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All Journal Jurnal Fitopatologi Indonesia VALENSI Jurnal Kimia (Journal of Chemistry) Agrikultura Biotika: Jurnal Ilmiah Biologi Journal of Marine Research Cropsaver : Journal of Plant Protection Jurnal Penelitian Hasil Hutan Padjadjaran Journal of Dentistry Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia Jurnal Penelitian Hasil Hutan Jurnal Ilmiah Berkala Sains dan Terapan Kimia Makara Journal of Science Molekul: Jurnal Ilmiah Kimia Media Penelitian dan Pengembangan Kesehatan Jurnal Penelitian Hasil Hutan
Tri Mayanti
Jurusan Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Eudesman-Type Sesquiterpenoids from Stem Bark Dysoxylum gaudichaudianum and Cytotoxic Evaluation Against Human HeLa Cervical Cancer Maira, Faizah; Naini, Al Arofatus; Mayanti, Tri; Farabi, Kindi; Fajriah, Sofa; Retnowati, Rurini; Supratman, Unang
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46788

Abstract

Two eudesmane-type sesquiterpenoids were isolated from the stem bark of Dysoxylum gaudichaudianum: 6α-hydroxy-eudesm-4(15)-en-1-one (1) and eudesm-4(15),7-dien-1β-ol (2). This study represents the first report of these compounds not only from D. gaudichaudianum but also from the genus Dysoxylum. The cytotoxic potential of two sesquiterpenoids was assessed against human cervical carcinoma (HeLa) cells employing the Resazurin-based PrestoBlue assay. Using cisplatin as a positive control, compound 1 exhibited moderate cytotoxicity with an IC₅₀ of 28.04 µM, whereas compound 2 showed comparatively weaker activity, with an IC₅₀ of 58.37 µM. Their structures were elucidated through comprehensive spectroscopic analyses, including HR-ESI-MS, ¹H NMR, and ¹³C NMR. Structure–activity relationship analysis indicates that hydroxylation at C-6 enhances cytotoxic activity, whereas the C-6/C-7 olefinic moiety reduces potency, likely due to increased molecular rigidity, highlighting key structural features for activity modulation in the eudesmane scaffold.
A New Limonoid from the Seeds of Chisocheton lasiocarpus (Meliaceae) Ronauli Fitriana; Nurlelasari Nurlelasari; Darwati Darwati; Desi Harneti; Rani Maharani; Tri Mayanti; Unang Supratman
ALCHEMY Jurnal Penelitian Kimia Vol 17, No 2 (2021): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.17.2.44782.219-226

Abstract

 A New Limonoid from the Seeds of Chisocheton lasiocarpus (Meliaceae). Chisocheton is one of Meliaceae genus, which has about 53 species spreading in subtropical and tropical regions. One of the species is Chisocheton lasiocarpus. Chisocheton is rich in limonoids that have various biological activities such as anticancer, antimalarial, anti-inflammatory, antifeedant, antiviral, neuroprotective, and antimicrobial properties. This study aims to isolate limonoids from the seeds of C. lasiocarpus, and determine the structures. The dry powder of seeds of C. lasiocarpus (203.75 g) was macerated with subsequent n-hexane, ethyl acetate, and methanol. Extract of ethyl acetate was separated and purified using chromatography methods until a new limonoid, lasiocarpines (1) and one known limonoid, 14β,15β-epoxynimonol (2) were obtained. The purification process was guided by Ehrlich reagent. The chemical structures were identified by UV, IR, 1H-NMR, 13C-NMR, 2D NMR, and mass spectrometry.
Co-Authors Abdillah, Lutfi Ace Tatang Hidayat Achmad Zainuddin Aditya Seiza Wibisono Agus Safari Agus Safari Agus Safari Agus Susanto Ahmad Darmawan Ajeng Diantini, Ajeng Al Arofatus Naini Andre A. Sonda Aneu Wahyuni Anindyta, Annisa Anjari, Intan Hawina Annisa Anindyta Aoliya, Salwa Rohmatul Aprilia Permata Sari Azmi, Mohamad Nurul Azzahra, Fathia Celcius Waranmaselembun Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati, Darwati, Darwati Deden Indra Dinata, Deden Indra Desak Made Malini Desi Harneti Putri Huspa Dewa Gede Katja Dikdik Kurnia Dini Oktaviani DUDI RUNADI Elizabeth Fitriana Sari Endah Yulia Erina Hilmayanti Euis Julaeha Euis Julaeha Evan Hadrian Faizah Maira Fajar Fauzi Abdullah Farabi, Kindi Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Fidela Histiya Gunawan Ghina Izdihar Gunawan, Latifah Harizon Harizon Hideo Hayashi Hideo Hayashi Hideo Hayashi Hikmat Kasmara Hilmayanti, Erina Indri Indriyani Indriyani, Indri Iqbal Wahyu Mustaqim Isramiharti Isramiharti Jamaluddin Al Anshori Jamaludin Al-Anshori Julinton Sianturi Julinton Sianturi Julita Nahar Kautsari, Arsi Khalijah Awang Khalijah Awang Khalijah Awang Khalijah Awang Khalijah Awang Khlaijah Awang Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kusumiyati Lutfi Abdillah Madihah Madihah Maira, Faizah Mayshah Purnamasari Melanie Melanie Mia Miranti Rustama Mohamad Nurul Azmi Mohamad Nurul Azmi Mohamad Nurzaman Muchlis, Handi Nugraha Muhamad Nurul Azmi Muhammad Andry Muhammad Hanafi Muhammad Hanafi Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Nabila Maudi Nafiah, Mohamad Azlan Naini, Al Arofatus Noor Istifadah Nur Insani Amir Nurcahyanti, Ois Nurjihan, Khansa Nurlelasari Nurlelasari Nurlelasari Nurul Qomarilla Purnama Purnama Purnama Purnama Qomarilla, Nurul Rani Maharani Rani Maharani Rani Maharani Reina Yulianti Reina Yulianti Yulianti Rida Evalina Tarigan Rika Meliansyah Risyandi Anwar Riza Yulisar Romundza, Febbry Ronauli Fitriana Ronny Lesmana Rurini Retnowati Salam, Supriatno Sandra Amalia Riyadi Setiani, Cahya Shabarni Gaffar Shiono, Yoshihito Sianturi, Julinton Siska Elisahbet Sinaga Siva Siti Patimah Sofa Fajriah Sofa Fajriah Sofa Fajriah Sofa Fajriah Sri Hartati Sri Purwani Sri Rejeki Rahayuningsih Supriatno Salam Surbakti, Chemayanti Sylvia Rachmawati Meilanie Tati Herlina Tenny Putri Wikayani Tenny Putri Wikayani, Tenny Putri Unang Supratman Vidia Afina Nuraini Vita Novianti Wahyuni, Aneu Wawan Hermawan Wawan Hermawan Wibisono, Aditya Seiza Winda Sukmawati Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yulisar, Riza Zahidah Nurulhaq Zulfikar Zulfikar