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All Journal Jurnal Fitopatologi Indonesia VALENSI Jurnal Kimia (Journal of Chemistry) Agrikultura Biotika: Jurnal Ilmiah Biologi Journal of Marine Research Cropsaver : Journal of Plant Protection Jurnal Penelitian Hasil Hutan Padjadjaran Journal of Dentistry Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia Jurnal Penelitian Hasil Hutan Jurnal Ilmiah Berkala Sains dan Terapan Kimia Makara Journal of Science Molekul: Jurnal Ilmiah Kimia Media Penelitian dan Pengembangan Kesehatan Jurnal Penelitian Hasil Hutan
Tri Mayanti
Jurusan Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Sesquiterpenoids from Dysoxylum amooroides Stem Bark: Isolation, Structure Determination, and Cytotoxicity Against MCF-7 Breast Cancer Cells Gunawan, Latifah; Mustofa, Hidayat Nurul; Naini, Al Arofatus; Harneti, Desi; Hidayat, Ace Tatang; Nurlelasari, Nurlelasari; Maharani, Rani; Mayanti, Tri; Fajriah, Sofa; Awang, Khalijah; Azmi, Mohamad Nurul; Supratman, Unang
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.99121

Abstract

Three sesquiterpenoids, guaianediol (1), alismol (2), and spathulenol (3), were isolated from the n-hexane and ethyl acetate extracts of the stem bark of Dysoxylum amooroides. The three compounds were found in D. amooroides species for the first time. The structures of the isolated compounds were identified and established based on an extensive spectroscopic analysis involving HR-TOF-ESI-MS, IR, and NMR data, as well as a comparison with the previously reported works of literature. Compounds 1-3 were further assessed for cytotoxic effects against MCF-7 breast cancer cells. Guaianediol (1) showed inactive activity with IC50 > 100 µM, alismol (2) showed weak activity with IC50 value of 82.1 µM and spathulenol (3) showed considerable activity with an IC50 value of 15.2 µM. A brief structure-activity relationship and comparison with the previous works were also discussed to understand better the role of guaiane- and aromadendrane-type sesquiterpenoids in the biological activity perspective.
AKTIVITAS ANTINEFROLITIASIS EKSTRAK ETANOL DAUN SAMBUNG NYAWA [Gynura procumbens (LOUR.) MERR.] PADA TIKUS PUTIH JANTAN (Rattus norvegicus) Evalina Tarigan, Rida; Mayanti, Tri; Andry, Muhammad; Surbakti, Chemayanti
Media Penelitian dan Pengembangan Kesehatan Vol. 33 No. 1 (2023): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v33i1.1908

Abstract

Gynura procumbens is a diuretic plant that has been used traditionally to cure kidney stones. In order to determine the calcium levels in the rats' kidneys, the anti-nephrolithiasis activity of male white rats was tested in this study.This research method was carried out experimentally in a laboratory which included sampling, plant identification, making simplicia, making ethanol extract of sambung nyawa leaves, characteristics of simplicia, phytochemical screening, administering animal test preparations, then the data was analyzed using the Anova test. Oral administration of succulent leaf extract is done at three different doses: 50, 100, and 200 mg/kg bw. A positive control is provided with Batugin elixir, which is 0.54 mL/125 g BW and induced at a volume of 7.5 mL/125 g BW/day using ethylene glycol 0.75% and ammonium chloride 2%. The study's findings demonstrated that, with a kidney stone inhibitor percentage of 31.71%, the ethanol extract of Sambung Nyawa leaves at a dose of 200 mg/kg BW was more successful in preventing the formation of kidney stones than doses of 50 mg/kg BW and 100 mg/kg BW. This proves that the ethanol extract from Sambung Nyawa leaves can be an alternative way to prevent kidney stones. The conclusion is that the ethanol extract of Gynura procumbens L. leaves has antinephrolithiasis activity in male white rats, especially at a dose of 200 mg/kg BW. It also reduced calcium oxalate levels in mice induced by ethylene glycol and ammonium chloride.
The antibacterial effect of β-pinene derived from Citrus aurantifolia peel against oral Streptococcus mutans ATCC 25175 Julaeha, Euis; Herlina, Tati; Nurzaman, Mohamad; Mayanti, Tri; Kurnia, Dikdik; Sari, Elizabeth Fitriana
Padjadjaran Journal of Dentistry Vol 33, No 1 (2021): March 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no1.29200

Abstract

Introduction: Streptococcus mutans has been known to play a major role in dental caries development. This tooth decay is the most common oral disease affecting people in the world. Hence, discovering the new herbal antibacterial agent seems to become more promising yet challenging. One of natural antibacterial source is the peel of Citrus aurantifolia, as it may contain antibacterial active compounds against pathogenic oral microbes. This study was aimed to isolate antibacterial compound from essential oil of Citrus aurantifolia and to analyse its antibacterial activity against oral Streptococcus mutans ATCC 25175. Methods: Type of research was laboratory experimental. The essential oil was isolated from peel of Citrus aurantifolia by hydro-distillation technique and further isolation of antibacterial compounds was conducted by combination column chromatography using organic solvent, and the structure was determined by UV-Vis, infrared (IR), 1D NMR of 1H-, 13C-NMR and DEPT 135° in CDCl3 spectrometers methods. The antibacterial activity was tested against Streptococcus mutans ATCC 25175 using the Kirby-Bauer method. Results: 0.75% yield was obtained from the essential oil of peel Citrus aurantifolia and after purification, an antibacterial compound was identified as β-pinene with the molecular formula C10H16. Furthermore, the β-pinene from peel of Citrus aurantifolia exerted inhibition growth against Streptococcus mutans at concentration of 2000, 1000, and 500 ppm by showing respectively, inhibition values of 13.0, 11.9, and 11.6 mm on paper disk. Conclusion: In the present study, the essential oil of Citrus aurantifolia peel is proven to contain prospective antibacterial compound (β-pinene) that potentially can be used as natural antibacterial alternative choice to manage oral disease associated with Streptococcus mutans infection.
Tirucallane-Type Triterpenoids from the Dysoxylum gaudichaudianum Stem Bark: Phytochemical Study and Cytotoxicity Evaluation Against Human HeLa Cervical Cancer Cells Maira, Faizah; Naini, Al Arofatus; Mayanti, Tri; Fajriah, Sofa; Kusumiyati, Kusumiyati; Supratman, Unang
Indonesian Journal of Chemistry Vol 25, No 4 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.103523

Abstract

A total of three tirucallane-type triterpenoids were successfully isolated from the n-hexane extract of the stem bark of Dysoxylum gaudichaudianum: 4,4,14-trimethyl-3-oxo-24-nor-5α,13α,14β,17α,20S-chol-7-en-23-oic (1), toonapubesin B (2), and 3β,22S-dihydroxy-tirucalla-7,24-dien-23-one (3). These compounds were isolated from D. gaudichaudianum for the first time. Structural characterization of the isolated compounds was accomplished through a series of spectroscopic analyses, including HR-TOF-MS, IR, and NMR. Based on previous reports, compound 1 was isolated from a member of the Meliaceae family for the first time. The cytotoxic properties of the isolated tirucallane-type triterpenoids were evaluated against cervical HeLa cancer cells. Among them, compounds 1 and 3 were inactive, with IC50 values > 100 µM, while compound 2 exhibited the highest cytotoxicity, with an IC50 value of 29.23 µM, with moderate activity. A structure–activity relationship also indicated the variation in cytotoxicity attributed to substituent effects within the molecular structures. The modification of the side chain in tirucallane-type triterpenoids was shown to be essential for their cytotoxic activity against human cervical cancer lines.
Chemical Constituents from Indonesian Dysoxylum parasiticum (Osbeck). Kosterm and Their Cytotoxicity Against MCF-7 Breast Cancer Cells Harizon, Harizon; Romundza, Febbry; Miharti, Isra; Naini, Al Arofatus; Fajriah, Sofa; Mayanti, Tri; Supratman, Unang
Molekul Vol 20 No 2 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.2.16066

Abstract

ABSTRACT. The exploration of naturally occurring secondary metabolites from plants, which serve as direct sources or precursors for new drug development, motivates us to conduct a comprehensive investigation into their presence. Indonesia stands out as a global biodiversity hotspot, boasting a significant number of endemic species that offer a rich reservoir of untapped resources for pharmaceutical, agricultural, and environmental uses. The Dysoxylum genus, belonging to the Meliaceae family, is recognized as a vital source of secondary metabolites and is well-known for its traditional medicinal applications. Consequently, we focus on analyzing the chemical constituents found in the stem bark of one Indonesian Dysoxylum species, specifically D. parasiticum (Osbeck) Kosterm., and assess their biological activity as anticytotoxic agents. Our research identified three known compounds: a tirucallane-type triterpenoid, cneorin-NP36 (1), a seco-limonoid from the preurianin group, amotsangin A (2), and an ergostane-type steroid, 22(E)-ergosta-6,22-dien-3β,5α,8α-triol (3). The biological evaluation against the human breast cancer cell line MCF-7 revealed that compound 2 exhibited a notable inhibitory effect, with an IC50 value of 34.5 μM. The existence of a highly oxidized structure in compound 2, due to its ester substituents, highlights its effectiveness in inhibiting cancer cell proliferation, outperforming the reference drug cisplatin, which has an IC50 of 53.0 μM. These findings indicate that amotsangin A (2) is a promising anticancer agent, particularly in the treatment of breast cancer. Further studies, including in silico analysis and structural modification, are needed to enhance its cytotoxic activity and selectivity. Keywords: Cytotoxic activity, Dysoxylum parasiticum, MCF-7, seco-limonoid amotsangin A, Secondary metabolites
Dammarane Triterpenoids from Aglaia eximia Miq. and Their Cytotoxic Activity Against P388 Murine Leukemia Cell Farabi, Kindi; Harneti, Desi; Nurlelasari, Nurlelasari; Maharani, Rani; Mayanti, Tri; Hidayat, Ace Tatang; Fajriah, Sofa; Naini, Al Arofatus; Sofian, Ferry Ferdiansyah; Azmi, Mohamad Nurul; Supratman, Unang
Molekul Vol 20 No 1 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.1.12796

Abstract

ABSTRACT. Triterpenoids are a large group of secondary metabolites commonly found in plants, exhibiting high diversity in both structural features and biological activities. Meliaceae family is knows as a rich source of the triterpenoid compounds. As the most extensive genus within the Meliaceae family, Aglaia is known to contain many bioactive triterpenoid compounds, including cytotoxic triterpenoids. Among the various types of triterpenoids, dammarane is frequently found in Aglaia and has demonstrated potential cytotoxic activity. This purpose of the research was to isolate and structure determination of four dammarane triterpenoids from the methanol extract of Aglaia eximia stem bark. All four compounds were successfully isolated and identified as, dammar-24-en-3a,20-diol (1), 20S,24S-epoxy-dammar-3a,25-diol (2), (E)-dammar-23-en-3a,20,25-triol (3), and (E)-25-hydroperoxydammar-23-en-3a,20-diol (4), respectively. The compounds were analyzed using a combination of spectroscopic techniques, including HRMS (high-resolution mass spectroscopy), FTIR (fourier transform infrared spectroscopy), and NMR (nuclear magnetic resonance, one and two dimensional). Cytotoxicity assays using the MTT method were applied to compounds 1-4. All isolated compounds (1-4) generated moderate cytotoxic activity against P388 murine leukemia cells with IC50 9.09, 11.03, 5.89, and 5.74 μg/mL, respectively. Preliminary structure-activity relationship (SAR) analysis suggested that the presence of hydroxyl and hydroperoxyl groups at C-25 increases cytotoxicity, whereas the cyclization in the side chain to form an epoxide ring decreases cytotoxicity. Keyword: Triterpenoids, Meliaceae, Aglaia eximia, cytotoxicity, P388 murine leukemia cells
Kemampuan Senyawa Volatil Aureobasidium pullulans pada Beberapa Kerapatan Sel dalam Menekan Antraknosa Stroberi Hartati, Sri; Nurjihan, Khansa; Susanto, Agus; Istifadah, Noor; Mayanti, Tri
Agrikultura Vol 36, No 2 (2025): Agustus, 2025
Publisher : Fakultas Pertanian Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/agrikultura.v36i2.62929

Abstract

Antraknosa yang disebabkan oleh Colletotrichum acutatum menjadi salah satu penyakit utama pada buah stroberi. Pemanfaatan senyawa volatil khamir dapat menjadi salah satu alternatif pengendalian penyakit pascapanen yang aman dan ramah lingkungan. Kerapatan sel khamir dapat berpengaruh terhadap keefektifan cara pengendalian tersebut. Penelitian ini bertujuan untuk menguji kemampuan senyawa volatil khamir Aureobasidium pullulans Dmg 11 DEP pada beberapa kerapatan sel dalam menghambat pertumbuhan C. acutatum dan menekan penyakit antraknosa pada buah stroberi, serta untuk mendapatkan kerapatan sel khamir yang mampu menghasilkan penekanan tertinggi terhadap penyakit antraknosa pada buah stroberi. Penelitian menggunakan Rancangan Acak Lengkap (RAL) yang dilakukan secara in vitro dan in vivo. Perlakuan terdiri atas kerapatan sel khamir A. pullulans Dmg 11 DEP yaitu 106 sel/ml, 107 sel/ml, 108 sel/ml, 109 sel/ml, dan kontrol. Pengujian in vitro dilakukan dengan metode double dishes system pada media PDA. Pengujian in vivo dilakukan pada buah stroberi varietas Mencir dengan menempatkan khamir tanpa kontak fisik dengan buah. Hasil penelitian menunjukkan bahwa senyawa volatil khamir A. pullulans Dmg 11 DEP pada beberapa kerapatan sel mampu menghambat pertumbuhan C. acutatum secara in vitro sebesar 34,98% - 42,64% dan mampu menekan penyakit antraknosa pada buah stroberi sebesar 18,27% - 36,46%. Kerapatan sel 108 sel/ml menunjukkan persentase penekanan penyakit antraknosa tertinggi pada buah stroberi.
Synthesis of Two Analogues of Xylapeptide A and Their Potency as New Antimicrobial Agent Maharani, Rani; Muchlis, Handi Nugraha; Hidayat, Ace Tatang; Al-Anshori, Jamaludin; Nurlelasari, Nurlelasari; Harneti, Desi; Mayanti, Tri; Farabi, Kindi; Supratman, Unang
Indonesian Journal of Chemistry Vol 25, No 5 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.100353

Abstract

Xylapeptide A, derived from the fungus Xylaria sp. x Sophora tonkinensis, exhibits potent and selective antimicrobial properties. Our research group has successfully synthesized xylapeptide A. In our recent work, two xylapeptide A analogues (An1 and An2) were synthesized using a combination of solid- and solution-phase synthesis methods. The linear precursors of An1 and An2 were synthesized on 2-CTC resin with the Fmoc strategy. The coupling reagents HBTU/HOBt and HATU/HOAt were employed. Subsequently, the linear precursor was cleaved from the resin using either 20% TFA or a TFE mixture, and then cyclized in solution phase with HBTU. The synthesized products were purified using semi-preparative RP-HPLC, giving the percent yields 16% for An1 and 12% for An2. Both compounds were then characterized by HR-ToF-MS, 1H- and 13C-NMR. The synthesized xylapeptide A and its analogues were evaluated against Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and Candida albicans. The result showed that An2, possessing arginine residue, exhibited higher activity compared to xylapeptide A and An1. This research suggests that xylapeptide A analogues hold great promise as novel antimicrobial agents.
ISOLASI SENYAWA STEROID DARI AKAR TUMBUHAN ASAM KANDIS (Garcinia cowa Roxb. ex DC) SEBAGAI OBAT PENURUN DEMAM Darwati; Nurlelasari; Tri Mayanti
Jurnal Penelitian Hasil Hutan Vol. 37 No. 1 (2019): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2019.37.1.51-57

Abstract

Garcinia cowa is belong to the Guttiferae family. In Indonesia this plant is locally named asam kandis. Traditionally, the stem bark of Garcinia cowa are used as antipyretic dan antimicroba, the fruits and leaves used as expectorat, and laxative, and the roots is used for fever medicine. The variaty use are Garcinia cowa as traditional medicine is based it chemical compounds. In our continuing phytochemical investigation to found the secondary metabolite compounds of Garcinia plants found in Indonesia, The objective of this research was to find the steroid compound from the roots of Garcinia cowa. Isolation was conducted by extraction and chromatography methods. The structure of this compound was determined based on spectroscopic data from NMR and comparison with the reported data.
STUDI EKSTRAK n-HEKSANA DARI KULIT BATANG KANDIS HUTAN (Garcinia cymosa) Darwati; Nurlelasari; Tri Mayanti; Unang Supratman
Jurnal Penelitian Hasil Hutan Vol. 39 No. 3 (2021): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2021.39.3.148-154

Abstract

Plants of Garcinia genera (Fam: Guttiferae) that grows in Indonesia's tropical forests are potential of triterpenoidcompounds contents. Garcinia cymosa has been reported as the main source of triterpenoid compounds whichprovided useful biological activity such as anti-inflammatory, antibacterial, antifungal, antioxidant, cytotoxic, andanti-HIV. Currently, data and information of triterpenoid compounds in the G. cymosa is relatively low. Thispaper studies triterpenoid compound of G. cymosa. This compound was obtained from macerated G. cymosa stembark using n-hexane solvent. G. cymosa bark was macerated using n-hexsana solution, which was them separatedand purified by chromatography method, to produce pure isolate in the form of white needle crystals (10.8 mg). Thechemical structure was then determmined by using spectroscopy methods of IR, 1D-NMR, 2D-NMR, and massspectroscopy compared with published structure. Result show friedelin compound was succesfully isolated from extractedn-heksana of G. cymosa bark.
Co-Authors Abdillah, Lutfi Ace Tatang Hidayat Achmad Zainuddin Aditya Seiza Wibisono Agus Safari Agus Safari Agus Safari Agus Susanto Ahmad Darmawan Ajeng Diantini, Ajeng Al Arofatus Naini Alya Tsamrotul Andre A. Sonda Aneu Wahyuni Anindyta, Annisa Anjari, Intan Hawina Annisa Anindyta Aoliya, Salwa Rohmatul Aprilia Permata Sari Ari Hardianto Azmi, Mohamad Nurul Azzahra, Fathia Celcius Waranmaselembun Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati, Darwati, Darwati Deden Indra Dinata Deden Indra Dinata, Deden Indra Desak Made Malini Desi Harneti Putri Huspa Dewa Gede Katja Dikdik Kurnia Dini Oktaviani DUDI RUNADI Elizabeth Fitriana Sari Endah Yulia Erina Hilmayanti Euis Julaeha Euis Julaeha Evan Hadrian Faizah Maira Fajar Fauzi Abdullah Farabi, Kindi Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Fidela Histiya Gunawan Ghina Izdihar Gunawan, Latifah Harizon Harizon Hideo Hayashi Hideo Hayashi Hideo Hayashi Hikmat Kasmara Hilmayanti, Erina Indri Indriyani Indriyani, Indri Iqbal Wahyu Mustaqim Isramiharti Isramiharti Jamaluddin Al Anshori Jamaludin Al-Anshori Julinton Sianturi Julinton Sianturi Julita Nahar Kansy Haikal Kautsari, Arsi Khalijah Awang Khalijah Awang Khalijah Awang Khalijah Awang Khalijah Awang Khlaijah Awang Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kusumiyati Lutfi Abdillah Madihah Madihah Maira, Faizah Mayshah Purnamasari Melanie Melanie Mia Miranti Rustama Mohamad Nurul Azmi Mohamad Nurul Azmi Mohamad Nurzaman Muchlis, Handi Nugraha Muhamad Nurul Azmi Muhammad Andry Muhammad Hanafi Muhammad Hanafi Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Nabila Maudi Nafiah, Mohamad Azlan Naini, Al Arofatus Noor Istifadah Nur Insani Amir Nurcahyanti, Ois Nurjihan, Khansa Nurlelasari Nurlelasari Nurlelasari Nurul Qomarilla Ois Nurcahyanti Purnama Purnama Purnama Purnama Qomarilla, Nurul Rani Maharani Rani Maharani Reina Yulianti Reina Yulianti Yulianti Rida Evalina Tarigan Rika Meliansyah Risyandi Anwar Riza Yulisar Romundza, Febbry Ronauli Fitriana Ronny Lesmana Rurini Retnowati Salam, Supriatno Sandra Amalia Riyadi Setiani, Cahya Shabarni Gaffar Shiono, Yoshihito Sianturi, Julinton Siska Elisahbet Sinaga Siva Siti Patimah Sofa Fajriah Sofa Fajriah Sofa Fajriah Sofa Fajriah Sri Hartati Sri Purwani Sri Rejeki Rahayuningsih Supriatno Salam Surbakti, Chemayanti Sylvia Rachmawati Meilanie Tati Herlina Tenny Putri Wikayani Tenny Putri Wikayani, Tenny Putri Unang Supratman Vidia Afina Nuraini Vita Novianti Wahyuni, Aneu Wawan Hermawan Wawan Hermawan Wibisono, Aditya Seiza Widyana, Almas Winda Sukmawati Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yulisar, Riza Zahidah Nurulhaq Zulfikar Zulfikar