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All Journal Jurnal Kesehatan Andalas Journal of Agromedicine and Medical Sciences Buletin Ilmiah Nagari Membangun Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Majalah Patologi Indonesia International Journal of Nasopharyngeal Carcinoma Andalas obstetrics and gynecology journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Jurnal Riset Ilmiah Frontiers on Healthcare Research
Sukri Rahman
Bagian THT-KL Fakultas Kedokteran Universitas Andalas/ RSUP. Dr. M. Djamil Padang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Role of Human Papilloma Virus in Carcinogenesis of Head and Neck Squamous Cell Rahman, Sukri; Musyarifah, Zulda
Frontiers on Healthcare Research Vol. 1 No. 1 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n1.p12-18.2024

Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) is a malignancy that occur in head and neck region and originates from squamous epithelial cell in the upper respiratory tract mucosa. This malignancy has a high heteregenicity. Carcinogenesis due to HPV infection has a different moleculer pathway from HNSCC without HPV infection. Methods: We searched Pubmed collection for open access and English language articles publish access from years 2016-2022 with keyword HPV, HNSCC and carcinogenesis. Results: We had 16 articles that matched from the keywords. The mechanism of HPV leading carcinogenesis in HNSCC because the HPV has a specific protein that can cause malignant transformation in squamous epithelial cells. The E6 protein inactivates the p53 tumor suppressor gene by activating the ubiquitin ligase E6AP causing degradation of p53. The E7 protein inactivates the pRb (protein retinoblastoma) tumpr suppressor protein by blocking the interaction between pRb and E2F, causing E2F depression. Conclusion: Carcinogenesis and malignant transformation in HNSCC correlated with HPV infection (high risk type) via the E6 and E7 proteins. This combination can causes abnormal cell cycle and leads cells to escape cell cycle control and get a malignant transformation.
Co-Authors Ade Asyari Ade Chandra Ade Chandra Adnani, Syahredi Syaiful Adrian Erindra Afriwardi Afriwardi Ahmad, Baihaqi Al Hafiz Al Hafiz Al Hafiz Al Hafiz Aladin Aladin Almurdi Almurdi Amellya Sucieta Arif Fahmi Arrahman, Salsabilah Astri Sentyaningrum Aswiyanti Asri Aswiyanti Asri Bambang hermani Beni Indra, Beni Bestari J Budiman Bestari Jaka Budiman Bestari Jaka Budiman Cahyono, Arie Cimi Ilmiawati, Cimi Danuwirya, Muhammad Reko Debby Apri Grecwin Debby Apri Grecwin Deddy Saputra Delva Swanda Desmawati Desmawati Dolly Irfandy Effy Huriyati Efrida Efrida Efrida Eka Nofita Elmatris Sy Erlina Rustam Ermayanti, Sabrina Eti Yerizel Eva Decroli Fachzi Fitri Febri Arius Sari Firdawati, Firdawati Fitra Dwita, Lorensia Grecwin, Debby Apri Gusti Revilla Hadjat, Fachri Hafni Bachtiar Hafni Bachtiar Hafni Bachtiar Hakikah, Tika Hanifatryevi Hanifatryevi Hasmiwati Hera Novianti Heru Kurniawan Anwar Kurniawan Anwar Hirowati Ali, Hirowati Histawara Subroto Histawara Subroto I Nyoman Adi Putra Ilmiawati, Ilmiawati Irwan Triansyah Irwandanon Irwandanon Jacky Munilson Jacky Munilson Javandi, Muhammad Rayhan Abiyyu Jenny Tri Yuspita Sari Karsa, Nadya Dwi Khotimah, Rifqoh Lili Irawati Lorensia Fitra Dwita M. Abduh Firdaus M. Adib Farhan Malinda Meinapuri Masnadi, Nice Rachmawati Mayetti Mayetti Megawati, Melsi Melita Husna Melsi Megawati Mohamad Reza Muina Muina Musyarifah, Zulda Nadhifa Naura Reyani Nadya Dwi Karsa Nadya Dwi Karsa Nirza Warto Novialdi . Novianti, Hera Nur Afrainin Syah Nur Indrawaty Lipoeto Nuzulia Irawati Pamelia Mayorita Prima Astuti Handayani Putri Rahmawati Putri, Rahmi Novira Rahmadona Rahmadona Rahman, Rifna Alya Raina Maghri Jodie Restu Susanti Rizanda Machmud Rizki Saputra Rizki Saputra Roslaili Rasyid Rossy Rosalinda Salmiah Agus Sari, Jenny Tri Yuspita Selfi Renita Rusjdi Shofi Faiza Siti Nurhajjah Syahredi Syaiful Adnani Syamel Muhammad Tofrizal Tri Yuspitasari, Jenny Udiana Wahyu Deviantari Widayat Alviandi Yan Edward yandika, kevin rayhan Yayan Akhyar Yenita . Yolanda, Meuthia Yolazenia Yolazenia Yuliarni Syafrita Yusri, Elfira Yuwono Yuwono