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All Journal AcTion: Aceh Nutrition Journal Media Farmasi Media Keperawatan: Politeknik Kesehatan Makassar Jurnal Comprehensive Health Care Jurnal Kolaboratif Sains Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Mandala of Health : A Scientific Journal Jurnal Pengabdian Pada Masyarakat Medical and Health Journal Journal of Public Health and Pharmacy Prosiding Seminar Nasional Pengabdian Kepada Masyarakat: Peduli Masyarakat International Journal of Business and Quality Research Linggamas: Jurnal Pengabdian Masyarakat
Wahyudin Wahyudin
Departemen Anatomi, Fakultas Kedokteran Universitas Jenderal Soedirman, Purwokerto,
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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EKSTRAK TUMBUHAN SEBAGAI AGEN ANTIMIKROBA UNTUK METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA): REVIEW Pauzi, Rizqi Yanuar; Septiya, Lia; Ihtiaringtyas, Suci; Wahyudin, Wahyudin
Medical and Health Journal Vol 4 No 1 (2024): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.4.1.12282

Abstract

Plant extracts have become an intriguing subject of research in the search for effectiveantimicrobial agents against Methicillin-Resistant Staphylococcus Aureus (MRSA), which is a global health issue due to its resistance to various antibiotics. Several studies have shown that compounds such as alkaloids and polyphenols in plants are responsible for their antimicrobial properties. Extracts from plants such as Azadirachta indica, Psidium guajava, and Rhamnus californica have demonstrated antibacterial activity against MRSA. Other research indicates that compounds like Psorothatin C from Psorothamnus fremontii are also effective against MRSA. The main challenge in managing MRSA infections is resistance to conventional antibiotics like vancomycin. Therefore, further research on plant extracts and synthetic compounds with antimicrobial activity against MRSA could provide significant contributions to the development of new therapies. Approaches involving the combination of plant extracts with conventional antibiotics also show potential in enhancing treatment effectiveness. A deep understanding of the mechanisms of action of these plant extracts is crucial for developing effective treatment strategies, and with further research, plant extracts could become an important alternative in addressing MRSA infections that are resistant to antibiotics.
Black Garlic Supplementation and Glomerular Protection in Hyperuricemic Rats: A Study on Kidney Health Prevention Wahyudin, Wahyudin; Wahyu Pribadi, Fajar; Nawangtantrini, Gita; Riski Fatah, Muhammad; Zainuddin, Zainuddin
Journal of Public Health and Pharmacy Vol. 4 No. 3: NOVEMBER 2024
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v4i3.5496

Abstract

Introduction: Hyperuricemia is a significant risk factor for the development of chronic kidney disease. Excessive uric acid can deposit in the kidneys, triggering inflammatory reactions and oxidative stress, leading to structural damage in the glomeruli. Black garlic, with its antioxidant and bioactive compounds, has the potential to protect the kidneys from hyperuricemia-induced damage. Our objective is to evaluate the effect of black garlic supplementation on the histopathological features of glomeruli in a hyperuricemic rat model. Methods: This study was an analytical observational study using Biological Remnant Materials (BRM) from a previous study. The sample consisted of 30 male Sprague-Dawley rats divided into 5 groups: disease control, drug control (allopurinol), and 3 black garlic dose groups (240 mg/day, 480 mg/day, and 960 mg/day). Data were collected through histopathological examination of kidney tissue using the glomerular damage scoring method (0-3). Data analysis was performed using one-way ANOVA and post hoc LSD tests. Results: Black garlic demonstrated protective effects on the histopathological features of glomeruli in hyperuricemic rats. The 240 mg/day dose showed the most significant improvement in kidney health, reducing glomerular damage scores compared to the disease control group (p < 0.05). These findings suggest that black garlic can serve as a preventive agent against kidney complications caused by hyperuricemia. Conclusion: Black garlic provides protective effects on glomerular histopathology in hyperuricemic rats, with the 240 mg/day dose being the most effective. These results suggest potential use for black garlic in preventing kidney complications in hyperuricemia.
THE RELATIONSHIP BETWEEN BLOOD PRESSURE AND BLOOD SUGAR LEVELS: THE MODERATING ROLE OF AGE AND GENDER Wahyudin, Wahyudin; Pauzi, Rizqi Yanuar; Yunika, Novia; Setyanto, Muhamad Rifqi; Hidayah, Arfi Nurul
Medical and Health Journal Vol 4 No 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.4.2.14571

Abstract

This study aimed to evaluate the relationship between blood pressure and blood sugar levels, and how age and gender moderate the relationship. The study involved 105 respondents who underwent health check-ups in Banyumas Regency. Blood pressure was categorized as normal or hypertension, while blood sugar levels were divided into normal, prediabetes, and diabetes. The Chi-Square test showed a significant association between blood pressure and blood sugar levels (p < 0.05), although the strength of the association was relatively weak. Individuals with hypertension have a higher risk of developing blood sugar disorders, especially in women and individuals over 45 years old. Ordinal regression analysis showed that age and gender played an important role in influencing this association. These findings emphasize the importance of an integrated approach in screening and management of hypertension and diabetes, to prevent long-term complications such as cardiovascular disease and renal failure. The practical implications of this study can be used to design more effective public health programs
THE RELATIONSHIP BETWEEN ANTHROPOMETRIC PARAMETERS AND BODY MASS INDEX WITH BLOOD GLUCOSE LEVEL: AN ANALYTICAL STUDY Pauzi, Rizqi Yanuar; Wahyudin, Wahyudin; Nur'aini, Indah
Medical and Health Journal Vol 4 No 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.4.2.14573

Abstract

This study aims to analyze the relationship between body weight, height, body mass index (BMI), and blood glucose levels among 105 study subjects . Descriptive analysis results show that the average body weight of subjects is 64.81 kg, height is 1.62 m, and blood glucose level is 107.05 mg/dl, with significant variation in glucose levels. Scatter plots indicate that blood glucose does not have a significant relationship with body weight and height, while there is a tendency for increased blood glucose levels with increasing BMI. Correlation analysis reveals a strong positive relationship between body weight and BMI, but blood glucose does not show significant relationships with other variables. Using quantile regression, the analysis shows no significant relationship between independent variables and blood glucose at the median quantile. These findings highlight the need for further research to understand the factors influencing blood glucose levels and the importance of comprehensive assessment of anthropometric parameters.
EFFECTIVENESS OF YOGA THERAPY EDUCATION ON KNOWLEDGE AND ATTITUDES OF T2DM PATIENTS IN TAKALAR REGENCY Suardi, Suardi; Ernawati, Ernawati; Oktaviana, Dina; Alwi, Alwi; Patmawati, Patmawati; Dewiyanti, Dewiyanti; Wahyudin, Wahyudin; Zainuddin, Zainuddin; Ilham, Rosmin; Thalib, Abdul
Mandala Of Health Vol 18 No 1 (2025): Mandala of Health: A scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.1.15820

Abstract

Background: Diabetes mellitus is a chronic disease characterized by increased blood sugar levels (hyperglycemia) and glucose intolerance caused by the pancreas not producing enough insulin or the body being unable to use the insulin produced effectively. Objective: to determine the effectiveness of yoga therapy education on knowledge and attitudes in T2DM patients in Takalar Regency. Method: This research uses an experimental approach with a one-group pre-post test design. The number of respondents was 30 using the Accidental Sampling sampling method. The statistical test used is the paired sample test with ρ<0.05. Results: In this study, pre-intervention knowledge results were obtained with a mean of 5.47, and mean post-intervention knowledge increased to 8.47 with a value of ρ=0.001, while pre-intervention attitudes had a mean of 20.20, while post-intervention attitudes the mean increased to 26.83, with a value of ρ=0.001. Conclusion: there is an influence of yoga therapy education on the knowledge and attitudes of T2DM patients in Takalar Regency.
INHIBITION OF Asystasia gangetica ETHANOLIC EXTRACT ON Porphyromonas gingivalis AND Fusobacterium nucleatum BIOFILM FORMATION Ichsyani, Meylida; Laksitasari, Anindita; Supriyati, Supriyati; Sari, Dwi Nur Indah; Wahyudin, Wahyudin
Mandala Of Health Vol 18 No 1 (2025): Mandala of Health: A scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum develop a biofilm on the surface of the dental apex, causing inflammation in the teeth' supporting tissues. Asystasia gangetica has been observed for its analgesic, anti-inflammatory, and antimicrobial effect. The ethanolic extract of A. gangetica may be developed as a root canal sterilization dressing due to its benefits. This study aims to determine the inhibitory effect of ethanolic extract of A. agangetica on P. gingivalis and F. nucleatum from forming biofilm. Antibacterial activity was determined using Kirby-Bauer disk diffusion. The inhibition of biofilm formation was evaluated using microtiter plate biofilm assay with various concentrations of extract. Base on the classification of inhibition zone, ethanolic extract of A. gangetica had moderate to strong antibacterial effects on P. gingivalis at 12.5-50 mg/mL, and moderate effect on F. nucleatum at 25-50 mg/mL. Results also showed that the extract at 50 mg/mL, inhibited biofilm formation by more than 72% against P. gingivalis (p<0.05) and up to 75% against F. nucleatum (p<0.05). The value of MBIC50 was determined at 5.19 mg/mL and 7.44 mg/mL, respectively. Ethanolic extract of Asystasia gangetica has a potential inhibitory effect on P. gingivalis and F. nucleatum biofilm formation. Studies suggest more detailed approaches to a better understanding of the interactions between lead compounds and bacterial cells within the biofilm structure.
D-SAFE (Digital Self-Assessment and Facilitation Education) Program Penyuluhan dan Skrining Mandiri Kecanduan Game Online untuk Remaja Zainuddin, Zainuddin; Sulaiman, Ibrahim; Wahyudin, Wahyudin; Setiawan, Ferdy
Linggamas: Jurnal Pengabdian Masyarakat Vol 2 No 2 (2025): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2025.2.2.15774

Abstract

Fenomena kecanduan game online pada remaja semakin meningkat seiring dengan perkembangan teknologi digital. Hal ini menimbulkan berbagai dampak negatif, baik dari segi kesehatan fisik, mental, maupun sosial. Program penyuluhan dan skrining mandiri, yang disebut D-SAFE (Digital Self-Assessment and Facilitation Education), diimplementasikan di SMP Negeri 1 Bulango Selatan untuk mengatasi masalah ini. Program ini bertujuan untuk memberikan pemahaman kepada remaja tentang bahaya kecanduan game online serta cara pencegahan dan penanganannya. Metode yang digunakan meliputi penyuluhan interaktif dan skrining mandiri menggunakan alat penilaian berbasis digital dan menggunakan kuesioner. Hasil dari program ini menunjukkan peningkatan kesadaran dan pemahaman remaja mengenai penggunaan teknologi yang sehat, serta penurunan signifikan dalam kebiasaan bermain game online yang berlebihan. Kolaborasi antara sekolah, orang tua, dan komunitas menjadi faktor kunci dalam keberhasilan program ini.
Peningkatan Perilaku Hidup Bersih dan Sehat (PHBS) pada Lansia Melalui Edukasi Dan Demonstrasi Sartika, Sartika; Zainuddin, Zainuddin; Wahyudin, Wahyudin
Linggamas: Jurnal Pengabdian Masyarakat Vol 2 No 2 (2025): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2025.2.2.15895

Abstract

Lansia merupakan kelompok rentan terhadap masalah kesehatan akibat penurunan fungsi fisik dan imunitas. Perilaku Hidup Bersih dan Sehat (PHBS) menjadi kunci pencegahan penyakit, namun pemahaman dan praktiknya seringkali belum optimal pada kelompok ini. Pengabdian masyarakat ini berfokus pada peningkatan pengetahuan dan keterampilan PHBS, khususnya cuci tangan pakai sabun (CTPS), pada lansia di Panti Griya Lansia Jannati. Tujuan kegiatan adalah meningkatkan pemahaman lansia mengenai pentingnya PHBS dan mempraktikkan CTPS dengan benar. Metode yang digunakan meliputi penyuluhan interaktif menggunakan media visual (Video melalui Proyektor, leaflet) dan demonstrasi langsung langkah-langkah CTPS. Evaluasi dilakukan melalui observasi partisipasi, tanya jawab, dan redemonstrasi oleh lansia. Hasil pengabdian menunjukkan peningkatan antusiasme dan pemahaman lansia terhadap materi yang disampaikan, serta mayoritas lansia mampu mempraktikkan kembali langkah CTPS dengan benar setelah intervensi. Kegiatan ini berkontribusi pada upaya promotif dan preventif kesehatan di lingkungan panti lansia
Peningkatan Literasi Kesehatan Masyarakat melalui Penyuluhan Hipertensi di Desa Topejawa Suardi, Suardi; Zainuddin, Zainuddin; Ernawati, Ernawati; Wahyudin, Wahyudin; Kamriana, Kamriana
Linggamas: Jurnal Pengabdian Masyarakat Vol 2 No 2 (2025): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2025.2.2.16088

Abstract

Latar Belakang: Hipertensi merupakan penyakit tidak menular (PTM) yang menjadi salah satu penyebab utama kematian di dunia dan menjadi ancaman kesehatan masyarakat karena potensinya yang mampu mengakibatkan kondisi komplikasi seperti stroke, penyakit jantung koroner dan gagal ginjal. Peningkatan kasus hipertensi di Indonesia terjadi dari 28,5% menjadi 34,1%. Tujuan : Kegiatan Pengabdian ini untuk Memberikan Penyuluhan Kesehatan tentang Penyakit Hipertensi pada Masyarakat dalam meningkatkan Literasi Kesehatan. Metode: Kegiatan ini dilaksanakan pada hari Sabtu, 29 Juni 2024 di Rumah masyarakat Dusun Kajang Desa Topejawa Kab.Takalar dengan jumlah peserta yang hadir sebanyak 29 orang. Sasaran kegiatan ini adalah Seluruh Masyarakat di Dusun Kajang, Desa Topejawa Kec. Mangarabombang Kab. Takalar. Hasil: Terjadi peningkatan Literasi Kesehatan, dimana Literasi Kesehatan baik sebelum pemberian penyuluhan yaitu 6 responden (21%) dan setelah dilakukan penyuluhan meningkat menjadi 21 responden (72%). Dengan demikian masyarakat tetap harus mendapatkan pemahaman tentang Penyakit Hipertensi agar tetap hidup sehat.
Comparative Antibacterial Effects of Honey Bee Propolis on Gram Negative Bacteria Escherichia coli and Gram Positive Bacteria Staphylococcus aureus Hestiyani, Rani Afifah Nur; Handini, Tri Okmawati; Nitihapsari, Galuh Yulieta; Ning Widhi, Anriani Puspita Karunia; Wahyudin, Wahyudin
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.15814

Abstract

Antimicrobial resistance in pathogens such as Escherichia coli and Staphylococcus aureus poses an urgent global health challenge. Honeybee propolis is known for its promising antibacterial potential.This study aimed to compare the antibacterial effectiveness of propolis against E. coli (Gram-negative) and S. aureus (Gram-positive) using the in vitro disk diffusion method. Propolis was tested at concentrations of 6.25%, 12.5%, 25%, 50%, and 100% against both bacterial species. Disk diffusion assays were conducted on Mueller Hinton Agar, and inhibition zones were measured using a vernier caliper. Data were analyzed using one-way ANOVA. The results showed the Inhibition zone diameters increased with higher propolis concentrations. At 100% concentration, S. aureus showed a 15 mm inhibition zone, while E. coli showed only 7 mm. One-way ANOVA indicated significant differences (p < 0.05) in both bacteria. These findings indicate that propolis exhibits antibacterial activity against both S. aureus and E. coli, with greater effectiveness against Gram-positive S. aureus. These findings support the potential use of propolis as a natural antibacterial agent, particularly for Gram-positive infections.
Co-Authors A Fahira Nur Ahmad Yani Alfi Muntafiah Alwi Alwi arafah, Salmah Arfi Nurul Hidayah Arfi Nurul Hidayah Ariadne Tiara Hapsari Astanti, Amini Dwi Ayunissa, Desty Lofita Bahiyah, Fiona Annisa Basori, Devina Stevanova Najwa Philo Desi Ratna Sari, Desi Ratna Dewiyanti, Dewiyanti Dina Oktaviana Diyah Woro Dwi Lestari Dwi Nur Indah Sari Eman Sutrisna Ernawati Ernawati Fajar Wahyu Pribadi Fajar Wahyu Pribadi, Fajar Wahyu Farkhria, Iffa Naila Fitranto Arjadi Fitranto Arjadi Habibie, Kimi Handini, Tri Okmawati Hartina, Hartina Hasanuddin Nuru Hasnah Mutfii Hendra Stevani Hidayah, Arfi Nurul Ihtiaringtyas, Suci Jajar Setiawan Joko Setyono Joko Setyono Kamriana Kamriana Kamriana, Kamriana Kautsarmesya, Audivalensi Kusuma, Muhammad Nanang Himawan Laksitasari, Anindita Lantip Rujito Lily Kusumawati Burkon Meida Sofyana Meylida Ichsyani Miftahul’ulum, Rizal Miko Ferine Muhamad Rifqy Setyanto Muhammad Iqbal Firdaus Najmudin Nawangtantrini, Gita Nendyah Roestijawati Ning Widhi, Anriani Puspita Karunia Nining Yusnitasari Nitihapsari, Galuh Yulieta NUR'AINI, INDAH Nurachmy Sahnir Nuroaena, Nuroaena Octavia Permata Sari Octavia Permata Sari, Octavia Permata Ormat, Ormat Patmawati Patmawati, Patmawati Pauzi, Rizqi Yanuar Putri, Salsa Apriliana Qodri Santosa Rafika Zamri Rani Afifah Nur Histiyani Ratnasari Iskandar Riski Fatah, Muhammad Rismayanti Rismayanti Rizak Tiara Yusan Rizki Amelia Sinensis Rizqi Yanuar Pauzi Rochidati, Tavi Rosmin Ilham Rosmin Ilham Sallazaria Hanin Prameswari Syafiqa Ardli Saputra, Said Rendi Sarinah Basri K Sartika, Sartika Septiya, Lia Setiawan, Ferdy Setiawati Setiawati Setyanto, Muhamad Rifqi Sofro, Zaenal Muttaqien Suardi Suardi Sudarto Sudarto Sulaiman, Ibrahim Supriyati . Susiawan, Lieza Dwianasari Syamsul, Muharti Thalib, Abdul Thianti Sylviningrum Untung Gunarto, Untung Wardani, Inggit Yulia Wisnu Budi Pramono, Wisnu Budi Yudhi Wibowo Yudhistira Tri Wardhana Yunika, Novia Zainuddin Zainuddin Zainuddin Zainuddin Zainuddin, Zainuddin