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Journal : Heca Journal of Applied Sciences

Investigating Scabies Pathogenesis and Therapeutic Potential of Nutmeg Extract in Experimental Animals Erizal, Erizal; Hanafiah, Muhammad; Mudatsir, Mudatsir; Helmi, Teuku Zahrial
Heca Journal of Applied Sciences Vol. 4 No. 1 (2026): March 2026 (In Press)
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v4i1.333

Abstract

Nutmeg (Myristica fragrans) is one of Indonesia’s agricultural commodities with recognized health benefits as a traditional medicine. In addition, nutmeg has potential as a natural treatment for scabies. This study aimed to evaluate the effectiveness of nutmeg fruit bioactive compounds in scabies treatment. Nutmeg extraction was conducted using three different solvents: ethanol, ethyl acetate, and n-hexane. The extract with the most dominant phytochemical composition was further analyzed for bioactive compounds using GC-MS and antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Subsequently, the extract was tested against Sarcoptes scabiei mites obtained from 15 stray cats. The effectiveness of nutmeg extract was evaluated in a spray formulation by observing mite mortality and lesion reduction. The results demonstrated that the ethanol extract of nutmeg fruit contained the most abundant phytochemicals, with 3-Methyl-2,5-Furandione (21.26%) and Maleic Anhydride (14.21%) as the dominant compounds. The ethanol extract also exhibited strong antioxidant activity with an IC₅₀ value of 21.41 ppm. In vitro testing showed 100% mite mortality at a 25% extract concentration within 24 hours, while in vivo testing on scabies-infected cats treated with the nutmeg spray extract revealed a significant reduction in scab lesions compared to the control group. These findings indicate that nutmeg extract possesses potent acaricidal and antioxidant properties, making it a promising alternative treatment for scabies. Further studies are required to refine the formulation and explore its clinical applications.
Co-Authors . Zulfan Abda Abda Abdul Malik Setiawan Abidin, Taufik F. Abram L. Wagner Adlim Adlim Agung Pranata Agus Hendra Al Rahmad Agussabti Agussabti Ainal Mardhiah Aksa, Rahmad Al-kautsar Al-kautsar Alfingsih, Dede Alfonso J. Rodriguez-Morales Ali A. Rabaan AlKautsar, AlKautsar Allaily Allaily Amalia Sutriana Amanda Yufika Amanulloh, Fahmi Rahmat Amir-Behghadami, Mehrdad Anak Agung Dewi Megawati, Anak Agung Dewi Andhy Romdani, Andhy Armayanti, Feby Asrudi, Asrudi Ayulinda, Arianisah P. Bakhtiar Bakhtiar Binti Firdaus, Shausan Bouchra, Assarag Damayanti Damayanti Damayanti Damayanti Dedhi Yustendi Dedy Syahrizal Dewi Puji Rahayu Diah, Muhammad El Ghifari, Muhammad Raka Elfrida Ratnawati Empung, Empung Endah Widyastuti1 Enitan, Seyi Samson Erizal Erizal Evendi Evendi Fajar, Jonny Karunia Farhan, M. Farrah Fahdhienie Fathima, Raisha Fauhan, Gharsina Ferdi Riansyah Firzan Nainu Firzan, Firzan Gani, Azhari Garjito , Triwibowo Ambar Habeahan, Nova Lina Sari Hafnati Rahmatan Hamny Sofyan Hanipah, Sri Harapan Harapan Harapan Harapan Hasan, Denny I. Herlina Dimiati, Herlina Hibran, Syukron Hilman Syarif Hizir Sofyan Ibnu Khaldun Ichsan Ichsan Ikram Ikram Ikram, Aamer Ima Maria Iqbal, Qanita Irwan Saputra Ismail Ismail Ismail, M. Nasir Iswahyudi Iswahyudi Jayawarsa, A.A. Ketut Jeksi, Sri Kamil, Qatrunnada Khader, Yousef S. Koyanagi, Ai Kuldeep Dhama Kurnia F. Jamil Latief, Kamaluddin Lemu, Yohannes K. Linguissi, Laure SG. M. Aman Yaman M. Ikbal, M. M.Aman Yaman Maelani, Imelda Maimun Syukri, Maimun Makmur, Ali Mamun, Mohammed A. Maulana, Teuku Maulina Maulina Mellinia, Sania A. Monica, Santy Muhammad Daud Muhammad Hanafiah Müller, Ruth Mulyadi Mulyadi Mutiara, Suci Mutiya Oktariani Nalapraya, Widhy Y. Nanda, Cut M. Nirwana, Aura Nur Wahyuniati, Nur Nurjannah Nurjannah Nurjannah Nurjannah Oktariani, Mutiyah Pandji Wibawa Dhewantara Parera, Aser Parperis, Konstantinos Puspita, Laurensia Elya Putri, Tryantini Sundi Putri, Widia Rademaker, Marius Rafika Rafika Rahly, Fawwa Rahman, Riski Ambia Rahmawati, Rahmawati Ramadana, Rizki R. Ramadhana, Ika F. Ramli, Ratu Bulkis Ratu Bulkis Ramli Rayhan, Muhammad A. Reza Maulana Rina Purnama Sari Roy Nusa Rudi Kurniawan Sah, Ranjit Said Usman Saktianggi, Panji Probo Sallam, Dina E. Salsabila, Nailis Samingan Samingan Samsul Anwar Saputra, Irwan Saputra, Jefri Dwi Sarifuddin Sarifuddin Sasmono, R. Tedjo Selvina, Selvina Shylvana Adella* Siagian, Afwandy Taga Siregar, Tongku N. Sirinam, Salin Sofyan, Sarwo E. Sri Hanifah Sri Jeksi Sriyanti, Cut Susanna Susanna Syahraini, Aigia Synat Keam Te, Haypheng Teuku Heriansyah, Teuku Teuku Zahrial Helmi Tiara Mustika Wardani* Tridayana, Icha Usman, Said Utomo, Prattama S. Vento, Sandro Viveiros-Rosa, Sandro G. Wahyuniar Wahyuniar Wartha , Eva Wartha, Eva Wira Winardi Wollina, Uwe Yesi Astri Yolandika Arsyad Yossadania, Asyriva Yufika, Amanda Yuliana Yuliana Yusmanidar Yusmanidar Zahrul Fuadi Zinatul Hayati Zinatul Hayati Zulfan Zulfan Zulfikar Zulfikar Zulkifli Zulkifli