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All Journal Jurnal Kebidanan Journal on Mathematics Education (JME) KES Jurnal Prima Edukasia Briliant: Jurnal Riset dan Konseptual Journal of Development Research Edukasi Islami: Jurnal Pendidikan Islam Jurnal Epidemiologi Kesehatan Komunitas Martabe : Jurnal Pengabdian Kepada Masyarakat Jiko (Jurnal Informatika dan komputer) Jurnal Basicedu Jurnal Ilmiah Fillia Cendekia JURNAL PENDIDIKAN MATEMATIKA ACITYA Journal of Teaching & Education Ina Kidney Jurnal Riset Pendidikan dan Inovasi Pembelajaran Matematika (JRPIPM) Jurnal Pengabdian Dharma Bakti Mosharafa: Jurnal Pendidikan Matematika Jurnal Pengabdian dan Pemberdayaan Nusantara (JPPNu) Journal of Science Nusantara The Journal of Palembang Nursing Studies Anoa: Journal of Animal Husbandry Jurnal Basicedu Medika Respati : Jurnal Ilmiah Kesehatan Jurnal Pengabdian Masyarakat Bangsa Jurnal Pembelajaran dan Riset Pendidikan Jurnal Pendidikan MIPA
Lestariningsih Lestariningsih
STKIP PGRI Sidoarjo
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Journal : Ina Kidney

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Vitamin D Insufficiency with Elevated ADMA and hs-CRP: A Single-center Study of Chronic Kidney Disease Patients Undergoing Hemodialysis Lusito, Lusito; Lestariningsih, Lestariningsih; Partiningrum, Dwi Lestari; Chasani, Shofa; Arwanto, Arwedi; Nurani, Ayudyah; Makarim, Fadhli Rizal
Indonesian Journal of Kidney and Hypertension Vol 1 No 2 (2024): Volume 1 No. 2, August 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i2.134

Abstract

Background: Vitamin D deficiency is a common issue among patients with chronic kidney disease (CKD) due to its ability to convert vitamin D into the active form of calcitriol, which is crucial for controlling cell inflammation. Low vitamin D levels are associated with increased inflammation and higher levels of biomarkers such as c-reactive protein and asymmetric dimethylarginine as an endogenous inhibitor of nitric oxide synthase. Those two combined become a specific marker for cardiovascular diseases, which become one of the common causes of CKD mortality. Objective: This study examines the correlation between vitamin D insufficiency, elevated high-sensitivity c-reactive protein, and asymmetric dimethylarginine in CKD patients receiving hemodialysis. Methods: This study used a cross-sectional design of CKD patients receiving hemodialysis in Dr. Kariadi Central General Hospital, Semarang, Indonesia, in November 2021. Thirty-six patients were randomly enrolled after meeting inclusion and exclusion criteria. Primary outcomes of Vitamin D, hs-CRP, and ADMA were measured from patients’ blood after hemodialysis. A statistical analysis of Pearson's correlation was used for primary outcomes. Results: No significant difference was found in the patient's baseline characteristics. A significant correlation between vitamin D and ADMA has been found; however, no correlation between vitamin D and hs-CRP has been found Conclusion: Vitamin D deficiency is correlated with elevated ADMA, indicative of endothelial dysfunction.
Association Between Intradialysis Hypotension and Interdialytic Weight Gain in Deceased Hemodialysis Patients at Banyumas Regional General Hospital Poernomo, Gigih Rahmandanu; Partiningrum, Dwi Lestari; Lestariningsih, Lestariningsih; Nurani, Ayudyah; Arwanto, Arwedi; Chasani, Shofa; Alatas, Haidar
Indonesian Journal of Kidney and Hypertension Vol 2 No 1 (2025): Volume 2 No. 1, April 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i1.178

Abstract

Background: Intradialytic hypotension (IDH) occurs in 5-40 percent of chronic kidney disease (CKD) with hemodialysis patients, it is associated with increased cardiovascular events and mortality. High Interdialytic Weight Gain (IDWG) requires higher ultrafiltration, increases the incidence of IDH, associated with a worse prognosis, patients with a history of diabetes are at higher risk. Objective: This study aimed to assess the association between IDWG and the occurrence of IDH in deceased patients undergoing hemodialysis, with a particular focus on the differences between diabetic and non-diabetic patients Methods: A retrospective study was conducted for one year at Banyumas Regional General Hospital, involving deceased hemodialysis patients. IDWG was calculated as the average of the last three hemodialysis sessions. Patients were further categorized based on their history of diabetes. Results: Among 37 deceased hemodialysis patients, 56.8% experienced IDH, including 50% of those with diabetes mellitus. IDWG was normally distributed (p = 0.283) and showed a weak but statistically significant correlation with IDH (r = 0.333, p = 0.044). Logistic regression indicated that each 1% increase in IDWG was associated with an 8% increase in the predicted probability of IDH. Diabetic status did not significantly modify this association (p = 0.772). Conclusion: Higher IDWG was associated with increased incidence of IDH in deceased hemodialysis patients, independent of diabetic status.
The Effect of Hemodialysis Adequacy on Inflammatory Status in Stage 5 Chronic Kidney Disease Patients Winarto, Dedi; Partiningrum, Dwi Lestari; Lestariningsih, Lestariningsih; Nurani, Ayudyah; Arwanto, Arwedi; Chasani, Shofa
Indonesian Journal of Kidney and Hypertension Vol 2 No 2 (2025): Volume 2 No. 2, August 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i2.183

Abstract

Background: Chronic Kidney Disease (CKD) is a critical global health issue, particularly Stage 5 CKD, where kidney function is severely impaired. Hemodialysis, essential for managing such patients, aims to remove waste and excess fluids. Chronic inflammation, common among CKD5-HD patients, heightens cardiovascular risks and worsens quality of life. Hemodialysis adequacy, measured by the Kt/V ratio, plays a vital role in outcomes, yet its relationship with inflammatory markers, such as Hs-CRP, albumin, and TIBC, remains unclear. Objective: This study aimed to evaluate the relationship between hemodialysis adequacy, as reflected by Kt/V values, and inflammatory markers such as c-reactive protein (CRP), albumin, and total iron binding capacity (TIBC) in CKD stage 5 patients undergoing hemodialysis, providing insights into optimizing dialysis protocols to mitigate inflammation. Methods: A cross-sectional study of 45 CKD5-HD patients assessed Kt/V values and inflammatory markers (Hs-CRP, albumin, TIBC). Data were analyzed using Shapiro-Wilk, Independent t-tests, or Mann-Whitney U tests based on data distribution. Results: The mean Kt/V value was 1.31 ± 0.21. Lower Kt/V values were significantly associated with elevated Hs-CRP levels (p = 0.018). No significant differences in Kt/V values were observed concerning albumin (p = 0.546) or TIBC (p = 0.523). Correlations between Hs-CRP and albumin or TIBC were non-significant (p = 1.000). Conclusion: Adequate hemodialysis, reflected in optimal Kt/V values, is crucial for reducing systemic inflammation marked by Hs-CRP. Albumin and TIBC levels showed no significant association, underscoring the multifactorial nature of inflammation in CKD5 patients.
Co-Authors Abd. Syakur Afrilia, Tika Fitria Wulan Afroh Fauziah Agung, Fajar Agung Agus Edi Winarto, Agus Edi Agus Mulyanto Setiawan, Agus Mulyanto Ahmad Saifudin, Ahmad Alatas, Haidar Alfin, Chairumin Amin, Ahmad Makinul Anifiatiningrum, Anifiatiningrum Anna Lidiyawati Anshori, M Subhan Anshori, Subhan Arbi, Anggun Purnomo Arwanto, Arwedi Atallah, Mukhammad Tsafiq Bachtiar, Aldo Tri Bintarti, Lilik Cahyaningrum, Elaesa Putri Indah Cholida, Nur Darmawijoyo, Darmawijoyo Dwi Lestari Partiningrum Eli Ermawati Fadilah, Eka Fareza, Mohamad Zulfahmi Al FATRA NONGGALA PUTRA Fauzi, Moh Mimbar Fauzi, Moh. Mimbar Fikriyah, I'anah El Firdaus, Iftinan Nida Hakim, Muhammad Helmi Hartanto, Wido Heri Nugroho Huda, H.M. Dimyati Imam Muchlisin, Mochammad Imam Rofiki Irwani Zawawi Kasanah, Risa Datul Khasanah, Ani Uswatun Khopsoh, Binti khusnul khotimah Kusyanti, Florentina Lailatul Musyarofah, Lailatul Lailatul, Oxsy Lestari, Febbi Senna Lestari, Indah Dewi Lilik Bintartik Lusito, Lusito M. Ridwan M. Zainuddin Mahanani Nugroho, Setyo Mahmudah Mahmudah Makarim, Fadhli Rizal Makrifah, Anisatul Marselina Endah Hiswati Maulidah, Nita Safitri Mere, Jeniati Inka Jaka Moch. Lutfianto Mohammad Zainuddin, Mohammad Muashomah, Muashomah Muhammad Anwar Muhammad Zainuddin Mulyono, Enggal Chairyadi Munawar Munawar Murtadho, Ahmad Rizqi Muti'atussalafi, Muti'atussalafi Mu’minin, Umril Nahdiyah, Umi Nining Haryuni Nisa, Zulfatun Nona, Murtiliana Nurani, Ayudyah Okinarum, Giyawati Yulilania Oktaviani, Fransiska Sela Poernomo, Gigih Rahmandanu Putra, Fatra Nongala Putri, Marsanda Avilia Ramila, Audiza Asssyifa Ramila, Audiza Assyifa Ratu Ilma Indra Putri Rika Mellyaning Khoiriya Rini, Sulistio Risdiana Chandra Dhewy, Risdiana Chandra Rizqita, Ayomi Rosidah, Hidayatul Sapariyah, Sapariyah Selamat Budijitno Setianingtyas, Hetty Eka Setyo Mahanani Nugroho Shofa Chasani Sri Rahyuni Sri Suryanti Sudiyatmi, Sudiyatmi Suharyo Hadisaputro Sulaksono, Anang Catur Sulistyaningsih Sulistyaningsih SURAYANAH . Syarifudin, Aris Tholibin, Muhamad Sirojut Tri Nur Kristina Tricahyo, Vion Age Ulfa Niswatul W. Utami, J. Nugrahaningtyas Wagimun, Wagimun Wahyu Hidayati wahyuni, kenik sri Winarto, Dedi Winurdana8, Alfan Setya Yohannes Kurniawan Barus Yuliani, Istri Zainuddin, M Zainudin, M Zainudin, Mohammad