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All Journal International Journal of Renewable Energy Development Journal on Mathematics Education (JME) GRADIEN Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Masharif al-Syariah: Jurnal Ekonomi dan Perbankan Syariah J-EBIS (Jurnal Ekonomi dan Bisnis Islam) TUNAS BANGSA JURNAL SERAMBI ILMU TAZKIR: Jurnal Penelitian Ilmu-ilmu Sosial dan Keislaman JURNAL PENDIDIKAN TAMBUSAI Jurnal Basicedu Jurnal Dedikasi Pendidikan At-tijaroh: Jurnal Ilmu Manajemen dan Bisnis Islam EDUTEC : Journal of Education And Technology Journal of halal product and research (JHPR) International Journal of Marketing and Human Resource Research Munaddhomah: Jurnal Manajemen Pendidikan Islam Jurnal Bisnis Mahasiswa Journal Of Sharia Banking INSANIA : Jurnal Pemikiran Alternatif Kependidikan Jurnal Basicedu JIFTECH: Journal Of Islamic Financial Technology Jurnal Kedokteran Hewan Nanggroe: Journal Of Scholarly Service Nanggroe: Journal of Scholarly Service JSIKOM (Jurnal Studi Ilmu Komunikasi) Krigan: Journal of Management and Sharia Business Jurnal Mediasas : Media Ilmu Syari'ah dan Ahwal Al-Syakhsiyyah Jurnal Medika Veterinaria At Tahkim Jurnal Hukum Ekonomi Syariah Profetik Jurnal Ekonomi Syariah Jurnal Pendidikan MIPA Yuriska : Jurnal Ilmiah Hukum Singkite Journal Jurnal Ilmiah Mahasiswa Pendidikan Geografi ILLAT-J
Muhammad Isa
Universitas Sumatera Utara
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Journal : Jurnal Medika Veterinaria

 1 
Antidiabetic Test of Ethanolic Extract of Ant Nest Plants (Myrmecodia sp.) Against the -Glucosidase Enzyme In Vitro Daniel, Daniel; Isa, Muhammad; Hasan, Muhammad; Sari, Wahyu Eka; Rosmaidar, Rosmaidar; Aisyah, Siti; Athaillah, Farida; Frengki, Frengki
Jurnal Medika Veterinaria Vol 18, No 1 (2024): J.Med.Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v18i1.37431

Abstract

The use of plants, one of the biological sources, as an alternative medicine for degenerative diseases is increasingly being studied. Usually, the biological effects of these plants come from the secondary metabolite components contained therein. Ant nest is one of them which is reported to contain compounds belonging to the class of flavonoids, tannins, and polyphenols. This research was conducted in vitro by observing the antidiabetic potential of the ethanolic extract of ant nests against the -glucosidase enzyme following the modified "Wako Pure Chemical Industries Ltd., Japan" protocol. The results showed that the inhibitory power of -glucosidase of the extract was stronger than that of the quercetin control with IC50 values of 10.59 g/mL and 38.09 g/mL, respectively. These results proved that the ethanolic extract of ant nest had very strong -glucosidase inhibitory property. Predictive analysis of the pharmacokinetics and toxicity of the bioactive compounds contained in the ant nest extract showed that rutin has similar characteristics to acarbose as a first-line anti-diabetic drug of choice through an -glucosidase inhibitor mechanism, so rutin is worthy of consideration for development as an anti-diabetic candidate.
Co-Authors Abir, Ismail Ahmad Adjeng Moelyati, Trisniarty Adzkia, Nida Agasta, Rio Ahmasi, Latif Al Aji, Mochamat Bayu Ali Hardana Almegi, Almegi Aris Haryanto Asnil Aidah Ritonga Athaillah, Farida Azhar Azhar Azwar Hamid Bayurini Samudra, Sari Cesarian, Dwiky Pobri Charles Rangga Tabbu Daniel Daniel Dasrul Dasrul Deni Kurniawan, Deni Didik Sugiyanto Efendi, Ilham Eka Safitri Elin Yusibani Erdiansyah Rahmi Fachruddin Azmi, Fachruddin Fadlilah, Hamni Fathurrahman, Fadhil Frengki Frengki, Frengki Ginting, Budi Setiawan Hambali Hambali Harahap, Desi Anora Heni Pujiastuti Henni Vanda Hutagaol, Abdul Latif Hutasuhut, Sartika Irwansya, Muhammd Juli Melia Khairunisa, Fauzia Khurniawan, Deni Lestari, Emmi Lubis, Aswadi Lubis, Zulfahmi M. Yusuf Mesiono, Mesiono Mudofir, Imam Muhammad Hasan Muhammad Yusuf Ibrahim Mulyadi Adam, Mulyadi Murni Murni Musni, Nailah Mutia, Fara Nasution, Adanan Murroh Neliwati Nofinawati Nofinawati Nofinawati, Nofinawati Noviabahari, Jannatul Laily NURLIANA NURLIANA Nurul fadillah, Nurul Nuzul Asmilia Palupi, Dian Prasetyo Yekti Utomo Priatna, Rusdiana Putra, Septian Dwi Maulana Rahil Helmi Rahmadi Rahmadi Rasmaidar Rasmaidar Reza Aprianti, Reza Riski, Novia Roslizawaty Roslizawaty, Roslizawaty Rosmaidar Rosmaidar, Rosmaidar Rully Charitas Indra Prahmana Saleh, Idris Sari, Wahyu Eka Saudah Setyawan, Dimas Ari Simahatie, Mai SIREGAR, BUDI GAUTAMA Siti Aisyah Siti Khadijah Siti Sarah, Siti SRI RAHAYU Sri Wahyuni Suci Maulina Sugito Sugito Sukmawati, Nur Sulaeman Sulaeman Surbakti, Muhammad Syukri Sutantohadi, Alief Suyatmika, Yulita Syafruddin Syafruddin Tauvani, A Yuli Teuku Zahrial Helmi Umar, Muksin Utari, Lin Putri Vahreza, Anshar Wardah Manurung, Sri Rezeqi Rafiqah Wayan Tunas Artama Widodo, Yulius Harry Willy Syarif Yandy, Eza Tri Yani, Nuriza Yundari, Yundari Yusuf Hadijaya Zahratun Zaini, Nasrullah