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In Silico and In Vitro Antibiofilm Activity of Zingiber montanum Ethyl Acetate Fraction Against Propionibacterium acnes: Antibiofilm of Zingiber montanum Aji, Nur; Kumala, Shirly; Mumpuni, Esti; Rahmat, Deni
Journal of Tropical Life Science Vol. 15 No. 1 (2025)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/

Abstract

Propionibacterium acnes (P. acnes), a symbiotic bacterium involved in the development of acne, is recognized for its capacity to develop resistance due to its ability to generate biofilms. According to a previous investigation, the ethyl acetate fraction derived from Zingiber montanum exhibited anti-bacterial properties against P. acnes. Nevertheless, the causative role of biofilm formation in its resistance was not previously recognized. This study aims to ascertain the antibiofilm efficacy using in silico and in vivo methodologies. In this study, in silico examination utilized molecular docking to inhibit the quorum sensing mechanism by blocking the autoinducer 2 (AI-2) signal. The target protein was AI-2 binding periplasmic protein LuxP (PDB code: 4YRZ). Following that, an in vitro test was conducted using the crystal violet staining method, which was read using a microplate reader at a wavelength of 600 nm. The readings were expressed as percent inhibition and IC50. The in silico results showed that there were six compounds in the ethyl acetate fraction that have the potential to inhibit AI-2 signaling. Curcumin showed the highest inhibitory activity. Meanwhile, the in vitro results revealed that the ethyl acetate fraction of Z. montanum obtained the minimum biofilm inhibitory concentration (MBIC) of 2.5 % (w/v) and IC50 = 0.28 % (w/v). It can be concluded that the ethyl acetate fraction of Zingiber montanum could inhibit the biofilm formation of P. acnes.  
Co-Authors . Desi . Suhaimi . Syamsudin . Yuliani Abdul Aziz Setiawan Adefira Elisyia Juniharti Adini, Syilvi Afrini Saraswati Agan Syahrial Agung Dewantoro Ahmad Subhan Aji, Nur AMEILIA AMEILIA Anarisa Budiati Andri Prasetiyo Andria Agusta Andrianopsyah Mas Jaya Putra Anggelina Aprilia Pangalila Anggi Isnaasar Anny Victor Purba Anwar Wahyudi Anwar Wahyudi Anwar, Yelfi Ariyani Kiranasari Ariyani Kiranasari Armansyah, Septiyana Lia Asnah Tarigan Atut Ruswita Atut Ruswita Handayani Aulena, Desi Nadya Aulia Tisna Dewi Ayuditiawati, Meita Bekti, Novi Dyah Purnama Bekti, Novi Dyah Purnama Carrista Carrista Dandung Ruskar Datubara, Martaulina Elisabet Delina Hasan Deni Rahmat Desi Nadya Aulena Devana Devana Dewi Laxmi Diah Dethriani Dian Indriani Dian Ratih L. Dian Ratih Laksmitawati Didik Tulus Didik Tulus Dimas Adrianto Dimas Adrianto Dosi Ahmad Yani Dwi Aryanti, Anindita Dwi Fitriyani, Dwi Dwi Hapsari Juniarti Dwi Windi Sapitri Dwi Windi Sapitri EDY MEIYANTO Elvina Dhiaul Iftitah Elvina Dhiaul Iftitah ENDRO BUDI SISWANTO Erlita Agustina Erlita Erlita Esti Mumpuni Esti Mumpuni Esti, Esti Fachry Abda El Rahman Farida, Yunahara Faridah Faridah Fauzi Setyo Fandheo Fauzia Noprima Okta Febbyasi Megawaty Gabriel Gabriel Gabriel, Gabriel Gandes Winarni Gumilar Adhi Nugroho Halim, Marta Hasan, Delina Herru Setiawan Hersunaryati, Yetti Heru Santosa Heru Santosa Hery Prambudi Hesty Utami Hesty Utami Hesty Utami R Huda, Badrul I Ketut Suada I. G.A. Ayu Wiratih Iha Haryani Hatta Iha Haryani Hatta Indah Masri Indarwati Indarwati Khairunnisa Tamimi Kurota Aini Laili Savitri Noor Lea P. Retnoningsih Leonardus B.S. Kardono Lestari Rahayu Lies Putriana Lilik Sulastri Mardiastuti, . Mardiastuti, . Marlin M. Raunsai Meiyanto, Edy Meva Sari Chandra Miftahurrohmah, Nur Mochtar, Dede Mochtar, Dede Mulatsari, Esti Muthi Ikawati Nancy Dewi Yuliana Nancy Dewi Yuliana Nancy Raisa Nancy Raisa, Nancy Noor, Laili Savitri Noviyantih, Noviyantih Nur Aji NUR ANNISA FITRI Nurmaini Nurmaini Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Pasanema, Dimas A. M. Pasanema, Dimas A. M. Pasaribu, Rita Kristina Peny Budiarti Pieter Hazmen Pratama, Anton Pratiwi Pujilestari Sudarmono Prih Sarnianto Prih Sarnianto Priyo Wahyudi Qodriah, Rahmatul R, Hesty Utami Rachmani, Rum Rachmani, Rum RAHMAT, DENI Raihan, Dany Ramadaniati, Hesty Utami Raymond R. Tjandrawinata Reise Manninda Restu Restiani Reubun, Yonathan Tri Atmodjo Reza Agung Sriwijaya RIRIS ISTIGHFARI JENIE Risma Marisi Tambunan, Risma Marisi Rita Kristina Pasaribu Robert Utji Rochimah Ros Sumarny RR. Ella Evrita Hestiandari Ruskar, Dandung S.Farm., M.Farm., Apt, Sondang Khairani Sarah Zaidan Sarnianto, Prih Saru Noliqo Rangkuti Sembiring, Rinawati Septisetyani, Endah Puji Sesilia A. Keban Sesilia Andriani Keban Sesilia Andriani Keban Setiadi, Feri Setiawan, Abdul Aziz Setiyarini, Setiyarini Shanny, Fransisca Shanny, Fransisca Simanjuntak, Partomuan Siswa Setyahadi Siswa Setyahadi Siswa Setyahadi Siswa Setyahadi Siswa Setyahadi Siti Jabal Mastura Sofyan Ramani Sri Widyastuti Stiani, Sofi Nurmay Sugiastuti, Fenty Suhaimi Suhaimi Suhaimi, . Syamsudin Syamsudin Syarifah Aini Syarmalina Syarmalina Teti Indrawati Teti Indrawati Umilawati Rawi Utami R, Hesty Violeta, Violeta Vyacheslav Dushenkov Wahyudi Uun Wibowo Mangunwardoyo Wida Feriningsih Widiyastuti, Asih Yati Sumiyati, Yati Yetti Hersunaryati Yonathan Atmodjo Reubun Yun Astuti Nugroho Yuniarto, Ari Yusransyah, Yusransyah