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All Journal Jurnal Gizi dan Pangan Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Jurnal Pengolahan Hasil Perikanan Indonesia Hemera Zoa Jurnal Sain Veteriner Jurnal Ilmu Komputer dan Informasi Jurnal Veteriner Majalah Kedokteran Bandung Jurnal Ilmu Ternak Veteriner Jurnal Media Gizi Indonesia (MGI) INDONESIAN JOURNAL OF PHARMACY Pharmascience Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Jurnal Medik Veteriner Amerta Nutrition Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Jurnal Farmamedika (Pharmamedica Journal) Jurnal Dunia Gizi Narra J Journal of Health and Nutrition Research Journal of Global Pharma Technology Jurnal Kedokteran Hewan Current Biomedicine Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research)
Ekowati Handharyani
Departemen Klinik Reproduksi Patologi, Fakultas Kedokteran Hewan, IPB University, Kampus IPB Dramaga Bogor, 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Exploring the potential of calcium-fortified sweet potato noodles for osteoporosis prevention: Insights from in vivo rat studies Ambarwati , Karsi; Giriwono, Puspo E.; Handharyani, Ekowati; Yasni, Sedarnawati
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1075

Abstract

Calcium (Ca) deficiency is a primary contributor to osteoporosis, a condition characterized by low bone density and increased fracture risk. Fortifying widely consumed foods with calcium is one approach for addressing this insufficiency. Given the popularity of noodles, adding Ca to them offers a promising approach to enhancing Ca intake within communities. The aim of this study was to investigate the effects of Ca-fortified sweet potato noodles on osteoporosis prevention. This study used 4-month-old Sprague-Dawley rats. A completely randomized design was used with four treatment groups: CS (SHAM, control diet), CO (Sham, test diet), US (OVX, control diet), and UO (OVX, test diet). Both control and test diets, which included Ca-fortified sweet potato noodles, were administered to OVX (ovariectomy-induced osteoporosis model) and SHAM (control for surgical procedure) groups for two months. At the end of the experiments, serum Ca levels were collected and analyzed for Ca and alkaline phosphatase (ALP) levels and their bones were analyzed for physical properties and bone mineral density (BMD) using X-ray analysis. Data were analyzed using one-way analysis of variance (ANOVA) followed by Duncan as a post hoc test. The intervention of Ca-fortified sweet potato noodles for two months significantly increased serum Ca levels and reduced ALP levels compared to controls, both in SHAM (Ca: 38.03±0.877 mg/dL; ALP: 355±38.0 IU/L) and OVX (Ca: 36.18±2.810 mg/dL; ALP: 340±5.5 IU/L) groups. The test diet maintained the ratio of bone weight to bone volume and preserved the Ca content in the rats' bones. OVX rats consuming the test diet for two months exhibited significantly higher femur bone strength than OVX rats consuming the control diet (test: 6.50±0.300 kg; control: 4.83±0.289 kg). There was no significant difference in BMD between the SHAM and OVX groups on the test diet, indicating that the test diet can maintain bone BMD despite accelerated aging. These findings suggest that Ca-fortified sweet potato noodles can serve as a dietary Ca source, contributing to the prevention of osteoporosis by maintaining serum Ca levels, preserving bone Ca content, as well as maintaining bone density and strength.
EFEK PEMBERIAN GULA KELAPA YANG DIPERKAYA MINYAK SAWIT MERAH TERHADAP PENINGKATAN BERAT BADAN DAN KADAR RETINOL SERUM TIKUS DEFISIEN VITAMIN A (EFFECT OF THE FEEDING OF BROWN SUGAR ENRICHED WITH RED PALM OIL ON BODY WEIGHT GAIN AND SERUM RETINOL LEVELS Hidayah Dwiyanti; Hadi Riyadi; Rimbawan Rimbawan; Evy Damayanthi; Ahmad Sulaeman; Ekowati Handharyani
Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Vol. 36 No. 1 (2013)
Publisher : Persagi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/pgm.v36i1.3397.73-81

Abstract

ABSTRACT Vitamin A deficiency (VAD) is an important cause of blindness and premature death. Vitamin A also plays an important role on growth and immune function.  Red palm oil is the richest naturally occurring source of β-carotene, a carotenoid that the human body can convert into usable vitamin A (retinol). This research was to evaluate the effect of feeding red palm oil enriched brown sugar on improving body weight and serum retinol level of vitamin A depletion Sprague-Dawley rats. Twenty four of six weeks old-male Sprague Dawley rats were used. After 2 weeks of adaptation period, rats were given vitamin A deficient diet (modified  AIN-93M) for 10 weeks, and then divided into 3 groups and received for 2 weeks the different treatment as repletion period: 1) RPO group which received red palm oil enriched brown sugar (1.5 mL/d), 2) CPO group which received crude palm oil enriched brown sugar (1.5 mL/d) and 3) and RE group which received retinyl palmitate (0.6 mL/d) . Each treatment contains approximately 40 µg beta carotene/day. Intervention by feeding brown sugar enriched with RPO and CPO for 2 weeks can increase the body weight of rats by 3.54 percent and 5.23 percent, respectively, which is markedly better than the group that was given retynil palmitat (9.38%) (p<0.05). However, an increase in serum retinol concentrations in all group showed no significant differences (p>0.05). Consumption of brown sugar enriched with RPO or CPO enhances body weight and serum retinol concentration of vitamin A deficient rats. Keywords: brown sugar, red palm oil, serum retinol, vitamin A deficiency, rats  ABSTRAK Kurang vitamin A (KVA) merupakan penyebab utama kebutaan dan kematian dini.  Vitamin A juga berperan pada perkembangan dan fungsi imun.  Minyak sawit merah merupakan sumber β-karoten, dimana tubuh dapat merubahnya menjadi retinol.  Tujuan penelitian untuk mengevaluasi efek pemberian gula kelapa yang diperkaya minyak sawit merah terhadap peningkatan berat badan dan kadar serum retinol tikus Sprague-Dawley defisien vitamin A.  Digunakan 24 ekor tikus jantan usia 6 minggu.  Setelah 2 minggu masa adaptasi, tikus diberi diet bebas vitamin A selama 10 minggu, selanjutnya dibagi menjadi 3 kelompok, yaitu 1) RPO, menerima larutan gula yang diperkaya dengan RPO (1,5 ml/hari), 2) CPO, menerima larutan gula yang diperkaya CPO (1,5 ml/hari)), dan 3) RE, yaitu kelompok yang mendapatkan retynil palmitat dalam minyak sebagai kelompok kontrol positif (0,6 ml/hari). Masing-masing perlakuan mengandung beta karoten setara 7 RE per hari.  Intervensi selama 2 minggu dengan memberikan gula kelapa yang diperkaya RPO maupun CPO mampu  meningkatkan berat badan tikus masing-masing 3,54 persen dan 5,23 persen yang secara nyata lebih baik  dibandingkan kelompok yang diberi retynil palmitat (-9,38%) (p<0,05). Disisi lain, peningkatan konsentrasi serum retinol pada semua kelompok tidak menunjukkan perbedaan yang nyata (p>0,05).  Konsumsi gula kelapa yang diperkaya RPO maupun CPO meningkatkan berat badan dan memperbaiki konsentrasi serum retinol tikus defisien vitamin A. [Penel Gizi Makan 2013, 36(1):73-81] Kata kunci: gula kelapa, sawit merah, retinol serum, defisiensi vitamin A, tikus
Method Modification of Developing Ischemic Stroke Animal Models Using Intravenous Catheters in Rats Perdhana, Ika Satya; Handharyani, Ekowati; Darusman, Huda Shalahuddin; Nugroho, Setyo Widi; Maheshwari, Hera; Fitri, Arni Diana
Acta VETERINARIA Indonesiana Vol. 13 No. 1 (2025): Maret 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.1.67-76

Abstract

In various parts of the world, including Indonesia, the incidence of ischemic stroke remains high, and its impact poses a significant burden. This condition is influenced by numerous limitations in ischemic stroke therapy. Research on ischemic stroke is therefore crucial to develop, making the creation of appropriate animal models a vital necessity. One of the most commonly used methods by researchers to create animal models is the Middle Cerebral Artery Occlusion (MCAO) method. However, in Indonesia, its application remains limited due to the lack of available facilities. Method modifications can be implemented to enable the development of animal models in Indonesia. This study employed modifications to the MCAO method on eight Sprague Dawley rats. The modification involved using an intravenous catheter to facilitate the insertion of the filament as an occluder in the middle cerebral artery of the rats. Based on clinical and pathological observations, it can be concluded that the modified MCAO method used in this study is suitable for creating ischemic stroke animal models. With this modification, the creation of ischemic stroke animal models can be carried out in a simpler and more cost-effective manner.
Evaluation of Dietary Fiber, Antioxidant Capacity, Physicochemical Properties, and Consumer Acceptability of a Green Okra (Abelmoschus esculentus L.) Pudding Armenia Eka Putriana; Damayanthi, Evy; Palupi, Eny; Nasution, Zuraidah; Handharyani, Ekowati
Journal of Health and Nutrition Research Vol. 4 No. 2 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i2.461

Abstract

Green okra is obtained from the planting process and harvested after 3 months of cultivation. Analysis was carried out in the form of Dietary fiber, Microbial Content, Physical properties tests, and Antioxidant Capacity Analysis. This green okra pudding product study employed a Completely Randomized Design (CRD). The formula comparison treatment was divided into three treatment levels, namely the comparison of mucilage addition (10, 15, and 20 ml). The response variable of this study was the organoleptic properties of okra pudding. There are 3 (three) stages in making green okra pudding, consisting of blanching green okra fruit, extracting green okra (mucilage), and making pudding. Based on the results of this study, the selected green okra pudding formula from the hedonic test is formula 3 which contains 1.24% dietary fiber, no Staphylococcus aureus and contamination by Escherichia coli bacteria is very minimal, pH of 7.21, aroma and texture were rated as typical SNI 01-2891-1992 standard and IC50 result of 24.27% indicates the concentration of the product needed to inhibit 50% of free radical activity, which means that this product has indicating notable antioxidant effectiveness. Conclusion: Green okra pudding with the addition of 20 ml mucilage has the potential to control fasting blood glucose
Co-Authors ., Chairul A Winarto Adi Winanto Adi Winarto Afiff , Usamah Agus Buono Agus Setiyono Ahmad Biharidin Ahmad Sulaeman Akhmad Endang Zainal Hasan Aldo Yanuar Wuriyantara Armenia Eka Putriana Arni Diana Fitri Aulia Andi Mustika Aziz Kustiyo Bambang Kiranadi Bambang Sumiarto Bambang Widyo Prastowo BIBIANA W LAY Budiono, Novericko Ginger Chairul - Chairul Chairul Clara Meliyanti Kusharto Deni Noviana DEWI APRI ASTUTI Dewi Ratih Agungpriyono Dewi Ulfa Trisdiani Dhany Nugraha Ramdhany Dondin Sajuthi Dwi Santy Damayati Dwi Utari Rahmiati Eflisa Endah Putri Elly Munadziroh Eny Palupi Erni Sulistiawati Erwin Erwin Etriwati E Evy Damayanthi Fadjar Satrija Fajar Kawitan Fitri Ariyani Fitri, Arni Diana Franciscus Dhyana Giri Suyatna Geneva Ariesta Giriwono, Puspo E. Gunanti . Hadi Riyadi Handayu Untari Hapsari Mahatmi Hardi Firmansyah HERA MAHESHWARI Hernomoadi . Hernomoadi Hernomoadi Hidayah Dwiyanti Huda Shalahudin Darusman I wayan Teguh Wibawan Ikeu Ekayanti Irma Herawati Suparto K Ochiai Karsi Ambarwati Katrin Roosita KHOIRIYAH, ROMYUN ALVY Kiranadi Bambang Komariah Komariah Komariah Lili Andriani Lina Noviyanti Sutardi M.B. Malole . MARIA BINTANG Masdiana C. Padaga Masriani . Muhamad Rizal Martua Damanik Nabilah, Avida Shahnaz Nasution, Zuraidah Ni Luh Putu Ika Mayasari Nisrina Rosyida Noor Rifai Novera Nirmalasanti Nugraha, Arifin Budiman Nugroho, Setyo Widi Octarina Okti Nadia Poetri Olga Purnama Bakti Opyn Mananta Perdhana, Ika Satya Putri Puncak Anjani R. Susanti Rahayu WoroWiranti Retno Damajanti Soejoedono Retno Damayanti Soejoedono Retno Setyaningsih Retno Setyaningsih Rimbawan , Rimbawan Rimbawan Risti Rosmiati Riyadh Firdaus Ruqiah Ganda Putri Panjaitan safrina dyah hardiningtyas Sangko Sayuti Nasution SEDARNAWATI YASNI Silmi Mariya Sophia Setyawati Sri Anna Marliyati sri murtini . Sri Purwaningsih Sri Rahmatul Laila Sri Wahyuni Suhendi, Adnan Rizal Surachmi Setiyaningsih Tanjung Penataseputro Tantri, Aida Rosita Trini Suryowati Umi Cahyaningsih Wasmen Manalu Wibowo, Artdhea Regita Wisnu Jaka Dewa Wiwin Winarsih Yetty Ramli Yuli Purwandari Kristiangingrum Yuni Andriani Yusuf Ridwan Zulfa Zakiah