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All Journal International Journal of Evaluation and Research in Education (IJERE) Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Pendidikan Sains Biogenesis: Jurnal Ilmiah Biologi Biotropika Proceeding International Conference on Global Resource Conservation Jurnal Pendidikan Biologi Indonesia Biology, Medicine, & Natural Product Chemistry Mutiara Medika: Jurnal Kedokteran dan Kesehatan Bioeksperimen: Jurnal Penelitian Biologi Journal of Tropical Biodiversity and Biotechnology Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Jurnal Pendidikan Biologi BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Penelitian Pendidikan IPA (JPPIPA) BIOEDUKASI Biosfer: Jurnal Pendidikan Biologi Saintifik : Jurnal Matematika, Sains, dan Pembelajarannya Jurnal Jamu Indonesia Bio-Inoved : Jurnal Biologi-Inovasi Pendidikan JPPIPA (Jurnal Penelitian Pendidikan IPA) JPP (Jurnal Pendidikan dan Pembelajaran) Prosiding Seminar Nasional Biologi, Teknologi dan Kependidikan (Biotik) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal PRIMED:Primary Education Journal atau Jurnal Ke-SD An Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Jurnal Kedokteran Hewan Jurnal Ilmu Hayat Indonesian Journal of Jamu

Betty Lukiati

Universitas Negeri Malang

Author-ID : 309378

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Bioinformatics approach based research of profile protein carbonic anhydrase II analysis as a potential candidate cause autism for the variation of learning subjects biotechnology Dian Eka A. F. Ningrum; Mohamad Amin; Betty Lukiati
JPBI (Jurnal Pendidikan Biologi Indonesia) Vol. 3 No. 1 (2017): MARCH
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/jpbi.v3i1.3799

This study aims to determine the needs of learning variations on Biotechnology courses using bioinformatics approaches. One example of applied use of bioinformatics in biotechnology course is the analysis of protein profiles carbonic anhydrase II as a potential cause of autism candidate. This research is a qualitative descriptive study consisted of two phases. The first phase of the data obtained from observations of learning, student questionnaires, and questionnaires lecturer. Results from the first phase, namely the need for variations learning in Biotechnology course using bioinformatics. Collecting data on the second stage uses three webserver to predict the target protein and scientific articles. Visualization of proteins using PyMOL software. 3 based webserver which is used, the candidate of target proteins associated with autism is carbonic anhydrase II. The survey results revealed that the protein carbonic anhydrase II as a potential candidate for the cause of autism classified metaloenzim are able to bind with heavy metals. The content of heavy metals in autistic patients high that affect metabolism. This prediction of protein candidate cause autism is applied use to solve the problem in society, so that can achieve the learning outcome in biotechnology course.

Quercetin: the bioactive compound from Allium cepa L. as anti-inflammation based on in silico screening Mohamad Amin; Kurniawan Setia Putra; Ihya Fakhrurizal Amin; Nanda Earlia; Dina Maulina; Betty Lukiati; Umie Lestari
Biology, Medicine, & Natural Product Chemistry Vol 7, No 1 (2018)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Inflammation is a tissue injury that occurs due to physical trauma or microbiological substances that involve the activities of many cell types. Inflammation can be prevented using the natural medicines from Allium cepa L. Quercetin is one of the bioactive compounds found in Allium cepa L and has been reported to have anti-inflammatory activity. The natural medicines have been used to minimize non-steroidal anti-inflammatory drugs. This study aims to investigated the modeling structures and the protein receptor from quecertin in inflammation mechanism and their optimization of the effectiveness in the human body. The bioinformatics tools used in this study are the database of quercetin compounds, Pubchem and Swis Target Prediction protein prediction databases, PyRx 0.8 molecular docking software, ligand docking, and binding site analysis with PyMOL and LigPlus software. The results from in silico show that quercetin compounds can interact with Muscleblind-like protein 1 target protein with a Binding Affinity minus value which is not much different from the dexamethasone compound. Dexamethason is a standart because it is a corticosteroid drug that can be used as an anti-inflammatory to reduce inflammation, allergic reactions, arthritis and other inflammatory diseases.

Senyawa Alami Bawang Putih Tunggal sebagai Inhibitor LpxC Bakteri Pseudomonas aeruginosa melalui Virtual Screening Nur Fitriana; Sri Rahayu Lestari; Betty Lukiati
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 18, No 1 (2018): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.180111

Pseudomonas aeruginosa merupakan salah satu bakteri Gram negatif penyebab infeksi nosokomial yang memiliki resistensi tinggi terhadap berbagai antibiotik karena adanya lipid A, komponen LPS bersifat toksik pada inang. Sintesis lipid A dimulai dari Kdo2 -lipid A, difasilitasi oleh enzim LpxC. Enzim LpxC merupakan target pengembangan antibiotik karena adanya kofaktor Zn2+. Bawang putih tunggal merupakan herbal potensial pengganti antibiotik sintetis. Alliin, Allicin dan Ajoene yang terkandung dalam bawang putih tunggal memiliki aktivitas antibakteri. Penelitian ini bertujuan memprediksi potensi senyawa organosulfur bawang putih tunggal sebagai agen antibakteri melalui virtual screening menggunakan metode molecular docking. Metode yang dilakukan adalah memprediksi potensi senyawa organosulfur menggunakan web server PASS dan melakukan docking untuk mengetahui interaksi ligan-protein target. Hasil penelitian menunjukkan, senyawa organosulfur berpotensi sebagai antibakteri, antibiotik, dan immunomodulator. Aktivitas antibakteri terbaik ditunjukkan oleh senyawa Alliin dengan nilai afinitas pengikatan -5,2 kkal/mol. Semua senyawa organosulfur memiliki sisi aktif yang sama dengan kontrol (Ciprofloxacin dan Imipenem) pada enzim LpxC. Sisi aktif ditunjukkan dengan adanya residu asam amino (Ser295, Val182, dan Tyr 296) yang berikatan dengan ikatan hidrogen dan interaksi hidrofobik (Phe152, Phe181, Gly85, Phe176, Ala84, Val182, Ser180, Ile241, Leu86, Tyr296, Ser295 dan Met297) antara ligan-protein target.

REVIEW: PENYEBAB GANGGUAN AUTIS MELALUI JALUR NEUROINFLAMASI Alvina Putri Purnama Sari; Mohamad Amin; Betty Lukiati
Bioeksperimen: Jurnal Penelitian Biologi Vol 3, No 2: September 2017
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v3i2.5177

Autis merupakan gangguan perkembangan yang kompleks pada anak yang dipengaruhi oleh banyak faktor. Faktor penyebab autis diantaranya genetik, lingkungan, gangguan sistem imun, dan inflamasi. Inflamasi terjadi karena adanya mediator yang mengganggu kerja suatu jaringan sehingga menimbulkan respon terhadap mediator tersebut. Salah satu mediator inflamasi adalah sitokin (IL-6 dan TNF-α). IL-6 dan TNF-α dengan jumlah tinggi dalam otak mengakibatkan gangguan atau penurunan adhesi dan migrasi sel saraf yang mengakibatkan terganggunya kerja dari Blood Brain Barrier (BBB) atau sawar darah otak yang berfungsi menjaga normalitas homeostasis sistem saraf pusat. Inflamasi yang terjadi pada sel otak atau neuroinflamasi yang sudah kronis menjadi salah satu penyebab terjadinya gangguan autis pada anak.

The Role of Sechium edule Fruits Ethanolic Extract in Insulin Production and Malondialdehyde Level in Stz-Induced Diabetic Rat Betty Lukiati; Nugrahaningsih Nugrahaningsih; Siti Nur Arifah
Journal of Tropical Biodiversity and Biotechnology Vol 4, No 1 (2019): April
Publisher : Universitas Gadjah Mada

The objectives of this research were to examine the effect of Sechium edule ethanolic extract in insulin and Malondialdehyde (MDA) levels in streptozotocin (STZ) induced diabetic rats. Type 1 diabetic rat were obtained by intraperitonially injected with multiple low dose STZ (MLD-STZ) 20 mg/kgBW for 5 days. The animals were divided into 5 groups: untreated rats in group (K) were considered as negative control, MLD-STZ induced type 1 diabetic rats in group (S) were considered as positive control. In another 3 group (A, B, C) type 1 diabetic rats were orally treated with three doses of S. edule ethanolic extract (14, 28, 42 mg/kg BW) for 7 days. The animals were sacrificed in two days after last treatment, serum were collected for measuring of the insulin concentration by ELISA method. Level of MDA on kidney, liver and pancreas were measured by TBA method. The treatment with S. edule ethanolic extracts unable to increase of insulin yet but the treatment with 42 mg/kg BW of S. edule ethanolic extract showed significantly decreased MDA levels on liver but not significant on kidney and pancreas.

Developing Android-Based Mobile Learning On Cell Structure And Functions Lesson Subject Topic To Optimize Grade XI Students’ Cognitive Comprehension Muhammad Saefi; Betty Lukiati; Endang Suarsini
Jurnal Pendidikan Sains Vol 5, No 2: June 2017
Publisher : Pascasarjana Universitas Negeri Malang (UM)

Abstracts: The objective of this study is to develop an android-based mobile learning media for Cell Structure and Function lesson subject in compliance with ADDIE development mode. The developed mobile learning takes in general explanation, learning objective, animal and plant cells material explanation complemented with activities and cell exploration clip, evaluation questions, dictionary, and technical guidance. In addition, the reviews of media expert, material expert, and academicians have shown that the developed media is valid. Also, the response of students has proven that the practicality rate of the developed media is 84.65%-100% and the classical pass of Abstrl cognitive tests upon learning by way of the developed media is equal to 84.61%.Key Words: learning media, mobile learning, android system, cellAbstrak: Tujuan penelitian adalah mengembangkan media mobile learning berbasis android pada pembelajaran Struktur dan Fungsi Sel yang mengacu pada model pengembangan ADDIE. Mobile learning yang dikembangkan terdiri dari penjelasan umum, tujuan pembelajaran, pemaparan materi sel hewan dan tumbuhan yang dilengkapi aktivitas dan video jelajah sel, soal evaluasi, kamus, dan petunjuk penggunaan. Penilaian ahli media, ahli materi, dan praktisi pendidikan menunjukkan bahwa media yang dikembangkan valid. Tanggapan siswa menunjukkan bahwa tingkat kepraktisan media hasil pengem-bangan sebesar 84,65%-100% dan ketuntasan klasikal tes kognitif setelah pembelajaran menggunakan media yang dikembangkan sebesar 84,61%. Kata kunci: media pembelajaran, mobile learning, sistem android, sel

Critical Thinking Skiils and Students' Achievement on Biology Lesson using Genetic Instructional Material based on Learning Cycle 5E: A Correlational Study Muhammad Shobirin; AD. Corebima; Betty Lukiati
Jurnal Pendidikan Sains Vol 7, No 1: March 2019
Publisher : Pascasarjana Universitas Negeri Malang (UM)

Abstract: The aim of this research is to uncover correlation between critical thinking skills and student achievement and the contributions of critical thinking skills on student achievement through learning Biology using genetic teaching material that developed based on learning cycle 5E model. This research used correlational design. The population of this research was all of student grade XII-IPA at state senior high school. The sample were student of class XII-IPA3 that consist of 30 students. The result showed that there is correlation between critical thinking skills and student achievement in Biology learning using genetic teaching material that developed based on learning cycle 5E model with the regression equation Y = 0,511X–35,271. Based on the value R square analysis showed that critical thinking skills gives contribution 55,2% on student achievement.Key Words: critical thinking skills, student achievement, learning cycle 5E, genetic teaching materialsAbstrak: Penelitian ini bertujuan untuk mengetahui hubungan keterampilan berpikir kritis dengan hasil belajar siswa SMA serta sumbangan keterampilan berpikir kritis terhadap hasil belajar dalam pembelajaran Biologi menggunakan bahan ajar genetika berbasis learning cycle 5E. Rancangan penelitian yang digunakan adalah penelitian korelasional. Populasi adalah seluruh siswa kelas XII IPA di SMA Negeri. Sampel adalah siswa kelas XII IPA 3 yang terdiri dari 30 siswa. Hasil penelitian menunjukkan bahwa ada hubungan antara keterampilan berpikir kritis dengan hasil belajar siswa pada pembelajaran Biologi menggunakan bahan ajar genetika berbasis learning cycle 5E dengan persamaan regresi hubungan kedua variabel adalah Y = 0,511X – 35,271. Berdasarkan nilai R2 diketahui sumbangan keterampilan berpikir kritis terhadap hasil belajar siswa sebesar 55,2%.Kata kunci: keterampilan berpikir kritis, hasil belajar, learning cycle 5E, bahan ajar genetika

PENGEMBANGAN HANDOUT BIOLOGI SMA “PEMBUATAN NATA SARI BUAH NANGKA” Yessi Hermawati; Utami Sri Hastuti; Betty Lukiati
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Vol 2, No 9: September 2017
Publisher : Graduate School of Universitas Negeri Malang

Handout can help students to improve their lesson and help them accept new information easier. The purpose of this research is to produce a Handout for Biotechnology. This development model uses 4D Thiagarajan model (1974). Handout trial subjects include: expert media validator, material expert validator, field practitioners and respondents as many 20 students of class XII as respondents. Data collection technique is done by questionnaire. The research results of this study is the Biology Handout for Senior High School students title Nata de Jack Fruit has been done. This handout is worthy of being used as a learning media for class XII on Biology material.Handout dapat membantu siswa untuk meningkatkan pemahaman dan memperoleh informasi baru. Tujuan penelitian ini yaitu untuk menghasilkan Handout materi Bioteknologi. Model pengembangan ini menggunakan model 4D Thiagarajan (1974). Subjek uji coba handout meliputi validator ahli media, validator ahli materi, praktisi lapangan dan responden sebanyak 20 orang siswa kelas XII. Teknik Pengumpulan data dilakukan melalui penyebaran angket. Hasil penelitian ini adalah Handout Biologi SMA dengan judul Pembuatan Nata de Nangka telah tersusun. Handout ini layak digunakan sebagai media pembelajaran Biologi kelas XII.

PENERAPAN PEMBELAJARAN RECIPROCAL TEACHING BERBANTUAN PETA KONSEP UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS SISWA PADA PEMBELAJARAN BIOLOGI Hera Adiwijaya; Endang Suarsini; Betty Lukiati
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Vol.1, No.12, Desember 2016
Publisher : Graduate School of Universitas Negeri Malang

This research aims to determine the influence of reciprocal teaching learning aided concept maps to students critical thinking skills in learning biology. The design of the study is a quasi-experimental design with research subjects in class X student of Agricultural Product Processing Technology (TPHP) and class X student of Fishery Products Processing Technology (TPHPi). Differences of the students critical thinking skills in the both class analyzed by using Anacova test. The results showed that there is an positive effect of reciprocal teaching learning aided concept maps to the critical thinking ability of students. The critical thinking of students’ in the experimental class (average percentage of critical thinking skills of students 73,36%) was higher than the control group (average percentage of students' critical thinking skills 53,20%). From the results of the study it can be concluded that the application of reciprocal teaching learning aided concept maps can enhance students’ critical thinking skills in learning biology.Penelitian ini bertujuan mengetahui pengaruh pembelajaran reciprocal teaching berbantuan peta konsep terhadap kemampuan berpikir kritis siswa pada pembelajaran biologi. Rancangan penelitian yang digunakan adalah rancangan eksperimen semu dengan subjek penelitian siswa pada kelas X Teknologi Pengolahan Hasil Pertanian (TPHP) dan siswa kelas X Teknologi Pengolahan Hasil Perikanan (TPHPi). Perbedaan kemampuan berpikir kritis siswa pada kedua kelas dianalisis menggunakan uji Anacova. Hasil penelitian menunjukkan bahwa ada pengaruh positif pembelajaran reciprocal teaching berbantuan peta konsep terhadap kemampuan berpikir kritis siswa. Kemampuan berpikir kritis siswa pada kelas eksperimen (rata-rata persentase kemampuan berpikir kritis siswa 73,36%) lebih tinggi dibandingkan kelas kontrol (rata-rata persentase kemampuan berpikir kritis siswa 53,20%). Dari hasil penelitian disimpulkan bahwa penerapan pembelajaran reciprocal teaching berbantuan peta konsep dapat meningkatkan kemampuan berpikir kritis siswa pada pembelajaran Biologi.

Eksplorasi Kebutuhan Bahan Ajar pada Matakuliah Bioprospeksi Nelda Anasthasia Serena; Endang Suarsini; Betty Lukiati
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Vol 5, No 5: MEI 2020
Publisher : Graduate School of Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/jptpp.v5i5.13555

Abstract: This study aims to determine the necessity of teaching materials in Bioprospection subject. This type of descriptive qualitative research with observation, questionnaire and test data collection techniques. Necessity analysis results 92% students had difficulty understanding Bioprospect material because the concept is difficult to apply (48%), complex material (24%), lack of teaching materials (20%). Students need teaching materials that are flexible, easy to understand, reliable, practical, and easy access. Preliminary test show cognitive learning outcomes score is 52, 4 (low) and critical thinking skills score is 48.2% (low). The conclusion is needed a module by research based on Problem-Based Learning that can improve critical thinking and cognitive learning outcomes of students in the Bioprospection subject.Abstrak: Penelitian ini bertujuan mengetahui kebutuhan bahan ajar pada matakuliah Bioprospeksi. Jenis penelitian deskriptif kualitatif dengan teknik pengambilan data observasi, angket, dan tes. Hasil analisis kebutuhan 92% mahasiswa kesulitan memahami Bioprospeksi karena sulit mengaplikasikan konsep (48%), materi kompleks (24%), kurangnya bahan ajar (20%). Mahasiswa membutuhkan bahan ajar yang fleksibel, mudah dipahami, terpercaya, praktis, dan akses informasinya mudah. Hasil tes awal menunjukkan hasil belajar kognitif dengan rerata 52, 4 (rendah) dan keterampilan berpikir kritis mahasiswa sebesar 48,2% (rendah). Simpulan penelitian dibutuhkan modul Problem Based Learning berdasarkan hasil penelitian untuk meningkatkan keterampilan berpikir kritis dan hasil belajar kognitif mahasiswa pada matakuliah Bioprospeksi.

Co-Authors Abda Abda Abdul Fattah Noor Abdul Gofur Abdul Gofur AD. Corebima Agus Muji Santoso Alif Rofiqotun Nurul Alimah Alvina Putri Purnama Sari Alvina Putri Purnama Sari Anindya Nirmala Permata Anindya Nirmala Permata Arwinda Probowati Atik Kurniawati Balqis balqis Bayu Guruh Binangkit Dian Eka A. F. Ningrum Dianing Eka Pupitasari Dina Aribah Dina Maulina DYAH ASTRIANI Eko Sri Sulasmi Endang Suarsini Fatchur Rohman Fathul Zannah Fitriani, Rita Frida Kunti Setiowati Hadi Suwono Hanzen, W.F Edi Hendra Susanto Hera Adiwijaya Herawati Susilo Ibrohim Ida Rahmawati Ihya Fakhrurizal Amin Jeni Jeni Jeni Jirana, Jirana Khaq, Rizki Amalia Nurul Kurniawan Setia Putra Liah Badriah M. Amien Rais M. Saiful Fahmi M. Saiful Fahmi, M. Saiful Fahmi Mariana Ade Cahaya Miftahul Mufinadiroh Mimien Henie Irawati Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohammad Amin Mohammad Amin Mohammad Amin Mohammad Amin Muhamad Khoirul Anwar, Muhamad Khoirul Muhammad Khalil Muhammad Saefi Muhammad Shobirin Mumun Nurmilawati Murni Sapta Sari Muslihasari, Adzimatnur Nanda Earlia Nazilatul Khoiroh Nelda Anasthasia Serena Ningrum, Dian Eka A. F. Novia Sigma Amalina Nugrahaningsih N, Nugrahaningsih Nugrahaningsih Nugrahaningsih Nur Fitriana Nur Fitriana Nursyahbani Saraha Poppy Rahmatika Primandiri Puspitasari, Dianing Eka Putri Diyah Anggraini Putri Purnama Sari, Alvina Putri Purnama Sari, Alvina Risanti Dhaniaputri Serena, Nelda Anasthasia Siti Aisyah Firdani Siti Imroatul Maslikah Siti Nur Arifah Sitoresmi Parabaningtyas Sitoresmi Prabaningtyas Sitorus, Mido Ester Solly Aryza Sri Rahayu Lestari Sulistiono Sulistyo Dwi Kartining Putro Sulistyo Dwi Kartining Putro, Sulistyo Dwi Kartining Susriyati Mahanal Sutiman Bambang Sumitro Tahir, Jirana Triastono Imam Prasetyo Umi Hasanah, Umi Umie Lestari Utami Sri Hastuti W. F. Edi Hanzen W.F Edi Hanzen Widodo Widodo Yayoi Kodama Yessi Hermawati Zauhara Faiqohtun Wuriana

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