and nutrient-rich approach for hypertension management.
Sun Exposure on the Incidence of Allergies in Adult Women Pertiwi, Fenti Dewi; Damayanthi, Evy; Rimbawan, Rimbawan
Jurnal Kesehatan Masyarakat Vol. 20 No. 4 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i4.31230

Abstract

Exposure to UVB rays in humans largely affects vitamin D synthesis, and approximately 90%–95% of vitamin D is produced in the skin. Allergic diseases have a significant impact on the health of the affected individuals. This study aimed to determine the relationship between sun exposure and the incidence of allergies in adult women. This research used a quantitative cross-sectional design. This research was conducted in Bogor from August to November 2023. The population investigated consisted of the entire adult female population living in the city of Bogor. This study used simple random sampling to select representative respondents. The data were collected using a questionnaire. The study sample comprised of 395 people. The inclusion criteria were women aged between 19 and 49 years who permanently resided in Bogor City. The exclusion criteria are women who are pregnant, breastfeeding, experiencing menopause, using hormonal contraception, and diagnosed with diabetes or other infectious or non-communicable diseases. Bivariate data was analyzed using the chi-square test to determine the relationship between sun exposure and the incidence of allergies in women in Bogor City. Processed shellfish foods and products are a common cause of allergies in women in Bogor. The frequency of sunbathing and the use of sunscreen have a significant effect on allergies. Sunbathing 2 times/week reduces allergies, whereas never sunbathing causes allergies. Sunscreen use increases allergies, and more research is needed to develop effective prevention strategies.
Potensi Asam Amino pada Tempe untuk Memperbaiki Profil Lipid dan Diabetes Mellitus Utari, Diah M.; Rimbawan, Rimbawan; Riyadi, Hadi; Muhilal, Muhilal; Purwantyastuti, Purwantyastuti
Kesmas Vol. 5, No. 4
Publisher : UI Scholars Hub

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Abstract

Prevalensi penyakit degeneratif dari tahun ke tahun meningkat akibat perubahan gaya hidup, khususnya perubahan pola makan. Walaupun tempe sebagai makanan tradisional Indonesia yang banyak dikonsumsi masyarakat karena mudah diperoleh dan harga terjangkau, tidak banyak yang mengetahui manfaat tempe bagi kesehatan. Tempe lama dikenal sebagai sumber protein yang dikonsumsi oleh kalangan masyarakat berpenghasilan rendah. Kajian lebih mendalam mengenai kandungan gizi dan manfaat tempe dan bagi kesehatan, khusus sebagai pencegah penyakit degeneratif perlu dilakukan. Proses fermentasi kedelai menjadi tempe mengakibatkan perubahan zat gizi dan non gizi yang mengakibatkan manfaat tempe jauh lebih baik dibandingkan kedelai. Protein tempe lebih mudah di cerna tubuh, sedangkan asam amino arginin yang meningkat hampir dua kali lipat pada tempe, sangat tinggi manfaatnya bagi kesehatan terutama dalam memperbaiki profil lipid dan diabetes mellitus. Mempertimbangkan hal tersebut tempe dapat dipertimbangkan sebagai pangan fungsional yang bermanfaat bagi kesehatan. Degenerative diseases prevalence had been arining over years. One of the causes is the life style changes including eating pattern. Tempeh, an Indonesian soybean traditionally fermented food, was known and consumed by almost all Indonesian people. However, only a few know the health benefit of tempeh. Tempeh was also well known and cheap protein source food affordable for the poor. Hence, there is a need to explore the nutritious content of tempeh and health benefit of it deeper such as in preventing degenerative diseases. Fermentation process of soybean to become tempeh had improved nutrient and non-nutrient contents that make tempeh better than soybean. Tempeh protein is more digestible than soybean and the arginine content increases twice, that could improve lipid profile and diabetes mellitus. Tempeh could be considered as functional food having health benefit.
Peranan Ultraviolet B Sinar Matahari terhadap Status Vitamin D dan Tekanan Darah pada Wanita Usia Subur Yosephin, Betty; Khomsan, Ali; Briawan, Dodik; Rimbawan, Rimbawan
Kesmas Vol. 8, No. 6
Publisher : UI Scholars Hub

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Abstract

Sinar ultraviolet B adalah sumber utama vitamin D, tetapi wanita usia subur yang bekerja di dalam ruangan mempunyai vitamin D yang rendah meskipun Indonesia negara tropis. Tujuan penelitian ini untuk mengevaluasi peranan paparan sinar matahari pada wanita usia subur terhadap status vitamin D dan tekanan darah. Desain penelitian yang digunakan adalah eksperimen tanpa kelompok kontrol pada 21 wanita sehat. Penelitian ini membandingkan status vitamin D dan tekanan darah sebelum dan setelah mendapat paparan sinar matahari pada wajah dan lengan tiga kali seminggu selama 12 minggu. Analisis data menggunakan uji t-berpasangan. Paparan sinar matahari dapat meningkatkan vitamin D. Serum 25(OH)D meningkat 15,9% dari 15.7 ng/dL menjadi 18,2 ng/dL. Paparan sinar matahari menurunkan tekanan darah sistolik (nilai p = 0,004) dan diastolik (nilai p = 0,011). Ultraviolet B dari sinar matahari 30 menit tiga kali seminggu selama 12 minggu dapat memperbaiki status vitamin D dan tekanan darah. Ultraviolet B sunlight exposure is a primary source of vitamin D, but women of childbearing age who worked in room every day had low serum vitamin D despite Indonesia is a tropical country. The objective of this study was to evaluate the role of sun exposure in women of childbearing age on vitamin D status, and blood pressure. An intervention before-after study without group control was conducted on 21 healthy women. This study compared vitamin D status, and blood pressure before and after receiving ultraviolet B (UVB) from sun exposure on the face and both arms three times a week for 12 weeks. Anthropometric parameter and blood pressure were measured, were determined at baseline and after 12 weeks of sun exposure. The effect of sun exposure can improve vitamin D. Serum 25 (OH)D increase 15.9% from 15.7 ng/dL to 18.2 ng/dL. Sun exposure significantly reduced systolic blood pressure (p value = 0.004), and diastolic blood pressure (p value = 0.011). Ultraviolet B from sun exposure for 30 minutes, 3 times a week for 12 weeks improves the vitamin D status, and blood pressure.
Co-Authors Adi Teruna Efendi Adi Teruna Effendi Adi Teruna Effendi Adi Winarto Agustino Agustino Ahmad Sulaeman Ainia Herminiati Ainia Herminiati Ainia Herminiati Akifa Laila Rusyda Ali Khomsan Angga Hardiansyah Angga Rizqiawan Anna Vipta Resti Mauludyani Aprinia Dian Nurhayati Ascobat, Purwantyastuti Asep Rusyana Aslis Wirda Hayati Astrid Noviana Astuti Lamid Azizi, Elsa Carla Bambang P. Priosoeryanto Bambang Pontjo Priosoeryanto Betty Yosephin Simanjuntak Bibi Ahmad Chahyanto Budi Setiawan Budi Setiawan Budi Setiawan Budi Setiawan Budi Setiawan Cassandra Permata Nusa Cesilia M Dwiriani Clara Meliyanti Kusharto Dadan Rohdiana Dadang Sukandar Damayanti, Rinda Daus, Firdaus Firdaus Deddy Muchtadi Deddy Muchtadi Deni Elnovriza DEWI APRI ASTUTI Dewi Kusumawati Dewi Kusumawati Diah M. Utari Diah M. Utari Diffah Hanim Dira Warisanti Dodik Briawan Drajat Martianto Ekowati Handharyani Emma S Wirakusumah Ennita Fahriza Eva Susanti Evi Damayanthi Evy Damayanthi Faisal Anwar Fajriaty, Deannisa Febrina Sulistiawati Firdaus Firdaus Firdaus Firdaus Fitrah Ernawati Fitrah Ernawati Fivi Melva Diana, Fivi Melva Gifari, Nazhif Hadi Riyadi Hardinsyah Harianti, Rini Hidayat Syarief Hidayat Syarief I Gusti Bagus Wiksuana I.Wayan T.Wibawan, I.Wayan Ika Heri Kustanti Ikeu Ekayanti Ikeu Tanziha Ikue Ekayanti Ilmi Dewi Astuti Ilmi, Ibnu Malkan Bakhrul Indhira Shagti Iswahyudi Iswahyudi Katrin Roosita Khaerul Fadly Khairina, Dini Nur Kharisma Tamimi Kharisma Tamimi Laeli Nur Hasanah Latifah Darusman Latifah K Darusman Latifah K. Darusman Leily Amalia Leily Amalia Furqon Lidwina Lidwina Lilik Kustiyah Linar Zalinar Udin Lubis, Anwar MADE ASTAWAN MARIA BINTANG Mira Dewi Mohamad Rafi Muhamad Rizal Martua Damanik Muhammad Aries Muhilal ., Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Mukhlidah Hanun Siregar Mulya Agustina Mury Kuswari Mury Kuswari Muti'ah Mustaqimatusy Syahadah Nasir, Syifa Qolbiyah Nasution, Zuraidah Naufal Muharam Nurdin Nawaf Tresnanda Nazhif Gifari Ni Ketut Sutiari Ni'ma Hilyatin Novitasari, Putri Nur Indrawaty Lipoeto Nuri Andarwulan Pertiwi, Fenti Dewi Picauly, Intje Pipih Suptijah Purwantyastuti Ascobat Purwantyastuti Purwantyastuti Purwantyastuti Purwantyastuti Puspo Edi Giriwono Putri Puncak Anjani Rahman, Dewi Rahmayani Rakhmawati FKR Ratu Diah Koerniawati Reisi Nurdiani, Reisi Resita Nurbayani Restu Pertiwi Riana, Nidya Ulfah Rosyanne Kushargina Safitri, Debby Endayani Sari, Eny Kurnia Siti Madanijah Sri Anna Marliyati Sri Hartati R. Suradijono Sri Nur Amalia Sri Purwaningsih Sri Sumarmi Sri Wahyu Angga Dewi Subangkit, Mawar Sudjana Sibarani Suryana, Suryana Susi Desminarti Susi Nurohmi Sutrisna, Aang SYAHRIAL SYAHRIAL Syartiwidya Syartiwidya TATI NURHAYATI Trini Suryowati Tunggul Waloya V Prihananto Vetnizah Juniantito Wiwin Winarsih Yunianto, Andi Eka Yusra Egayanti Zakiudin Munasir Zakiudin Munasir Zuraidah Nasution