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All Journal Jurnal Ilmiah Farmasi ILMU KELAUTAN: Indonesian Journal of Marine Sciences JURNAL KIMIA SAINS DAN APLIKASI Transformasi: Jurnal Pengabdian Masyarakat Jurnal Kedokteran JURNAL PENGABDIAN KEPADA MASYARAKAT BERITA BIOLOGI JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Kimia Riset Jurnal Biologi Tropis Majalah Farmaseutik Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Agrotek UMMat JCES (Journal of Character Education Society) Jurnal Riset Akuakultur WIDYABHAKTI Jurnal Ilmiah Populer Jurnal Ilmu Kefarmasian Indonesia Scripta Biologica Jurnal Gema Ngabdi ad-Dawaa : Journal of Pharmaceutical Sciences Acta Chimica Asiana Jurnal Abdi Insani Indonesia Natural Research Pharmaceutical Journal (INRPJ) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Ilmiah Abdi Mas TPB Unram Jurnal Kesehatan Tambusai Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Warta Desa (JWD) Prosiding Konferensi Nasional PKM-CSR Jurnal Pijar MIPA Journal of Agritechnology and Food Processing Makara Journal of Science Jurnal Pepadu Jurnal Pendidikan dan Pengabdian Masyarakat Journal of Fisheries & Marine Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan Analit: Analytical And Environmental Chemistry Journal of Pharmascience
Handa Muliasari
Department Of Pharmacy, Faculty Of Medicine And Health Science, University Of Mataram, Mataram, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Exploration of secondary metabolite profile in the n-hexane fraction of Rhizophora mucronata, Avicennia marina, and Sonneratia alba Raehanul Maziya; Lina Permatasari; Rizqa Fersiyana Deccati; Handa Muliasari; Fania Rahman; Zulfiana Fatianingrum Annas; Rahula Vijja Sammanta
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.231

Abstract

Indonesia is a maritime and archipelagic country with an ocean area of almost two-thirds of its total area, with a coastline stretching 99.123 km from Sabang to Merauke. According to Indonesian Law Number 1 of 2014, it is mentioned that one of the most important biological resources of the coast is mangroves. Some mangrove species commonly found on Lombok Island are Rhizophora mucronata, Sonneratia alba, and Avicennia marina. However, there has not been much exploration of the compound content in these mangroves. Therefore, this study aimed to identify the secondary metabolites of the n-hexane fraction of the three mangrove species using Gas Chromatography-Mass Spectrometry (GC-MS). The leaves of each mangrove species were extracted by sonication method using 96% ethanol solvent, followed by multistage fractionation using n-hexane and water. GC-MS analyzed the n-hexane fraction of each mangrove species. The GC-MS analysis revealed that in the n-hexane fraction of mangrove leaves Rhizophora mucronata and Avicennia marina there were 10 compounds, while Sonneratia alba obtained five compounds. The compounds with the highest intensity in the n-hexane fraction of mangrove leaves of Rhizophora mucronata, Sonneratia alba, and Avicennia marina were squalene (41.71%), ethyl oleate (87.53%), and ethyl oleate (44.02%), respectively. Squalene was reported to have antioxidant and anticancer activities. The ethyl oleate was reported to have bactericidal activity on gram-positive and negative bacteria. The three types of mangrove leaves can be an alternative source of medicine
Gravity column chromatography of n-hexane fraction of Rhizophora mucronata leaves from West Nusa Tenggara and their antioxidant activity Lina Permatasari; Handa Muliasari; Qori'atul Hafizah; Annisa Rizka Nirmala; Hilkatul Ilmi
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.243

Abstract

In the last few decades, many diseases have been caused by Radical Oxidative Stress (ROS) or free radicals. Compounds that act as natural antioxidants have been widely developed to counteract these free radicals. Rhizpora mucronata was a mangrove species reported to possess strong antioxidant activity. However, the research is limited to extracts; fractions with more specific compound components have not been explored. The n-hexane fraction of R. mucronata leaves was reported to have high total flavonoid content (TFC). The TFC has a positive correlation with antioxidant activity. Therefore, this study aimed to simplify the compound components in the n-hexane fraction of R. mucronata leaves using gravity column chromatography (GCG) and determine their antioxidant activity. The n-hexane fraction was fractionated using GCG with increasing solvent polarity (n-hexane, chloroform, ethyl acetate, and methanol). The fractions were tested for antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods. The fractionation using GCG resulted in 80 fractions. These fractions were grouped based on their thin-layer chromatography (TLC) profiles, resulting in 12 groups of fractions (A-L). Fractions D, F, G, H, J, K, and L, the fractions with enough yield, determined their antioxidant activity using the DPPH and ABTS methods. Fractions D and J tested by the DPPH method had IC50 values of 28.68 ± 1.58 ppm and 9.59 ± 0.39 ppm, respectively. Meanwhile, fractions D and J tested by the ABTS method had IC50 values of 15.10 ± 1.00 ppm and 3.16 ± 0.55 ppm, respectively. Meanwhile, fractions F, G, H, K, and L exhibit antioxidant activity with IC50 values greater than 100 ppm. Fractions D and J have potent antioxidant activity, and both were tested using DPPH and ABTS methods. Therefore, fractions D and J can be further developed as natural antioxidants.
ANALISIS KADAR FENOLIK TOTAL DAN AKTIVITAS ANTIRADIKAL BEBAS MADU DAN PROPOLIS Trigona sp. ASAL LOMBOK UTARA Nur Nadhifah Zahra; Handa Muliasari; Yayuk Andayani; I Made Sudarma
Analit : Analytical and Environmental Chemistry Vol. 6, No. 01 April (2021) Analit : Analytical and Environmental Chemistry
Publisher : Jurusan Kimia FMIPA Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/aec.v6i1.2021.p74-82

Abstract

Eksplorasi madu dan propolis Trigona sp sebagai antioksidan alami semakin ditekuni. Produksi madu dan propolis Trigona sp. di Kabupaten Lombok Utara semakin berkembang dengan total koloni sebesar 22.657 pada tahun 2019. Produksi yang melimpah tersebut belum dilengkapi dengan data ilmiah. Penelitian ini bertujuan menentukan kadar fenolik total serta menghitung nilai IC50 dari madu dan propolis Trigona sp. asal Lombok Utara. Ekstrak madu Trigona sp. diperoleh menggunakan teknik sentrifugasi dan ekstrak propolis Trigona sp. menggunakan metode Ultrasound-assisted Extraction (UAE). Kadar fenolik total ditentukan menggunakan metode Folin-ciocalteu dan aktivitas radikal bebas ditentukan menggunakan metode DPPH. Ekstrak madu Trigona sp. asal Lombok Utara memiliki kadar senyawa fenolik total sebesar 1,25 0,08 mg GAE/g, dan Nilai IC50 sebesar1550 ± 0,02 μg/ml. Ekstrak propolis Trigona sp. asal Lombok Utara memiliki kadar senyawa fenolik total ekstrak propolis sebesar 6,02 0,55 mg GAE/g, dan Nilai IC50 sebesar 493,3±0,01 μg/ml.http://dx.doi.org/10.23960/aec.v6.i1.2021.p74-82 
Uji Aktivitas Antioksidan Kombinasi Ekstrak Kulit Pisang Kepok (Musa paradisiaca L.) dan Kulit Buah Naga Merah (Hylocereus polyrhizus (Weber) Britton & Rose) dengan Metode DPPH Baiq Ridho Amalia; Handa Muliasari; Agriana Rosmalina Hidayati
Journal of Pharmascience Vol. 10 No. 1 (2023): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i1.14863

Abstract

Senyawa antioksidan mampu meredam senyawa radikal bebas sehingga menjadi substansi yang tidak berbahaya. Sumber antioksidan dibagi dalam dua kategori, antioksidan sintetis dan alami. Antioksidan alami dapat diperoleh dari bahan alam, salah satunya kulit pisang kepok (Musa paradisiaca L.) dan kulit buah naga merah (Hylocereus polyrhizus (Weber) Britton & Rose). Penelitian ini dilakukan untuk mengetahui aktivitas antioksidan yang dihasilkan ekstrak tunggal kulit buah pisang kepok (KPK) dan kulit naga merah (KNM) serta aktivitas antioksidan kombinasi keduanya. Kombinasi ekstrak KPK dan KNM dibuat dengan rasio (1:1); (1:2); dan (2:1). Ekstrak KPK dan KNM mengandung senyawa flavonoid yang berperan dalam aktivitas antioksidan yang dihasilkan. Uji aktivitas antioksidan dilakukan dengan metode DPPH. Nilai IC50 ekstrak tunggal KPK dan KNM adalah 79,34 ± 1,139 ppm dan 79,96 ± 0,899 ppm. Nilai IC50 Kombinasi ekstrak KPK dan KNM dengan variasi (1:1); (1:2); dan (2:1) adalah 19,50 ± 2,552 ppm; 58,38 ± 2,338 ppm; dan 18,76 ± 1,605 ppm. Uji one way ANOVA menunjukkan nilai IC50 ekstrak tunggal dan kombinasinya berbeda signifikan (p < 0,05). Kombinasi ekstrak KPK dan KNM menghasilkan aktivitas antioksidan yang lebih kuat dibandingkan dengan ekstrak tunggalnya. Kata Kunci: Sonikasi, KLT, Flavonoid, Kombinasi Ekstrak, DPPH Antioxidant compounds can reduce free radical compounds and become harmless substances. Antioxidants are divided into two, which are synthetic and natural antioxidants. Natural antioxidants can be obtained from natural ingredients, such as the peel of kepok banana (Musa paradisiaca L.) and the peel of the red dragon fruit (Hylocereus polyrhizus (Weber) Britton & Rose). The goals of this study are to determine the antioxidant activity of extract kepok banana peel (KPK), red dragon fruit peel (KNM) and extract combination of both. The combination of KPK and KNM extracts was made in a ratio of (1:1); (1:2); and (2:1). KPK and KNM extracts contain flavonoid compounds which are responsible for the antioxidant activity produced. The antioxidant test was carried out using the DPPH method. The IC50 values of the single extracts of KPK and KNM were 79.34 ± 1.139 ppm and 79.96 ± 0.899 ppm. IC50 value combination of KPK and KNM extracts with variation (1:1); (1:2); and (2:1) are 19.50 ± 2.552 ppm; 58.38 ± 2.338 ppm; and 18.76 ± 1.605 ppm. One way ANOVA test showed that the IC50 values of single extracts and their combinations were significantly different (p < 0.05). The combination of KPK and KNM extracts had stronger antioxidant activity than the single extracts.
Penentuan Kadar Flavonoid Total dalam Ekstrak Etanol Buah Renggak (Amomum dealbatum Roxb.) Menggunakan Spektrofotometri UV–Vis Lalu Ardian Hadi; Rizqa Fersiyana Deccati; Handa Muliasari; Nisa Isneni Hanifa
Acta Chimica Asiana Vol. 9 No. 1 (2026)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v9i1.278

Abstract

The local plant, Amomum dealbatum Roxb. (A. dealbatum), is native to Lombok Island. This plant is a member of the Zingiberaceae family, which is recognised to have antifungal and antibacterial properties due to the presence of secondary metabolites, particularly flavonoids. Nevertheless, there is still little information and few reports regarding the overall flavonoid content of A. dealbatum fruit. As a chemical marker to support an extract’s quality control and pharmacological effects, Total Flavonoid Content (TFC) determination is crucial. The purpose of this work was to use UV-Vis spectrophotometry to measure the TFC in the ethanol extract of A. dealbatum fruit. Using a 1:10 solvent: simplicia ratio and maceration with 96% ethanol, the extraction procedure was completed. Thin Layer Chromatography (TLC) and the Wilstatter test were then used to identify the extracted material qualitatively. Using a UV-Vis spectrophotometer and a colourimetric approach, TFC was measured. The ethanol extract of A. dealbatum fruit contained flavonoids, as indicated by the qualitative analysis. The TFC values were 3.0833 ± 0.1439 mg rutin equivalent (RE)/g extract and 0.4858 ± 0.0014 mg quercetin equivalent (QE)/g extract. These findings suggest that the ethanol extract of A. dealbatum contains more flavonoid glycosides than flavonoid aglycones. This finding shows potential for further development. As this study is still limited to TFC at the extract level, further research on TFC at the fraction, sub-fraction, and isolate levels is needed to obtain more specific information about the active compounds contributing to its biological activities. In addition, further pharmacological testing is required to confirm the therapeutic potential of A. dealbatum and support its development as a candidate raw material for traditional medicine industries.
In Silico Analgesic and Toxicity Analysis of Modified Paracetamol on COX-2 Receptor (PDB ID: 3LN1) Nurul Hidayah; Lina Permatasari; Agriana Rosmalina Hidayati; Handa Muliasari
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.312-324

Abstract

Background: Paracetamol is often used as the main analgesic in Indonesia. The use of more than 4 g/day or a single dose above 10 g can cause hepatotoxicity. This can be overcome by modifying the structure through a computer-aided drug design (CADD) approach, particularly molecular docking, which aims to produce compounds with greater potency and fewer side effects. Objective: This study aimed to determine the analgesic activity and toxicity of paracetamol derivatives modified using the Topliss method. Methods: Analgesic activity was tested by molecular docking of the COX-2 receptor (PDB ID 3LN1) using AutoDock Tool 4.2 and toxicity testing using pkCSM and Protox Online Tool. Results: The results of docking showed that the free binding energy values ​​for test compounds 1 to 5 are -10.59 kcal/mol, -10.17 kcal/mol, -8.79 kcal/mol, -10.01 kcal/mol, and -9.32 kcal/mol, respectively, with corresponding inhibition constants of 17.29 nM, 35.21 nM, 360.88 nM, 46.36 nM, and 146.65 nM. These values are lower than paracetamol, which has a free binding energy of -6.21 kcal/mol and an inhibition constant of 28,043 nM. The results showed that the test compound was more stable in ligand-receptor binding. Toxicity tests showed that all the test compounds and paracetamol belonged to toxicity class IV. The test compound had an LD50 value of 1551 mg/kg, which was higher than that of paracetamol (338 mg/kg), indicating better effectiveness. Conclusions: Compound 2 was predicted to have the best biological activity and potential as an alternative to paracetamol.
Co-Authors Afriza Faishal, Imam Agriana Rosmalina Hidayati Agus D. Ananto Agus Dwi Ananto, Agus Agus saputra Ahmad Wirahadi Ali Harris Aliefman Hakim Almira Amini Alwi, Andi Siti Fatimah Alya, Ainun Amalia, Marshanda Fitri Amini, Almira Anandia Intan Maulidya, Selvira Ananta, Muhammad Naufal Farras Anggit Listyacahyani Sunarwidhi Annas, Zulfiana Fitrianingrum Annisa Rizka Nirmala Azariani, Wiwin Baiq Handayani Rinuastuti Baiq Ressa Puspita Rizma Baiq Ridho Amalia Baiq Ridho Amalia Baiq Sofianti Annisa Baiq Sopiah Bayu Priyambodo Bela Azkiana Candra D Hamdin Candra D. Hamdin Candra Dwipayana Hamdin Candra Dwipayana Hamdin Candra Dwipayana Hamdin Candra Dwipayana Hamdin Candra Dwipayana Hamdin Candra Eka Puspitasari Dani Syaiful Akbar Deccati, Rizqa Fersiyana Dedianto Hidajat Devy Shandra Purwati Dhony Hermanto Diba, Asmara Yauma Putri Farah Diva Almira Dzulqaidah, Intan Edi M Jayadi Elliya Rosyada Emmy Yuanita Emmy Yuanita Ernin Hidayati Erwinayanti, Gusti Ayu Putu Sri Fahrurazi Fahrurazi Fania Rahman Farobbi, Muhammad Iqbal Febriyanto Febriyanto Fersiyana Deccati, Rizqa Guban Juniarza, A'yuni Hafizah, Qori'atul Hajrin, Wahida Hamdin, Candra Dwipayana Hasanah, Nunung Uswatun Hayyatun Nufus, Fadirah Hesti Wulandari Hidayati, Agriana Rosmalina Hilkatul Ilmi I MADE SUDARMA I Made Sudarma Ihsan, Muhsinul Ima Arum Lestarini Indah Permata Sari Jones, Clive Junaida, Alfini Jurnal Pepadu Kabir, Mila Mayanti Laksono Trisnantoro Lalu Ardian Hadi Lalu Husnul Hidayat Lina Permatasari Lina Permatasari Lina Permatasari Luh Putu Intan Paramitha Sari M. Elyadi M. Rifqi Azami S, Lalu Magfira Nurmalasanti, Nadia Mahacita Andanalusia Megawati Muhsinul Ihsan Muhsinul Ihsan Muhsinul Ihsan Muhsinul Ihsan Muhsinul Ihsan Muhsinul Ihsan Mujiburrohman Mujiburrohman Mukhlishah, Neneng Rachmalia Izzatul Mukminah Mursidi, Siswandi Nankervis, Leo Ni Kadek Intan Wulan Sinta Dewi Ni Luh Arisa Prahastuti Winastri Ni Made Amelia Ratnata Dewi Ningsih, Baiq Nila Sari Nining Purwati Nirmala, Annisa Rizka Nisa Isneni Hanifa Novita Eliya Wardani Novita Eliya Wardani Nur Nadhifah Zahra Nur Nadhifah Zahra Nurul Hidayah Patya Putri, Hudaynu Permatasari, Lina Permatasari, Ni Made Ayu Dinda Priyambodo, Bayu Qori'atul Hafizah Qurnia Aini Rachmalia Izzatul Mukhlishah, Neneng Raehanul Maziya Rahmayanti, Wulan Desi Rahula Vijja Sammanta Regita Pramesti Retno Zahara Reza Sagista Riadi, Putri Oktaviati Risa Dwi Sosalia Riza Rusyiana Rizkika, Adila Rizqa F. Deccati Rizqa Fersiyana Deccati Rizqa Fersiyana Deccati Rizqa Fersiyana Deccati Rizqa Fersiyana Deccati Rizqa Fersiyana Deccati Romi Juniawan Sahila, Dinda Salsabila, Arista Rizkika Putri Sammanta, Rahula Vijja Saprizal Hadisaputra Saprizal Handisaputra Saputra, Yoga Dwi Setiawan, Wahyu Aldi Sopiah, Baiq Sosalia, Risa Dwi Suhirman suhirman Tasya Kamila, Afifah Tunggal Arya Rezky, Noval Ulul Khairi Zuryati Ulul Khairi Zuryati Virnia Wanda Utami Wahida Hajrin Wahida Hajrin Wahyu Bintang Ilahi Windah Anugrah Subaidah Wirasisya, Dyke Gita Yayuk Andayani Yayuk Andayani Yayuk Andayani Yohanes Juliantoni Yuli Eka Hardianti Zahra, Nur Nadhifah Zanuba, Regina Brigita Zulfiana Fatianingrum Annas