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All Journal Medula Science and Technology Indonesia Jurnal Ilmu Kedokteran dan Kesehatan Community Development Journal JURNAL PENELITIAN PERAWAT PROFESIONAL Jurnal Abmas Negeri (JAGRI) Journal of Language and Health Jurnal Pengabdian Fakultas Pertanian Universitas Lampung Jurnal Pengabdian Masyarakat JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Ety Apriliana
Bagian Mikrobiologi, Fakultas Kedokteran, Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Aktivitas Antibakteri Epigallocatechin Gallate (EGCG) Teh Hijau pada Bakteri Gram Positif dan Bakteri Gram Negatif Afifah, Syafira Hasna; Apriliana, Ety; Setiawan, Gigih; Berawi, Khairun Nisa
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1446

Abstract

Epigallocatechin gallate (EGCG) is a catechin compound found in green tea and is known for its various health benefits, including antioxidant, anti-inflammatory, and antibacterial activity. Research on the antibacterial effects of EGCG shows that this compound has significant potential in inhibiting the growth of various pathogens, both Gram-positive and Gram-negative bacteria. Gram-positive bacteria, such as Staphylococcus aureus and Streptococcus pneumoniae, are more sensitive to EGCG than Gram-negative bacteria. The antibacterial mechanism of EGCG in Gram-positive bacteria involves disrupting cell membrane integrity and inhibiting biofilm formation, while in Gram-negative bacteria, EGCG can increase the permeability of the outer membrane and increase the penetration efficiency of antibiotics. However, the main challenge in using EGCG against Gram-negative bacteria is the structural barrier present in the outer membrane, which limits the penetration of the compound. The use of EGCG in combination therapy with antibiotics shows great potential in overcoming antibiotic-resistant infections, strengthening antibacterial activity, and reducing side effects. Although EGCG shows promise as an antibacterial therapy, challenges related to bioavailability, stability, and formulation need to be overcome to optimize its potential in the treatment of difficult-to-treat bacterial infections.
Co-Authors Adisti, Fransiska Afifah, Syafira Hasna Agustin, Nur Aini Ahmadi, Peni Alvinasyrah, Alvinasyrah Alvista, Valentina Nancy Ambarwati, Yuli Andi Setiawan Andrifianie, Femmy Arafah, Aisyah Putri Arai, Masayoshi Ari Wahyuni Aspita Laila Baradatu, Mirza Sultan Bayu Anggileo Pramesona Betta Kurniawan, Betta Carolia, Imelda Daulay, Suryani Dian Isti Angraini Dian Septinova Dwi Indria Anggraini Dyah Wulan Sumekar Rengganis Wardani Efrida Warganegara Efriyan Imantika Fitria Saftarina Frauprades, Kaltihennah Oktavia Giska Tri Putri Hafidah, Hazima Hasna Hanna Mutiara, Hanna Helmi Ismunandar Hendra Tarigan Sibero Hermawan, Alan Ildha Rosendy Kurnianda Indri Windarti Intanri Kurniati Irawati, Nur Ayu Virginia Islamy, Suryadi Janar Wulan, Anggraini Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi John Hendri Juliasih, Ni Luh Gede Ratna Karima, Nisa Kartika, Juspeni Khairun Nisa Kurniawan, Diva Ardhana Kurniawaty, Evi Legowo, Ahmad Bambang Lusina, Septia Eva Madi Hartono Marcellia, Selvi Mayasari, Diana Morfi, Chicy Widya Muatiara, Hanna Muhammad Aditya, Muhammad Muhammad Ricky Ramadhian Muhammad Yusran Novi Nurhayati, Novi Novita Carolia Nugraha, Ega Nurul Utami Oktafany, Oktafany Oktaryona Trisera Puspita, Ratna Dewi Putra, Muhammad Ferdiansyah Qonita, Adzrok Rahel, Clara Arta Uli Rahmadian, M. Ricky Ramadhana Komala Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Ratna, Maya Ganda Reni Zuraida Rika Lisiswanti Rito, Hardiansyah Faisal Rodiani, Rodiani Sabila, Ghina Salsabila, Nafila Khansa Saputra, Kurnia Hadi Saputra, Wahyu Agung Dwi Sari, Merry Indah Selawati, Diyah Septia Eva Lusina Septiani, Linda Setiawan, Gigih Shinta Dewi, Brigitta Shinta Nareswari, Shinta Sihaloho, San Maulina Silitonga, Yona Arisena Magdalena Sinaga, Herman Fransiskus Sofyan Musyabiq Wijaya Suharmanto Suryadi Islami Susianti, Susianti Sutarto Sutarto Suwandi, Jhosn Fatriyadi SYAIFUL BAHRI Tengku Riza Zarzani N Tri Umiana Soleha Tugiyono Tugiyono Utari Gita Mutiara WAWAN ABDULLAH SETIAWAN, WAWAN ABDULLAH Widyastuti Widyastuti Yuningrum, Hest Yusran, M