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All Journal ComEngApp : Computer Engineering and Applications Journal VALENSI JURNAL KIMIA SAINS DAN APLIKASI Jurnal Natur Indonesia Teknika Jurnal Riset Kimia SEMIRATA 2015 Jurnal Pengabdian UntukMu NegeRI Jurnal Surya Medika Jurnal CoreIT Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PHOTON JURNAL PENDIDIKAN TAMBUSAI J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Building of Informatics, Technology and Science Jurnal Yustitia Zonasi: Jurnal Sistem Informasi JOURNAL OF INFORMATION SYSTEM RESEARCH (JOSH) Journal of Computer System and Informatics (JoSYC) Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara Information System Journal (INFOS) KLIK: Kajian Ilmiah Informatika dan Komputer JUSTIN (Jurnal Sistem dan Teknologi Informasi) Dinamika Lingkungan Indonesia Makara Journal of Science Tsaqofah: Jurnal Penelitian Guru Indonesia Aurelia: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Counseling and Humanities Review Jurnal Aplikasi IPTEK Indonesia AHKAM : Jurnal Hukum Islam dan Humaniora Mestaka: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasi Indonesia Molekul: Jurnal Ilmiah Kimia Journal Of Artificial Intelligence And Software Engineering Journal of Hypermedia & Technology-Enhanced Learning Jurnal Pengabdian Nusantara Jurnal Kesehatan Masyarakat
Jasril Jasril
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Studi Molecular Docking dan Evaluasi Farmakokinetik Senyawa Analog Pirazol Turunan Benzen-Sulfonilurea sebagai Inhibitor Enzim Aldose Reduktase and α-Glukosidase Menggunakan Pendekatan In Silico Fatisa, Yuni; Utami, Lisa; Syahri, Jufrizal; Jasril, Jasril; Lazulva, Lazulva
Jurnal Riset Kimia Vol. 15 No. 2 (2024): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v15i2.633

Abstract

The pyrazole scaffold modification in various chemical structures on several studies has shown various biopharmacological activities. This study aims to predict the potential inhibition of pyrazole analogs derived benzene-sulfonylurea (4A, 4B, 4E, 5A, 5C, 5D) against the α-glucosidase (3A4A) and aldose reductase (3RX2) enzymes based on a molecular docking approach using Molecular Operating Environment (MOE) 2020.0102 software and evaluate pharmacokinetic profile (ADMET). In this study, the six test compounds were obtained from previous studies that have been proven antihyperglycemic. The results showed that all the 3,5-disubstituted benzene-sulfonylurea derivative pyrazole analogs are predicted to have low inhibitory activity against the α-glucosidase enzyme. Further, all compounds showed good aldose reductase inhibitor activity and had lower binding free energy values ​​than tolrestat as the positive control (-6.82 kcal/mol). Compound 5C has the best potential inhibitory activity against the aldose reductase enzyme compared to the other test compounds, because it has the lowest binding free energy value (-8.76 kcal/mol) and interacts with important residues on the receptor forming four hydrogen bonds, namely the carbonyl group of SO2 with residues Trp111 and His110, and the carbonyl group of the amide with residues His110 and Tyr48, as well as 3 hydrophobic bonds, namely a pyrazole ring with residues Leu300, Trp219 and a furan ring with Phe122. ADMET properties of the compounds are also predicted. This information provides an opportunity for a 5C compound as an aldose reductase inhibitor agent to develop drug candidates with better and safer activities.
PEMBERDAYAAN UMKM MELALUI PEMANFAATAN LIMBAH KULIT NANAS MENDUKUNG GREEN ECONOMY DAN BISNIS BERKELANJUTAN Nofirda, Fitri Ayu; Hilma, Rahmiwati; Faladhin, Johan; Firmathoina, Aisyah; Fauzi, Faradiba Kamilia; Hamersat, Danu; Zikra, Nadila
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 5 (2024): Vol. 5 No. 5 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i5.35918

Abstract

Penelitian ini bertujuan untuk mengeksplorasi dan mengimplementasikan strategi pemberdayaan Usaha Mikro, Kecil, dan Menengah (UMKM) melalui pemanfaatan limbah kulit nanas di Desa Kualu Nenas, Kabupaten Kampar, sebagai bagian dari upaya mendukung green economy dan bisnis berkelanjutan. Metode yang diterapkan meliputi sosialisasi, pelatihan keterampilan, dan pendampingan dalam pengolahan limbah menjadi produk bernilai tambah, seperti sabun cair dan pupuk organik. Hasil dari program ini menunjukkan peningkatan signifikan dalam keterampilan anggota kelompok tani, yang berdampak pada peningkatan pendapatan dan daya saing produk di pasar. Selain itu, program ini berhasil meningkatkan kesadaran lingkungan di kalangan petani, yang kini lebih memahami pentingnya pengelolaan limbah untuk mengurangi dampak negatif terhadap ekosistem. Keberhasilan inisiatif ini tidak hanya memberikan manfaat langsung kepada peserta, tetapi juga membuka peluang untuk replikasi di komunitas lain, sehingga dapat memperluas dampak positif dalam konteks pembangunan berkelanjutan. Penelitian ini menegaskan pentingnya kolaborasi antara berbagai pihak, termasuk pemerintah dan lembaga pendidikan, untuk memastikan keberlanjutan dan skalabilitas program di masa depan.
The Influence of Educational Games in Problem-Based Learning on Student Learning Outcomes in Informatics Subjects at SMP Negeri 1 Angkola Barat Siregar, Alfi Salimah; Efrizon, Efrizon; Dewi, Ika Parma; Jasril, Ilmiyati Rahmy
Jurnal Pengabdian Nusantara Vol. 3 No. 4 (2025): DESEMBER
Publisher : Konsorsium Nasional Pengelola Jurnal Pengabdian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/jpn.v3i4.118

Abstract

This research aims to determine the effect of using Wordwall-based educational games in Problem-Based Learning (PBL) on the learning outcomes of Informatics subject at SMP Negeri 1 Angkola Barat. The research method used is a quasi-experimental design with a non-equivalent control group design approach. The research sample consists of two classes: the experimental class using Wordwall educational games in PBL-based learning and the control class using conventional methods. Data collection was carried out through pretest and posttest to measure students' learning outcomes. The analysis results show that the data are normally distributed and homogeneous, so an independent t-test was conducted. The calculated t-value of 3.04 is greater than the t-table value of 2.002 with a significance of 0.004 (<0.05), indicating a significant difference between the two groups. The posttest mean score for the experimental class was 87.83, while for the control class it was 80.63, demonstrating a significant improvement in students' learning outcomes through the use of educational games. The results of this research affirm that integrating interactive learning media such as Wordwall in PBL can enhance students' motivation, engagement, and understanding of Informatics material, serving as an effective alternative in 21st-century learning.
A Support Vector Regression Approach for Predicting the Remaining Useful Life of Turbofan Engines Hardiansyah, Muhammad Vio; Insani (Scopus ID: 57190404820), Fitri; Handayani, Lestari; Jasril, Jasril; Sanjaya, Suwanto
Jurnal CoreIT: Jurnal Hasil Penelitian Ilmu Komputer dan Teknologi Informasi Vol 11, No 2 (2025): December 2025
Publisher : Fakultas Sains dan Teknologi, Universitas Islam Negeri Sultan Syarif Kasim Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24014/coreit.v11i2.38532

Abstract

Turbofan engines are crucial components in the aviation and manufacturing industries, where estimating the Remaining Useful Life (RUL) has a significant impact on operational efficiency and safety. This study aims to predict the RUL of turbofan engines using the Support Vector Regression (SVR) method, a machine learning approach that has proven effective in modeling nonlinear relationships between variables. Operational data related to turbofan engines include operational parameters, sensors, and maintenance records. The initial stage of this research involves data analysis based on unit number, time, operational control, and sensor parameters. This process begins with preprocessing to initialize the initial data values, normalize, and select sensors that have stagnant values, as these sensors do not affect the machine learning system. Subsequently, regression calculations are performed to compare predicted values and actual values using the Support Vector Regression method optimized with Grid Search Optimization. In this study, testing was conducted with Parameters C [1, 10, 50, 100] and ε [1, 5, 10, 50], resulting in the best model with an RMSE error of 19.56 and MAE of 14.73.
Interactive Macromedia Flash–Based Learning Media for K3LH Instruction in Vocational Electronics Education Fatila, Mutia; Jasril, Ilmiyati Rahmy; Ayasrah, Firas Tayseer
Journal of Hypermedia & Technology-Enhanced Learning Vol. 4 No. 1 (2026): Journal of Hypermedia & Technology-Enhanced Learning—Future Education
Publisher : Sagamedia Teknologi Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58536/j-hytel.209

Abstract

This study developed interactive learning media using Macromedia Flash to enhance Occupational Health, Safety, and Environmental Awareness (K3LH) instruction within the Basic Electronics curriculum in vocational high schools. The research employed a Research and Development approach guided by the 4D model (Define, Design, Develop, and Disseminate) to produce a validated multimedia learning product aligned with the Merdeka Curriculum. During the Define stage, needs assessment and learner analysis revealed low student engagement and conceptual difficulties with electronics safety topics, underscoring the need for technology-based instructional innovation. The designed media integrated text, visuals, animations, audio, and interactive assessments to support autonomous and student-centred learning. Expert validation involving material and media specialists resulted in high validity scores of 94.7% and 94.8%, indicating strong curriculum alignment, conceptual clarity, interface organisation, and language quality. Field testing with Grade 10 Electronics Engineering students yielded a practicality score of 85.1%, confirming that the media was easy to operate, pedagogically relevant, visually engaging, and effective in supporting understanding and participation. These outcomes demonstrate that Macromedia Flash-based learning media remain highly functional for vocational classroom environments, particularly where technological infrastructure is limited. The study concludes that the developed media can serve as a robust instructional tool to strengthen student motivation, improve comprehension of K3LH concepts, and enrich technology-enhanced learning in vocational electronics education. Future research is recommended to expand implementation across different school contexts and migrate the product to modern digital platforms to improve scalability and accessibility.
Interactive Multimedia Learning for Vocational Electronics Education: Development, Validation, and Classroom Implementation Marzalius, Lira Rahma; Jasril, Ilmiyati Rahmy
Journal of Hypermedia & Technology-Enhanced Learning Vol. 4 No. 1 (2026): Journal of Hypermedia & Technology-Enhanced Learning—Future Education
Publisher : Sagamedia Teknologi Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58536/j-hytel.210

Abstract

This study presents the design, development, and empirical evaluation of an interactive multimedia learning application for basic electronics instruction in vocational education. To address persistent challenges such as passive learning, limited conceptual understanding, and low learner engagement, the research employed the 4D (Define, Design, Develop, and Disseminate) development model to create a digital learning environment in Adobe Animate. The application integrates dynamic animations, vector-based visualizations, explanatory text, and embedded interactive assessments to support conceptual change and active learning. Content and media validity were assessed through expert evaluations from subject-matter and instructional media specialists, while usability and practicality were examined through field tests involving Grade X students in an Audio-Video Engineering program. The findings show high levels of content accuracy, pedagogical alignment, and interface usability. Practicality results indicate strong learner acceptance, intuitive navigation, and consistent engagement during classroom implementation. Observational and questionnaire data reveal positive effects on students’ learning motivation and participatory behaviors. This study provides empirical evidence of the pedagogical value of interactive multimedia for competency-based technical education and offers a replicable development framework for integrating digital learning media in vocational settings. The findings hold practical and theoretical implications for educators, curriculum designers, and policymakers seeking to improve learning quality in technology-oriented vocational education.
Synthesıs and in Sılıco Studıes of 1,3,5-Trıaryl-2-Pyrazolıne Derıvatıves Contaınıng Chloro Substıtuent and Pyrrolıdıne Moıety Jasril, Jasril; Iktiarudin, Ihsan; Ulhukmi, Nisa; Novianty, Riryn; Syaifullah, Mhd Muslim; Frimayanti, Neni
Molekul Vol 21 No 1 (2026)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2026.21.1.11084

Abstract

ABSTRACT. Pyrazoline is a well-known group of five-ring heterocyclic compound containing two nitrogen atoms that has a wide range of promising biological activities. The aim of this research is to synthesize 1,3,5-triaryl-2-pyrazoline derivatives with chloro substituent and pyrrolidine moiety and to explore their potency as inhibitors for cervical cancer. The synthesis was performed through three-steps reactions. Firstly, synthesis of chlorinated naphthalenyl chalcones through Claisen-Schmidt condensation. Secondly, synthesis of chlorinated naphthalenyl pyrazolines through nucleophilic addition of phenylhydrazine to the chalcone and followed by intramolecular cyclization. Thirdly, synthesis of pyrazoline derivatives by adding the pyrrolidine moiety through O-alkylation reaction. Then, the in silico studies through molecular docking, ADME profiling, and toxicity prediction were performed to explore the potency of the synthesized compounds as inhibitors of cervical cancer by inhibiting the activity of Sirtuin-1 (SIRT-1) (PDB ID: 4I5I). The structure of all pyrazoline derivatives (4a-4c) were confirmed by spectroscopic analysis including UV, FT-IR, HRMS, and NMR. Based on the docking study, compound 4a with binding free energy of -12.59 kcal/mol exhibited better potency as SIRT-1 inhibitor than previously reported inhibitor (EX527). Then, based on the ADME profiling and toxicity prediction, it can be concluded that compound 4a exhibited reasonable drug properties with low toxicity potency (predicted LD50 = 1000 mg/kg). Keywords: : Cervical cancer, molecular docking, pyrazoline-pyrrolidine, pyrazoline synthesis, sirtuin-1
Profil Sitotoksik ekstrak Lithocarpus bancanus dan Fraksinya Terhadap Lini Sel Kanker Paru-Paru A549 Teruna, Hilwan Yuda; Hendra, Rudi; Lestari, Retno Puji; Nugroho, Titania Tjandrawati; Saryono, Saryono; Jasril, Jasril; Almurdani, Muhammad; Abdulah, Rizky
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.128

Abstract

Lithocarpus bancanus is a medicinal plant used by communities in Riau Province, Indonesia. This plant is a tree locally known in the province as mempening. In this study, the cytotoxic activity profiles of the methanolic extract, n-hexane fraction, dichloromethane fraction, and ethyl acetate fraction from L. bancanus leaves were evaluated against human lung cancer cells (A549 cell line) using the MTT assay. IC₅₀ values were calculated from dose–response curves analyzed using the 4-parameter logistic (4PL) model. The results showed IC₅₀ values of 455.1, 361.9, 132.9, and 304.7 µg/mL for the methanolic extract, n-hexane fraction, dichloromethane fraction, and ethyl acetate fraction, respectively, with the dichloromethane fraction exhibiting relatively higher cytotoxic activity (IC₅₀ = 132.9 µg/mL). Cisplatin was used as the positive control and showed an IC₅₀ of 103.9 µg/mL. Meanwhile, the methanolic extract as well as the n-hexane and ethyl acetate fractions showed low cytotoxic activity, with IC₅₀ values greater than 300 µg/mL. Therefore, the dichloromethane fraction can serve as a basis for further isolation to identify bioactive anticancer compounds.
Pengaruh Model Pembelajaran Problem Based Learning Berbantuan Baamboozle terhadap Hasil Belajar Siswa pada Mata Pelajaran Informatika di Kelas XI SMA Negeri 2 Padang Panjang Salsabiela, Fadhilla; Marta, Rizkayeni; Jasril, Ilmiyati Rahmy; Zaus, Mahesi Agni
TSAQOFAH Vol 5 No 6 (2025): NOVEMBER
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/tsaqofah.v5i6.7753

Abstract

The issue of low student learning outcomes, particularly in Informatics subjects, remains a challenge in school-based learning processes. One potential solution is the use of instructional models that enhance student engagement, understanding, and motivation. This study aims to examine the effect of implementing the Problem Based Learning (PBL) model assisted by Baamboozle on students’ learning outcomes in Informatics at Grade XI of SMA Negeri 2 Padang Panjang. A quantitative method with a quasi-experimental design, specifically the Nonequivalent Control Group Design, was employed. The study population included all Grade XI students, with a sample of 72 students divided equally into an experimental class (36 students) and a control class (36 students). Data were collected through learning outcome tests and statistically analyzed. The results showed that the average post-test scores of the experimental class were higher than those of the control class. Data analysis confirmed a significant effect of the PBL model assisted by Baamboozle on the improvement of Informatics learning outcomes. These findings suggest that combining problem-based learning with educational game media such as Baamboozle can create a more engaging and interactive learning environment, positively impacting students’ academic achievement.
Synthesis and Molecular Docking Assay of 2-(3-3,4-dimethoxyphenyl)-6-oxopyridazin-1(6H)-yl)acetohydrazide as a candidate for breast anticancer Shalihah, Putri Mar Atus; Zulmy, Winda Permata; Hendra, Rudi; Jasril, Jasril
Photon: Jurnal Sain dan Kesehatan Vol. 16 No. 1 (2025): Journal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v16i1.9167

Abstract

Pyridazinones are a class of heterocyclic compounds with broad biological activities, one of which is as an anticancer. This study synthesized N-acetohydrazide substituted pyridazinone derivatives and evaluated their potential as breast cancer therapy through molecular docking studies. The target compound, 2-(3-(3-methoxyphenyl)-6-oxopyridazine-1(6H)-yl)acetohydrazide(3), was synthesized through three reaction steps: condensation to form the pyridqzinone core, functionalization of ethyl chloroacetate at the nitrogen position, and substitution of the ethoxy group with hydrazine hydrate. The yield obtained was 48.14%. The purity of the synthesized compound was confirmed through melting point determination and high-performance liquid chromatohraphy (HPLC) analysis, which showed a single dominant peak. Structural elucidation using Fourier-transform infrared (FTIR), mass spectrometry (MS), proton nuclear magnetic resonance (1H-NMR), and carbon-13 nuclear magnetic resonance (13C-NMR) verified the expected structure.  Molecular tethering studies against tyrosine kinase (PDB ID: 3ERT) showed that compound (3) has a binding free energy of -7.93 kcal/mol, with two hydrogen bonds formed with residues Glu353 and Leu387. These results indicate that compound (3) has not shown better inhibitory activity than tamoxifen. Nonetheless, this compound fulfils good physicochemical characteristics based on Lipinski's rule, so it remains promising for further development.
Co-Authors - Aisyah - Nurlaili -, Sulismayati Abdul Aziz Adel Zamri Adel Zamri Afrita, Indra agistia, nesa Ahmad Fauzan Aisyah Aisyah Aisyah, - Akbar, Unggul Al Fiqri, M. Faiz Alfarabi.B, Alif Ananda, Sherly Anggita, Anggi Fisi Anori, Sartika Aprilia, Tasya Asmawati Asmawati Ayasrah, Firas Tayseer Baehaqi Bintal Amin Christine Jose Christine Jose Dampang, Hasria Darian Alfatos Delsina Faiza Denai Wahyuni Denai Wahyuni Desviana, Laila Dewi, Erna Puspita Elin Haerani Elka Yuslinda Elvia Budianita Elviyenti, Elviyenti Fadhilah Syafria Faladhin, Johan Fatila, Mutia Fauzi, Faradiba Kamilia Fawrin, Heralda Febi Yanto Fernando, Rivan Fiffah, Chainul Firmathoina, Aisyah Fitri Insani Fitria Novitasari Frischa Meivilona Yendi Gusti, Siska Kurnia Haiyul Fadhli Hamersat, Danu Hardiansyah, Muhammad Vio Haresman, Haresman Hariansyah, Jul Hasmalina Nasution Hendra, Rudi Hilwan Yuda Teruna Hurria, Hurria Ihsan Ikhtiarudin Iis Afrianty Ika Parma Dewi Ikhtiaruddin, Ihsan Iktiarudin, Ihsan Illahi, Ridho Indah Wulandari Insani (Scopus ID: 57190404820), Fitri Işık, Kenan Isnaniar Iswantir M Jufrizal Syahri Laila Desviana Lazulva Lazulva, Lazulva Lestari Handayani Lestari, Retno Puji Lisa Utami M Almurdani Mahesi Agni Zaus Mar'arif, Muhammad Mulky Marta, Rizkayeni Marzalius, Lira Rahma Masykur Hz Masykur HZ Muhammad Affandes Muhammad Irsyad Muhdarina Muhdarina Muhdarina Muliani, Sarifah Muslim Syaifullah, Mhd Nazir, Alwis Nazruddin Safaat H Negara, Benny Sukma Neni Frimayanti Nofirda, Fitri Ayu Novianty, Riryn Nuraini Ramadhani Nurhayati Nurlaili Nurlaili Nurlaili, - Nurwijayanti Oktavia, Lola Pranata, Joni Prasetya Prasetya, Prasetya Putra, Ade Herdian Putra, Rido Putri, Atika Putri, Rahmayani Indah Rahayu, Anggi Putri Rahma Dona Rahmadini Syafri Rahmiwati Hilma Ramadhani, Eka Ramadhani, Siti Ramadhanti, Aulia Rizki Retno Hidayati Rizky Abdulah Rudi Hendra Salsabiela, Fadhilla Sardi, Hajra Sari, Meidita Kemala Sari, Nila Puspita Saryono Saryono Shalihah, Putri Mar Atus Silvera Devy Siregar, Alfi Salimah Siregar, Sri Hilma Siregar, srihilma Soeci Izzati Adlya Sofyan Husein Siregar Sulismayati - Surya Agustian Suwanto Sanjaya Sya'ban, Andrian Nur Syaifullah, Mhd Muslim Thamrin Titania Tjandrawati Nugroho Tri Windarti Tri Windarti Tria Harlianti Triana, Yeni Ulhukmi, Nisa Veithzal Rivai Zainal Wan, Xue Wenni, Osriza Wulan Sari, Wulan Yan Guspriadi Yasthophi, Arif Yeni, Wila Mutiara Yuana Nurulita Yuca, Verlanda Yuharmen - Yum Eryanti Yuni Fatisa Zadrian Ardi Zahra, Fadhila Az Zahri, Firman Zikra, Nadila Zulmy, Winda Permata `Nasution, Hasmalina