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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) PROSIDING SEMINAR KIMIA INDONESIAN JOURNAL OF PHARMACY Jurnal Penelitian Sains Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Syntax Literate: Jurnal Ilmiah Indonesia PENDIPA Journal of Science Education JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Kesehatan Jurnal Pendidikan dan Konseling Contagion: Scientific Periodical Journal of Public Health and Coastal Health Syntax Idea Jurnal Ners Jurnal Riset Kefarmasian Indonesia Jurnal Farmagazine Bioscientist : Jurnal Ilmiah Biologi Daengku: Journal of Humanities and Social Sciences Innovation Jurnal Info Sains : Informatika dan Sains Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Sciences of Pharmacy Jurnal Sosial dan Sains Sanskara Ekonomi dan Kewirausahaan Jurnal Farmasi Indonesia Parapemikir Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Natural Product for Degenerative Diseases
Shirly Kumala
Universitas Pancasila
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
n-Butanolic fraction of endofitic fungi of Buah Makasar increases apoptotic effect of doxorubicin on MCF-7 cells Kumala, Shirly
Indonesian Journal of Pharmacy Vol 20 No 1, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm0iss0pp42-47

Abstract

Makassar fruit, Brucea javanica (L.) Merr., showed chemopreventive activity. Secondary metabolites come from B. javanica fruit, brucatol and bruceantine, induced cell differentiation and apoptosis on Leukemia cell, while quassinoid and its derivates acted as antitumor promoter. Butanolic fraction of supernatan of endofitic fungi 1.2.11 isolate fermentation which isolated from B. javanica fruit showed cytotoxycity toward several cancer cells. This fraction has been predicted contain secondary metabolites from B. javanica and has been identified as Bruceosin and Canthin-6-one derivates. Butanolic fraction (FB) of supernatan from endofitic fungi 1.3.11 isolate fermentation is predicted for having similiar cytotoxycity as active as 1.2.11 isolate. This research is aimed to explore cytotoxycity potention and apoptosis induction of BF from 1.3.11 isolate and combination effect of BFdoxorubicinon MCF-7 breast cancer cell.Synergism of BF-doxorubicin combination detect from cell viability inhibition and apoptosis induction on MCF-7, a breast cancer cell lines which shows resistancy toward doxorubicin. Cell viability on single treatment of FB and doxorubicin and its combination were carried out by MTT assay to determine IC50 and combination index (CI). Apoptosis induction of FB, doxorubicin and its combination were carried out by ethidium bromideacridine orange DNA staining.n- Butanolic fraction and doxorubicin showed cell viability inhibition on MCF-7 cell with IC50 48 μg/mL dan 148 nM, respectively. Both of FB and doxorubicin showed apoptosis induction on IC50. Combination of FBdoxorubicin showed synergism and increased apoptosis induction on MCF-7cell.Key words: Brucea javanica, endofitic fungi, MCF-7 cell, synergism, doxorubicin.
Co-Authors . Desi . Suhaimi . Syamsudin . Yuliani Abdul Aziz Setiawan Adini, Syilvi Ahmad Subhan Aji, Nur Anwar Wahyudi Anwar, Yelfi Ariyani Kiranasari Ariyani Kiranasari Armansyah, Septiyana Lia Atut Ruswita Aulena, Desi Nadya Ayuditiawati, Meita Bekti, Novi Dyah Purnama Bekti, Novi Dyah Purnama Datubara, Martaulina Elisabet Delina Hasan Deni Rahmat Dian Indriani Dian Ratih L. Didik Tulus Dimas Adrianto Dosi Ahmad Yani Dwi Aryanti, Anindita Dwi Fitriyani, Dwi Dwi Hapsari Juniarti Dwi Windi Sapitri Elvina Dhiaul Iftitah Erlita Agustina Esti Mumpuni Esti Mumpuni, Esti Fachry Abda El Rahman Farida, Yunahara FARIDAH Febbyasi Megawaty Gabriel Gabriel Gabriel, Gabriel Gandes Winarni Gumilar Adhi Nugroho Halim, Marta Hasan, Delina Herru Setiawan Hersunaryati, Yetti Heru Santosa Heru Santosa Hery Prambudi Hesty Utami Hesty Utami R Huda, Badrul I Ketut Suada Iha Haryani Hatta Indarwati Indarwati Kurota Aini Lea P. Retnoningsih Leonardus B.S. Kardono Lestari Rahayu Mardiastuti, . Mardiastuti, . Marlin M. Raunsai Mochtar, Dede Mochtar, Dede Nancy Dewi Yuliana Nancy Raisa Nancy Raisa, Nancy Noor, Laili Savitri Nur Aji Nurmaini Nurmaini Partomuan Simanjuntak Partomuan Simanjuntak Pasanema, Dimas A. M. Pasanema, Dimas A. M. Pasaribu, Rita Kristina Pieter Hazmen Pratama, Anton Pratiwi Pujilestari Sudarmono Prih Sarnianto Priyo Wahyudi R, Hesty Utami Rachmani, Rum Rachmani, Rum RAHMAT, DENI Raihan, Dany Ramadaniati, Hesty Utami Restu Restiani Reubun, Yonathan Tri Atmodjo Reza Agung Sriwijaya Risma Marisi Tambunan, Risma Marisi Rita Kristina Pasaribu Robert Utji Rochimah Ros Sumarny RR. Ella Evrita Hestiandari Ruskar, Dandung Sarnianto, Prih Saru Noliqo Rangkuti Sembiring, Rinawati Sesilia A. Keban Sesilia Andriani Keban Setiadi, Feri Setiyarini, Setiyarini Shanny, Fransisca Shanny, Fransisca Simanjuntak, Partomuan Siswa Setyahadi Siswa Setyahadi Siti Jabal Mastura Sofyan Ramani Sri Widyastuti Stiani, Sofi Nurmay Sugiastuti, Fenty Suhaimi Suhaimi Suhaimi, . Syarifah Aini Teti Indrawati Umilawati Rawi Utami R, Hesty Violeta, Violeta Wahyudi Uun Widiyastuti, Asih Yati Sumiyati, Yati Yusransyah, Yusransyah Zaidan, Sarah