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All Journal Jurnal Gizi dan Pangan Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Masyarakat Althea Medical Journal Nexus Kedokteran Komunitas Nexus Biomedika Nexus Kedokteran Translasional Biomedika Jurnal Media Gizi Indonesia (MGI) GIZI INDONESIA Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Jurnal SOLMA Indonesian Journal of Medicine Journal of Maternal and Child Health MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan JPSCR : Journal of Pharmaceutical Science and Clinical Research World Nutrition Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Nusantara Science and Technology Proceedings Journal of Multidisciplinary Applied Natural Science Nutriology: Jurnal Pangan, Gizi, Kesehatan Proceedings of the International Conference on Nursing and Health Sciences Journal of Health and Nutrition Research Smart Society Empowerment Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Health Dynamics Media Penelitian dan Pengembangan Kesehatan Indonesian Journal of Pharmacology and Therapy APMa Jurnal Pengabdian Masyarakat
Ratih Puspita Febrinasari
Universitas Sebelas Maret
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : althea medical journal

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Therapeutic Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Dyslipidemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Hikmayani, Nur Hafidha; Febrinasari, Ratih Puspita; Satwika, Ariq Ratya
Althea Medical Journal Vol 12, No 3 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n3.4209

Abstract

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represent a novel class of medications for managing dyslipidemia. Although previous meta-analyses have confirmed their efficacy in lowering low-density lipoprotein cholesterol (LDL-C), few have evaluated their effects on broader lipid parameters. Moreover, most studies focus on the general dyslipidemic population, provided limited insight into specific subgroups. This study specifically investigated the effects of PCSK9 inhibitors on multiple lipid parameters in individuals with dyslipidemia who were statin-intolerant, statin-resistant, or required intensified lipid-lowering treatment.Methods: This study systematically searched PubMed, ScienceDirect, and the Cochrane Library for phase 3 randomized controlled trials (2013-2023), evaluating PCSK9 inhibitors against placebo or non-statin standard care in dyslipidemic patients aged ≥18 years. The main outcome was the changes from baseline in lipid parameters. Random-effects meta-analyses were conducted using RevMan. Results: Eight studies involving 2,343 participants met eligibility criteria. PCSK9 inhibitors significantly reduced LDL-C (MD -46.8, 95% CI [-53.2; -40.4]), non-HDL-C (MD -41.1 [-46.9; -35.3]), total cholesterol (MD -31.5 [-37.8; -25.2]), triglycerides (MD -11.7 [-15.0; -8.4], Lp(a) (MD -19.2 [-25.7; -12.6]), and ApoB (MD -39.4 [-45.0; -33.7]). PCSK9 inhibitors also significantly increased HDL-C (MD 6.3 [4.7; 7.9]) and ApoA-I (MD 4.1 [2.8; 5.5]).Conclusion: PCSK9 inhibitors significantly improve a broad spectrum of lipid parameters, including non-traditional markers such as non-HDL-C, ApoA-I, ApoB, and Lp(a), underscoring their potential role in managing dyslipidemia, particularly in patients inadequately controlled with standard therapies.
Co-Authors . Suyatmi . Suyatmi . Widardo ., Hudiyono ., Muthmainah ., Suyatmi A.A. Ketut Agung Cahyawan W Adi Magna Patriadi Nuhriawangsa AGYA GHILMAN FAZA Ahmad Ahid Mudayana Ahmad Ahid Mudayana Akhmad Azmiardi Alfi Yasmina Ali, Agni Shalha Amer Abdulwahab Al-aghbari, Nuha Amira, Nadya Kemala Anggraeni, Selvia Anis Nurhidayati Anshari, Shafira Yasmine Argyo Demartoto, Argyo Ari Natalia Probandari Ari Probandari Arsita Eka Prasetyawati Arsita Eka Prasetyawati Asaduddin, Aiman Hilmi Asih Anggraini Asih Anggraini Astrida Fesky Febrianty Astrika Yunita, Fresthy Bachnas, Muhammad Adrianes Berlian Permata Sakti Bhisma Murti Binti Maulina Binti Maulina Putri Brian Wasita Brian Wasita Brian Wasita Bustami, Mursyid Chintya Wulandarie Colti Sistiarani Colti Sistiarani Dara, Rizki Wulan Dedi Febriandaru Desy Puspa Putri Devi Ratna Mayasari DIAN LESTARI Didik Gunawan Tamtomo Dilma’aarij, Dilma’aarij Dyonisa Nasirochmi Pakha Endang Listyaningsih Suparyanti Erna Kristin Ernawati, Dwi Arini Eti Poncorini Pamungkasari Fairuz Zamani FAZA, AGYA GHILMAN Hamka, Dwi Wulandari Aaas Hanif Mustikasari Harioputro, Dhani Redhono Hariyanti, Lusiana Pradana Hartono Hartono Haruni, Diah Sekar Heni Hastuti Hudiyono . Hutami Sri Ummiyati Ida Nurwati Ignatius Gonggo Prihatmono Imanisa, Octavia Intan Indarta, Ardhia Fefrine Irma Prasetyowati iwan Dwiprahasto Kenneth Tan Khoiriyah, A'maliatul Kisrini . Komang Windayani Kristiani, Shinta Laksmi Wardhani, Tri Martya Ningrum Leli Saptawati Lilik Wijayanti Lilik Wijayanti Lilik Wijayanti Wijayanti Lisyawati, Shanti Lukman Aryoseto Ma'rifatul Khoiriyah Ayda Maryati, Warsi Mashuri, Yusuf Ari Meintansari Manik MIFTAKHUL JANNAH Mochammad Fairuz Zahran Muchsin Doewes Mustara, Mustara Mustiqa Febriniata MUTHMAINAH . Muthmainah Muthmainah Nadya Kemala Amira Nafi'ah, Radifatun Naila Shofwati Putri Nanang Wiyono Nila Authoria Authoria Nita Dwi Astikasari Novelia Qothrunnada Novika, Revi Gama Hatta Nur Hafidha Hikmayani Nur Hafidha Hikmayani Nur Hasanah, Laras Eka Nur Hidayah Nurhasan Agung Prabowo Nurholis Majid Oktaviani oktaviani Paramasari Dirgahayu Paramasari Dirgahayu Poncorini Pamungkasari, Eti Primaningtyas, Widana Putri, Naila Shofwati Rahardjo, Setyo Sri Rio Nanda Pratama Rio Nanda Pratama Riris Arizka Wahyu Kumala Riris Arizka Wahyu Kumala, Riris Arizka Wahyu Rizaldy Pinzon RR. Ella Evrita Hestiandari Sakti, Berlian Permata Saptawati, Leli Satwika, Ariq Ratya Selvia Anggraeni Setyani, Rizka Ayu Setyani, Rizka Ayu Setyo Sri Rahardjo Setyo Sri Rahardjo Shinta Kristianti Shinta Retno Wulandari Shinta Shinta Sigit Setyawan Siswahyudianto Siti Fatimah R Solikah, Tri Agusti Sopianti, Densi Selpia Sri Darnoto Sri Mulyani Sri Mulyani Sugiarto Sumandjar, Tatar Sumardiyono Sumardiyono Sumardiyono Sumardiyono Suparyanti, Endang Listyaningsih Suparyanti, Endang Listyaningsih Susanto, Agnes Suyatmi . Syamsiar, Syamsiar Tri Agusti Sholikah Uki Retno Budihastuti Ummiyati, Hutami Sri Veronika Ika Budiastuti Vitri Widyaningsih Vitri Widyaningsih Wahyu Anjas Sari Wasita, Brian Widardo . Windayani, Komang Wiyono, Nanang Wulandari, Shinta Retno Yanuarini, Triatmi Andri Yulia Lanti Retno Dewi Yulia Sari